Jean-Philippe Chippaux

Jean-Philippe Chippaux
Institute of Research for Development | IRD

About

521
Publications
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10,541
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Publications

Publications (521)
Article
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Snakebite envenomation is a neglected tropical disease that causes over 100,000 deaths each year. The only effective treatment consists of antivenoms derived from animal sera, but these have been deemed with highly variable potency and are usually inaccessible and too costly for victims. The production of antivenoms by venom-independent techniques,...
Article
Résumé Introduction Les morsures de serpents sont mondialement reconnues comme problème de santé publique, accentué par une insuffisance des données épidémiologiques, particulièrement en Afrique subsaharienne, limitant l’organisation de la prise en charge des morsures de serpent en Afrique subsaharienne. Les centres antipoisons (CAP) devraient con...
Article
Full-text available
Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of clinical and biological syndromes including local and systemic bleeding, incoagulability, thrombotic microangiopathy and macrothrombosis. Beyond hemostais disorders, toxins are also involved in the pathogenesis of edema and in most complications such as hypovolemi...
Article
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We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee ( Apis mellifera ) Antivenom (AAV) in a phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20 participants with multiple stings. Participants received 2 to 10 vials of AAV depending on the number of stings they suffe...
Preprint
Full-text available
Safety, optimal minimum dose, and, preliminary effectiveness of a new generation Africanized honeybees ( Apis mellifera ) antivenom (AAV) were evaluated. A phase I/II, multicenter, non- randomized, single-arm clinical trial involving 20 participants showing multiple stings were studied. Participants have received either 2 to 10 vials of AAV based o...
Article
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Background: Acute kidney injury (AKI) is a frequent complication of snakebite envenomation, which is still little known in sub-Saharan Africa. This study aims to describe the clinical, biological and ultrasonographic aspects of AKI following severe snakebite envenomation managed in the intensive care unit. Method: A prospective observational surve...
Article
Context: Heloderma bites are rare and generally mild, but a few cases can be life threatening. Methods: Description of Heloderma bite was searched in medical literature. Discussion: We present a synthesis of clinical and biomedical effects of envenomation by Heloderma sp. based on 22 well identified cases described in medical literature. Three life...
Article
In Mexico, scorpion sting envenomation (SSE) is a significant public health issue that has engaged the attention of health authorities for more than a century. Rigorously characterized today, scorpion sting incidence is stable around 230 stings per 100,000 population, i.e. 300,000 annual stings treated in Mexican health centers and hospitals. Highe...
Article
Snakebite envenomation is a global health crisis and is classified as a Category A neglected tropical disease by the World Health Organization (WHO). Snakebite envenomations account for a significant amount of morbidity and morbidity in tropical and subtropical regions. Recently, publications have illustrated the potential for snake envenomations c...
Article
Background Heloderma bites are rare and generally mild, but a few cases can be life threatening. Case report We report a case of Heloderma suspectum envenomation in a healthy 39-year-old herpetologist. The patient rapidly developed tongue and lip swelling associated with stridor. On arrival at ICU, he was hypotensive, and in shock with atrial fibr...
Article
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Background: Snakebite envenoming (SBE) is an environmental and occupational hazard in Africa and a disease of poverty that is responsible for an estimated 30,000 - 50,000 deaths and 90,000 - 150,000 disabilities and disfigurements every year across the continent. There is little data on the clinical presentation and management of snakebites in sub-...
Article
Background: Snakebite envenoming (SBE) is an environmental and occupational hazard in Africa and a disease of poverty that is responsible for an estimated 30,000 - 50,000 deaths and 90,000 - 150,000 disabilities and disfigurements every year across the continent. There is little data on the clinical presentation and management of snakebites in sub-...
Article
Background: Snakebite envenomation is a global health crisis and is classified as a Category A neglected tropical disease by the World Health Organization. An overwhelming majority of snakebites worldwide occur in remote areas far from equipped medical facilities. Most clinicians that have the opportunity to treat neurotoxic victims are unprepared...
Article
Full-text available
Snakebite is a critical public health issue in tropical countries, particularly in Africa, where 20% of snakebites globally occur. In 2017, the WHO added snakebite envenoming to the category A of neglected tropical diseases. In 2019, thanks to broad institutional and international NGO support, including strong mobilization of African experts and go...
Article
Full-text available
Traditional medicine plays an important role in the daily lives of people living in rural parts of Ethiopia. Despite the fact that Ethiopia has a long history of using traditional medicinal plants as an alternative medicine source, there is no checklist compiling these plants used for snakebite treatment. This review collected and compiled availabl...
Article
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A 20-year-old man presented to a rural hospital in Bembéréké, northern Benin, after a witnessed bite from a small, dark snake to his left foot that occurred 3 hours earlier. The description of the snake was consistent with several neurotoxic elapids known to inhabit the area in addition to various species from at least 10 different genera of non-fr...
Article
The West African carpet viper (Echis ocellatus) causes more deaths than any other snake in sub-Saharan Africa. Carpet viper envenomations are characterized by a venom-induced consumption coagulopathy and systemic bleeding syndrome, in addition to local symptoms of painful progressive swelling and tissue destruction. The highest mortality rate is se...
Poster
Full-text available
Over 600,000 people are killed or maimed by snakebites every year in rural areas of the developing world in austere environments without automated laboratory testing for diagnosis or monitoring of envenomed patients. Venom-induced coagulopathies are one of the most common manifestations of snake envenomation worldwide and occur in over two-thirds o...
Article
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Em 2015 as revistas científicas impressas completaram 350 anos de existência. É fácil compreender que neste longo período de tempo as padronizações de citação (metadados) foram bem estabelecidas. A partir de 1991 Paul Ginsparg lançou nos EUA a primeira revista eletrônica que se tem notícia. Infelizmente até o momento não existe uma padronização def...
Article
There is no reliable estimate of burden of snakebite-envenoming (SBE) in Sub-Saharan Africa (SSA). We derived from a meta-analysis the burden of SBE related deaths, amputations and Post-Traumatic Stress Disorder (PTSD) in 41 countries in SSA. The annual burden was estimated at 1.03 million DALYs (95% Confidence Interval: 0.80–1.28 million DALYs). T...
Article
Background: In Senegal, a sub-Sahara African country, snakebite represents a huge issue now considered as neglected disease. Objective: The purpose of this study was to assess the efficacy and tolerance of Inoserp® Panafrican antivenom in peripheral health structures. Method: A management algorithm defined according to preliminary clinical studies...
Article
Full-text available
Background In central Africa, millions of individuals infected with Loa loa have received the anthelminthic drug ivermectin as part of mass drug administration (MDA) campaigns targeting onchocerciasis control or elimination. Nonetheless, the parasitological surveys which are occasionally conducted to evaluate the impact of ivermectin treatments on...
Article
Background. - In Senegal, a sub-Sahara African country, snakebite represents a huge issue now considered as neglected disease. Objective. - The purpose of this study was to assess the efficacy and tolerance of Inoserp (R) Panafrican antivenom in peripheral health structures. Method. - A management algorithm defined according to preliminary clinical...
Article
Full-text available
The whole blood clotting test (WBCT) is a simple test of coagulation that is often used in the assessment, diagnosis, and therapeutic monitoring of snakebite patients in sub-Saharan Africa. WBCT requires only a clean glass tube and several milliliters of venous blood and is ideal for use in poorly equipped health centers throughout the rural areas...
Article
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Yellow fever was transported during the slave trade in the 15th and 16th centuries from Africa to the Americas where the virus encountered favorable ecological conditions that allowed creation of a sustainable sylvatic cycle. Despite effective vector control and immunization programs for nearly a century, yellow fever epidemics reemerged in many La...
Article
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Atualmente não se questiona mais a substituição do formato impresso pelo eletrônico. Entretanto, no final do século XX esse tema era fonte de debate acalorado entre os editores das revistas cientificas. O objetivo deste trabalho foi mostrar a evolução da primeira revista eletrônica científica brasileira, mantida e editada ininterruptamente desde 19...
Article
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Background Snakebite has only recently been recognized as a neglected tropical disease by the WHO. Knowledge regarding snakebites and its care is poor both at the population level, and at the health care staff level. The goal of this study was to describe the level of knowledge and clinical practice regarding snakebite among health care staff from...
Article
Background: Pregnant women are more susceptible to P. falciparum than before pregnancy, and infection has consequences for both mother and offspring. WHO recommends that pregnant woman in areas of transmission receive intermittent preventive treatment starting in the second trimester. Consequently, women are not protected during the first trimeste...
Article
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O The Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) foi indexado nas bases Web of Science (WoS) e Scopus (Scimago) em 2006. Entre 2007 e 2012 o fator de impacto (FI) estabilizou-se entre 0.30 e 0.55. Para aumentá-lo, em 2013 estabeleceu-se parceria com a BioMed Central-Springer-Nature e uma série de ações foram propos...
Article
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Background Envenomation caused by multiple stings from Africanized honeybees Apis mellifera constitutes a public health problem in the Americas. In 2015, the Brazilian Ministry of Health reported 13,597 accidents (incidence of seven cases per 100,000 inhabitants) with 39 deaths (lethality of 0.25%). The toxins present in the venom, which include me...
Article
Full-text available
On June 9th, 2017 WHO categorized snakebite envenomation into the Category A of the Neglected Tropical Diseases. This new situation will allow access to new funding, paving the way for wider and deeper researches. It should also expand the accessibility of antivenoms. Let us hope that it also leads to cooperation among stakeholders, aiming at impro...
Article
The venom of Crotalus durissus terrificus produces a neurotoxic and myotoxic syndrome that can lead to the death. Specific antivenom is the only treatment to neutralize the toxicity of the venom and the precocity in applying the antivenom is crucial for the efficiency of the treatment. We studied the variation of the immunochemical reactivity and n...
Chapter
In Africa, snakebites are neglected medical and surgical emergencies despite their high incidence and severity. Lacking mandatory reporting, in contrast to most Latin America and Asian countries, there is no official and consolidated epidemiological data. The main consequence is the lack of accurate assessment of therapeutic needs.
Article
Full-text available
Background: Better knowledge of the epidemiological characteristics of snakebites could help to take measures to improve their management. The incidence and mortality of snakebites in the Americas are most often estimated from medical and scientific literature, which generally lack precision and representativeness. Methodology/principal findings:...
Article
Background: The antigen VAR2CSA plays a pivotal role in the pathophysiology of pregnancy-associated malaria (PAM) caused by Plasmodium falciparum. A VAR2CSA-based vaccine candidate, PAMVAC, is under development by an EU-funded multi-country consortium (PlacMalVac project). As part of PAMVAC's clinical development, we quantified naturally acquired...
Chapter
Discovered 120 years ago, passive immunotherapy remains the sole etiological treatment of envenomations, particularly those caused by snakes and scorpions. Antivenoms are composed of immunoglobulins produced by animals immunized against certain venoms. Improvement of antivenoms, most notably by advances in the methods used for immunoglobulin purifi...
Article
Snakebite envenoming has a heavy burden in the public health in sub-Saharan Africa. The viperid species Echis ocellatus (carpet viper or saw-scaled viper) is the medically most important snake in the savannahs of western sub-Saharan Africa. Several antivenoms are being distributed and used in this region for the treatment of envenomings by E. ocell...
Article
Full-text available
Common in the southern and eastern Mediterranean basin, scorpion stings can develop into a severe medical emergency, especially in young children. Here we review several principles of diagnosis and treatment. The indications for antivenom and symptomatic treatment are detailed according to the symptoms and clinical severity of envenomation.
Article
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Background: Snakebite poisoning is a significant medical problem in agricultural societies in Sub Saharan Africa. Antivenom (AV) is the standard treatment, and we assessed the cost-effectiveness of making it available in 16 countries in West Africa. Methods: We determined the cost-effectiveness of AV based on a decision-tree model from a public...
Article
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Background: Snakebite is a common neglected public health issue, especially in poor rural areas of sub-Saharan Africa, Asia and Latin America. Passive immunotherapy with safe and effective antivenom is the only approved treatment for it. This study aimed to determine the incidence of snakebites, and to assess the availability and accessibility of...
Article
Full-text available
Background: Although considered a public health issue in Senegal, the actual incidence and mortality from snakebite are not known. In the present study, an epidemiological survey was carried out in Kédougou region, southeastern Senegal, where envenomations, particularly by Echisocellatus, are frequent and severe. Methods: Three sources of data w...
Article
Full-text available
Background: In Africa, snakebite envenomations are frequently complicated by life-threatening hemorrhagic syndromes. The authors of the present study conducted a prospective analysis at the University Hospital of Parakou (north of Benin) for seven months (January 1 to July 31, 2014) to assess the contribution of ultrasonography to the diagnosis of...
Article
Full-text available
Background Snakebites cause considerable death and injury throughout the globe, particularly in tropical regions, and pose an important yet neglected threat to public health. In 2008, the Centre Anti Poison et de Parmacovigilance du Maroc (CAPM) started to set up a specific strategy for the control of snakebites that was formalized in 2012. The aim...
Article
Full-text available
During the 6(th) International Conference on Envenomation by Snakebites and Scorpion Stings in Africa held in Abidjan, from 1 to 5 June 2015, the measures for the management of envenomation were discussed and new recommendations were adopted by the participants. The high incidence and severity of this affliction were confirmed by several studies co...
Article
Full-text available
Particulièrement fréquentes au sud et à l’est du Bassin méditerranéen, les piqûres de scorpion peuvent constituer une urgence médicale grave, notamment chez le jeune enfant. Nous rappelons ici quelques principes diagnostiques et thérapeutiques. L’indication de l’antivenin et le traitement symptomatique sont précisés en fonction de la symptomatologi...
Chapter
In Africa, snakebites are neglected medical and surgical emergencies despite their high incidence and severity. Lacking mandatory reporting, in contrast to most Latin America and Asian countries, there is no official and consolidated epidemiological data. The main consequence is the lack of accurate assessment of therapeutic needs.
Article
Full-text available
Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-...
Article
Full-text available
Background Envenomation remains a neglected public health issue in most tropical countries. A better understanding of the epidemiology of bites and stings by venomous animals should facilitate their prevention and management. This study aimed to explore the benefits that could be derived from the compulsory notification of cases as it is now routin...
Article
Snakebite envenoming causes a heavy toll in sub-Saharan Africa in terms of mortality and sequelae. In the West African savannah, the viperid Echis ocellatus is responsible for the vast majority of bites. In the last decades, several new antivenoms have been introduced for the treatment of these envenomings, although the assessment of their preclini...
Article
Full-text available
Background: Snakebite envenoming (SBE) is a major problem in rural areas of West Africa (WA). Compared to other Neglected Tropical Diseases (NTD), the public health burden of SBE has not been well characterized. We estimated the impact of snakebite mortality and morbidity using the Disability Adjusted Life Years (DALYs) metrics for 16 countries in...
Article
Full-text available
The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such manifestation in which Pf infected erythrocytes (IE) bind to chondroitin sulphate A (CSA) through expression of VAR2CSA, a parasite-derived antigen. Protection agai...
Article
Although common in sub-Saharan Africa, snakebites remain a neglected topic. The paper reviews some diagnostic and therapeutic rules for this medical and surgical emergency that occurs mainly in remote health centers. Intravenous administration of polyvalent antivenom is the preferred treatment in any proven envenomation. Antivenom should be associa...
Article
Full-text available
The aim of this study was to investigate the seroprevalence of antichikungunya virus (anti-CHIKV) antibodies in pregnant women living in an urban area of Benin (West Africa). Results were obtained by screening sera collected in 2006 and 2007 with enzyme-linked immunosorbent assay (ELISA) for anti-CHIKV immunoglobulin G (IgG) and IgM. Positive resul...
Article
The authors describe a case of perinoscrotal gangrene in a patient who had been bitten by a snake. He was treated with antivenom immunotherapy and surgery. The outcome was good. They present a brief review of the literature regarding the epidemiological, clinical, and treatment issues.