Jean Pettersson

Jean Pettersson
Uppsala University | UU · Department of Chemistry - BMC

About

35
Publications
1,168
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655
Citations

Publications

Publications (35)
Conference Paper
Full-text available
Distribution of Nutritional and Toxic Elements in Traditional and Improved Rice Varieties Found in Sri Lanka: Inductively Coupled Plasma Mass Spectrometric (ICP-MS) and Inductively Coupled Plasma Atomic Emission Spectroscopic (ICP-AES) Study Presenting Author’s Name (K.C.T. Kodikara) Co-Author’s Name/s (S.J.K.A. Ubhayasekera, J. Bergquist, S.P. N...
Article
Neuropathic pain affects 1-10% of the general population and is caused by a lesion or disease of the somatosensory nervous system. Spinal cord stimulation (SCS), a method where implanted electrodes stimulate the spinal cord, has been successfully used to treat drug-resistant neuropathic pain, but the mechanism of action is largely unknown. Studies...
Poster
In 2015 the Swedish National Food Agency performed a survey of inorganic arsenic in rice and rice products available on the Swedish market [1]. In this survey also total arsenic (tAs) was determined together with other toxic and nutritional elements, in total 46 elements, by HR-ICP-MS. The aim is to study the variations in the elemental composition...
Poster
Aim of the study To investigate possible differences in the concentration of toxic elements (Cd, Pb, As) and some nutrients (Fe, Se, Mo) in pasta products on the Swedish market for improving estimations of the daily intake for Swedish citizens. Results Detectable amounts of all the elements As, Cd, Pb, Mo, Se and Fe were found in all pasta product...
Article
A method for the detection and speciation of inositol phosphates (InsPn) in sediment samples was tested, utilizing oxalate/oxalic acid extraction followed by determination by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) using electrospray ionization (ESI) in negative mode. The chromatographic separation...
Article
Perfusion assessment by monitoring the transport of a tracer bolus depends critically on conversion of signal intensity into tracer concentration. Two main assumptions are generally applied for this conversion; (1) contrast agent relaxivity is identical in blood and tissue, (2) change in signal intensity depends only on the primary relaxation effec...
Article
In an intercomparison study three low alloy steel materials were analyzed on their content of the trace element Mg, and five different analytical techniques were used, namely spark-OES, inductively coupled plasma optical emission spectrometry (ICP-OES), inductively coupled plasma time of flight mass spectrometry (ICP-TOFMS), inductively coupled pla...
Article
A fast method for direct multi-element analysis of non-digested biological samples is presented. The only sample preparation needed is 1 min homogenization with a Polytron mixer in a small volume of neutral phosphate buffer saline solution (PBS). The total time for analysis (sample preparation and measurement) is 4 min only. This "mix and measure"...
Article
Column-switching liquid chromatography followed by low resolution ICP-MS was evaluated as a tool for speciation analysis of aluminium-containing biomolecules. The strategy was applied on siderophores, small organic molecules (Mr < 1500) which normally act as strong iron chelators. The drawbacks normally encounterd with aluminium detection using low...
Article
The extent and the causes of the reduction in boron signal by organic modifiers typically used in liquid chromatography inductively coupled plasma mass spectrometry (LC-ICP-MS) have been investigated. Three boron containing compounds in three organic solvents were analysed with both ICP-MS and ICP-AES to distinguish between ion effects in the inter...
Article
Electrochemically controlled solid-phase extractions of anions were interfaced on-line to electrospray mass spectrometry (ESI-MS) and inductively coupled plasma mass spectrometry (ICP-MS), using polypyrrole coated electrodes and a thin-layer electrochemical (EC) flow cell. The results indicate that electrochemically controlled solid-phase extractio...
Article
Column-switching liquid chromatography followed by low-resolution ICPMS was evaluated as a tool for speciation analysis of metal-containing biomolecules. The strategy was applied on siderophores, strong iron chelators of low molecular weight (M(w) < 1500). Prior to the LC-ICPMS analysis, reductive displacement of iron by gallium was performed using...
Article
The necessity of using coupled techniques to analyze samples from boron neutron capture therapy (BNCT) patients prior to element-specific detection has been demonstrated. BNCT patients were infused with p-boronophenylalanine (BPA)-fructose complex before the therapy started. Urine and blood plasma samples were collected at different times after the...
Article
A method for the extraction, transfer and desorption of anions and cations under controlled potential conditions employing a new integrated three-electrode device is described. The device, containing working, reference and counter electrodes, was prepared from tubes that could be moved vertically with respect to each other. In this way, a small amo...
Article
An inductively coupled plasma atomic emission spectrometer (ICP-AES) and an ICP-time-of-flight mass spectrometer (ICP-TOF-MS) have been investigated in terms of their generic behaviour, i.e. if their responses can be considered as structure independent or not in the simple matrices prevailing during, e.g., a liquid chromatographic (LC) run. The sig...
Article
The processes that cause the failure of sheathless electrospray ionization (ESI) emitters, based on different kinds of gold coatings on fused-silica capillaries, are described and explained. The methods chosen for this study include electrochemical methods, ICPMS analysis of the electrolytes used, SEM studies, and electrospray experiments. Generall...
Article
Five boronated DNA-intercalating compounds [5-ortho-carboranyl phenanthridinium (5-o-CP), 5-para-carboranyl phenanthridinium (5-p-CP), 6-para-carboranyl phenanthridinium, water-soluble boronated phenanthridinium and water-soluble boronated acridine (WSA1)], primarily developed for boron neutron capture therapy (BNCT), were analysed regarding their...
Article
Full-text available
Silver is accumulated to high concentrations in certain microbial strains. Here a bomb digestion method is proposed, using HNO3 and HCl, for the extraction and digestion of silver and silver compounds from the organic matrix. The method is applicable for the quantitative determination of silver by inductively coupled plasma atomic emission spectros...
Article
Full-text available
The spontaneous degradation of racemic o-carboranylalanine [3-(1,2-dicarbacloso-dodecaboran(12)-1-yl)-2-aminopropanoic acid], a carborane analogue of the amino acid phenylalanine, to the corresponding diastereomeric, racemic pairs of nido-carboranylalanine [containing the dodecahydro-7,8-dicarba-nido-un-decaborate (-1) cage] has been studied in buf...
Article
To study the uptake, toxicity and radiation effects in vitro of a diol-amino acid-carborane (DAAC-1) and make comparisons with the previously studied diol-amine-carborane (DAC-1). Toxicity and radiation effects were studied with clonogenic survival, uptake by measuring the cellular boron content and the subcellular distribution was investigated aft...
Article
In boron neutron capture therapy (BNCT), 10B is delivered selectively to the tumour cells and the nuclide then forms high-LET radiation (4He2+ and 7Li3+) upon neutron capture. Today much research is focused on development of a variety of boron compounds aimed for BNCT. The compounds must be thoroughly analysed in preclinical tests regarding basic c...
Chapter
The amount of boron needed for successful treatment of tumour cells has been calculated to be about 109 10B-atoms when the boron is in the cytoplasm or 108 10B-atoms when located in the cell nucleus.1,2 An amount of 108 10B-atoms in the cell nucleus gives a boron dependent dose of about 2 Gy high-LET irradiation if a reasonable thermal neutron flue...
Article
The toxicity and binding of the three new carborane based compounds: 2 (1,2-dicarba-closo-dodecaborane (12)-1(-yl-methoxy)-2-(3-amino-propyl))-1,3-propanediol, called DAC-1; 7-(3-amino-propyl)-7,8-dicarba-nido-undecarborate (-1) called ANC-1; and rac-1-(9-o-carboranyl)-nonyl-2-methyl-glycero-3- phosphocholine, called B-Et-11-OMe, were analyzed with...
Article
A cold trap system for the determination of selenium by hydride generation-atomic absorption spectrometry (HG-AAS) is described. For a 30-ml sample the limit of detection is <2 ng/l. and the precision is better than 4% at the 30 ng/l. level. A number of digestion procedures for the destruction of organic matter prior to the determination of total d...
Article
The reduction of selenium(VI) to selenium(IV) in 4, 5 and 6M hydrochloric acid was studied at temperatures between 50 and 95 degrees . The reaction rate was determined by measurement of the selenium(IV) formed, by continuous-flow hydride-generation atomic-absorption spectrometry. The most notable feature of the reaction is the strong increase in ra...
Article
The rate of the reaction between iodide and selenium(IV) at trace levels to form selenium and iodine has been determined in 1-6M hydrochloric acid. The reaction rate increases rapidly with acidity. When hydrochloric acid is added to reduce selenate to selenite prior to the determination of total selenium, some selenium may be lost by reduction to t...
Article
The concentration and oxidation state of selenium have been determined in fly ash, flue gas cooler condensate, and sludge from the refuse incinerator in Uppsala, Sweden. Analytical procedures were developed for selenium determinations, using hydride generation atomic absorption spectrometry (HG-AAS) and X-ray fluorescence spectrometry (XRFS). Both...
Article
Selenium was determined in freeze-dried fish flesh from perch, pike-perch and the fish flesh reference materials MA-A-2 No. 1174 and MA-B-3 No. 151 (both from the International Atomic Energy Agency) by hydride generation atomic absorption spectrometry. Four different decomposition procedures were tested. They yielded consistent results for the four...
Article
Full-text available
We separated blood from five healthy blood donors into plasma, erythrocytes, platelets, and leukocytes; counted the number of cells in each fraction; and determined the selenium content of each component by hydride generation atomic absorption spectrometry. The mean (+/- SD) selenium concentrations and amounts measured were as follows: whole blood...
Article
Full-text available
A digestion procedure involving nitric acid, magnesium nitrate hexahydrate, and hydrochloric acid suffices for selenium determinations in whole blood, serum, and urine by molecular fluorescence spectrometry. To test the accuracy of the method we compared the results with those from hydride-generation atomic absorption spectrometry, and we also anal...
Article
Two digestion procedures have been tested on samples of flour, blood and urine for application in the determination of selenium by hydride-generation atomic-absorption spectrometry. The first utilizes a mixture of concentrated nitric, perchloric and sulphuric acids and the second a mixture of magnesium nitrate hexahydrate, concentrated nitric acid...
Article
A flow system for hydride generation and atomic-absorption spectrometry is described, and the results from the optimization of the equipment for selenium determination are reported. For a sample volume of 0.6 ml the limit of detection for selenium was 0.1 mug l . and the imprecision less than 1% RSD at the 10-mug l . level. Four digestion procedure...

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