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Guinea pigs are used as models for study of ventricular tachyarrhythmias (VT); however, the tachyarrhythmia often is transient and does not persist. We developed an open-thorax guinea pig model of sustained ventricular fibrillation (VF). Bilateral thoracotomy was performed on eight guinea pigs weighing 865 to 1,464 g, and two sutures were positione...
Guinea pigs are frequently used as models for ventricular tachyarrhythmias, including polymorphic ventricular tachycardia (VT) and ventricular fibrillation. However, applications of the model for short-term therapies are limited because the arrhythmias are transient, typically lasting <5 sec. Thus, spontaneous termination cannot be easily distingui...
Guinea pigs are frequently used as models for ventricular tachyarrhythmias, including polymorphic ventricular tachycardia and ventricular fibrillation. However, applications of the model for the development of new cardioversion and defibrillation technology are limited because the arrhythmias typically last less than five seconds. This study demons...
Normal adult Dirofilaria immitis from a microfilaremic donor dog and D. immitis from donors rendered microfilaria (MF) negative by seven consecutive monthly doses of milbemycin oxime (500 micrograms/kg) were transplanted into three previously uninfected and untreated dogs. Two dogs received reciprocal combinations of treated and untreated D. immiti...