Jean Baptiste NgilirabangaUniversity of the Western Cape | uwc · School of Pharmacy
Jean Baptiste Ngilirabanga
Doctor of Philosophy (Pharmaceutical Sciences)
About
9
Publications
1,138
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
137
Citations
Citations since 2017
Introduction
Additional affiliations
April 2015 - present
Position
- PhD Student
Description
- 1. Solid-state and solution-based synthesis of supramolecular systems such as pharmaceutical co-crystals, amorphous forms, solvates and binary eutectics. 2. Characterisation of these using Analytical instruments such as DSC, HSM, TGA, FT-IR and Raman spectroscopy, Scanning electron Microscopy, X-ray diffraction and HPLC method development and validation. 3. In-vitro solubility and dissolution rate Evaluation 4. Quality ensuring of various pharmaceutics formulations
Education
May 2015 - December 2020
University o the western cape
Field of study
- Non-covalent synthesis of multidrug combinations derivative of anti HIV and anti-TB drugs
February 2012 - November 2014
Field of study
- Solid-state and solution based synthesis, characterisation of different self-assembly molecular systems and polymorphism investigation
Publications
Publications (9)
Objective
In the present work, solid-state co-grinding also known as mechanochemistry is employed to investigate the co-crystal formation between two HIV nucleoside reverse transcriptase inhibitors lamivudine (3TC) and zidovudine (AZT).
Methods
Thermal analyses by DSC, HSM, and TGA provided thermodynamic parameters of the samples over the heating...
The conventional approach in the tablet formulation of acetaminophen (ACM) suggests the use of five or more different excipients in a wet granulation tableting process. The use of many excipients in tablet formulation may negatively create excipient-excipient interactions, excipient-drug interactions, exaggerated product side effects, and high drug...
A growing number of co‐crystals in the literature are proof of how significant the co‐crystallization concept has become. Co‐crystallization enhances physicochemical properties through the formation of intermolecular interactions between a drug and a co‐former. A co‐crystal is a single crystalline material consisting of at least two molecular compo...
The present work reports two novel pharmaceutical co-crystals; 2:1 isoniazid-glutaric acid (INHGA) and 2:1 pyrazinamide-glutaric acid (PGA). Isoniazid and pyrazinamide are key first-line drugs used for the treatment of tuberculosis. The co-crystals were produced via solid-state and solvent assisted grinding methods. Thermal characteristics of the s...
Two pharmaceutical solid state co-crystals EFZA and NEF of two non-nucleoside reverse transcriptase inhibitors (efavirenz, EFV and nevirapine, NVP) and a nucleoside reverse transcriptase inhibitor, zidovudine (AZT) were prepared. Currently, these drugs are essential in various front-line HIV treatment regimens due to their potential in the manageme...
Copper oxide nanoparticles were successfully synthesised via cost effective approach using aqueous extracts obtained from red flowers of Euphorbia pulcherrima. Green precipitates were obtained post-drying which were thermally oxidised to pure single phase monoclinic CuO at 500 °C as per the XRD analysis. Further characterization of un-annealed and...
This work reports for the first time the possibility of green synthesis and the antibacterial effect of silver nanoparticles (AgNPs) on commercialized polycarbonate membrane. The AgNPs were loaded on the polycarbonate membrane serving as the substrate via ultra-sonication and centrifugation. The extracts from the red flowers of Callistemon viminali...
