Jean Lesage

Jean Lesage
Université de Lille · Department of Biology

Prof

About

115
Publications
13,206
Reads
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4,540
Citations
Citations since 2016
30 Research Items
2002 Citations
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2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
Introduction
Developmental physiology, endocrinology, stress axis, perinatal physiology, fetal development, rodents, human
Additional affiliations
January 1998 - January 2015
University of Lille Nord de France
Position
  • Professor (Full)
Description
  • Developmental endocrinology and physiology, stress neuroendocrine axis, placental physiology, fetal development, rodents, human

Publications

Publications (115)
Article
The APJ receptor and its two endogenous ligands, apelin and elabela, exert key roles in fetoplacental development. In adult, this system is altered by obesity but no data are available during pregnancy. We measured apelin and elabela levels in maternal plasma and cord blood and quantified placental gene expression of apelin, elabela and APJ in obes...
Article
Full-text available
Preterm infants are highly susceptible to oxidative stress due to an imbalance between endogenous oxidant and antioxidant systems. In addition, these newborns are frequently fed with donor milk (DM) treated by Holder pasteurization (HoP) at 62.5 °C for 30 min, which is known to alter numerous heat-sensitive factors, including some antioxidants. Hig...
Article
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(1) Background: Type 2 diabetes (T2D) is associated with a duodenal hypermotility in postprandial conditions that favors hyperglycemia and insulin resistance via the gut-brain axis. Enterosynes, molecules produced within the gut with effects on the enteric nervous system, have been recently discovered and pointed to as potential key modulators of t...
Article
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Several studies have demonstrated that high protein diets improve glucose homeostasis. Nevertheless, the mechanisms underlying this effect remain elusive. This exploratory study aims to screen and compare the acute effects of dietary proteins from different sources on intestinal glucose absorption. Six dietary proteins from various sources were thu...
Article
Full-text available
Background: High hydrostatic pressure (HHP) processing is a non-thermal method proposed as an alternative to Holder pasteurization (HoP) for the sterilization of human breast milk (BM). HHP preserves numerous milk bioactive factors that are degraded by HoP, but no data are available for milk apelin and glucagon-like peptide 1 (GLP-1), two hormones...
Article
In human milk banks (HMBs), donor milk (DM) is commonly sterilized by Holder pasteurization (HoP). High hydrostatic pressure (HHP) processing is an innovative, alternative method for DM sterilization. We evaluated the impact of HHP processing on the concentration of seven metabolic milk hormones. Eight samples of raw DM were aliquoted. One aliquot...
Article
Full-text available
Background & Aims High hydrostatic pressure (HHP) processing is a non-thermal method proposed as an alternative to Holder pasteurization (HoP) for the treatment of human milk. HHP preserves numerous milk bioactive components that are degraded by HoP, but no data are available for milk oligosaccharides (HMOs) or the formation of Maillard reaction pr...
Article
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Objective Recent evidence indicates that levels of breast milk (BM) hormones such as leptin can fluctuate with maternal adiposity, suggesting that BM hormones may signal maternal metabolic and nutritional environments to offspring during postnatal development. The hormone apelin is highly abundant in BM but its regulation during lactation is comple...
Article
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Objective: The enteric nervous system (ENS) plays a key role in controlling the gut-brain axis under normal and pathological conditions, such as type 2 diabetes. The discovery of intestinal actors, such as enterosynes, able to modulate the ENS-induced duodenal contraction is considered an innovative approach. Among all the intestinal factors, the...
Article
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Despite constant research and public policy efforts, the obesity epidemic continues to be a major public health threat, and new approaches are urgently needed. It has been shown that nutrient imbalance in early life, from conception to infancy, influences later obesity risk, suggesting that obesity could result from “developmental programming”. In...
Article
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Objective: The lactation-suckling period is critical for white adipose tissue (WAT) development. Early postnatal nutrition influences later obesity risk but underlying mechanisms remain elusive. Here, we tested whether altered postnatal nutrition specifically during suckling impacts epigenetic regulation of key metabolic genes in WAT and alter lon...
Article
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Clinical and animal studies have reported an association between low birth weight and the development of non-alcoholic fatty liver disease (NAFLD) in offspring. Using a model of prenatal maternal 70% food restriction diet (FR30) in rat, we previously showed that maternal undernutrition predisposes offspring to altered lipid metabolism in adipose ti...
Article
Pregnancy is a dynamic and precisely organized process during which one or more baby develops. Embryonic development relies on the formation of the placenta, allowing nutrient and oxygen exchange between the mother and the fetus. Dysfunction of placental formation lead to pregnancy disorders such as preeclampsia (PE) with serious deleterious conseq...
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Background Extraintestinal manifestations (EIM) have been associated with more severe course of inflammatory bowel disease. The aim was to study the frequency of EIM in pediatric- and elderly-onset Crohn′s disease (CD) and the factors associated with EIM and their impact on long-term disease outcome. Methods Pediatric- (age at diagnosis younger th...
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A qualitative study is presented, where the main question was whether food-derived hemorphins, i.e., originating from digested alimentary hemoglobin, could pass the intestinal barrier and/or the blood–brain barrier (BBB). Once absorbed, hemorphins are opioid receptor (OR) ligands that may interact with peripheral and central OR and have effects on...
Article
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According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and accelerated growth in neonates program obesity later in life. White adipose tissue (WAT) has been the focus of developmental programming events, although underlying mechanisms remain elusive. In rodents, WAT development primarily occurs during lactatio...
Article
Food-derived hemorphins were studied for their interactions with intestinal cells in relation to food intake regulations. LLVV-H4, LVV-H4, VV-H4, VV-H7 and H7 were identified in the 2 h-intestinal hydrolysate of haemoglobin simulated gastrointestinal digestion and synthesised. These food-derived hemorphins showed secretagogue properties of the anor...
Article
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Objectives: Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period. Methods: Pediatric-onset IBD (<17 years) was issued from a populatio...
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Objective According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and accelerated growth in neonates predispose offspring to white adipose tissue (WAT) accumulation. In rodents, adipogenesis mainly develops during lactation. The mechanisms underlying the phenomenon known as developmental programming remain elus...
Article
Based on the Developmental Origin of Health and Disease concept, maternal undernutrition has been shown to sensitize adult offspring to metabolic pathologies such as obesity. Using a model of maternal 70% food restriction in pregnant female rats throughout gestation (called FR30), we previously reported that obesity-prone adult male rat offspring d...
Article
Introduction et but de l’étude Le concept de l’origine développementale de la santé et des maladies (DOHaD) stipule qu’un environnement périnatal délétère prédispose la descendance à l’apparition de troubles métaboliques. En particulier, l’obésité maternelle, la surnutrition des nouveau-nés et la croissance postnatale accélérée sensibilisent la des...
Article
Full-text available
Apelin is a bioactive peptide involved in the control of energy metabolism. In the hypothalamus, chronic exposure to high levels of apelin is associated with an increase in hepatic glucose production, and then contributes to the onset of type 2 diabetes. However, the molecular mechanisms behind deleterious effects of chronic apelin in the brain and...
Conference Paper
Full-text available
Food intake regulation relies on appetite modulation which lies on the brain-gut axis. Short and long-term signals are sent from stomach, upper and lower intestine in response to nutrients activating neuronal, hormonal and metabolic pathways. Dietary proteins already gave evidence to generate a strong satiety feeling when entering the GI tract by s...
Article
According to the Developmental Origin of Health and Disease (DOHaD) concept, alterations of nutrient supply in the fetus or neonate result in long-term programming of individual body weight set-point. In particular, maternal obesity, excessive nutrition and accelerated growth in neonates have been shown to sensitize offspring to obesity. The white...
Article
Apelin and its receptor APJ have been implicated in pathologies including cardiovascular disease, diabetes and obesity. Little is known about the function of the apelinergic system during gestation. We evaluated in mice this system at the feto-maternal interface in insulin-resistant obese female (HF) mice. Maternal apelinemia was decreased at term...
Article
The nutritional imprinting, whose mechanisms remain still dark and which seem to continue through the following generations, highlight the key-role of the inadequacy between the pre-and postnatal nutritional environment and the programming of the obesity. © 2016 médecine/sciences – Inserm.
Article
Full-text available
The adequate control of glucose homeostasis during both gestation and early postnatal life is crucial for the development of the fetoplacental unit and adaptive physiological responses at birth. Growing evidences indicate that apelin and its receptor APJ, which are expressed across a wide range of tissues, exert important roles in glucose homeostas...
Article
The aim of the present study is to investigate how peptides released by gastrointestinal (GI) digestion of one dietary protein can interact with regulating processes of food intake. An in vitro GI digestion of bovine haemoglobin was carried out and the bioactivity of the digests on CCK and GLP-1 secretion and dipeptidyl peptidase IV (DPP-IV) activi...
Article
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Significance Epidermis, the outer layer of skin, is a protective barrier and a sensing interface. Although deviation of the ambient temperature is one of the most ubiquitous stimuli affecting the skin, the influence of mild cold on epidermal homeostasis is not well understood. Using a large range of techniques, we identified a novel mild-cold senso...
Article
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A close link between intrauterine growth restriction (IUGR) and development of chronic adult diseases such as obesity, diabetes and hypertension has been established both in humans and animals. Modification of growth velocity during early postnatal period (i.e. lactation) may also sensitize to the development of metabolic syndrome in adulthood. Thi...
Data
Full-text available
Undernutrition exposure during the perinatal period reduces the growth kinetic of the offspring and sensitizes it to the development of chronic adult metabolic diseases both in animals and in humans. Previous studies have demonstrated that a 50% maternal food restriction performed during the last week of gestation and during lactation has both shor...
Article
Full-text available
Aims: We have previously demonstrated that central apelin is implicated in the control of peripheral glycemia, and its action depends on nutritional (fast versus fed) and physiological (normal versus diabetic) states. Intracerebroventricular (icv) injection of a high-dose of apelin, similar to that observed in obese/diabetic mice, increase fasted g...
Article
Full-text available
Aims: We have previously demonstrated that central apelin is implicated in the control of peripheral glycemia, and its action depends on nutritional (fast versus fed) and physiological (normal versus diabetic) states. An intracerebroventricular (icv) injection of a high dose of apelin, similar to that observed in obese/diabetic mice, increase fast...
Article
Epidemiological studies demonstrated that adverse environmental factors leading to intrauterine growth retardation (IUGR) and low birth weight may predispose individuals to increased risk of metabolic syndrome. In rats, we previously demonstrated that adult male IUGR offspring from prenatal 70% food-restricted dams throughout gestation (FR30) were...
Article
Full-text available
Genetic variants in the FTO (fat mass- and obesity-associated) gene have the highest association of all obesity-associated genes. Its placental expression was shown to relate to birth weight, suggesting that it may participate in the control of fetal weight gain. To gain more insight into the implication of FTO in fetal growth, we measured its plac...
Article
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Males and females responses to gestational overnutrition set the stage for subsequent sex-specific differences in adult onset non communicable diseases. Placenta, as a widely recognized programming agent, contibutes to the underlying processes. According to our previous findings, a high-fat diet during gestation triggers sex-specific epigenetic alt...
Data
Histograms of epigenetic machinery expression levels in microarrays and RT-qPCR. Line indicates statistical significance and the number refers to log2 fold change. (PDF)
Data
Full-text available
Analysis of E15.5 placental structure. on HE-stained paraffin sections, of the placental layers in female and males (F or M) from mother fed a control (CD) or high-fat (HFD) diet. (A) Details of the labyrinth layer. (B) Details of the junctional zone. Scale bars indicate 200 µm. (C) Measurement of the area and shape of the labyrinth and total place...
Data
Limma tables for the 4 comparisons (F HFD vs CD, M HFD vs CD, CD F vs M, HFD F vs M). Excel file. (XLS)
Article
Full-text available
Low birth weight is associated with an increased risk to develop type 2 diabetes and metabolic diseases. The placental capacity to supply nutrients and oxygen to the fetus represents the main determiner of fetal growth. However, few studies have investigated the effects of maternal diet on the placenta. We explored placental adaptive proteomic proc...
Article
Numerous data indicate that Rho kinase inhibitors, such as Fasudil, may constitute a novel therapy for cardiovascular and metabolic diseases. We evaluated long-term effects of exposure to Fasudil during late gestation (10 mg/day) in male rat offspring from birth until 9 months. We also analyzed its effects in offspring from hypertensive mothers tre...
Article
Full-text available
Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function of some of these selenium-contai...
Article
Full-text available
Several studies have shown that maternal undernutrition leading to low birth weight predisposes offspring to the development of metabolic pathologies such as obesity. Using a model of prenatal maternal 70% food restriction diet (FR30) in rat, we evaluated whether postweaning high-fat (HF) diet would amplify the phenotype observed under standard die...
Article
Full-text available
An association is established between schizophrenia and the development of metabolic alterations including cardiovascular diseases, type 2 diabetes and obesity. Perinatal insults, such as undernutrition, have been shown to increase the propensity to develop these pathologies, reinforcing the idea that schizophrenia may have a neurodevelopmental ori...
Article
Epidemiological and experimental data indicate that maternal undernutrition may sensitize the offspring to the apparition of chronic diseases such as metabolic syndrome and schizophrenia, suggesting that these pathologies may have a developmental origin. To test this hypothesis, we have compared the effects of a 4 weeks treatment of clozapine (30 m...
Conference Paper
In addition to unhealthy diets, poor exercise during adulthood and genetic background, additional factors have been shown to contribute to the development of diet-related diseases (1). Among these, the 'Developmental Origins of Adult Health and Disease' (DOHaD) concept proposes that environmental conditions during mammalian development can have las...