Jean Golding

Jean Golding
University of Bristol | UB · Centre for Child and Adolescent Health

About

673
Publications
79,461
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43,405
Citations
Citations since 2016
124 Research Items
16447 Citations
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201620172018201920202021202205001,0001,5002,0002,500
201620172018201920202021202205001,0001,5002,0002,500

Publications

Publications (673)
Article
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective birth cohort, based in and around Bristol, UK, established to explore genetic and environmental factors impacting health and development. 14,541 pregnancies were initially recruited from 20,248 eligible pregnancies. As the G1 offspring turned 7 years of age, children from...
Article
Within the ALSPAC (Avon Longitudinal Study of Parents and Children) resource, information concerning the health of the mother during pregnancy is available from three sources: (i) computerised data collected by midwives after the birth of the baby, known as the STORK database; (ii) data abstracted by ALSPAC staff from detailed medical obstetric rec...
Article
Background: Early life environmental health exposures related to housing can have a significant impact on an individual’s physical and mental health and physical development. Housing exposures can fall into two main areas – a representation of social circumstances and physical conditions. Methods: During pregnancy and post-delivery, self-completion...
Article
There are few studies that chart the ways in which the religious beliefs and practices of parents and their offspring vary over time. Even fewer can relate this to aspects of their physical and mental health or distinguish the different facets of the environment that may have influenced the development or loss of religious/spiritual belief and beha...
Article
Background : Research in non-genetic inheritance indicates that grandparents’ smoking habits and their childhood experiences of trauma can influence the physical and psychological attributes of their grandchildren. This was particularly apparent for outcomes such as autism and obesity where the population prevalence changed over time. Other factors...
Preprint
Longitudinal data on religious/spiritual beliefs and behaviours (RSBB) are essential for understanding both how religion shapes our lives and the factors determining religiosity. Despite this importance, there are few longitudinal studies with detailed and repeated RSBB data. Using data spanning nearly 30 years from the parental generation of the A...
Article
Background: Previous studies using the Avon Longitudinal Study of Parents and Children (ALSPAC) have shown that if men commenced smoking prior to the onset of puberty their sons, their granddaughters and great-granddaughters were more likely to have excess fat (but not lean) mass during childhood, adolescence and early adulthood. In this study we a...
Preprint
Full-text available
Background: This study explores whether differences in religious/spiritual beliefs and behaviours (RSBB) are associated with dietary patterns in the parental generation of the Avon Longitudinal Study of Parents and Children (ALSPAC).Methods: 13,689 enrolled mothers and their associated partners from a prospective cohort study (ALSPAC) in Southwest...
Article
Within the ALSPAC (Avon Longitudinal Study of Parents and Children) resource, information concerning the health of the mother during pregnancy is available from three sources: (i) computerised data collected by midwives after the delivery of the baby, known as the STORK database; (ii) data abstracted by ALSPAC staff from detailed medical obstetric...
Article
Full-text available
Background : We explored associations between possible demographic and socioeconomic causes of religious/spiritual beliefs and behaviours (RSBB) in the parental generation of the Avon Longitudinal Study of Parents and Children (ALSPAC). Methods: We used a prospective birth cohort study (ALSPAC) in Southwest England with 14,157 enrolled mothers and...
Article
Health advice to pregnant women concerning consumption of mercury-containing foods has resulted in anxiety, with subsequent avoidance of fish consumption during pregnancy. However, seafood contains many nutrients crucial for children's growth and development. Longitudinal studies in the Seychelles, where fish is a major component of the diet, have...
Preprint
Full-text available
Our previous studies using the Avon Longitudinal Study of Parents and Children (ALSPAC) have shown that if men started smoking before the onset of puberty their sons, their granddaughters and great-granddaughters were more likely to have excess fat mass during childhood, adolescence and early adulthood. Here we assess associations between ancestral...
Article
Full-text available
The idea that information can be transmitted to subsequent generation(s) by epigenetic means has been studied for decades but remains controversial in humans. Epidemiological studies have established that grandparental exposures are associated with health outcomes in their grandchildren, often with sex-specific effects; however, the mechanism of tr...
Article
Full-text available
Although there are many examples in the experimental literature of an environmental exposure in one generation impacting on the phenotypes of subsequent generations, there are few studies that can assess whether such associations occur in humans. The Avon Longitudinal Study of Parents and Children (ALSPAC) has, however, been able to determine wheth...
Article
Full-text available
Previously, using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) we showed that sons of fathers who had started smoking regularly before puberty (< 13 years) had increased fat mass during childhood, adolescence, and early adulthood. We now show that if the paternal grandfather had started smoking pre-puberty, compared with l...
Article
In a previous Data Note, we outlined the data obtained from clinical obstetric records concerning many details of the pregnancies resulting in the births of the children in the Avon Longitudinal Study of Parents and Children (ALSPAC). Here we describe the data that have been abstracted from medical records concerning the fetus and neonate. Full det...
Preprint
The prevalence of religious belief has fallen dramatically. A possible reason is that environmental exposures to previous generations are involved, e.g., evidence of an association between childhood exposures of grandparents and outcomes in their grandchildren including obesity, autistic traits, and survival have been reported. Generally, the assoc...
Article
Background Previous epidemiological studies have found positive associations between maternal infections and childhood leukaemia; however, evidence from prospective cohort studies is scarce. We aimed to examine the associations using large-scale prospective data. Methods Data were pooled from six population-based birth cohorts in Australia, Denmar...
Article
Religious/spiritual belief and practices have sometimes been demonstrated to have positive associations with outcomes such as coping with serious illness, anxiety, depression, negative life events and general well-being, and therefore warrants consideration in many facets of health research. For example, increasing secularisation evidenced, particu...
Article
There are few studies that chart the ways in which the religious beliefs and practices of parents and their offspring vary over time. Even fewer can relate this to aspects of their physical and mental health or distinguish the different facets of the environment that may have influenced the development or loss of religious/spiritual belief and beha...
Article
Full-text available
The adverse effects on the child of maternal smoking in pregnancy is well-recognised, but little research has been carried out on the possible non-genetic effects of ancestral smoking prior to the pregnancy including parental initiation of cigarette smoking in their own childhoods or a grandmother smoking during pregnancy. Here we summarise the stu...
Article
Full-text available
The FRAXE section of the FMR2 gene, located on the X chromosome, contains varying numbers of trinucleotide repeats; boys with over 200 repeats tend to have mild cognitive impairments, though this is rare. Little is known, however, concerning the phenotypes of individuals with smaller numbers of repeats. Here we answer the research question as to wh...
Article
Background: There is evidence that childhood stresses or traumas influence individuals’ descendants’ health and wellbeing through epigenetic mechanisms. However, few longitudinal studies have details of such ancestral data. Methods: Nearly 7,000 parents of the original Avon Longitudinal Study of Parents and Children (ALSPAC) cohort completed questi...
Article
Background . Despite convincing animal experiments demonstrating the potential for environmental exposures in one generation to have demonstrable effects generations later, there have been few relevant human studies. Those that have been undertaken have demonstrated associations, for example, between exposures such as nutrition and cigarette smokin...
Article
Background: Lead is a neurotoxic metal that crosses the placenta freely. It has adverse effects on a range of birth outcomes. The few studies reporting on the associations of prenatal exposure to lead and child growth have had conflicting results. This study aimed to examine the effect of prenatal exposure to lead on children’s growth from 4 to 61...
Article
Background: When the Avon Longitudinal Study of Parents and Children (ALSPAC) was planned, it was assumed that the clinical obstetric data would be easily accessible from the newly developed National Health Service computerised ‘STORK’ system. Pilot studies, however, showed that, although fairly accurate in regard to aspects of labour and delivery,...
Article
Full-text available
Background: The concept of locus of control of reinforcement was introduced by Julian Rotter and has been the focus of intense research for nearly half a century. Surprisingly little research has been directed at clarifying antecedents of locus of control (LOC) orientations in adult men apart from a few small studies. We previously identified a num...
Article
Full-text available
Deficiencies of many nutrients in pregnancy have adverse effects on fetal brain development with consequent impaired cognitive function in childhood. However, it is unclear whether deficiencies of vitamin B12 prenatally are harmful to the developing fetus. We therefore used the Avon Longitudinal Study of Parents and Children to test the hypothesis...
Article
Background: Lead is a neurotoxic metal that crosses the placenta freely. It has adverse effects on a range of birth outcomes. The few studies reporting on the associations of prenatal exposure to lead and child growth have had conflicting results. This study aimed to examine the effect of low-level prenatal exposure to lead on children’s growth fro...
Article
Enrolling a cohort in pregnancy can be methodologically difficult in terms of structuring data collection. For example, some exposures of interest may be time-critical while other (often retrospective) data can be collected at any point during pregnancy. The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prime example of a cohort whe...
Article
Full-text available
Congenital anomalies (CAs) are structural or functional disorders that occur during intrauterine life. Longitudinal cohort studies provide unique opportunities to investigate potential causes and consequences of these disorders. In this data note, we describe how we identified cases of major CAs, with a specific focus on congenital heart diseases (...
Article
Full-text available
This data note describes the linked antenatal and delivery records of the mothers and index children of the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort study. These records were extracted from the computerised maternity record system ‘STORK’ used by the two largest NHS trusts in the study catchment area. The STORK database...
Article
Background: Cohort studies tend to be designed to look forward from the time of enrolment of the participants, but there is considerable evidence that the previous generations have a particular relevance not only in the genes that they have passed on, their cultural beliefs and attitudes, but also in the ways in which previous environmental exposur...
Article
Background: In spite of convincing animal experiments demonstrating the potential for environmental exposures in one generation to have demonstrable effects generations later, there have been few relevant human studies. Those that have been undertaken have demonstrated associations, for example, between exposures such as nutrition and cigarette smo...
Article
Full-text available
The purpose of the present study was to examine, in a large representative population, the association between self-reported religious beliefs, attitudes and behavior and locus of control (LOC) of reinforcement as defined by Rotter. Results of previous research have failed to clearly determine what, if any, associations existed. In this study, anal...
Article
Enrolling a cohort in pregnancy can be methodologically difficult in terms of structuring data collection. For example, some exposures of interest may be time-critical while other (often retrospective) data can be collected at any point during pregnancy. The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prime example of such a cohor...
Article
Full-text available
Background: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were analysed to investigate associations between parents’ locus of control (LOC) and their use of their children’s symptoms to pursue a diagnosis of autism. Methods: Comparison of parental LOC obtained prenatally with various aspects of the child’s (<12 years) devel...
Article
Full-text available
Background : Early life experiences can have a significant impact on an individual’s later behaviour, the way they view the world, their beliefs and their success at forming strong interpersonal relationships. These factors may subsequently influence the way that the individual may parent their children, which in turn may have an effect on their ch...
Article
Experimental evidence suggests that perinatal light imprinting of circadian clocks and systems may affect downstream physiology and cancer risk in later life. For humans, the predominant circadian stimulus is the daily light-dark cycle. Herein, we explore associations between perinatal photoperiod characteristics (photoperiod: duration of daylight...
Article
Full-text available
Recent research using the Avon Longitudinal Study of Parents and Children (ALSPAC) demonstrated an association between maternal grandmother smoking in pregnancy and the autistic traits of impaired social communication and repetitive behaviour in granddaughters but not grandsons, but of paternal grandmother smoking and early development of myopia in...
Article
Full-text available
The FRAXA and FRAXE alleles of the FMR1 and FMR2 genes located on the X chromosome contain varying numbers of trinucleotide repeats. Large numbers of repeats at FRAXA (full mutations) manifest as Fragile X syndrome, associated with mental impairment that affects males more severely. In this paper, we present the dataset of frequencies of FRAXA and...
Article
Full-text available
Maternal locus of control (LOC) as measured in pregnancy has been shown to be associated with parenting attitudes and behaviors as well as with children’s comprehension of mathematical and scientific concepts. The present study evaluates whether the child’s emergent literacy skills are similarly associated with maternal LOC: i.e., do children of pr...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Full-text available
Longitudinal cohort studies provide unique opportunities to investigate the health impact of air pollution. We aimed to enhance the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort study through the systematic collection of routinely monitored air pollution data collected by local authorities and the Department for Environment,...
Article
Full-text available
Myopia (near sightedness) is the most common vision disorder resulting in visual impairment worldwide. We tested the hypothesis that intergenerational, non-genetic heritable effects influence refractive development, using grandparental prenatal smoking as a candidate exposure. Using data from the Avon Longitudinal Study of Parents and Children (ALS...
Article
Full-text available
Optimal maternal caregiving is critical for children’s healthy development, yet quality of maternal caregiving may be influenced by a negative birth experience. We examined whether the birth experience was associated with maternal caregiving attitudes and behavior throughout the first year. We conducted secondary analysis of the Avon Longitudinal S...
Article
Full-text available
Background: The majority of epidemiological studies concerning possible adverse effects of paracetamol (acetaminophen) in pregnancy have been focussed on childhood asthma. Initial results of a robust association have been confirmed in several studies. Recently, a few cohort studies have looked at particular neurocognitive outcomes, and several hav...
Article
Full-text available
The FRAXA and FRAXE alleles of the FMR1 and FMR2 genes located on the X chromosome contain varying numbers of trinucleotide repeats. Large numbers of repeats at FRAXA (full mutations) manifest as Fragile X syndrome, associated with mental impairment that affects males more severely. In this paper, we present the dataset of frequencies of FRAXA and...
Article
Full-text available
There is evidence that, in general, the West is becoming more secular. Religious belief has been shown in some studies to have positive associations with outcomes such as coping with serious illness and other life events and general well-being. In this paper, we describe the data from parents enrolled in the Avon Longitudinal Study of Parents and C...
Article
Parental occupational exposure to pesticides, animals, and organic dust have been associated with an increased risk of childhood cancer based mostly on case‐control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort C...
Article
Full-text available
Animal experiments demonstrate ways in which an exposure in one generation can be reflected in a variety of outcomes in later generations. In parallel human observational studies have shown associations between grandparental and parental exposures to cigarette smoking and/or nutrition and growth and survival of the grandchild. These studies have co...
Article
Full-text available
Objectives: To investigate whether parental external locus of control (ELOC) measured in pregnancy is related to obesity in their adolescent offspring and whether the child's own ELOC measured at age 8 contributes. To determine whether associations are due to types of behaviour used by externally oriented participants. Subjects/methods: Longitud...
Article
Full-text available
There is evidence that, in general, the West is becoming more secular. Religious belief has been shown in some studies to positively impact on outcomes such as coping with serious illness and other life events and general well-being. In this paper, we describe the data collected from parents enrolled in the Avon Longitudinal Study of Parents and Ch...
Article
Full-text available
A personality scale that identifies individuals’ general attitude to what happens to them as largely a matter of luck or fate or of powerful others (externality) or whether they feel they can influence the consequences (internality) is known as locus of control (LOC). A continuous scale can distinguish those who are more external from those who are...
Article
Full-text available
An association between maternal smoking in pregnancy and autism may be biologically plausible, but the evidence to date is inconsistent. We aimed to investigate the causal relationship between maternal smoking during pregnancy and offspring autism using conventional analysis and causal inference methods. In the Avon Longitudinal Study of Parents an...