jean-claude Perez

After an exploration of the state of the art concerning the possible interactions between gene P53, zinc fingers, spike protein of viruses and sarscov2 Covid19 injections, and Prions, we strengthen this thesis by demonstrating, through the theory of the Master Code of Biology , why P53 hot spots are so mutagenic and why these regions have a high po...

In COVID-19 mRNA vaccines, natural uracil bases are replaced with modified pseudouracil. This study investigates the potential consequences of this modification on protein synthesis. Occasionally, ribosomes may overlook these modified bases, leading to a shift in the reading frame of the genetic code. We examine the spike protein in the context of...

Injection technology mRNA COVID19 substitutes to all the natural Uracile bases by modified pseudo Uracile bases. These modified bases are sometimes ignored by the ribosome which skips them, thus causing a shift in the codon reading frame. Here we analyze the Spike protein when it is read following the second or third reading frame of the codons. We...

1) Dans un art, une science, dans un groupe quelconque, personne qui agit en isolé avec une complète indépendance par rapport aux autres. "…/...Ce qui est intéressant, que mon collègue mathématicien Perez pense, c'est qu'il y a une sorte d'harmonisation des séquences de l'information génétique qui est portée aussi bien par nos propres chromosomes q...

Hommage Nobelprizewinner Luc Montagnier by jean claude perez relayed in India by Pr E.G Rajan and Dr Ramanujam

In (Venetz et al., 2019), authors rebuilt the essential genome of Caulobacter crescentus through the process of chemical synthesis rewriting and studied the genetic information content at the level of its essential genes. Then, they reduced the native Caulobacter crescentus native Caulobacter NA1000 genome sequence real genome (4042929 bp) to the 7...

The Benford method can be used to detect manipulation of epidemiological or trial data during the validation of new drugs. We extend here the Benford method after having detected particular properties for the Fibonacci values 1, 2, 3, 5 and 8 of the first decimal of 10 runs of official epidemiological data published in France and Italy (positive ca...

Creutzfeldt-Jakob Disease, the formerly rare but universally fatal prion disease in humans, normally progresses over several decades before it leads to death. In the Appendix to this paper, we highlight the presence of a prion region in the spike protein of the original SARS-CoV-2, and in all the “vaccine” variants built from the Wuhan virus. The p...

Creutzfeldt-Jakob Disease, the formerly rare but universally fatal prion disease in humans, normally progresses over several decades before it leads to death. In the Appendix to this paper, we highlight the presence of a prion region in the spike protein of the original SARS-CoV-2, and in all the “vaccine” variants built from the Wuhan virus. The p...

When we compare the respective rankings of 31 European countries, on the one hand according to their covid19 vaccination rates, and, on the other hand, according to the excess mortality observed during the summer of 2022, we demonstrate a significant correlation of 53%, which suspects a possible causal link between these 2 phenomena, excess mortali...

We highlight presence of Prion in the Spike proteins of original SARS-CoV2 as well as of all its successive variants and of all the vaccines built on this same sequence of the Spike SARS-CoV2 from Wuhan. Paradoxically, with a density of mutations 8 times greater than that of the rest of the spike, the possible harmfulness of this Prion region disap...

Are there link between the famous KABALLE and FIBONACCI numbers?

CONCLUSIONS The objective was here to present a genome characteristic that may partly explain the sudden propagation of the monkeypox virus in the form we observe in May 2022 in quite a number of countries. The role of the peculiar 30-T base long sequence right in the middle of the virus genome is still to be determined.

We compare the evolution of 14 monkeypox virus genomes til that of May 2022 that is currently spreading across humans in numerous countries outside Africa. Our aim was to discover mutations or other viral evolutions (recombination) that may explain the sudden impact of this very low-level circulating epidemic or alert on a potential peculiar pathog...

.The emergence of the Omicron variant of SARS-CoV2 identified first in South Africa was announced with anxiety in media following alarm and concern by many researchers in the scientific community and the WHO has declared it a variant of concern (VOC): “The discovery of a highly mutated coronavirus variant in South Africa has triggered a global scra...

We compare the evolution of 14 genomes of monkeypox viruses including that of May 2022 that is currently spreading among humans in numerous countries outside Africa. Our aim was to discover mutations and other viral evolutions (recombination) of the virus genome that may explain the sudden impact of this epidemic circulating at very low-level and a...

We analyzed 15 genomes and Spikes of the new OMICRON variant, on the one hand 7 from the very first 21K lineage (South Africa, USA, Belgium, Canada), on the other hand 8 from the later second sister-clade 21L (USA , Switzerland, UK). We applied, at the scale of the whole genome and the spike gene, the biomathematics method of Fibonacci meta-struct...

In this theoretical discovery of a law of Life, there is MATHEMATICS (Geometry, Bits and Numbers) that UNIFY 3 universes as complementary as ATOMIC MASS, WAVES, and INFORMATION (DNA, RNA and Amino Acids). The discovery of a simple numerical formula for the projection of all the atomic mass of life-sustaining CONHSP bioatoms leads to the emergence o...

The discovery of a simple numerical formula for the projection of all the atomic mass of life-sustaining CONHSP bioatoms leads to the emergence of a set of Nested CODES unifying all the biological, genetic and genomic components by unifying them from bioatoms up to 'to whole genomes. In particular, we demonstrate the existence of a digital meta-cod...

In this paper, we run for all INDIA mutations and variants a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions (Perez, 2021). In this study, we limit ourselves to the analysis of whole genomes, all coming from the mutations and variants of SARS-CoV2 sequenced in India in 2020 and...

The Benford method can be used to detect manipulation of epidemiological or trial data during the validation of new drugs. We extend here the Benford method after having detected particular properties for the Fibonacci values 1, 2, 3, 5 and 8 of the first decimal of 10 runs of official epidemiological data published in France and Italy (positive ca...

The Benford method can be used to detect manipulation of epidemiological or trial data during the validation of new drugs. We extend here the Benford method after having detected particular properties for the Fibonacci values 1, 2, 3, 5 and 8 of the first decimal of 10 runs of official epidemiological data published in France and Italy (positive ca...

The Benford method can be used to detect manipulation of epidemiological or trial data during the validation of new drugs. We extend here the Benford method after having detected particular properties for the Fibonacci values 1, 2, 3, 5 and 8 of the first decimal of 10 runs of official epidemiological data published in France and Italy (positive ca...

In this paper, we suggest a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS currently circulating within the world population. The 10 main results proposed to be reproduced by pe...

In this paper, we run for all INDIA mutations and variants a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions (Perez, 2021). In this study, we limit ourselves to the analysis of whole genomes, all coming from the mutations and variants of SARS-CoV2 sequenced in India in 2020 and...

In this paper, we run for all INDIA mutations and variants a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions (Perez, 2021). In this study, we limit ourselves to the analysis of whole genomes, all coming from the mutations and variants of SARS-CoV2 sequenced in India in 2020 and...

In this paper, we run for all INDIA mutations and variants a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions (Perez, 2021). In this study, we limit ourselves to the analysis of whole genomes, all coming from the mutations and variants of SARS-CoV2 sequenced in India in 2020 and...

In this paper, we suggest a biomathematical numerical method for analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS currently circulating within the world population. The 10 main results proposed to be reproduced by pe...

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 10 main results proposed to be reproduced by peers are: 1/ SA...

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 9 main results proposed to be reproduced by peers are: 1/ SARS...

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 9 main results proposed to be reproduced by peers are: 1/ SARS...

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 8 main results proposed to be reproduced by peers are: 1/ SARS...

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 8 main results proposed to be reproduced by peers are: 1/ SARS...

We are facing the worldwide invasion of a new coronavirus. This follows several limited outbreaks of related viruses in various locations in a recent past (SARS, MERS). Although the main current objective of researchers is to bring efficient therapeutic and preventive solutions to the global population, we need also to better understand the origin...

HIV MAN-MANIPULATED CORONAVIRUS EVOLUTION TRENDS ####################### HIV MAN-MANIPULATED CORONAVIRUS EVOLUTION TRENDS ########### ABSTRACT. ########### Summary of the work of Perez/Montagnier on COVID_19 origin based on its published RNA sequences 1) HIV/SIV sequences (>or=18 nucleotides, ie. 6 amino acids) particularly localized in a sm...

We are facing the worldwide invasion of a new coronavirus. This follows several limited outbreaks of related viruses in various locations in a recent past (SARS, MERS). Although the main objective of researchers is to bring efficient therapeutic and preventive solutions to the global population, we need also to better understand the origin of the n...

We are facing the worldwide invasion of a new coronavirus. This follows several limited outbreaks of related viruses in various locations in a recent past (SARS, MERS). Although the main current objective of researchers is to bring efficient therapeutic and preventive solutions to the global population, we need also to better understand the origin...

The main result of this updated release is the formal proof that 2019-nCoV coronavirus is partially a SYNTHETIC genome. We proof the CONCENTRATION in a small région of wuhan New genome (300bp) of 3 different régions from HIV1 ENVELOPPE gene and 3 others from HIV2 and SIV (ENV and POL RT). All this is remarkable and bears the mark of a desire for or...

We are facing the worldwide invasion of a new coronavirus. This follows several limited outbreaks of related viruses in various locations in a recent past (SARS, MERS). Although the main objective of researchers is to bring efficient therapeutic and preventive solutions to the global population, we need also to better understand the origin of the n...

We are facing the worldwide invasion of a new coronavirus. This follows several limited outbreaks of related viruses in various locations in a recent past (SARS, MERS). Although the main objective of researchers is to bring efficient therapeutic and preventive solutions to the global population, we need also to better understand the origin of the n...

We human are facing the worldwide invasion of a new coronavirus. This follows several limited outbreaks of related viruses in various locations in a recent past (SARS, MERS). Although the main objective of researchers is to bring efficient therapeutic and preventive solutions to the global population, we need also to better understand the origin of...

The main result of this updated release is the formal proof that 2019-nCoV coronavirus is partially a SYNTHETIC genome. We proof the CONCENTRATION in a small région of wuhan New genome (300bp) of 3 different régions from HIV1 ENVELOPPE gene and 3 others from HIV2 and SIV (ENV and POL RT). All this is remarkable and bears the mark of a desire for or...

The main result of this updated release is the formal proof that 2019-nCoV coronavirus is partially a SYNTHETIC genome. We proof the CONCENTRATION in a small région of wuhan New genome (300bp) of 3 different régions from HIV1 ENVELOPPE gene and 3 others from HIV2 and SIV (ENV and POL RT). All this is remarkable and bears the mark of a desire for or...

Wuhan nCoV-2019 SARS Coronaviruses Genomics Fractal Metastructures Evolution and Origins “Where there is matter, there is geometry.” Johannes Kepler Jean-claude PEREZ, PhD Maths § Computer Science Bordeaux University, RETIRED interdisciplinary researcher (IBM Emeritus, IBM European Research Center on Artificial Intelligence), 7 avenue de terre-roug...

The main result of this updated release is the formal proof that 2019-nCoV coronavirus is partially a SYNTHETIC genome. We proof the CONCENTRATION in a small région of wuhan New genome (300bp) of 3 different régions from HIV1 ENVELOPPE gene and 3 others from HIV2 and SIV (ENV and POL RT). All this is remarkable and bears the mark of a desire for or...

In (Venetz et al., 2019), authors rebuilt the essential genome of Caulobacter crescentus through the process of chemical synthesis rewriting and studied the genetic information content at the level of its essential genes. Then, they reduced the native Caulobacter crescentus native Caulobacter NA1000 genome sequence real genome ( 4042929 bp ) to the...

Abstract : We present 1) a novel unified conception of science, cognition and phenomenology in terms of the Klein Bottle logophysics, 2) as a supradual creative agency based on self and hetero-reference and multistate logic associated to the non-orientable topologies of the Möbius strip and Klein Bottle surfaces, 3) related to the Golden ratio in s...

Abstract : We present 1) a novel unified conception of science, cognition and phenomenology in terms of the Klein Bottle logophysics, 2) as a supradual creative agency based on self and hetero-reference and multistate logic associated to the non-orientable topologies of the Moebius strip and Klein Bottle surfaces, 3) the Golden ratio in several are...

The discovery of a simple numerical formula for the projection of all the atomic mass of life-sustaining CONHSP bioatoms leads to the emergence of a set of Nested CODES unifying all the biological, genetic and genomic components by unifying them from bioatoms up to 'to whole genomes. In particular, we demonstrate the existence of a digital meta-cod...

The discovery of a simple numerical formula for the projection of all the atomic mass of life-sustaining CONHSP bioatoms leads to the emergence of a set of Nested CODES unifying all the biological, genetic and genomic components by unifying them from bioatoms up to 'to whole genomes. In particular, we demonstrate the existence of a digital meta-cod...

Using the circular nature of the 16k base-pairs human mtDNA genome, we are looking for hypothetical proportions between the C+A and T+G bases. Remarkable proportions are thus discovered, the length of which may be much greater than the length of the genome. We then analyze the impact of evolution on these “numerical resonances” by comparing the ref...

The global analysis of 3 human genomes of increasing levels of evolution (neanderthal / sapiens build34 of 2003 / sapiens hg38 of 2013) reveals 2 levels of numerical constraints controlling, structuring and optimizing the DNA sequences of these genomes. A global constraint-which we will call "HGO" for "Human Genome Optimum"-optimizes the genome at...

A set of jean-claude perez's research papers on Numerical structure of DNA and genomes (peer review articles, books, websites links)

Abstract This article presents multi-layered basic research culminating in what we call the Master Code of Biology. First, we review the “Formula for Life” discovery. This simple formula unifies all the components of life, structuring them in a kind of “Periodic table of Biology”. These components include bio-atoms, CONHSP, nucleotides, UTCAG, amin...

1991 : « Chaos DNA and Neuro-computers » The first scientific article on Fibonacci Numbers in DNA sequences Perez J.C. Chaos, DNA and neuro-computers: a golden link. in Speculations in Science and Technology ; Vol. 14, No. 1 (1991): pp. 336-346 ;ISSN 0155-7785 ; 1991.

WELCOME – Bienvenue – Bienvenido -Discover more on jean-claude perez's 25 years research on « NUMERICAL ARCHITECTURES of DNA and GENOMES »... A 20 years old video on FIBONACCI patterned structures within Genes coding DNA sequence (the « DNA supracode »):

We propose here the following law : « A necessary but not sufficient condition qualifying an integer as a magic number is that it could be computed by a binary addition of numbers of elements of the periodic table of Mendeleev. » Corollary CONJECTURE : All MAGIC NUMBERS could be encoded by a binary 0/1 vector where the numerical BASE is the list o...

This article proves the existence of a hyper-precise global numerical meta-architecture unifying, structuring, binding and controlling the billion triplet codons constituting the sequence of single-stranded DNA of the entire human genome. Beyond the evolution and erratic mutations like transposons within the genome, it’s as if the memory of a fossi...

Recursive Fractal Genome Function in the geometric mind frame of Tensor Network Theory (TNT) leads through FractoGene to a mathematical unification of physiological and pathological development of neural structure and function as governed by the genome. The cerebellum serves as the best platform for unification of neuroscience and genomics. The mat...

Recursive Fractal Genome Function in the geometric mind frame of Tensor Network Theory (TNT) leads through FractoGene to a mathematical unification of physiological and pathological development of neural structure and function as governed by the genome. The cerebellum serves as the best platform for unification of neuroscience and genomics. The m...

This new bioinformatics research bridges Genomics and Mathematics. We propose a universal “Fractal Genome Code Law”: The frequency of each of the 64 codons across the entire human genome is controlled by the codon’s position in the Universal Genetic Code table. We analyze the frequency of distribution of the 64 codons (codon usage) within single-st...