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Jean-Christophe Fricain

Jean-Christophe Fricain
University bordeaux · Oral surgery

Bachelor of Medicine

About

147
Publications
44,059
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949
Citations
Citations since 2016
115 Research Items
922 Citations
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2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
Introduction
oral mucosa diseases bio printing tissue engineering

Publications

Publications (147)
Article
Because synthetic vascular prostheses perform poorly in small-diameter revascularization, biological vascular substitutes are being developed as an alternative. Although their in vivo results are promising, their production involves long, complex, and expensive tissue engineering methods. To overcome these limitations, we propose an innovative appr...
Book
Full-text available
This book forms part of a European project directed at European healthcare professionals and aims to provide updated guidance to clinicians who encounter patients with head and neck pathology, to recognise, investigate, diagnose and manage OPMDs. The contents of the book has been extensively reproduced from the published work of the WHO Collaborati...
Article
Full-text available
Medication-related osteonecrosis of the jaw (MRONJ) is a complication of certain pharmacological treatments such as bisphosphonates, denosumab, and angiogenesis inhibitors. There are currently no guidelines on its management, particularly in advanced stages. The human amniotic membrane (hAM) has low immunogenicity and exerts anti-inflammatory, anti...
Article
Full-text available
To face the increasing demand for organ transplantation, currently the development of tissue engineering appears as the best opportunity to effectively regenerate functional tissues and organs. However, these approaches still face the lack of an efficient method to produce an efficient vascularization system. To answer these issues, the formation o...
Article
Full-text available
Bone tissue engineering (BTE) strategies are increasingly investigated to overcome the limitations of currently used bone substitutes and to improve the bone regeneration process. Among the natural polymers used for tissue engineering, dextran and pullulan appear as natural hydrophilic polysaccharides that became promising biomaterials for BTE. Thi...
Article
Full-text available
Oral submucous fibrosis (OSF) is a chronic progressive condition affecting the oral cavity, oropharynx and upper third of the oesophagus. It is a potentially malignant disorder. The authors collated and analysed the existing literature to establish the overall malignant transformation rate (MTR). A retrospective analysis of medical and dental scien...
Article
When considering regenerative approaches, the efficient creation of a functional vasculature, that can support the metabolic needs of bioengineered tissues, is essential for their survival after implantation. However, it is widely recognized that the post-implantation microenvironment of the engineered tissues is often hypoxic due to insufficient v...
Article
Fibroblasts and myofibroblasts play a central role in skin homeostasis through dermal organization and maintenance. Nonetheless, the dynamic interactions between (myo)fibroblasts and the extracellular matrix (ECM) remain poorly exploited in skin repair strategies. Indeed, there is still an unmet need for soft tissue models allowing to study the spa...
Article
Introduction Diverses causes génétiques ont été récemment identifiées dans la candidose cutanéo-muqueuse chronique (CCMC) dont des mutations hétérozygotes gain de fonction du gène codant pour le transcripteur et l’activateur de la transcription 1 (STAT1 GOF). Nous rapportons le cas d’un patient chez lequel l’inhibiteur de JAK 1/2 a permis une rémis...
Article
Introduction Le lichen oral est une pathologie inflammatoire chronique, dont la prise en charge implique différents praticiens : dermatologues, chirurgiens oraux, stomatologues, chirurgiens maxillo-faciaux, chirurgiens-dentistes, anatomopathologistes. Notre objectif était de réaliser des recommandations multidisciplinaires afin d’homogénéiser les p...
Article
Introduction La « gingivite plasmocytaire » est une entité définie comme une inflammation gingivale caractérisée par un infiltrat sous-épithélial de cellules plasmocytaires matures. Elle est peu décrite dans la littérature, et l’étiologie est controversée (allergique, réactionnelle, tumorale…). L’objectif de cette étude était de décrire les caracté...
Article
Bioprinting technologies are powerful new bioengineering tools that can spatially reproduce multiple microenvironmental cues in a highly controlled, tunable, and precise manner. In this study, microvalve bioprinting technology was successfully used to print in close proximity endothelial and tumor cells at higher concentrations than previously thou...
Article
Full-text available
The aim of this study was to perform a systematic review on the clinical applications where chorion membrane (CM) and amnion/chorion membrane (ACM) were used for oral tissue regeneration procedures. Selection of articles was carried out by two evaluators in Pubmed and Scopus databases, and Outcomes (PICO) method was used to select the relevant arti...
Article
Full-text available
Due to its intrinsic properties, there has been growing interest in human amniotic membrane (hAM) in recent years particularly for the treatment of ocular surface disorders and for wound healing. Herein, we investigate the potential use of hAM and amnion-chorion membrane (ACM) in oral surgery. Based on our analysis of the literature, it appears tha...
Article
Full-text available
An important component of tissue engineering (TE) is the supporting matrix upon which cells and tissues grow, also known as the scaffold. Scaffolds must easily integrate with host tissue and provide an excellent environment for cell growth and differentiation. Human amniotic membrane (hAM) is considered as a surgical waste without ethical issue, so...
Article
Full-text available
Thanks to their biological properties, amniotic membrane (AM), and its derivatives are considered as an attractive reservoir of stem cells and biological scaffolds for bone regenerative medicine. The objective of this systematic review was to assess the benefit of using AM and amniotic membrane-derived products for bone regeneration. An electronic...
Chapter
Lichenoid lesions are very similar to lichen planus lesions histopathologically and clinically in form, extend, and occasional associated pain. Many drugs are capable of inducing them in the oral mucosa. Lichenoid reactions should be evoked in the context of the introduction of a new treatment. The duration of onset of lichenoid lesions varies wide...
Article
Microbeads consisting of pullulan and dextran supplemented with hydroxyapatite have recently been developed for bone tissue engineering applications. Here, we evaluate the bone formation in two different preclinical models after injection of microbeads reconstituted with either saline buffer or autologous blood. Addition of saline solution or autol...
Article
The field of bioprinting has shown a tremendous development in recent years, focusing on the development of advanced in vitro models and on regeneration approaches. In this scope, the lack of suitable biomaterials that can be efficiently formulated as printable bioinks, while supporting specific cellular events, is currently considered as one of th...
Article
Thanks to its biological properties, the human amniotic membrane (HAM) combined with a bone substitute could be a single-step surgical alternative to the two-step Masquelet induced membrane (IM) technique for regeneration of critical bone defects. However, no study has directly compared these two membranes. We first designed a 3D-printed scaffold u...
Article
Full-text available
Cell oxygenation and nutrition are crucial for the viability of tissue-engineered constructs, and different alternatives are currently being developed to achieve an adequate vascularisation of the engineered tissue. One of the alternatives is the generation of channel-like patterns in a bioconstruct. Here, the formation of full-formed channels insi...
Article
Full-text available
Introduction: White Sponge Nevus (WSN) is a leukokeratosis characterized by white lesions of the oral mucosa. These lesions are bilateral, thickened and raised compared to the adjacent mucosa. Their aspect are folded and spongy. It is a benign disorder with asymptomatics lesions which often appear during the childhood or the adolescence. The intere...
Article
Bioprinting is an emergent technology that has already demonstrated the capacity to create complex and/or vascularized multicellular structures with defined and organized architectures, in a reproducible and high throughput way. Here, we present the implementation of a complex liver model by the development of a three-dimensional extrusion bioprint...
Article
Purpose: The aim of this study was to evaluate and compare bone growth and implant integration in circumferential defects with two commercially available bone substitutes (demineralized bovine bone mineral [DBBM]). Materials and methods: Circumferential defects were created in the mandibles of minipigs (n = 10), and Bone Level Tapered implants (...
Article
Full-text available
Introduction: Pterygoid hamulus syndrome (PHS) is a little-known differential diagnosis of orofacial pain. It is characterized by oropharyngeal pain, secondary to inflammatory bursitis of the tensor veli muscle of post-traumatic origin, frequently fostered by an associated hypertrophy of the hamular process. Observation: A 64-year-old female patien...
Article
Importance: A validated biomaterial would have several medical advantages in septorhinoplasties requiring a large-volume graft such as avoiding donor site morbidity, making ambulatory surgery possible, and reducing surgical costs. Objective: To assess the safety and efficacy of a ceramic to treat saddle and crooked noses. The main endpoint was the...
Article
Thanks to its biological properties, the human amniotic membrane (HAM) can be used as a barrier membrane for guided bone regeneration (GBR). However, no study has assessed the influence of the preservation method of HAM for this application. This study aimed to establish the most suitable preservation method of HAM for GBR. Fresh (F), cryopreserved...
Chapter
Bioprinting is a novel technological approach that has the potential to solve unmet questions in the field of tissue engineering. Laser-assisted bioprinting (LAB), due to its unprecedented cell printing resolution and precision, is an attractive tool for the in situ printing of a bone substitute. Here, we describe the protocol for LAB and its use f...
Article
Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy of the pancreas. It has shown a poor prognosis and a rising incidence in the developed world. Other pathologies associated with this tissue include pancreatitis, a risk condition for pancreatic cancer. The onset of both pancreatitis and pancreatic cancer follows a common pattern:...
Article
Full-text available
Background Older persons comprise a growing proportion of the European population and may have a distinct epidemiological oral profile requiring specific preventive and curative care poorly documented. The objectives of this study were to assess the oral health status of people ≥ 90 years of age in France, to compare their perceived and observed or...
Conference Paper
Full-text available
Les mucites sont des inflammations muqueuses secondaires à un traitement anticancéreux : radiothérapie, chimiothé- rapie, thérapie ciblée. Les mucites se développent sur l’ensemble du tractus digestif, de la bouche à lanus. La sévérité des mucites orales conditionne lalimentation et par conséquent le pronostic de la maladie. Le traitement des mucit...
Conference Paper
Full-text available
Le vitiligo est une leucodermie affectant 0,5 à 1% de la population mondiale. Il n’y a pas de différence de prévalence concernant l’âge, le sexe ou le type de peau. La disparition des mélanocytes entraine une hypopigmentation localisée en plaques symétriques blanches ivoire, à bords nets souvent hyperpigmentés. Les lésions sont le plus souvent retr...
Article
Full-text available
Introduction: Direct tissue autofluorescence (AF) visualization devices such as VELscope ® are gaining interest to improve early detection of oral potentially malignant disorders (OPMD) and cancers. The main objective of this study was to assess inter-observer reproducibility of incandescent light (IL) and AF observations for OPMD and cancer. Mater...
Article
Full-text available
Applications in additive manufacturing technologies for bone tissue engineering applications requires the development of new biomaterials formulations. Different three‐dimensional (3D) printing technologies can be used and polymers are commonly employed to fabricate 3D printed bone scaffolds. However, these materials used alone do not possess an ef...
Poster
Full-text available
Current bone tissue engineering strategies are based on porous biocompatible scaffolds seeded with tissue-specific cells. Improvement in rapid prototyping technologies, such as 3D printing, allows fabrication of custom-made 3D scaffolds with high resolution. Our group has developed a new material, made of medical grade poly(lactic-co-glycolic) acid...
Article
Full-text available
Introduction: Cystic maxillary lesions are common. In 1962, Gorlin described a rare cystic form termed the calcifying odontogenic cyst (COC) or Gorlin's cyst. Two cases of this form were treated at Bordeaux University Hospital. Observation: The first case was a 17-year-old patient with mandibular odontoma, which had developed over the previous 6 mo...
Article
Full-text available
Introduction: The prevention and treatment of thromboembolic events is generally based on the prescription of antithrombotics. These drugs are associated with an increased hemorrhagic risk. The procedures for the management of patients under antithrombotic treatment are described in the recommendations of the Société Française de Chirurgie Orale (S...
Article
Layer‐by‐layer (LBL) BioAssembly method was developed to enhance the control of cell distribution within 3D scaffolds for Tissue Engineering applications. The objective of this study was to evaluate in vivo the development of blood vessels within LBL bioassembled membranes seeded with human primary cells, and to compare it to cellularized massive s...
Article
Full-text available
Benign migratory glossitis or geographic tongue is a benign condition that usually manifests as asymptomatic erythematous and migratory circinate patches, involving the lateral and dorsal aspects of the tongue. Extra-lingual lesions uncommonly occur and are mainly located on labial and buccal mucosae, lips and floor of the mouth. The present report...
Article
Because of its low immunogenicity, biological properties, and high availability, the Human Amniotic Membrane (HAM) is widely used in the clinic and in tissue engineering research. However, while its biological characteristics are well described, its mechanical properties remain understudied especially in terms of inter- and intra-HAM variability. T...
Article
Human amniotic membrane (hAM) is considered as an attractive biological scaffold for tissue engineering. For this application, hAM has been mainly processed using cryopreservation, lyophilization and/or decellularization. However, no study has formally compared the influence of these treatments on hAM properties. The aim of this study was to develo...
Article
Vascularization plays a crucial role in bone formation and regeneration process. Development of a functional vasculature to improve survival and integration of tissue-engineered bone substitutes remains a major challenge. Biofabrication technologies, such as bioprinting, have been introduced as promising alternatives to overcome issues related to l...
Article
Background: The development of an artificial glomerular unit may be pivotal for renal pathophysiology studies at a multicellular scale. Using a tissue engineering approach, we aimed to reproduce in part the specific glomerular barrier architecture by manufacturing a glomerular microfibre (Mf). Methods: Immortalized human glomerular cell lines of...
Book
Full-text available
In Europe, 29% of individuals identify as smokers, with tobacco use directly related to 650,000 mortalities each year across the continent; roughly 14% of all deaths. Primary care staff at the frontline: nurses, pharmacists, doctors, dentists and other healthcare professionals encounter patients who are regular smokers on a daily basis. By familiar...
Article
Purpose: Only limited information on the effect of implant surface hydrophilicity in conjunction with simultaneous bone augmentation is available. In this study, new bone growth around implants with a superhydrophilic modSLA (SLActive) and hydrophobic SLA (SLA) surface were compared in circumferential defects when grafted in conjunction with miner...
Book
Full-text available
The dental profession therefore has a critical role in the fight against oral cancer, fulfilling an invaluable task across the three levels (Primary, Secondary and Tertiary) of prevention. Primary prevention is aimed at reducing the incidence of the disease and protecting healthy people from developing oral cancer. Primary prevention is the most id...
Article
Full-text available
Observation: A 19-week-old patient seen in an oral dermatology clinic had small labial commissures pits associated with auricular abnormalities. Similar clinical elements were found in the family medical history. A diagnosis of branchio-oto-renal syndrome (BOR) was quickly evoked. Commentary: BOR syndrome is a rare disease. This autosomal dominant...
Article
Full-text available
Case report: A 71-year-old patient, with no notable medical-surgical history, was referred for a specialized consultation with Oral Mucosal Pathology for tumefaction on the dorsal side of the tongue. It was a nodular lesion measuring one centimeter long, purplish, and painless. There was nothing found through palpation. Surgical excision with a las...
Article
Full-text available
Observation: A 68-year-old patient presented to us because of the gradual onset of symptoms associated with a mass located on an epithelial-mucosal graft performed approximately 20 years ago. A provisional diagnosis of exostosis was made and the mass was excised under local anesthesia. Comments: Exostosis is defined as a localized benign bone proli...
Article
Full-text available
Introduction: Nivolumab-induced oral and cutaneous bullous pemphigoid have been rarely reported in the literature. Observations: A 64-year-old male patient was treated with nivolumab for melanoma. He presented with oral lesions in the palatal and gingival mucosal lesions. Nine months after the initiation of nivolumab therapy, a cutaneous bullous pe...
Article
Full-text available
Background: In 2016, 459 dentists were registered in French West Indies and French Guyana. They represent 10% of French clinicians but they work in an environment very different from continental France. The aim of this study was to describe dental implantology practices among dentists in Guadeloupe, Martinique, and French Guyana. Materials and meth...
Article
Full-text available
Introduction: Vitiligo is a non-contagious leukoderma. The loss of melanocytes result in a local hypopigmentation like white symmetrical plaques with sharp edges, most of the time surrounded by hyperpigmentation. It might be an auto immune disease with a genetic predisposition linked to psychological disorders. Oral mucosa vitiligo has rarely been...
Article
Full-text available
Introduction: Post-traumatic painful trigeminal neuropathy is a chronic facial pain secondary to trigeminal nerve injury. The treatment of this pain is a therapeutic issue due to the alteration of quality of life that it generates. Observation: A 58-year-old man whose main history of facial trauma has been consulted in the Odontology Department for...
Article
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A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Article
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Recent advances in the field of Tissue Engineering allowed to control the three-dimensional organization of engineered constructs. Cell pattern imaging and in vivo follow-up remain a major hurdle in in situ bioprinting onto deep tissues. Magnetic Resonance Imaging (MRI) associated with Micron-sized superParamagnetic Iron Oxide (MPIO) particles cons...
Article
Full-text available