Jayanthi Abraham

Jayanthi Abraham
VIT University | VIT · Microbial Biotechnology Laboratory, School of Biosciences and Technology

M.Phil., Ph.D., FRSB.,

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185
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Publications

Publications (185)
Article
Bioactive silicates have transpired as valuable biomaterials for hard tissue engineering applications owing to their bioactivity, biocompatibility and osteogenic activity. The compositions of ceramics are found to be the main reason for stimulating bone growth. To achieve the desired product for 100% clinical success, it is necessary to understand...
Article
Asymptomatic bacteriuria is the presence of bacterial strains in urine samples obtained from a person without revelation of any symptoms of urinary infections. During pregnancy, women are prone to suffer from urinary tract infection at much higher rates due to certain physiological alterations. Thus, the awareness amongst women to protect themselve...
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The current work reports the biocompatibility and mechanical stability of enstatite and forsterite bioceramics prepared by sol–gel combustion method. XRD results conferred that enstatite and forsterite phase formation take place at 1000 °C and 900 °C respectively. TEM micrographs indicated the particle size of enstatite in the micron range while fo...
Article
The study includes isolation and screening of laccase enzyme producing fungus from marine soil sample collected from Kovalam beach (8.4004˚N, 76.9787˚E), Kerala. In this study, 12 fungal strains were isolated by serial dilution technique on different complex media. For primary screening of laccase production, plate assay was performed where the fun...
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Biocompatibility and bacterial infections are the primary concerns associated with the current bone graft substitutes. The application of wollastonite-based scaffolds for bone tissue engineering becomes a novel subject of interest. In the present study, a single phasic wollastonite scaffold was synthesised using citric acid-based sol–gel combustion...
Chapter
White rot fungi are versatile and possess nonspecific ability to degrade a wide variety of pollutants due to high tolerance to toxic substances in the environment and their extracellular lignin‐modifying enzymes. Recently, a lot of work has been done to develop and optimize bioremediation processes using white‐rot fungi, emphasizing their enzyme sy...
Article
This article presents the preparation and antibacterial activity of larnite bioceramics, an active calcium silicate ceramic material having the molecular formula Ca2SiO4. A stepwise sol–gel combustion approach was used to prepare the single phasic larnite. The synthesis of larnite was carried out with calcium nitrate tetrahydrate as a source of cal...
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The objective of designing a biocompatible and mechanically stable scaffold for hard tissue regeneration was achieved by fabricating diopside/forsterite composites. Superior mechanical strength, slow degradation, excellent antibacterial activity and good cell viability were attained with the increase in forsterite ratio in the composites whereas ap...
Article
This work is aimed to develop a biocompatible, bactericidal and mechanically stable biomaterial to overcome the challenges associated with calcium phosphate bioceramics. The influence of chemical composition on synthesis temperature, bioactivity, antibacterial activity and mechanical stability of least explored calcium silicate bioceramics was stud...
Article
In the present study, carbendazim (MBC) degrading bacterial strains were isolated and identified as Chryseobacterium sp. JAS14 and Aeromonas caviae JAS15. Both the strains completely degraded 200 mg l−1 of MBC in the aqueous medium and soil within 4–9 days of incubation. In an aqueous medium, the degradation process was characterized by a rate cons...
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Pyrethroids are the synthetic compounds derived from the Chrysanthemum cinerariaefolium plant. The first synthetic pyrethroids developed in the United States are allethrin and bioallethrin. According to the World Health Organization, the classification pyrethroids has a place in the fourth group of insecticides and includes 42 substances. More than...
Chapter
The very first development of avermectins was done from isolation in Kitasato Institute laboratories, using a novel soil-dwelling bacterium. It was transmittal to the Merck & Co. research laboratory incorporation. These belong to the 16-membered, closely related family, which are macrocyclic lactones constituting of four major and four minor homolo...
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Researchers and pharmacists are replacing synthetic chemicals with natural resources for drug manufacturing purposes. Plants produce secondary metabolites which possess antibacterial, antifungal, anticancer, antimalarial, antiprotozoal, antioxidant properties, etc. These metabolites are beneficial for plant growth and development by protecting them...
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Actinobacteria refers to a group of Gram-positive bacteria with higher G + C DNA base content than other groups of bacteria. They belong to one of the largest bacterial genera called Actinomycetes and are known for their enormous ability to adapt to any environment (including the less explored biota such as deep sea or oceans, hydrothermal vents, e...
Article
OBJECTIVE The aim of this study was to screen the antibacterial activities of methanol and petroleum ether extracts of Jatrophapodagrica leaves. METHODS The leaves were collected, dried, ground and extracted using Soxhlet apparatus with methanol and petroleum ether as solvents. The plant extracts were tested for antibacterial activity against bacte...
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Mangroves are aggregations of ecological community with a competency to grow in extreme environmental conditions. Endophytic microorganisms live within the plants in a symbiotic relationship where both the plants and the endophytes experience benefits. Several endophytic bacteria, including Bacillus sp., Staphylococcus sp., Sporosarcina sp., Pseudo...
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Nanobiotechnology is an emerging field of study in the recent era due to its ability to modify bulk compounds into smaller nanosized particles, namely nanoparticles. Nanoparticles have efficient chemical, physical, and optical characteristics. The unique nanoparticle characteristics are due to their submicroscopic size, which ranges from 1 to 100 n...
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Plant growth-promoting rhizobacteria (PGPR) have an important role in maintaining sustainable agricultural practices. Increased demand for crop production using minimal chemical fertilisers has become a great challenge for both researchers and farmers. This chapter focuses on the important classification of PGPR and their various commercial uses in...
Chapter
Linear alkylbenzene sulfonate (LAS) is one of the synthetic surfactants which has created havoc in wastewater treatment. Aerobic or conventional wastewater treatment was unable to remove the toxic compounds formed by synthetic surfactants. This book chapter focuses on the microbial degradation and the most effective way for the elimination of this...
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Coral reefs or ‘the rainforest of the sea’ is considered to be the most assorted and diversified aquatic ecosystem on earth. The reef offers a varied array of benefits and applications. Despite the fact that the coral reefs are responsible for supporting millions of flora and fauna, they are under high risk of endangerment. The gradual rise in natu...
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Polychlorinated biphenyls (PCBs) are organic molecules that are stable in nature. They were widely used in the early 1940s. PCBs have entered the ecosystem due to their wide applications via legal and illegal use. Due to its insoluble nature, these environmental contaminants are persistent in the environment, thereby contaminating different ecosyst...
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This work reports on the preparation and characterization of mesoporous nano diopside (CaMgSi2O6) using a simple and cost-effective sol-gel combustion route. Stoichiometric oxidant/fuel ratio was adopted for the combustion reaction. Eggshell was used as a calcium source, glycine (fuel) as reductant, magnesium nitrate and nitric acid as oxidant were...
Article
In the present study, a potent Aluminum (Al) resistant yeast strain CAM4 was isolated from rhizosphere soil of Rubus geoides, grown in acidic Andisols and identified as Rhodotorula mucilaginosa by 18S rRNA gene sequence analysis. The strain CAM4 was selected in terms of abiotic stress tolerance to Al, salinity and drought with multiple plant growth...
Article
The present study focuses on recovery of heavy metals from e-waste fungus isolated from heavy metal rich industrial sewage soil. Molecular identification revealed the organism to be Aspergillus nomius and was designated as A. nomius JAMK1. The isolate was subjected for heavy metals uptake following two mechanisms: bioaccumulation and biosorption. A...
Article
Fipronil is a most widely used insecticide. It has been found to be highly toxic to insects with alarming decline in honey bees' population. It has shown to cause severe contamination of soil and water. The present study was undertaken to understand the degradation of fipronil and its metabolite fipronil sulfone using actinomycetes. Fipronil degrad...
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In recent era, with increasing heavy metal pollution, several sorbents are used to remove heavy metals from environment. Application of chemical adsorbents and biosorbents for uptake of heavy metals from soil and waste water is studied thoroughly. Very less attention has been paid to the recovery of heavy metals from sorbents and their reuse. Few r...
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Extensive and inappropriate use of steroids in drugs and pharmaceutical products and improper release of steroids into the immediate environment has found to affect soil and water resulting in imbalance of ecosystem. The steroids reach environment due to inaccurate disposal of expired drugs as well as manufacturing disposal from pharmaceutical indu...
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The presence of sulphur in natural form is generally found in acid sulphate soils and in iron bearing sulphides regions. They are also found in effluents released from industries due to anthropogenic activity. The acid manufacturing industries release a huge amount of sulphates in soil that in turn affects the natural habitat of soil. Physical and...
Article
DNA is a molecule that carries most of the genetic instructions and interaction between small molecules and DNA often causes DNA damage in cancer cells, blocking the division, resulting in cell death. Towards the same, DNA interaction studies of transition metal complexes have been explored extensively. Further, the geometry of complexes can be tun...
Chapter
The underdeveloped state of waste management in developing country like India is a motivation for the study of eco-friendly processes like biomethanation and bioremediation. The current article focuses on bioremediation via methanotrophy by using methanotrophs. The biomethanation process is a multistep process leading to the production of biogas. A...
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Asthma, a chronic lung disease characterized by obstruction of airway passage is characterized by inflammation and hyperresponsiveness with increase in the number of eosinophils. Interleukin-13, plays a significant role in causing inflammation during an asthmatic attack by bronchial constriction. Mometasone, a glucocorticoid has been used as the fi...
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Background Melatonin is a hormone which is produced from pineal gland in human and is said to have various impacts in human body like controlling sleep wake cycle, regulating the immune and cardiovascular system and regulating the peripheral organ functioning to name a few. Researchers have reported that the melatonin levels correlates with cancer...
Article
The purpose of this study was to synthesise, characterize and evaluate environmental application (degradation of dyes and pesticides) of chitosan nanoparticles. The chitosan nanoparticles were synthesized by ionic gelation process and characterized. The physicochemical properties of the nanoparticles were determined by size and zeta potential analy...
Article
Background Pesticides are used to control various pests of agricultural crops worldwide. Despite their agricultural benefits, pesticides are often considered a serious threat to the environment because of their persistence. Pyrethroids are synthetic derivates of pyrethrins, which are natural organic insecticides procured from the flowers of Chrysan...
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Pesticides are considered among the most serious environmental pollutants, frequently used in the control of agricultural and domestic pests. Biodegradation of chlorpyrifos and its 3,5,6-trichloro-2-pyridinol (TCP) derivative was studied in mineral medium and soil with fungal consortium consisting of JAS1 and JAS4 strains which were isolated from p...
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In the current work, forsterite samples with different surface area were investigated for its antibacterial activity. Dissolution studies show that the lower degradation of forsterite compared to other silicate bioceramics, which is a desirable property for repairing bone defects. Forsterite scaffold shows superior compressive strength than the cor...
Article
Actinomycetes strain was isolated from leaf litter soil sample and was identified as Streptomyces sp. by conventional and molecular approaches. The biologically active compound responsible for antimicrobial and anticancer activity of the strain JAR6 was elucidated by solid state fermentation followed by subsequent chromatographic and spectroscopic...
Chapter
Over the years, there have been many methods proposed for the treatment of pharmaceutical wastes. Pharmaceutical wastewater has been difficult to treat as they comprise of chemicals and drugs such as antibiotics, hormones, antidepressants, anti-inflammatory drugs, analgesics, lipid regulators, animal and plant steroids, diuretics, antiepileptics. T...
Article
A bacterial strain capable of utilising carbendazim as the sole carbon and energy source was isolated from soil. The isolate was designated as JAS13 and identified as Rhodococcus sp., based on its biochemical and molecular characteristics carried out by 16S rRNA gene sequence analysis. The strain JAS13 was confirmed as R. erythropolis showing 99% s...
Article
This article addresses the joining of 5 mm thick plates of marine grade, super-austenitic (AISI 904L) and super-duplex stainless steels (UNS S32750) by pulsed current gas tungsten arc welding using duplex and austenitic stainless steel fillers. Microstructure studies revealed the segregation of Mo-rich phases in the fusion zone while employing ERNi...
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Low density polyethylene (LDPE) waste disposal remains one of the major environmental concerns faced by the world today. In past decades, major focus has been given to enhance the biodegradation of LDPE by microbial species. In this present study, Aspergillus versicolor with the ability to degrade LDPE was isolated from municipal landfill area usin...
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Mutinus elegans is a species of fungi that is commonly called as Elegant Stinkhorn. The aim of this study was to screen the crude extracts of the fungus for phytochemical analysis, antimicrobial activity, antioxidant assay and anticancer activity. Extraction of the fungal sample in Soxhlet apparatus was done with n-hexane and methanol as the solven...
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Objective: Prodigiosin is a red tripyrrole pigment which is synthesized as a secondary metabolite by biotypes A1, A2, and A6 of Serretia marcescens. This study was aimed to optimize production parameters for prodigiosin pigment produced by S. marcescens strain JAR8 and to determine its antimicrobial, cytotoxicity, and dyeing properties.Methods: The...
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Fipronil is a phenylpryazole insecticide which is extensively used for the protection of agricultural yields. However, this insecticide poses various threats to the environment. Therefore it is essential to develop an effective method to degrade or eliminate this pollutant from the environment. In this present study, a fungal strain AJAG1 capable o...
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To evaluate the silver nanoparticles (AgNPs) synthesis by aqueous extract of Cymodocea rotundata against clinical pathogens and human osteosarcoma cell line. Methods: In the present study, AgNPs were synthesized by Cymodocea rotundata by reducing 1 mM silver nitrate (AgNO3) solution. The green synthesized AgNPs were characterized by UV-vis spectros...
Chapter
There is an urgent need for new drugs with increasing threat posed by multidrug resistant bacteria. Among the various sources of natural products actinomycetes hold prominent position due to their diversity and proven ability to produce bioactive metabolites. Generally, analytical instrumentation and chemical methods are widely used to identify and...
Article
Indiscriminate use of antibiotics and the rise in drug resistance emphasizes the immediate need for managing pharmaceutical products sensibly. The pharmaceutical products end in wastewater due to the manufacturing process of pharmaceutical industries, misuse of antibiotics and improper disposal of expired drugs, which eventually ends in sewers. In...
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The herbicide atrazine (2-Chloro-4-ethylamino-6-isopropylamino-s-triazine) is widely used on crops such as maize, sugarcane, corn, pineapple and sorghum. Although atrazine is an effective herbicide, the persistence of this herbicide leads to contamination of soil, groundwater and surface water. This work presents the laboratory studies on the degra...
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Background: Physical and chemical methods of synthesizing metal nanoparticles have been on the focus for the last decade as it has been broadly exploited by researchers. Biological synthesis of metal nanoparticles was found to be easy and economical. The wide applications of titanium dioxide in various fields have drawn attention for biosynthesis o...
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The present study was planned with the aim to remove various dye decolorization using fungal strains. The fungi was isolated from soil samples collected from waste disposal areas and agricultural fields. Nine isolates were initially selected for testing their decolorization potential in the liquid medium. Three most effective strains were used t...
Chapter
Metals and their derivative compounds have been used as therapeutic agents from historical times until the present day. Recently, there has been tremendous development in the formulation of nanomaterials toward human benefit, among which silver and gold nanoparticles (AuNPs) have gained major attention due to their ease of preparation, low toxicity...
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Polythene and plastic waste are found to accumulate in the environment, posing a major ecological threat. They are found to be considered non-degradable, once it enters the environment it has been found to remain there indefinitely. However, significant attention has been placed on biodegradable polymer, identification of microbes with degradative...
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Basil seeds are traditionally believed to be used for therapeutic purpose to improve blood circulation, reduce inflammation, reduce the oxidation of cholesterol, and increase immune function and to control blood sugar level. In present study, basil (Ocimum basilicum) seeds were used as the raw material for evaluation of their bioactive compounds. A...
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Chemical pesticides are largely used in different types of crops all over the world. This particular study deals with the mycoremediation of the pesticide Monocrotophos (MCP) which is largely used for the protection of cash crops. Fungal isolates which had the potential to degrade MCP was isolated by means of enrichment technique from sugarcane fie...
Article
Seven different bacterial strains were isolated from chlorpyrifos contaminated paddy field. Isolates were characterized on the basis of phenotypic and biochemical characterization. Isolates were identified as Serratia sp., Citrobacter sp., Pseudomonas sp., Enterobacter sp., Klebsiella sp., Bacillus sp., and Alcaligenes sp. Bacterial strains were te...
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Aim: Green synthesis of nanoparticles include natural plant, fruit, leaf or seed extracts and can be used for medicinal applications. Lanthanum nanoparticles have been applied in various fields. In this study, fenugreek seed aqueous extract was used to synthesize lanthanum nanoparticles. Methods: The size and characteristics of the nanoparticles we...
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Two very potentexopolysaccharidebioflocculantproducing strains were isolated from compost pit and named as JA1 and JA2. They were identified using 16S rRNA gene sequence method. FTIR analysis was done to confirm the presence of bioflocculant produced by the two bacterial strains. Response surface methodology (RSM) was employed to optimize the produ...
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Low-density polyethylene (LDPE) is potential source of environmental pollution. In this study, biodegradation of LDPE was achieved by employing fungus and actinobacteria isolated from waste dumping site. Among all the isolates, two potential strains were obtained through enrichment technique. Based on 18S rRNA and 16S rRNA analyses the isolated str...
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Objective: The increasing prevalence of drug-resistant pathogens has gained the attention of pharmaceutical and scientific communities toward potential antimicrobial agents from plant-derived sources. The present work deals with the extraction, screening, and characterization of antimicrobial compounds from Alstonia scholaris against various pathog...
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Grapes belong to the Vitaceae family and scientifically known as Vitis vinifera. They are found to be rich in phenolics like resveratrol, anthocyanins, flavonoids. As the effect of grape leaves cytotoxicity is unexplored, the present work was aimed at evaluating the effect of extracts on cancer cell line and also on clinical pathogens. In this work...
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Context: Macrotyloma uniflorum, commonly called horse gram, is a leguminous crop. It is known to play a key role in plant defense responses with its unique characteristics. Aim: As the effect of Macrotyloma uniflorum extracts on the area of cytotoxicity is unexplored, the present work was aimed to evaluate the effect of extracts on cancer cell line...
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Abstract Electricals and electronic equipments that have reached its utilization period are disposed by the consumer are considered as e-waste. The categories of e-waste range from household appliances to machines used in offices and consumer goods. The rise in problem is due to scarcity of proper place for disposing the e-wastes. Hence, the wastes...
Article
The fungal strain AJA1 was isolated from leaf litter sample and identified as Penicillium decumbens through 18S rRNA gene sequencing. The antimicrobial potential of Penicillium decumbens strain AJA1 was investigated against medically important pathogenic microorganisms. The mycelium obtained in the presence of four different nitrogen sources sodium...
Article
Grapes belong to the Vitaceae family and scientifically known as Vitis vinifera.They are found to be rich in phenolics like resveratrol, anthocyanins, flavonoids. As the effect of grape leaves cytotoxicity is unexplored, the present work was aimed at evaluating the effect of extracts on cancer cell line and also on clinical pathogens. In this work,...
Article
Heavy metals are ubiquitous and persistent environmental pollutants that are introduced into environment via industrial operations. Copper affect environment as well as humans and animals when in excess concentration. Removal of copper from environment can be performed by physical, chemical and biological methods. Physical and chemical methods are...
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Objectives: Nanotechnology holds an important area in recent research due of its immense use in the different field of sciences. The small size, large surface area, orientation, and physical properties make them appropriate to be used in medical sciences, physics, and chemistry. Physical and chemical processes of synthesizing nanoparticles are cont...
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The work presented here attempts to screen for the presence of 4-Hydroxy-2,5-dimethyl-3(2H)-furanone in fruits and also any bioactive potential present in the fruit extracts. Curcurbita melo was selected for the study, and the fruit was crushed, filtered and extracted with ethyl acetate as the solvent. The resulting extract was subjected to disk di...
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Several attempts have been done to use different species of Hypomyces for the control of plant parasites. Though not much work has been done, this study was undertaken to explore antioxidant, antimicrobial and anticancer activity of Hypomyces chrysospermus through different screening tests. Antimicrobial activities were studied by agar well diffusi...
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Applying the concept of ethnobotany, plant extract was taken into consideration as an alternative to chemicals synthesis of silver nanoparticle. The extracts from the chilli seeds were used to synthesize silver nanoparticles (AgNPs). In this study two species of chilli, Capsicum annuum and Capsicum frutescens, have been used to analyse the characte...
Article
In the present investigation fungal strains were employed in degrading chromium which is found to be a major contaminant in leather processing waste water. The organisms were isolated from tannery effluent situated in Sengulam in Dindigul. Isolation of fungus was carried out on SDA by serial dilution and spread plate method. Seven prominent fungal...