Jay R Hoffman

Jay R Hoffman
Ariel University · Department of Physiotherapy

Ph.D.

About

527
Publications
317,529
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
16,526
Citations

Publications

Publications (527)
Article
Full-text available
BACKGROUND The International Ankle Consortium has recommended several instruments for assessing and diagnosing chronic ankle instability. These include the Ankle Instability Instrument (AII), Cumberland Ankle Instability Tool (CAIT), Identification of Functional Ankle Instability (IdFAI), and Foot and Ankle Ability Measure (FAAM). This study aimed...
Article
Full-text available
Elevations in the circulating concentration of androgens are thought to have a positive effect on the anabolic processes leading to improved athletic performance. Anabolic-androgenic steroids have often been used by competitive athletes to augment this effect. Although there has been concerted effort on examining how manipulating training variables...
Article
Full-text available
Background: The connection between physical exercise and the brain has long been studied. The evidence showing that physical exercise plays a significant role on neurogenesis and cognitive function has primarily been based on research examining aerobic exercise. In this review, we described three exercise modalities: aerobic, anaerobic, and resist...
Conference Paper
Full-text available
Two studies from our laboratory demonstrated that NCAA Division III male and female soccer players improve off-field aerobic and anaerobic performance measures during the competitive soccer season. Yet, competitive soccer season GPS-derived metrics in this population are limited. PURPOSE: To examine GPSderived metrics changes in female National Col...
Article
Full-text available
The effect of 3 weeks of amorphous calcium carbonate (ACC) supplementation (2000 mg per day) was examined on the recovery response to resistance exercise. Thirty men were randomized into a supplement (ACC) or placebo (PL) group. Following supplementation, participants performed six sets of 10 repetitions in the bench press (BP) and incline BP exerc...
Article
Full-text available
Exposure to high ambient temperature is a stressor that influences both biological and behavioral functions and has been previously shown to have an extensive impact on brain structure and function. Physiological, cellular and behavioral responses to heat-stress (HS) (40–41 °C, 2 h) were evaluated in adult male Sprague-Dawley rats. The effect of HS...
Article
Full-text available
Brain-derived neurotrophic factor (BDNF) is the brain’s most-produced neurotrophin during the lifespan, essentially involved in multiple mechanisms of nervous system development and function. The production/release of BDNF requires multi-stage processing that appears to be regulated at various stages in which the presence of a polymorphism “Val66Me...
Article
Full-text available
Chronic ankle instability (CAI) is a common condition that may develop after an ankle sprain. Compared with healthy individuals, those with CAI demonstrate excessive ankle inversion and increased peroneal electromyography (EMG) activity throughout the stance phase of gait, which may put them at greater risk for re-injury. Functional electrical stim...
Article
Full-text available
Hoffman, JR, Ostfeld, I, Zamir, A, Amedi, R, Fonville, TR, Horstemeyer, MF, and Gepner, Y. Examination of cognitive function, neurotrophin concentrations, and both brain and systemic inflammatory markers following a simulated game of American football. J Strength Cond Res 36(3): 686-694, 2022-This investigation examined the effect of a simulated Am...
Article
Full-text available
Elevations in the circulating concentration of androgens are thought to have a positive effect on the anabolic processes leading to improved athletic performance. Anabolic-androgenic steroids have often been used by competitive athletes to augment this effect. Although there has been concerted effort on examining how manipulating training variables...
Article
Full-text available
This consensus statement is an update of the 1987 American College of Sports Medicine (ACSM) position stand on the use of anabolic-androgenic steroids (AAS). Substantial data have been collected since the previous position stand, and AAS use patterns have changed significantly. The ACSM acknowledges that lawful and ethical therapeutic use of AAS is...
Article
Full-text available
Brain-derived neurotrophic factor (BDNF) plays an essential role in nervous system formation and functioning, including metabolism. Present only in humans, the "Val66Met" polymorphism of the BDNF gene (BDNF) is suggested to have a negative influence on the etiology of neurological diseases. However, this polymorphism has only been addressed, at the...
Article
Full-text available
There have been a multitude of reviews written on exercise-induced muscle damage (EIMD) and recovery. EIMD is a complex area of study as there are a host of factors such as sex, age, nutrition, fitness level, genetics and familiarity with exercise task, which influence the magnitude of performance decrement and the time course of recovery following...
Article
The effect of 30 days of β-alanine supplementation on neurophysiological responses of animals exposed to an acute heat stress (HS) was examined. Animals were randomized to one of three groups; exposed to HS (120 min at 40–41 °C) and fed a normal diet (EXP; n = 12); EXP and supplemented with β-alanine (EXP + BA; n = 10); or not exposed (CTL; n = 10)...
Article
Full-text available
Background Studies have reported beneficial effects of exercise training on autoimmunity, and specifically on multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, it is unknown whether different training paradigms affect disease course via shared or separate mechanisms. Objective To compare the effects and mechanis...
Article
Full-text available
Backward walking (BW) is being increasingly used in neurologic and orthopedic rehabilitation as well as in sports to promote balance control as it provides a unique challenge to the sensorimotor control system. The identification of initial foot contact (IC) and terminal foot contact (TC) events is crucial for gait analysis. Data of optical motion...
Article
Full-text available
Background: Alteration in brain-derived neurotrophic factor (BDNF) production is a marker of neuropathological conditions, which has led to the investigation of Val66Met polymorphism occurring in the human BDNF gene (BDNF). Presently, there are no reported methods available for the analysis of Val66Met impact on human BDNF functioning. Purpose: To...
Article
Hoffman, JR. Evaluation of a reactive agility assessment device in youth football players. J Strength Cond Res XX(X): 000-000, 2020-The purpose of this study was to examine the reliability and validity of the Blazepod reactive agility device on sport-specific movements in competitive youth football players. Thirty-one male athletes (16.7 ± 1.5 year...
Chapter
Physical and anthropometric assessments are commonly used in the evaluation of basketball players. Often, they are performed on an annual or semi-annual basis to monitor the effectiveness of a physical training program over the athlete’s career or may be assessed more frequently during a season to identify overtraining or fatigue. These measures ma...
Article
Full-text available
Objective: The purpose of this study was to examine the effect of exposure of a low-intensity blast wave on androgen receptor (AR) density in the hippocampus and the potential influence on behavioral and cognitive responses. Methods: Sprague-Dawley rats were randomly assigned to either a blast exposed group (n = 27) or an unexposed (control) group...
Article
Wells, AJ, Varanoske, AN, Coker, NA, Kozlowski, GJ, Frosti, CL, Boffey, D, Harat, I, Jahani, S, Gepner, Y, and Hoffman, JR. Effect of β-alanine supplementation on monocyte recruitment and cognition during a 24-hour simulated military operation. J Strength Cond Res XX(X): 000-000, 2020-Sustained military operations (SUSOPs) result in psychological s...
Article
Hoffman, JR, Marcus, I, Dubnov-Raz, G, and Gepner, Y. Ergogenic effects of 8 days of Sceletium tortuosum supplementation on mood, visual tracking, and reaction in recreationally trained men and women. J Strength Cond Res XX(X): 000-000, 2020-Sceletium tortuosum (ST) is a South African plant that has been reported to promote a sense of well-being in...
Article
here are limited data pertaining to the effects of sex on sprint interval cycling (SIC) training session performance. Purpose: We investigated sex-based differences on sprint interval cycling (SIC) performance in collegiate soccer players. Methods: Twelve men and twelve women completed two identical lab trials, 7–14 days apart. The first lab sessio...
Article
Objectives The effect of 30-days of β-alanine (BA) supplementation on heat shock protein 70 (HSP70), inflammatory and neurotrophin responses in the hippocampus and hypothalamus of rats exposed to an acute heat stress was investigated. Methods Animals were randomized to either a control (CTL) group or BA supplementation (100mg·kg−1) group. All anim...
Article
Full-text available
The purpose of this study was to assess the maturity-related differences in the aerobic and anaerobic adaptations to sprint interval training (SIT) among youth male athletes. Twenty-seven youth male athletes were assessed for years from peak height velocity (PHV) and classified into prepubescent (PRE, n = 7, years from PHV = -2.21 ± 0.47 years), pe...
Article
Introduction: β-alanine (BA) supplementation may improve cognition and mitigate symptoms of anxiety and depression associated with aging, neurological disorders, and physical exertion, which has been attributed to increases in brain carnosine and/or brain-derived neurotropic factor (BDNF). BA also provides beneficial effects on cognition, mood, and...
Article
Bartolomei, S, Nigro, F, Malagoli Lanzoni, I, Masina, F, Di Michele, R, and Hoffman, JR. A comparison between total body and split routine resistance training programs in trained men. J Strength Cond Res XX(X): 000-000, 2020-The purpose of the present investigation was to compare the effects of total body (TB) versus split routine (SR) resistance t...
Article
Full-text available
The purpose of this study was to compare the physiological responses of a single bout of an eccentric accentuated bench press protocol (120% of 1RM in the eccentric phase/80% in the concentric phase; [120/80]) versus a regular high-intensity exercise protocol (80%/80%; [80/80]) in resistance-trained men. Eleven men (age = 25.6 ± 3.9 y; body mass =...
Article
Hoffman, JR, Hoffman, MW, Zelicha, H, Gepner, Y, Willoughby, DS, Feinstein, U, and Ostfeld, I. The Effect of 2-Weeks of Inactivated Probiotic Bacillus coagulans on Endocrine, Inflammatory and Performance Responses During Self-Defense Training in Soldiers. J Strength Cond Res XX(X): 000-000, 2019-The effect of 2 weeks of inactivated Bacillus coagula...
Article
Carnosine and histidine content in the hippocampus of 14-month-old male rats was examined following 30 days of β-alanine supplementation. All animals were provided identical diets; however, 100 mg of β-alanine was mixed with glucomannan (80:20 blend) in the water of β-alanine supplemented animals. Hippocampal carnosine content was significantly gre...
Article
Full-text available
β-alanine supplementation increases muscle carnosine content and improves anaerobic exercise performance by enhancing intracellular buffering capacity. β-alanine ingestion in its traditional rapid-release formulation (RR) is associated with the symptoms of paresthesia. A sustained-release formulation (SR) of β-alanine has been shown to circumvent p...
Article
The aim of this study was to compare muscle oxygenation of the vastus lateralis during a high-volume isokinetic resistance exercise protocol (HVP) between young adult (YA) and middle-aged adult (MA) men. Twenty recreationally trained men were assigned to either the YA (age 21.8±2.0 years, body mass 90.7±11.6 kg, body height 179±4.7 cm) or MA (age 4...
Article
Introduction Intense military operations during deployment or training are associated with elevations in inflammatory cytokine markers. However, the influence of an inflammatory response on military-specific skills is unclear. This study examined the association between brain-derived neurotrophic factor (BDNF), glial fibrillar acidic protein, marke...
Article
Full-text available
Purpose This study evaluated the contributions of somatic maturity (years from estimated peak height velocity) and training experience as developmental indicators of muscle morphology, biomechanical parameters, and bilateral asymmetries in youth judo athletes. Methods Twenty-six judo athletes aged 8–18 years (mean ± SD; age = 12.9 ± 2.6 years, mat...
Article
Full-text available
Sustained military operations (SUSOPs) are associated with performance decrements and cognitive dysfunction. β‐Alanine (BA) supplementation may have a role in increasing soldier resiliency by enhancing muscle‐buffering capacity and reducing oxidative stress. The purpose of this study was to examine the effects of BA on physical performance, cogniti...
Article
We examined the effect of a proprietary spearmint extract containing rosmarinic acid (PSE) on physical, cognitive, and executive functioning of study participants after a high-risk tactical operation while sleep deprived for 24 hours. Ten Operators (mean ± standard deviation: age, 35.1 ± 5.2 years; height, 177.6 ± 5.3cm; weight, 81.3 ± 9.3kg) from...
Article
The effect of 30 days of β-alanine supplementation (100 mg/kg) on behavioral response and expression of brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), and markers of inflammation was examined in both young (4 months) and older (14 months) rats. We hypothesized that animals fed β-alanine would experience reduced inflammation and an...
Article
β-Hydroxy-β-Methylbutyrate (HMB) is a metabolite of the branched-chain amino acid leucine and its ketoacid α-ketoisocaproate. HMB has been widely used as an ergogenic supplement to increase muscle strength, muscle hypertrophy and enhance recovery. The physiological mechanisms that underlie these benefits are related to HMB's ability to stimulate mu...
Article
Objective: The present study evaluated the effects of repeated-sprint training in normobaric hypoxia and β-alanine supplementation (BA) on aerobic and anaerobic performance in recreationally active men. Methods: Participants were randomly assigned to one of the following groups: normoxia/β-alanine (NB, n = 11), normoxia/placebo (NP, n = 8), normoba...
Article
Introduction The weight that soldiers are required to carry in training and in combat has continually increased over the years. Changes in load carried or pace of activity will alter the physiological and biomechanical stress associated with the activity. Whether it is part of the soldier’s training or an actual operation, managing the proper load...
Article
Purpose: To examine the reliability and the maturity-related differences of fatigue thresholds (FTs) among youth males. Methods: Twenty-nine youth males (11-17 y) completed 2 ramp exercise tests on a cycle ergometer. Systemic FTs were calculated from gas exchange and ventilation variables. Localized FTs were calculated from electromyography and...
Article
Full-text available
Resistance training may differentially affect morphological adaptations along the length of uni-articular and bi-articular muscles. The purpose of this study was to compare changes in muscle morphology along the length of the rectus femoris (RF) and vastus lateralis (VL) in response to resistance training. Following a 2-wk preparatory phase, 15 res...
Data
Data. Note: 30 = 30% of longitudinal distance [Distal]; 50 = 50% of longitudinal distance [Middle]; 70 = 70% of longitudinal distance [Proximal]; CSA = Cross-sectional area; MT = Muscle thickness; PRE = Pre-training; POST = Post-training; RF = Rectus femoris; VL = Vastus lateralis. (XLSX)
Article
The majority of barefoot running studies have not considered speed as an influential factor on foot strike pattern. The aim of this study was to investigate differences in foot strike pattern and spatiotemporal characteristics between barefoot and shod overground running at varying speeds. We first determined maximal running speed (Vm) over 50 m in...
Article
The complex interactions and overlapping symptoms of comorbid posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) induced by an explosive blast-wave have become a focus of attention in recent years, making clinical distinction and effective intervention difficult. Because dysregulation of the HPA-axis is thought to underlie...
Article
Full-text available
Purpose: To examine the impact of polyphenol supplementation on the recruitment, mobilization and activation of monocyte subsets following resistance exercise. Methods: Thirty-eight recreationally active males (22.1 ± 3.1 yrs; 173.9 ± 7.9 cm; 77.8 ± 14.5 kg) were assigned to 28-days of polyphenol supplementation (PPB), placebo (PL) or control (C...
Preprint
Full-text available
Resistance training may differentially affect morphological adaptations along the length of uni-articular and bi-articular muscles. The purpose of this study was to compare changes in muscle morphology along the length of the rectus femoris (RF) and vastus lateralis (VL) in response to resistance training. Following a 2-wk preparatory phase, 15 res...
Article
Full-text available
Hoffman, JR, Gepner, Y, Hoffman, M, Zelicha, H, Shapira, S, and Ostfeld, I. Effect of high dose, short-duration β-alanine supplementation on circulating IL-10 concentrations during intense military training. J Strength Cond Res XX(X): 000-000, 2018-This study examined the effect of β-alanine as a potential anti-inflammatory agent during intense mil...
Article
Full-text available
The influence of baseline strength or muscle size on adaptations to training is not well-understood. Comparisons between novice and advanced lifters, and between stronger and weaker experienced-lifters, have produced conflicting results. This study examined the effect of baseline muscle strength and size on subsequent adaptations in resistance-trai...
Article
The purpose of the present study was to validate the ballistic push-up test performed with hands on a force plate (BPU) as a method to measure upper-body power. Twenty-eight experienced resistance trained men (age = 25.4 ± 5.2 y; body mass = 78.5 ± 9.0 kg; body height = 179.6 ± 7.8 cm) performed, two days apart, a bench press 1RM test and upper-bod...
Article
Full-text available
The purpose of this study was to examine the effects of 28-days of supplemen-tation with an aqueous proprietary polyphenol blend (PPB) sourced from Camellia sinensis on intramuscular apoptotic signaling following an acute lower-body resistance exercise protocol and subsequent recovery. Untrained males (n = 38, 21.8 2.7 years, 173.4 7.9 cm, 77.6 14....
Chapter
Full-text available
β-Alanine is one of the more popular sport supplements used by strength/power athletes today. The popularity of β-alanine stems from its ability to enhance intracellular muscle-buffering capacity thereby delaying fatigue during high-intensity exercise by increasing muscle carnosine content. Recent evidence also suggests that elevated carnosine leve...
Article
Full-text available
Introduction. The purpose of this study was to examine the effects of a 10-week introductory Judo class on force-time characteristics during an explosive isometric gripping task. Material and methods. Twenty-two healthy men and women (age: 21.8±3.2yr; height: 169.6±7.4cm; body mass: 75.4±13.2 kg), 10 in an introductory judo class and 12 age-matched...
Article
Purpose: To evaluate the effects of moderate normobaric hypoxia on the parameters of the work-time relationship in the upper body. Methods: Twenty-one recreationally active men completed a graded exercise test in both normobaric hypoxia (H) and normoxia (N) to exhaustion on an arm ergometer to determine V̇O2peak and peak power output (PPO). Each...
Article
Full-text available
Background Intramyocellular triacylglycerol (IMTG) is utilized as metabolic fuel during exercise and is linked to insulin resistance, but the long-term effect of weight loss strategies on IMTG among participants with abdominal fat, remain unclear. Methods In an 18-month trial, sedentary participants with abdominal fat/dyslipidemia were randomized...
Data
Changes in food group intake after 6 and 18 months of intervention across diet groups. Each bar in the figure represents the mean changes and direction of the food group as compared to baseline. T-test was used to assess differences between diet groups, *P < 0.05. (TIF)