Jay R Hoffman

Jay R Hoffman
Ariel University · Department of Physiotherapy

Ph.D.

About

579
Publications
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20,699
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Publications

Publications (579)
Article
Introduction The terror attack on October 7, 2023, in southern Israel resulted in approximately 1,200 civilians and security personnel killed. Of the civilians murdered, approximately 200 men, women, and children were murdered inside their homes, while the remaining casualties were murdered in an open field at a music festival, in their cars, or in...
Poster
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The isometric mid-thigh pull (IMTP) test using the traditional bar grip (Bar) is a reliable and effective way to measure strength performance in different populations. In addition, IMTP performance has been linked to jump performance. Recent research has shown that the pelvic belt (Pel) IMTP method produces higher absolute and relative peak force v...
Article
Full-text available
Bartolomei, S, Francesco, L, Latini, D, and Hoffman, JR. Autoregulation does not provide additional benefits to a mixed session periodized resistance training program in trained men. J Strength Cond Res XX(X): 000–000, 2024—The aim of this investigation was to study how autoregulation impacted training volume, performance, and muscle size on a 10-w...
Article
Purpose This study examined the acute and long-term effects of nandrolone decanoate (ND) on fractional synthetic rates (FSR). Methods Male C57BL/6 mice were randomized into ND (n = 20) or sham (n = 20) groups. ND injections (10 g·kg ⁻¹ ·wk ⁻¹ ) started at 7-month of ages and continued for 6-weeks. Ten animals from each group were randomly separate...
Article
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Purpose This study compared the recovery response of physical performance and cognitive function between high volume, low intensity (HV) and high intensity, low volume (HI) resistance training in resistance trained men. Methods Eight recreationally resistance trained men (27.8 ± 1.6 y; 85.5 ± 11.2 kg; 178.4 ± 8.3 cm), with at least one-year of res...
Article
BACKGROUND: Periodical testing during the competitive season is critical for optimal performance in soccer. In this study, we investigated seasonal changes in women’s National Collegiate Athletic Association (NCAA) Division III soccer players utilizing laboratory-based physical performance tests and game global positing system (GPS) metrics. METHOD...
Article
This study examined the effect of 6 weeks of supraphysiological nandrolone decanoate (ND) administration in adult mice (7 months) on cognitive function and neuroinflammation during aging. Male C57BL/6 mice were randomized into ND (10 mg⋅kg − 1 ⋅wk − 1) or control (CTL) groups. Half of the mice were tested at a young (Y) age (ND-Y and CTL-Y), 1 week...
Article
Ben-Zeev, T, Sadres, E, and Hoffman, JR. Comparison of force measures between start position, transition phase, and midthigh pull with weightlifting performance during Israel National Competition. J Strength Cond Res XX(X): 000-000, 2023-This study compared the relationship between peak force (PKF) and rate of force development (RFD) at isometric s...
Article
This study investigated 10 weeks of β-alanine (BA) supplementation on changes in cognitive function, mood, and physical performance in 100 older adults (70.6 ± 8.7 y). Participants were randomized into a BA (2.4 g·d-1) or placebo (PL) group. Testing occurred prior to supplementation (PRE), at the midpoint (MID), and at week-10 (POST). Participants...
Conference Paper
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Over the years, a number of studies have examined the relationship between neuromuscular performance and sprint times, however, the data on NCAA Division III female soccer players is limited. PURPOSE: To examine this specific relationship in this athletic population. METHODS: Sixteen members of an NCAA Division III women's soccer team (mean ± SD):...
Conference Paper
Full-text available
Several studies from our laboratory have demonstrated that NCAA Division III female soccer players may not be at peak anaerobic condition at the onset of the competitive season. It has also been demonstrated that there is a fair amount of countermovement jump (CMJ) performance variability between these players. PURPOSE: To examine the relationship...
Conference Paper
Full-text available
The isometric mid-thigh pull (IMTP) test is an effective and reliable method to measure strength performance in various populations. Using portable force plates, previous research had compared a bar grip (Bar) to a pelvic belt (Pel) method of the IMTP test and demonstrated good test-retest reliability. However, there is a limited data on sex differ...
Article
Full-text available
Introduction/Purpose Head impacts associated with American football have been associated with short- and long-term disrupted cognitive performance. In this study, we aimed to determine the effects of an acute game of American football on cognitive function, memory, morphological changes, and functional connectivity in the brain. Methods Twelve mem...
Article
Objective: To examine the relationship between two dynamic postural tasks in subjects with and without chronic ankle instability (CAI). Design: Cross-sectional study. Setting: Biomechanics lab. Participants: Thirty subjects with CAI and 30 healthy controls. Main outcome measure: Performance of two dynamic postural control tests: the modifi...
Article
Full-text available
β-alanine is a nonessential amino acid that combines with the amino acid histidine to form the intracellular dipeptide carnosine, an important intracellular buffer. Evidence has been well established on the ability of β-alanine supplementation to enhance anaerobic skeletal muscle performance. As a result, β-alanine has become one of the more popula...
Article
Full-text available
Citation: Ostfeld, I.; Ben-Zeev, T.; Zamir, A.; Levi, C.; Gepner, Y.; Springer, S.; Hoffman, J.R. Role of β-Alanine Supplementation on Cognitive Function, Mood, and Physical Function in Older Adults; Double-Blind Randomized Controlled Study. Nutrients 2023, 15, 923. https://doi.org/10.3390/ Abstract: This study investigated 10 weeks of β-alanine (B...
Article
Full-text available
Nitric-oxide-stimulating dietary supplements are widely available and marketed to strength athletes and weightlifters seeking to increase muscle performance and augment training adaptations. These supplements contain ingredients classified as nitric oxide (NO) precursors (i.e., “NO boosters”). Endogenous NO is generated via a nitric oxide synthase...
Article
Bartolomei, S, Zaniboni, F, Verzieri, N, and Hoffman, JR. New perspectives in resistance training periodization: mixed session vs. block periodized programs in trained men. J Strength Cond Res XX(X): 000-000, 2022-The purpose of this investigation was to compare the effects of 2 different periodized resistance training programs on maximal strength,...
Article
The purpose of this systematic review with meta-analysis was to explore the effects of concurrent resistance and endurance training (CT) incorporating continuous or intermittent endurance training (ET) on whole- muscle and type I and II muscle fiber hypertrophy compared with resistance training (RT) alone. Randomized and nonrandomized studies repor...
Article
Full-text available
Background The International Ankle Consortium has recommended several instruments for assessing and diagnosing chronic ankle instability. These include the Ankle Instability Instrument (AII), Cumberland Ankle Instability Tool (CAIT), Identification of Functional Ankle Instability (IdFAI), and Foot and Ankle Ability Measure (FAAM). This study aimed...
Article
Full-text available
Elevations in the circulating concentration of androgens are thought to have a positive effect on the anabolic processes leading to improved athletic performance. Anabolic-androgenic steroids have often been used by competitive athletes to augment this effect. Although there has been concerted effort on examining how manipulating training variables...
Article
Full-text available
Background: The connection between physical exercise and the brain has long been studied. The evidence showing that physical exercise plays a significant role on neurogenesis and cognitive function has primarily been based on research examining aerobic exercise. In this review, we described three exercise modalities: aerobic, anaerobic, and resist...
Conference Paper
Full-text available
Two studies from our laboratory demonstrated that NCAA Division III male and female soccer players improve off-field aerobic and anaerobic performance measures during the competitive soccer season. Yet, competitive soccer season GPS-derived metrics in this population are limited. PURPOSE: To examine GPSderived metrics changes in female National Col...
Article
Full-text available
The effect of 3 weeks of amorphous calcium carbonate (ACC) supplementation (2000 mg per day) was examined on the recovery response to resistance exercise. Thirty men were randomized into a supplement (ACC) or placebo (PL) group. Following supplementation, participants performed six sets of 10 repetitions in the bench press (BP) and incline BP exerc...
Article
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Exposure to high ambient temperature is a stressor that influences both biological and behavioral functions and has been previously shown to have an extensive impact on brain structure and function. Physiological, cellular and behavioral responses to heat-stress (HS) (40–41 °C, 2 h) were evaluated in adult male Sprague-Dawley rats. The effect of HS...
Article
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Unlabelled: Brain-derived neurotrophic factor (BDNF) is the brain's most-produced neurotrophin during the lifespan, essentially involved in multiple mechanisms of nervous system development and function. The production/release of BDNF requires multi-stage processing that appears to be regulated at various stages in which the presence of a polymorp...
Article
Full-text available
Chronic ankle instability (CAI) is a common condition that may develop after an ankle sprain. Compared with healthy individuals, those with CAI demonstrate excessive ankle inversion and increased peroneal electromyography (EMG) activity throughout the stance phase of gait, which may put them at greater risk for re-injury. Functional electrical stim...
Article
Full-text available
Hoffman, JR, Ostfeld, I, Zamir, A, Amedi, R, Fonville, TR, Horstemeyer, MF, and Gepner, Y. Examination of cognitive function, neurotrophin concentrations, and both brain and systemic inflammatory markers following a simulated game of American football. J Strength Cond Res 36(3): 686-694, 2022-This investigation examined the effect of a simulated Am...
Article
Full-text available
Elevations in the circulating concentration of androgens are thought to have a positive effect on the anabolic processes leading to improved athletic performance. Anabolic-androgenic steroids have often been used by competitive athletes to augment this effect. Although there has been concerted effort on examining how manipulating training variables...
Article
This consensus statement is an update of the 1987 American College of Sports Medicine (ACSM) position stand on the use of anabolic-androgenic steroids (AAS). Substantial data have been collected since the previous position stand, and AAS use patterns have changed significantly. The ACSM acknowledges that lawful and ethical therapeutic use of AAS is...
Article
Full-text available
Brain-derived neurotrophic factor (BDNF) plays an essential role in nervous system formation and functioning, including metabolism. Present only in humans, the "Val66Met" polymorphism of the BDNF gene (BDNF) is suggested to have a negative influence on the etiology of neurological diseases. However, this polymorphism has only been addressed, at the...
Article
Full-text available
There have been a multitude of reviews written on exercise-induced muscle damage (EIMD) and recovery. EIMD is a complex area of study as there are a host of factors such as sex, age, nutrition, fitness level, genetics and familiarity with exercise task, which influence the magnitude of performance decrement and the time course of recovery following...
Article
The effect of 30 days of β-alanine supplementation on neurophysiological responses of animals exposed to an acute heat stress (HS) was examined. Animals were randomized to one of three groups; exposed to HS (120 min at 40–41 °C) and fed a normal diet (EXP; n = 12); EXP and supplemented with β-alanine (EXP + BA; n = 10); or not exposed (CTL; n = 10)...
Article
Full-text available
Background Studies have reported beneficial effects of exercise training on autoimmunity, and specifically on multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, it is unknown whether different training paradigms affect disease course via shared or separate mechanisms. Objective To compare the effects and mechanis...
Article
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Backward walking (BW) is being increasingly used in neurologic and orthopedic rehabilitation as well as in sports to promote balance control as it provides a unique challenge to the sensorimotor control system. The identification of initial foot contact (IC) and terminal foot contact (TC) events is crucial for gait analysis. Data of optical motion...
Article
Full-text available
Background: Alteration in brain-derived neurotrophic factor (BDNF) production is a marker of neuropathological conditions, which has led to the investigation of Val66Met polymorphism occurring in the human BDNF gene (BDNF). Presently, there are no reported methods available for the analysis of Val66Met impact on human BDNF functioning. Purpose: To...
Article
Hoffman, JR. Evaluation of a reactive agility assessment device in youth football players. J Strength Cond Res XX(X): 000-000, 2020-The purpose of this study was to examine the reliability and validity of the Blazepod reactive agility device on sport-specific movements in competitive youth football players. Thirty-one male athletes (16.7 ± 1.5 year...
Chapter
Physical and anthropometric assessments are commonly used in the evaluation of basketball players. Often, they are performed on an annual or semi-annual basis to monitor the effectiveness of a physical training program over the athlete’s career or may be assessed more frequently during a season to identify overtraining or fatigue. These measures ma...
Article
Full-text available
Objective: The purpose of this study was to examine the effect of exposure of a low-intensity blast wave on androgen receptor (AR) density in the hippocampus and the potential influence on behavioral and cognitive responses. Methods: Sprague-Dawley rats were randomly assigned to either a blast exposed group (n = 27) or an unexposed (control) group...
Article
Wells, AJ, Varanoske, AN, Coker, NA, Kozlowski, GJ, Frosti, CL, Boffey, D, Harat, I, Jahani, S, Gepner, Y, and Hoffman, JR. Effect of β-alanine supplementation on monocyte recruitment and cognition during a 24-hour simulated military operation. J Strength Cond Res XX(X): 000-000, 2020-Sustained military operations (SUSOPs) result in psychological s...
Article
Hoffman, JR, Marcus, I, Dubnov-Raz, G, and Gepner, Y. Ergogenic effects of 8 days of Sceletium tortuosum supplementation on mood, visual tracking, and reaction in recreationally trained men and women. J Strength Cond Res XX(X): 000-000, 2020-Sceletium tortuosum (ST) is a South African plant that has been reported to promote a sense of well-being in...
Article
here are limited data pertaining to the effects of sex on sprint interval cycling (SIC) training session performance. Purpose: We investigated sex-based differences on sprint interval cycling (SIC) performance in collegiate soccer players. Methods: Twelve men and twelve women completed two identical lab trials, 7–14 days apart. The first lab sessio...
Article
Full-text available
Objectives The effect of 30-days of β-alanine (BA) supplementation on heat shock protein 70 (HSP70), inflammatory and neurotrophin responses in the hippocampus and hypothalamus of rats exposed to an acute heat stress was investigated. Methods Animals were randomized to either a control (CTL) group or BA supplementation (100mg·kg−1) group. All anim...
Article
Full-text available
The purpose of this study was to assess the maturity-related differences in the aerobic and anaerobic adaptations to sprint interval training (SIT) among youth male athletes. Twenty-seven youth male athletes were assessed for years from peak height velocity (PHV) and classified into prepubescent (PRE, n = 7, years from PHV = -2.21 ± 0.47 years), pe...
Article
Introduction: β-alanine (BA) supplementation may improve cognition and mitigate symptoms of anxiety and depression associated with aging, neurological disorders, and physical exertion, which has been attributed to increases in brain carnosine and/or brain-derived neurotropic factor (BDNF). BA also provides beneficial effects on cognition, mood, and...
Article
Bartolomei, S, Nigro, F, Malagoli Lanzoni, I, Masina, F, Di Michele, R, and Hoffman, JR. A comparison between total body and split routine resistance training programs in trained men. J Strength Cond Res XX(X): 000-000, 2020-The purpose of the present investigation was to compare the effects of total body (TB) versus split routine (SR) resistance t...
Article
Full-text available
The purpose of this study was to compare the physiological responses of a single bout of an eccentric accentuated bench press protocol (120% of 1RM in the eccentric phase/80% in the concentric phase; [120/80]) versus a regular high-intensity exercise protocol (80%/80%; [80/80]) in resistance-trained men. Eleven men (age = 25.6 ± 3.9 y; body mass =...
Article
Hoffman, JR, Hoffman, MW, Zelicha, H, Gepner, Y, Willoughby, DS, Feinstein, U, and Ostfeld, I. The Effect of 2-Weeks of Inactivated Probiotic Bacillus coagulans on Endocrine, Inflammatory and Performance Responses During Self-Defense Training in Soldiers. J Strength Cond Res XX(X): 000-000, 2019-The effect of 2 weeks of inactivated Bacillus coagula...
Article
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Carnosine and histidine content in the hippocampus of 14-month-old male rats was examined following 30 days of β-alanine supplementation. All animals were provided identical diets; however, 100 mg of β-alanine was mixed with glucomannan (80:20 blend) in the water of β-alanine supplemented animals. Hippocampal carnosine content was significantly gre...
Article
Full-text available
β-alanine supplementation increases muscle carnosine content and improves anaerobic exercise performance by enhancing intracellular buffering capacity. β-alanine ingestion in its traditional rapid-release formulation (RR) is associated with the symptoms of paresthesia. A sustained-release formulation (SR) of β-alanine has been shown to circumvent p...
Article
The aim of this study was to compare muscle oxygenation of the vastus lateralis during a high-volume isokinetic resistance exercise protocol (HVP) between young adult (YA) and middle-aged adult (MA) men. Twenty recreationally trained men were assigned to either the YA (age 21.8±2.0 years, body mass 90.7±11.6 kg, body height 179±4.7 cm) or MA (age 4...
Article
Introduction Intense military operations during deployment or training are associated with elevations in inflammatory cytokine markers. However, the influence of an inflammatory response on military-specific skills is unclear. This study examined the association between brain-derived neurotrophic factor (BDNF), glial fibrillar acidic protein, marke...
Article
Full-text available
Purpose This study evaluated the contributions of somatic maturity (years from estimated peak height velocity) and training experience as developmental indicators of muscle morphology, biomechanical parameters, and bilateral asymmetries in youth judo athletes. Methods Twenty-six judo athletes aged 8–18 years (mean ± SD; age = 12.9 ± 2.6 years, mat...
Article
Full-text available
Sustained military operations (SUSOPs) are associated with performance decrements and cognitive dysfunction. β‐Alanine (BA) supplementation may have a role in increasing soldier resiliency by enhancing muscle‐buffering capacity and reducing oxidative stress. The purpose of this study was to examine the effects of BA on physical performance, cogniti...
Article
This investigation examined the effect of a proprietary spearmint extract containing rosmarinic acid (PSE) on physical, cognitive and executive functioning following a high‐risk tactical operation while sleep deprived for 24‐hours. Ten operators (35.1 ± 5.2 y; 177.6 ± 5.3 cm; 81.3 ± 9.3 kg) from an elite counter‐terrorism unit volunteered to partic...
Article
The effect of 30 days of β-alanine supplementation (100 mg/kg) on behavioral response and expression of brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), and markers of inflammation was examined in both young (4 months) and older (14 months) rats. We hypothesized that animals fed β-alanine would experience reduced inflammation and an...
Article
β-Hydroxy-β-Methylbutyrate (HMB) is a metabolite of the branched-chain amino acid leucine and its ketoacid α-ketoisocaproate. HMB has been widely used as an ergogenic supplement to increase muscle strength, muscle hypertrophy and enhance recovery. The physiological mechanisms that underlie these benefits are related to HMB's ability to stimulate mu...