Javier Navarro Rueda

• Ph.D.
• Assistant Professor at Pontifical Xavierian University

In patients with tetralogy of Fallot (TOF) repaired with a transannular patch (TAP), right ventricular outflow tracts (RVOT) are classified by shape using complex 3D measurements. RVOT shape is crucial for evaluating transcatheter pulmonary valve replacement (TPVR). Aim: To evaluate if a simple graphical representation of the RVOT in TOF patients r...

Background Accurate diagnosis and treatment of complex cardiac tumors poses challenges, particularly when surgical resection is considered. 3D reconstruction and printing appear as a novel approach to allow heart teams for optimal surgical and post operative care. Methods We report two patients with uncommon masses including a cardiac angiosarcoma...

In this paper, we demonstrate the importance of gestational age information to diagnose Congenital Heart Disease using two different states of art methods, Vision Transformer and Swin Transformer, in a self-collected private ultrasound dataset. We represent the gestational age as a positional encoding and use it in different inputs in the models. U...

Presentamos el desarrollo de una biblioteca en línea de casos de cardiopatías congénitas (CC) orientada al ámbito educativo en un esfuerzo colaborativo.

Tendons are involved in multiple disorders and injuries, ranging from birth deformities to tendinopathies to acute ruptures. The ability to characterize embryonic tendon mechanical properties will enable elucidation of mechanisms responsible for functional tendon formation. In turn, an understanding of tendon development could inform approaches for...

Percutaneous biopsies (PBs) are the gold standard diagnostic procedures indicated for renal and hepatic disorders. Nevertheless, they can cause hemorrhages and are contraindicated for coagulopathic patients. In this study we designed, fabricated, and evaluated a small intestinal submucosa (SIS) plug to reduce, and potentially cease, bleeding to dec...

Autologous grafts are the current gold standard of care for coronary artery bypass graft surgeries, but are limited by availability and plagued by high failure rates. Similarly, tissue engineering approaches to small diameter vascular grafts using naturally derived and synthetic materials fall short, largely due to inappropriate mechanical properti...

Keratin is a natural material that can be derived from the cortex of human hair. Our group had previously presented a method for the printed, sequential production of 3D keratin scaffolds. Using a riboflavin-SPS-hydroquinone (initiator-catalyst-inhibitor) photosensitive solution, we produced 3D keratin-based constructs via UV crosslinking in a lith...

We have developed a dual‐chambered bioreactor (DCB) that incorporates a membrane to study stratified 3D cell populations for skin tissue engineering. The DCB provides adjacent flow lines within a common chamber; the inclusion of the membrane regulates flow layering or mixing, which can be exploited to produce layers or gradients of cell populations...

Purpose This paper aims to study the effects of part orientation during the 3D printing process, particularly to the case of using continuous digital light processing (cDLP) technology. Design/methodology/approach The effects of print orientation on the print accuracy of microstructural features were assessed using microCT imaging and mechanical p...

The skin is responsible for several important physiological functions and has enormous clinical significance in wound healing. Tissue engineered substitutes may be used in patients suffering from skin injuries to support regeneration of the epidermis, dermis, or both. Skin substitutes are also gaining traction in the cosmetics and pharmaceutical in...

The layers in skin determine its protective and hemostasis functions. This layered microstructure cannot be naturally regenerated after severe burns; we aim to reconstruct it using guided tissue regeneration (GTR). In GTR, a membrane is used to regulate tissue growth by stopping fast-proliferating cells and allowing slower cells to migrate and reco...

Epithelial barriers are the body’s natural defense system to regulating passage from one domain to another. In our efforts to understand what can and cannot cross these barriers, models have emerged as a reductionist approach to rigorously study and investigate this question. In particular, in vitro tissue models have become prominent as there is a...

The recapitulation of human anatomy and physiology is critical for organ regeneration. Due to this fundamental requirement, bioprinting holds great promise in tissue engineering and regenerative medicine due to the possibility of fabricating complex scaffolds that host cells and biochemical cues in a physiologically relevant fashion. The ever-growi...

Keratin, a naturally-derived polymer derived from human hair, is physiologically biodegradable, provides adequate cell support, and can self-assemble or be crosslinked to form hydrogels. Nevertheless, it has had limited use in tissue engineering and has been mainly used as casted scaffolds for drug or growth factor delivery applications. Here, we p...

Small intestinal submucosa grafts for vascular regeneration have produced variable patency (0-100%) that has been concurrent with variability in fabrication techniques. We hypothesized that 1) preservation (P) or removal (R) of the stratum compactum layer of the intestine and 2) a dehydrated (D) or hydrated (H) state, affect early graft patency and...

Abstract Poster Presentation

Mechanical properties of Small-Diameter Vessels (SDV) are scarcely studied. The proposed Pressure-Volume (PV) system, developed to evaluate stress-strain ( σ-ε) behavior of SDV, allows the controlled variation of internal pressure and simulation of pressure-induced diameter changes of tubes. Measurements were taken from contrast-improved images cap...