Javier S. Perona

Javier S. Perona
Spanish National Research Council | CSIC · Nutrition and Lipid Metabolism

PhD

About

150
Publications
15,183
Reads
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3,433
Citations
Citations since 2017
25 Research Items
1283 Citations
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2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
Additional affiliations
January 2016 - present
Universidad Pablo de Olavide
Position
  • Lecturer
January 2012 - December 2014
Position
  • Influence of a Mediterranean-style breakfast on postprandial lipid disorders and inflammatory processes in obese pre-adolescents and adults
January 2003 - December 2010
Spanish National Research Council

Publications

Publications (150)
Article
Full-text available
The definition of metabolic syndrome (MetS) based on dichotomous cut-off points is efficient in the adult population. However, to date, there is no international consensus on how to define MetS in the pediatric population. For that reason, a continuous MetS score (cMetS) has been proposed for the pediatric population. However, despite multiple atte...
Article
Full-text available
Oleanolic acid (OA) is a natural triterpene widely found in olive leaves that possesses antioxidant, anti-inflammatory, and insulin-sensitizing properties, among others. These OA characteristics could be of special interest in the treatment and prevention of insulin resistance (IR), but greater in-depth knowledge on the pathways involved in these p...
Article
Full-text available
Microglial cells can contribute to Alzheimer’s disease by triggering an inflammatory response that leads to neuronal death. In addition, the presence of amyloid-β in the brain is consistent with alterations in the blood–brain barrier integrity and triglyceride-rich lipoproteins (TRL) permeation. In the present work, we used lab-made TRL as carriers...
Article
Full-text available
Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is receiving outstanding attention from the scientific community due to its biological activity against multiple diseases. Oleanolic acid is endowed with a wide range of biological activities with therapeutic potential by means of complex and multifactorial mechan...
Article
Background: Inconsistent results due to age, ethnic, and geographic differences have been found on the predictive capacity of atherogenic indices in previous studies. The aim of this study was to assess the predictive value of 6 atherogenic indices for MetS in a Spanish adolescent population. Methods: A cross-sectional study was performed on 981 ad...
Article
Full-text available
Oleanolic acid (OA), a triterpene that is highly present in olive leaves, has been proposed as a component of functional foods for the prevention of metabolic syndrome, due to its anti-inflammatory activity. We analyzed the effects of OA on inflammatory parameters and signaling proteins in LPS-stimulated THP-1 macrophages. Thus, THP-1 macrophages w...
Article
Full-text available
Current research suggests that virgin olive oil (VOO) phenolics are potent preventive and therapeutic agents against metabolic diseases associated with inflammation and oxidative stress. Evidence-based medicine requires these effects be proved in randomized controlled trials (RCT), which are then assessed in meta-analyses, to ensure that the allege...
Article
Full-text available
Biomass of the acidophilic green alga Coccomyxa onubensis may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweig...
Article
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Small lipophilic molecules present in foods of plant origin have relevant biological activities at rather low concentrations. Evidence suggests that phytosterols, carotenoids, terpenoids, and tocopherols can interact with different metabolic pathways, exerting beneficial effects against a number of metabolic diseases. These small molecules can modu...
Article
Background The metabolic syndrome (MetS), although more frequent in adults, is a growing health problem in adolescent population. There are different criteria for the diagnosis, however without a consensus of which is the best to be used in this population. The heterogeneity of the different diagnostic criteria makes it necessary to carry out more...
Article
Full-text available
Microglia respond to adverse stimuli in order to restore brain homeostasis and, upon activation, they release a number of inflammatory mediators. Chronic microglial overactivation is related to neuroinflammation in Alzheimer’s disease. In this work, we show that oleanolic acid (OA), a natural triterpene present in food and medicinal plants, attenua...
Article
Full-text available
The high prevalence of obesity is a serious public health problem in today’s world. Both obesity and insulin resistance favor the development of metabolic syndrome (MetS), which is associated with a number of pathologies, especially type 2 diabetes mellitus, and cardiovascular diseases. This serious problem highlights the need to search for new nat...
Article
Full-text available
Metabolic syndrome (MetS) is a growing problem worldwide in adolescents. This study compared two sample populations of young people in Spain and China, and analyzed the association of birth weight and breastfeeding duration with MetS. A cross-sectional study was conducted in adolescents (10–15 years old); 1150 Chinese and 976 Spanish adolescents. T...
Article
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We previously reported, using the diagnostic criteria of the International Diabetes Federation (IDF), that waist circumference (WC) and abdominal volume index (AVI) were capable of predicting metabolic syndrome (MetS) in adolescents. This study was aimed at confirming this finding when other diagnostic criteria are used. A cross-sectional study was...
Article
Full-text available
Background Waist circumference has been suggested as predictor for metabolic syndrome (MetS) in adolescents but it has not been compared with newly proposed anthropometric indexes. This study aimed to disclose the capacity of ten classic and novel anthropometric indexes to discriminate by the presence of MetS in this young population. Materials an...
Article
Full-text available
The aim of this study was to compare the variations in the concentrations of tocopherols and retinol in obese adults in the postprandial state after the intake of a Mediterranean or Western-style breakfast. The study was designed as a randomized, controlled intervention trial in the postprandial state, for which 24 male adults (12 obese and 12 of n...
Chapter
Full-text available
It is well accepted that the consumption of very long-chain n-3 PUFA of marine origin have beneficial effects on plasma triglyceride concentrations and on systemic inflammation states. α-Linolenic acid (18: 3 n-3, ALA), although also a member of the n-3 PUFA family, is found predominantly in plants and its beneficial effects on health are more cont...
Article
Full-text available
Background: Breastfeeding duration has been associated with less low-grade inflammation in healthy adolescents, but there is scarce information regarding obese subjects. This study aimed to evaluate whether exclusive breastfeeding is related to serum concentrations of inflammatory markers in a population of Spanish adolescents. Method: A cross-s...
Article
The metabolic syndrome is a cluster of pathological conditions, including hypertension, hyperglycemia, hypertriglyceridemia, obesity and low HDL levels that is of great concern worldwide, as individuals with metabolic syndrome have an increased risk of type-2 diabetes and cardiovascular disease. Insulin resistance, the key feature of the metabolic...
Data
Data S1. Mediterranean diet in a primary cardiovascular prevention research plan.
Data
Table S1. Concordance of Estimated Cardiovascular Risk Between Framingham‐REGICOR and SCORE Strategies in the Whole Population Table S2. Concordance of Estimated Cardiovascular Risk Between Framingham‐REGICOR and SCORE Strategies in the Nondiabetic Population Table S3. Main Cardiovascular Risk Factors, Medication Use, and Treatment Goals by Frami...
Article
At present, few studies have assessed the possible influence of culture and religion on healthy eating habits among the university population. The aim of this study was to identify differences in healthy and eating habits among university students of different religions. A cross-sectional study was performed with a sample population of 257 students...
Article
Full-text available
Background: Insulin resistance plays a determinant role in the development of metabolic syndrome in adolescents. The objective of the present study was to determine the influence of factors commonly associated with insulin resistance in a sample of adolescents. Methods: This cross-sectional study included 976 adolescents from southeast Spain. An...
Article
Full-text available
The atherogenicity of triglyceride-rich lipoproteins (TRLs) is dependent of their particle size as it determines their metabolic fate. Since TRL possess a single apolipoprotein B (Apo B) molecule per particle, the triglyceride (TG)/Apo B ratio has been used as a convenient method to estimate TRL size. The aim of this study was to validate this appr...
Article
The metabolic syndrome (MetS) is precisely defined and the cardiovascular risk associated with the clustering of its components has been demonstrated in adults. However, data on children and adolescents are still scarce, in part, because of difficulties in transposing the definition from adults. The identification of risk factors for the developmen...
Article
Pomace olive oil (POO) is rich in minor components, which can modulate the composition of postprandial triglyceride-rich lipoproteins (TRL) and their uptake by macrophages. The aim of the present study was to investigate the effects of postprandial TRL obtained after the ingestion of meals containing POO or refined olive oil (ROO) on foam cell form...
Article
Although the beneficial role of EVOO in the Mediterranean Diet is well-known, its effects on health cannot be attributed solely to oleic acid. In addition to minor components, the presence of other fatty acids (FA), which depend largely on the cultivar among other factors, need to be considered. In the present study, we examined the effect of chylo...
Article
Full-text available
Analytical interest of OA determination in human serum has increased owing to the increasing interest in pharmaceutical research by pharmaceutical properties. A simple, specific, precise and accurate GC method with flame ionization detector (FID) developed and validated for the determination of oleanolic acid (OA) in human serum (HS). To an aliquot...
Article
Full-text available
Postprandial TAG-rich lipoproteins (TRL) can be taken up by macrophages, leading to the formation of foam cells, probably via receptor-mediated pathways. The present study was conducted to investigate whether the postprandial time point at which TRL are collected modulates this process. A meal containing refined olive oil was given to nine healthy...
Article
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Unhealthy dietary habits are key determinants of obesity in adolescents. Assuming that dietary fat profile influences membrane lipid composition, the aim of this study was to analyze structural changes in the erythrocyte membrane of obese compared to normal-weight adolescents. The study was conducted in a group of 11 obese and 11 normal-weight adol...
Chapter
With different degrees of evidence, many of the health-promoting effects of the Mediterranean diet have been attributed to olive oil consumption. Apart from oleic acid, the particular minor components present in olive oil, such as hydrocarbons, tocopherols, fatty alcohols, triterpenic compounds, and polyphenols, some of which are known to be anti-i...
Article
Full-text available
Different studies4, 5 relate that stress increases in children and adolescents with overweight and obesity, and consequently their salivary physiological responses (AEA salivary alpha-amylase, cortisol, cytokines, leptin), so in this study we relate these two parameters to see their progress through a program of physical activity. If we manage to r...
Article
Abstract Chylomicron remnants can penetrate into the artery wall, where they can initiate atherogenesis. Since it is difficult to isolate these particles from human blood because of contamination with other lipoproteins, the use of lipid emulsions as chylomicron remnant-like particles (CRLPs) has been proposed to study their metabolism. This study...
Article
Full-text available
To ascertain whether inflammation markers also correlate with parameters related to insulin resistance and the metabolic syndrome in a group of adolescents. Obesity is now considered a chronic low-grade inflammatory process, characterised by alterations in the systemic concentrations of some inflammation markers. Adiponectin, leptin and other infla...
Article
There is a general consensus that obesity is an eminently inflammatory process. This is justified by alterations observed in obese patients, which affect the secretion of certain cytokines such as ceruloplasmin, leptin, adiponectin, and interleukin-6 (IL-6), among others. In a parallel way, other research has also pointed out alterations in the com...
Article
There is a general consensus that obesity is an eminently inflammatory process. This is justified by alterations observed in obese patients, which affect the secretion of certain cytokines such as ceruloplasmin, leptin, adiponectin, and interleukin-6 (IL-6), among others. In a parallel way, other research has also pointed out alterations in the com...
Article
The postprandial lipid period takes place after the intake of food, involves the metabolic processes that occur following the ingestion of a meal containing fat, and it is characterized by a considerable increase in plasma triglyceride levels. An impaired metabolism of postprandial triglyceride-rich lipoproteins (TRL), comprising chylomicrons, very...
Article
Numerous studies have focused on establishing a relation between the serum values of biomolecules such as leptin, ceruloplasmin, and lipoprotein (a), and the nutritional state and levels of diastolic and systolic blood pressure in subjects with problems of overweight or obesity. However, in many cases, the results obtained have not been conclusive....
Article
Full-text available
Numerous studies have focused on establishing a relation between the serum values of biomolecules such as leptin, ceruloplasmin, and lipoprotein (a), and the nutritional state and levels of diastolic and systolic blood pressure in subjects with problems of overweight or obesity. However, in many cases, the results obtained have not been conclusive....
Article
Current evidence suggests that consumption of virgin olive oil (VOO) helps to protect against the development of atherosclerosis and that minor components such as oleanolic acid contribute to this effect. In this study, the effects of triacylglycerol-rich lipoproteins (TRLs) derived from olive oil on inflammatory processes in macrophages and how th...
Article
Full-text available
Also known as ferroxidase ceruloplasmin, belongs to the family of inflammation-sensitive proteins, and its main function to transport copper in the blood. Although, in addition to this transport function, at present, there are numerous studies that have attempted to use the determination of serum concentrations as a predictive indicator of cardiova...
Article
Also known as ferroxidase ceruloplasmin, belongs to the family of inflammation-sensitive proteins, and its main function to transport copper in the blood. Although, in addition to this transport function, at present, there are numerous studies that have attempted to use the determination of serum concentrations as a predictive indicator of cardiova...
Chapter
Virgin olive oil, as the main fat source of the Mediterranean diet, has been proposed as one of the healthiest dietary oils, since there is increasing evidence demonstrating beneficial effects on the pathophysiology of atherosclerosis. Certainly, a number of experimental studies have revealed that virgin olive oil consumption can have favorable eff...
Article
The postprandial lipid period takes place after the intake of food. Therefore, postprandial lipid metabolism refers to the metabolic processes that occur following the ingestion of a meal containing fat, and it is characterized by a considerable increase in plasma triglyceride (TG) levels. The postprandial response can last up to 8 hours depending...
Article
Full-text available
The excess weight that characterizes much of the population of the world today has led the World Health Organization to declare a obesity pandemic. The number of overweight and obese children in Spain is among the highest in Europe, and this number is even higher in Andalusia. The health consequences of excess weight for children are not as evident...
Article
The excess weight that characterizes much of the population of the world today has led the World Health Organization to declare a obesity pandemic. The number of overweight and obese children in Spain is among the highest in Europe, and this number is even higher in Andalusia. The health consequences of excess weight for children are not as evident...
Article
Virgin olive oil phenolic compounds have been revealed to be potent antioxidants as part of the Mediterranean diet. To test the hypothesis that these phenolics can modulate the serum and very low-density lipoprotein (VLDL) triacylglycerol concentrations in humans, a double-blind, randomized, crossover trial was designed. Thirty-three participants r...
Chapter
Hypertension (high blood pressure) is a major risk factor for cardiovascular disease. Hypertensive individuals have a higher risk of developing coronary heart disease, heart failure, stroke and kidney disease. In addition to its harmful effect on cardiovascular disease and mortality, hypertension is highly prevalent. In Western Europe, more than 40...
Chapter
In order to study the normotensive effect of virgin olive oil (VOO) in the elderly, and the possible influence of non-oleic acid components of the oil, two different VOO of the same variety, season and geographic localization were employed. The oils presented a similar composition in minor components and very little differences in oleic and linolei...
Article
Olive oil (OO) is the most representative food of the traditional Mediterranean Diet (MedDiet). Increasing evidence suggests that monounsaturated fatty acids (MUFA) as a nutrient, OO as a food, and the MedDiet as a food pattern are associated with a decreased risk of cardiovascular disease, obesity, metabolic syndrome, type 2 diabetes and hypertens...
Article
The first results of the PREDIMED (PREvencion con Dieta MEDiterranea) randomized trial, after 3-month intervention, showed that the Mediterranean Diet (MD), supplemented with either virgin olive oil (VOO) or nuts, reduced systolic blood pressure, serum cholesterol and triacylglycerol (TG) concentrations and increased high-density lipoprotein (HDL)-...