Javier Menéndez-Menéndez- PhD
- Researcher at Spanish National Research Council
Javier Menéndez-Menéndez
- PhD
- Researcher at Spanish National Research Council
Nanomaterials and Nanotechnology Research Center (CINN-CSIC)
About
24
Publications
2,242
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460
Citations
Introduction
PhD Molecular Biology and Biomedicine
Current institution
Additional affiliations
September 2010 - February 2015
August 2024 - present
ISPA-FINBA CINN-CSIC
Position
- Researcher
Description
- "Epigenetics of cancer and nanomedicine" research group. Prevention of obesity throughout life through early identification of risk factors, prognosis and intervention. Identification of risk factors related to excessive weight gain to establish effective strategies and personalized preventive measures against metabolic complications of overweight.
February 2020 - May 2020
Position
- PhD student
Description
- International stay with a fellowship from the European Molecular Biology Organisation (EMBO). "Cell signalling and proteomics" research group of the Haemato-Oncology Centre of the Barts Cancer Institute of Queen Mary University of London, at the John Vane Science Centre.
Education
November 2016 - January 2021
September 2015 - July 2016
September 2010 - February 2015
Publications
Publications (24)
The increasing presence of pollutants in environmental waters is an alarming problem,not only because of their harmful effects on the environment, but also because of their risk tohuman health. Studies carried out to assess water quality usually focus on priority pollutantssuch as heavy metals, hydrocarbons, microbial toxins, and additives. However...
Radiation therapy is an important component of cancer treatment scheduled for cancer patients, although it can cause numerous deleterious effects. The use of adjuvant molecules aims to limit the damage in normal surrounding tissues and enhance the effects of radiation therapy, either killing tumor cells or slowing down their growth. Melatonin, an i...
Melatonin is a hormone with different functions, antitumor actions being one of the most studied. Among its antitumor mechanisms is its ability to inhibit angiogenesis. Melatonin shows antiangiogenic effects in several types of tumors. Combination of melatonin and chemotherapeutic agents have a synergistic effect inhibiting angiogenesis. One of the...
Radiotherapy is one of the treatments of choice in many types of cancer. Adjuvant treatments to radiotherapy try, on one hand, to enhance the response of tumor cells to radiation and, on the other hand, to reduce the side effects to normal cells. Radiosensitizers are agents that increase the effect of radiation in tumor cells by trying not to incre...
Chemotherapeutics are sometimes administered with drugs, like antiangiogenic compounds, to increase their effectiveness. Melatonin exerts antitumoral actions through antiangiogenic actions. We studied if melatonin regulates the response of HUVECs to chemotherapeutics (docetaxel and vinorelbine). The inhibition that these agents exert on some of the...
Melatonin exerts oncostatic actions and sensitizes tumor cells to chemotherapeutics or radiation. In our study, we investigated the effects of docetaxel, vinorelbine, and radiation on human breast fibroblasts and its modulation by melatonin. Docetaxel or vinorelbine inhibits proliferation and stimulates the differentiation of breast preadipocytes,...
Melatonin mitigates cancer initiation, progression and metastasis through inhibition of both the synthesis of estrogens and the transcriptional activity of the estradiol-ER (Estrogen receptor) complex in the estrogen-dependent breast cancer cell line MCF-7. Moreover, melatonin improves the sensitivity of MCF-7 to chemotherapeutic agents and protect...
Radiotherapy is a part of cancer treatment. To improve its efficacy has been combined with radiosensitizers such as antiangiogenic agents. Among the mechanisms of the antitumor action of melatonin are antiangiogenic effects. Our goal was to investigate whether melatonin may modulate the sensitivity of endothelial cells (HUVECs) to ionizing radiatio...
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical trials and multiple experimenta...
Melatonin is the main secretory product of the pineal gland. It is an oncostatic agent that reduces the growth anddevelopment of various types of tumors, particularly those whose growth is dependent on estrogen. Data from nearly500 articles published in the last 20 years, call attention to the hypothesis that melatonin interacts with estrogen signa...
Results from clinical trials and multiple in vivo and in vitro studies point to melatonin as a promising adjuvant molecule with many beneficial effects when concomitantly administered with chemotherapy. Melatonin palliates side‑effects and enhances the efficacy of chemotherapeutic agents. However, the mechanisms through which melatonin regulates mo...
Melatonin, the main secretory product of the pineal gland, is an oncostatic agent that reducesthe growth and development of various types of tumors, particularly those whose growth isdependent on estrogen. Data from about 500 articles published in the last 20 years, point to thehypothesis that melatonin interacts with estrogen signaling pathways at...
Melatonin exerts oncostatic activity in breast cancer through antiangiogenic actions. There, the aim of the present study was to ascertain whether melatonin modulates, in a coordinated action, angiopoietin-1 (ANG-1), ANG-2, their cognate Tie2 receptor and VEGF in co-cultures of human endothelial cells (HUVECs) and breast cancer (MCF-7) cells. To ac...
Melatonin has antiproliferative actions in many kinds of cancers, especially on hormone-dependent mammary tumors. In vivo, administration of melatonin reduces the incidence and growth of chemically-induced mammary tumors in rodents and in vitro inhibits the proliferation and invasiveness of human breast cancer cells. In estrogendependent mammary tu...
Enhancing the radiosensitivity of cancer cells is one of the most important goals in clinical radiobiology. Melatonin exerts oncostatic effects on breast cancer by reducing estrogen biosynthesis in human breast cancer cells, surrounding fibroblasts and endothelial cells and by regulating cytokines that influence tumor microenvironment. This hormone...
Vascular endothelial growth factor (VEGF) produced from tumor cells plays a crucial role in the pathogenesis and neovascularization of neuroblastoma. Inhibition of VEGF secretion by tumor cells, as well as VEGF-regulated signaling in endothelial cells, are important to reduce the angiogenesis and growth of neuroblastoma. Since melatonin has anti-an...
Endothelial cells represent one of the critical cellular elements in tumormicroenvironment playing a crucial role in the growth and progression of cancer throughcontrolling angiogenesis. Vascular endothelial growth factor (VEGF) produced fromtumor cells is essential for the expansion of breast cancer. Since melatonin regulatestumor angiogenesis by...
The pathogenesis and growth of breast cancer are linked to estro-gens, which are considered key molecules in mammary carcino-genesis. About 80 % of all breast cancers are estrogen receptor-positive (ER+) and, therefore, they respond well to hormonaltherapy. Melatonin, the pineal gland hormone, has been shownby numerous in vivo and in vitro studies...
Enhancing the radiosensitivity of cancer cells is one of the most important tasks in clinical radiobiology. Endocrine therapy and radiotherapy are two cancer treatment modalities which are often given together in patients with locallyadvanced breast cancer and positive hormone-receptor status. Oncostatic actions of melatonin are relevant on estroge...
Nowadays radiotherapy and adjuvant endocrine therapy represent a standard treatment option in management of breast
cancer. Melatonin exerts oncostatic actions on human breast cancer cells. Therefore, the purpose of this study was to
investigate the effects of a combination of radiotherapy and melatonin on human breast cancer cells. Radiation inhibi...
