Javier Echeverría

Javier Echeverría
University of Santiago, Chile | USACH · Departamento de Ciencias del Ambiente

Doctor en Química (PhD Chemistry)
Director of Master in Chemistry and Head of Organic Chemistry at the University de Santiago de Chile.

About

371
Publications
65,911
Reads
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1,558
Citations
Introduction
Dr. Javier Echeverría is a chemist specializing in Bioactive Natural Product. Currently, is the Director of Master in Chemistry at the University de Santiago de Chile. His research areas are focused on Archaeological Chemistry (application of mass spectrometry to study human prehistory), Ethnopharmacology (study of ethnic groups and their use of natural resources as food and/or drugs) and Medicinal Chemistry (design, development and synthesis of bioactive and pharmaceutical drugs).
Additional affiliations
May 2021 - May 2021
University of Santiago, Chile
Position
  • Head of Department
Description
  • Director del programa de Magister en Química de la Universidad de Santiago de Chile
September 2018 - present
University of Santiago, Chile
Position
  • Head of Department
Description
  • Jefe del Área de Química Orgánica
April 2018 - present
Frontiers
Position
  • Editor
Description
  • Assistant Specialty Chief Editor of Ethnopharmacology (Frontiers in Pharmacology)
Education
March 2007 - February 2012
University of Santiago, Chile
Field of study
  • Chemistry
March 2001 - September 2006
University of Santiago, Chile
Field of study
  • Chemistry
March 2001 - December 2005
University of Santiago, Chile
Field of study
  • Chemistry

Publications

Publications (371)
Article
Every year, the number of studies that evaluate the pharmacological effects, (clinical) efficacy or the toxicity of medicinal plant extracts is constantly increasing, but the reporting quality remains unsatisfactory. One of the main reasons is that there is a lack of detailed reporting standards for guidance. In response to this long-standing chall...
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Full-text available
In this work, we report the synthesis of curcuminoids with ionic liquid characteristics, obtained by incorporating alkyl-substituted pyridinium moiety rather than one phenyl group through a two-step process. The antioxidant capacity of the obtained compounds was evaluated in vitro by 1,1-diphenyl-picrylhydrazyl (DPPH) free radical scavenging and fe...
Article
The skin and soft tissue infections (SSTIs) -producing pathogens have acquired resistance to a wide range of antimicrobials, thus it is highly relevant to have new treatment alternatives. In this study, we report the synthesis, characterization, and antibacterial activity of three novel series of ionic liquids (ILs) derived from benzoic and hydroxy...
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Full-text available
Honeybee pollen (HBP) chemical composition is highly variable conforming to the floral and geographical origin of the pollen grains. The beneficial effects and functional properties of the HBP are well-known and have been mainly attributed to their high content of antioxidant polyphenols. In this work, twelve HBPs samples from the Southern region o...
Article
Background : Chronic obstructive pulmonary disease (COPD) is a class of lung diseases including chronic bronchitis, asthma, and emphysema. Long-time smoking is considered the main reason for developing emphysema. Emphysema can be defined as damage to the walls of the air sacs (alveoli) of the lung. It has been demonstrated that natural compounds wi...
Article
Cancer is one of the leading causes of death in humans because of the lack of early diagnosis, distant metastases, and the resistance to adjuvant therapies, including chemotherapy and radiotherapy. In addition to playing an essential role in tumor progression and development, microRNAs (miRNAs) can be used as a robust biomarker in the early detecti...
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The genus Zingiber consists of about 85 species and many of these species are used as food, spices, and medicines. One of the species, Zingiber montanum (J. Koenig) Link ex A. Dietr. is native to Southeast Asia and has been extensively used as traditional medicines and food. The aim of this review was to collect and critically analyze the scientifi...
Article
A Pd(II) complex bearing N-((2,6-diisopropylphenyl)carbamothioyl)-4-methylbenzamide (C1) has been prepared and characterized by various spectroscopic studies, and elemental analysis. Crystal structure of the ligand (L1) and C1 was confirmed by single crystal X-ray diffraction tool, which revealed the square planar (trans) geometry for C1. Binding a...
Article
This review describes the chemical composition and biological properties of essential oils from plants of the Ocotea genus, from different origin. This taxon belongs to the Laureaceae family, which in turn, is best known for medicinal use, often related to the essential oils. The text includes studies about Ocotea species distributed mainly on the...
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Full-text available
Growing studies are revealing the critical manifestations of Influenza, Dengue virus infection, Zika virus disease, and Ebola, as emerging infectious diseases. However, their corresponding mechanisms of major complications headed for neuronal dysfunction are not completely understood. From the mechanistic point of view, during emerging infectious d...
Article
Bacterial infections are nowadays among the major threats to public health worldwide. Thus, there is an urgent and increased need for new antimicrobial agents. As a result, the exploration of the antimicrobial properties of different substances including ionic liquids (ILs) has recently attracted great attention. The present work is aimed at evalua...
Article
Background : As common, progressive, and chronic causes of disability and death, neurodegenerative diseases (NDDs) significantly threaten human health, while no effective treatment is available. Given the engagement of multiple dysregulated pathways in neurodegeneration, there is an imperative need to target the axis and provide effective/multi-tar...
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Full-text available
Coronavirus disease (COVID-19) is a global health challenge, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) triggers a plethora of respiratory disturbances and even multiple organs failure that can be fatal. Nutritional intervention is one of the key components towards to a proper management of COVID-19 patients, especia...
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Numerous investigations on quercetin have revealed that it effectively treats and prevents different diseases, acting as an anti-inflammatory, anti-bacterial, anti-proliferative, anti-atherogenic, anticoagulative, antioxidant, antidiabetic agent, etc. This work aimed to analyze the present research literature on quercetin in the context of human an...
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Background: Scleroderma is a complex disease involving autoimmune, vascular, and connective tissues, with unknown etiology that can progress through any organ systems. Objective: Yet, no cure is available; the thorough treatment of scleroderma and current treatments are based on controlling inflammation. Nowadays, medicinal plants/natural-based...
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Apples contain substantial amounts of polyphenols, and diverse phenolics – mainly flavonoids and phenolic acids, have been identified in their flesh and skins. This work aimed to analyze the overall landscape of the research literature published to date on apple phenolic compounds in the context of human and animal health. The Web of Science Core C...
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In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ov...
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Full-text available
Since its inception, the coronavirus disease 2019 (COVID-19) pandemic has infected millions of people around the world. Therefore, it is necessary to find effective treatments against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), as it is the viral source of COVID-19. Alkaloids are one of the most widespread plant-derived natural co...
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Due to the complicated pathogenic pathways of coronavirus disease 2019 (COVID-19), related medicinal therapies have remained a clinical challenge. COVID-19 highlights the urgent need to develop mechanistic pathogenic pathways and effective agents for preventing/treating future epidemics. As a result, the destructive pathways of COVID-19 are in the...
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Full-text available
Avocado oil is considered a highly prized food due to its nutritional contribution. On the other hand, Aristotelia chilensis (Molina) Stuntz (Elaeocarpaceae), common name “maqui”, is an endemic fruit in Chile, well known for its exceptional antioxidant properties. In general, maqui by-products such as leaves are considered as waste. Thus, maqui lea...
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Este trabajo entrega parte de los resultados de una investigación multidisciplinaria centrada en el estudio contextual de los ajuares funerarios de seis cementerios prehispánicos de los oasis de San Pedro de Atacama, Región de Antofagasta, Chile. El objetivo central fue profundizar en los aspectos sociales y rituales del sistema religioso prehispán...
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In recent decades, several neuroprotective agents have been provided in combating neuronal dysfunctions; however, no effective treatment has been found towards the complete eradication of neurodegenerative diseases. From the pathophysiological point of view, growing studies are indicating a bidirectional relationship between gut and brain termed gu...
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The present study evaluated for the first time citation-impacts of human research reporting guidelines in comparison to their animal version counterparts. Re-examined and extended also were previous findings indicating that a research reporting guideline would be cited more for its versions published in journals with higher Impact Factors, compared...
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The SARS-CoV-2 virus was reported for the first time in Wuhan, Hubei Province, China, and causes respiratory infection. This pandemic pneumonia killed about 1,437,835 people out of 61,308,161cases up to November 27, 2020. The disease’s main clinical complications include fever, recurrent coughing, shortness of breath, acute respiratory syndrome, an...
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The full UHPLC-MS metabolome fingerprinting and anti-Helicobacter pylori effect of Gunnera tinctoria (Molina) Mirb. (Nalca) total extract (GTE) and fractions prepared from its edible fresh petioles were evaluated. The activity of G. tinctoria against H. pylori strains ATCC 45504 and J99 was assessed in vitro by means of agar diffusion assay, Minimu...
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Full-text available
The novel coronavirus 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a wide range of manifestations. In this regard, growing evidence is focusing on COVID-19 neurological associations; however, there is a lack of established pathophysiological mechanisms and related treatments. Accordingly, a compreh...
Article
Background: Tribulus terrestris L. (T. terrestris) positive performance on the male sexual system has been confirmed, but little is known about its effects on the female reproductive system. Purpose: This review discussed in detail the beneficial impact of T. terrestris and its secondary metabolites on the female reproductive system. Study desi...
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Artemisia copa Phil. (Asteraceae) (known as copa-copa) is a native species of Chile used as an infusion in traditional medicine by Atacameños people in the Altiplano, highlands of northern Chile. In this research, we have investigated for the first time the cholinesterase inhibition potential against acetylcholinesterase (AChE) and butyrylcholinest...
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Este artículo da a conocer, mediante una aproximación multidisciplinaria un grupo de 14 tubos con iconografía pintada, provenientes de contextos funerarios excavados en distintos cementerios de los oasis de San Pedro de Atacama, cronológicamente asignables al período Medio (ca. 400-1000 DC). Develamos aquí la especial iconografía de estos tubos, cu...
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Lithraea caustica (Molina) Hook. and Arn. (Anacardiaceae), common name Litre, is an evergreen endemic plant used in the Mapuche Chilean folk medicine. The stem juice of L. caustica mixed with Rubus ulmifolius (blackberry) is used to treat cough and the infusion of leaves is used in baths to treat joint inflammations. In this study, the activities o...
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Full-text available
Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, millions of people have been infected and died worldwide. However, no drug has been approved for the treatment of this disease and its complications, which urges the need for finding novel therapeutic agents to combat. Among the complications due to COVID-19, lung injury ha...
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Full-text available
En el Norte Semiárido de Chile (NSA), entre las cuencas de los ríos Salado y Choapa (26º-31,5ºS) se destacan las pipas entre las expresiones culturales de los grupos del período Alfarero Temprano. Se exploró la idea de los complejos fumatorios en la región y se buscó encontrarle puntos de aprehensión, al igual que lo previamente intentado en la reg...
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The current study aimed to identify which natural products and which research directions are related to the major contributors to academic journals for diabetes therapy. Bibliometric data were extracted from the Web of Science online database using the search string TOPIC = (‘‘natural product*’ OR ‘‘natural compound*’ OR ‘‘natural molecule*’ OR ‘ph...
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Despite recent advancements in clinical drugs, diabetes treatment still needs further progress. As such, ongoing research has attempted to determine the precise molecular mechanisms of the disorder. Specifically, evidence supports that several signaling pathways play pivotal roles in the development of diabetes. However, the exact molecular mechani...
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Greigia sphacelata (Ruiz & Pav.) Regel (Bromeliaceae) is a Chilean endemic plant popularly known as “quiscal” and produce an edible fruit consumed by the local Mapuche communities named as “chupón”. In this study, several metabolites including phenolic acids, organic acids, sugar derivatives, catechins, proanthocyanidins, fatty acids, iridoids, cou...
Chapter
Artemisia annuaL.: Artemisia annua fo. macrocephala Pamp.; Artemisia chamomilla C. Winkl.; Artemisia stewartii C.B. Clarke; Artemisia wadei Edgew.
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Anthemis arvensisL.: Anthemis arvensis var. agrestis (Wallr.) DC; Chamaemelum arvense (L.) Hoffm. & Link.
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Ambrosia arborescensMill: Ambrosia artemisioides Willd.; Ambrosia frutescens Lam.; Ambrosia fruticosa Medik.; Franseria artemisioides Willd.; Franseria conwayi Rusby; Gaertneria artemisioides (Willd.) Kuntze; Xanthium artemisioides (Willd.) Delpino; Xanthium fruticosum L. f.
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Baccharis boliviensis(Wedd.) Cabrera: Baccharis boliviensis (Wedd.) Cuatrec., comb. superfl., Baccharis boliviensis (Wedd.) Cabrera var. latifolia, Baccharis boliviensis (Wedd.) Cabrera var. latifolia, Heterothalamus boliviensis Wedd., Heterothalamus boliviensis Wedd. var. latifolius, Pseudobaccharis boliviensis (Wedd.) Cabrera, Pseudobaccharis bol...
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Amaranthus caudatusL.: Amaranthus caudatus var. alopecurus Moq.; Amaranthus cruentus L.; Amaranthus edulis Speg.; Amaranthus hybridus var. paniculatus (L.) Uline & W.L. Bray; Amaranthus leucocarpus S. Watson; Amaranthus leucospermus S. Watson; Amaranthus mantegazzianus Pass.; Amaranthus sanguineus L.
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Polylepis racemosaRuiz & Pav.:Polylepis incana subsp. icosandra Bitter; Polylepis incana subsp. micranthera Bitter; Polylepis incana var. connectens Bitter; Polylepis incana var. primovestita Bitter; Polylepis villosa Kunth
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Pseudognaphalium dysodes(Spreng.) S. E. Freire, Bayón & C. Monti:Gnaphalium dombeyanum DC.; Gnaphalium dysodes Spreng.; Gnaphalium graveolens Kunth; Gnaphalium humilimum Spreng.; Gnaphalium nanum Kunth, Pseudognaphalium dombeyanum (DC.) Anderb.; Pseudognaphalium graveolens Anderb
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Neuontobotrys tarapacanus(Phil.) Al-Shehbaz: Arabis tarapacana Phil., Cardamine deserticola Phil., Neuontobotrys deserticola (Phil.) Al-Shehbaz, Sisymbrium amplexicaule Desf., Sisymbrium amplexicaule Phil., Sisymbrium intricatissimum (Phil.) Reiche, Sisymbrium intricatissimum var. berningeri O.E. Schulz, Sisymbrium intricatissimum var. brachycarpum...
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Tribulus terrestrisL.: Tribulus bimucronatus Viv.; Tribulus lanuginosus L.; Tribulus saharae A. Chev.; Tribukus terrestris var. sericeus Andersson ex Svenson
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Argyrochosma nivea (Poir.) Windham: Notholaena nivea (Poir.) Desv., Pellaea nivea (Poir.) Prantl, Pteris nivea Poir., Acrostichum albidulum Sw., Cincinalis nivea (Poir.) Desv., Gymnogramma nivea (Poir.) Mett., Cincinalis tarapacana Phil., Notholaena nivea (Poir.) Desv. var. oblongata.
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Tagetes erectaL.: Tagetes elongata Willd.; Tagetes ernstii H. Rob. & Nicholson; Tagetes excelsa Soule; Tagetes heterocarpha Rydb.; Tagetes major Gaertn.; Tagetes patula L.; Tagetes remotifolia Kunze; Tagetes tenuifolia Cav.
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Matricaria chamomillaL.: Chamaemelum chamomilla (L.) E.H.L. Krause; Chamomilla chamomilla (L.) Rydb.; Chamomilla courrantiana (DC.) K. Koch; Chamomilla recutita (L.) Rauschert; Chamomilla vulgaris Gray; Chrysanthemum chamomilla (L.) Bernh.; Chrysanthemum suaveolens (L.) Cav.; Matricaria chamomilla fo. courrantiana (DC.) Fiori; Matricaria chamomilla...
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Tarasa tarapacana(Phil.) Krapov.: Malva tarapacana Phil., Malvastrum tarapacanum (Phil.) Baker f.
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Stellaria chilensisPedersen: Stellaria circinata Ravenna, Stellaria concinna Ravenna, Stellaria celsa Ravenna.
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Haageocereus fascicularis(Meyen) F. Ritter: Cereus fascicularis Meyen, Trichocereus fascicularis (Meyen) Britton & Rose, Weberbauerocereus fascicularis (Meyen) Backeb.
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Baccharis latifolia(Ruiz. & Pav.) Pers.: Baccharis floribunda Kunth; Baccharis polyantha fo. genuina Hieron.; Baccharis polyantha Kunth.; Baccharis polyantha var. macrophylla Hieron.; Baccharis riparia Kunth; Molina latifolia Ruiz. & Pav.; Pingraea latifolia (Ruiz. & Pav.) F.H. Hellw.; Pluchea glabra Griseb.; Vernonia otavalensis Gilli
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Micromeria gilliesiiBenth: Bystropogon minutus Briq., Clinopodium gilliesii (Benth.) Kuntze, Micromeria eugenioides (Griseb.) Hieron., Micromeria gilliesii Benth., Oreosphacus parvifolia Phil., Satureja eugenioides Griseb., Satureja parvifolia (Phil.) Epling, Satureja oligantha Briq., Satureja gilliesii (Benth.) Briq., Xenopoma eugenioides Griseb.
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Trixis cacalioides(Kunth) D. Don: Perdicium cacalioides Kunth, Trixis frutescens P. Browne var. denticulata, Trixis hexantha S. Moore, Trixis papillosa Gillies ex D. Don, Trixis neaeana DC., Trixis papillosa Gilles ex Don; Trixix paradoxa Cass., Trixis subparadoxa B. Herrera
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Xanthium spinosumL.: Acanthoxanthium spinosum (L.) E. Fourn.; Xanthium ambrosioides Hook. & Arn.; Zanthium catharticum Kunth; Xanthium cloessplateaum D.Z. Ma; Xanthium spinosum var. inerme Bel