Javier Caravaca

University of California, San Francisco | UCSF · Department of Radiology and Biomedical Imaging

Background: Single photon emission computed tomography (SPECT) is an imaging modality that has demonstrated its utility in a number of clinical indications. Despite this progress, a high sensitivity, high spatial resolution, multi-tracer SPECT with a large field of view suitable for whole-body imaging of a broad range of radiotracers for theranost...

p>In our previous work on image reconstruction for single-layer collimatorless scintigraphy, the min-min weighted robust least squares (WRLS) optimization algorithm was proposed to address a general reconstruction problem in which both the system matrix and the projection data are uncertain. Whereas the WRLS algorithm has been successful in two-dim...

p>In our previous work on image reconstruction for single-layer collimatorless scintigraphy, the min-min weighted robust least squares (WRLS) optimization algorithm was proposed to address a general reconstruction problem in which both the system matrix and the projection data are uncertain. Whereas the WRLS algorithm has been successful in two-dim...

In vivo imaging of 225Ac is a major challenge in the development of targeted alpha therapy radiopharmaceuticals due to the extremely low injected doses. In this article, we present the design of a multimodality gamma camera that integrates both proximity and Compton imaging in order to achieve the demanding sensitivities required to image 225Ac wit...

Objective: The Office of Radiological Security, U.S. Department of Energy's National Nuclear Security Administration, is implementing a radiological risk reduction program which seeks to minimize or eliminate the use of high activity radiological sources, including 137Cs, by replacing them with non-radioisotopic technologies, such as x-ray irradia...

Theia would be a novel, "hybrid" optical neutrino detector, with a rich physics program. This paper is intended to provide a brief overview of the concepts and physics reach of Theia. Full details can be found in the Theia white paper [1].

The SNO+ experiment is located 2 km underground at SNOLAB in Sudbury, Canada. A low background search for neutrinoless double beta (0νββ) decay will be conducted using 780 tonnes of liquid scintillator loaded with 3.9 tonnes of natural tellurium, corresponding to 1.3 tonnes of 130Te. This paper provides a general overview of the SNO+ experiment, in...

SNO+ is a large-scale liquid scintillator experiment with the primary goal of searching for neutrinoless double beta decay, and is located approximately 2 km underground in SNOLAB, Sudbury, Canada. The detector acquired data for two years as a pure water Cherenkov detector, starting in May 2017. During this period, the optical properties of the det...

A liquid scintillator consisting of linear alkylbenzene as the solvent and 2,5-diphenyloxazole as the fluor was developed for the SNO+ experiment. This mixture was chosen as it is compatible with acrylic and has a competitive light yield to pre-existing liquid scintillators while conferring other advantages including longer attenuation lengths, sup...

This paper presents studies of the performance of water-based liquid scintillators (WbLS) in both 1-kt and 50-kt detectors. Performance is evaluated in comparison to both pure water Cherenkov detectors and a nominal model for pure scintillator detectors. Performance metrics include energy, vertex, and angular resolution, along with a metric for the...

SNO+ is a multi-purpose experiment whose main goal is to study the nature of the neutrino mass through the observation of neutrinoless double-beta decay. Detection of this rare process would indicate that neutrinos are elementary Majorana particles, proving that lepton number is not conserved. The SNO+ detector will operate in three distinct phases...

The Sudbury Neutrino Observatory (SNO), whose main purpose was to study the neutrinos produced in the Sun, demonstrated that neutrinos can change flavor and, thus, they are massive particles. SNO detected and recorded neutrino and cosmic ray interactions from 1999 to 2006 and several analyses have been completed in the past year using legacy data....

A search has been performed for neutrinos from two sources, the hep reaction in the solar pp fusion chain and the νe component of the diffuse supernova neutrino background (DSNB), using the full dataset of the Sudbury Neutrino Observatory with a total exposure of 2.47 kton−years after fiducialization. The hep search is performed using both a single...

This paper presents measurements of the scintillation light yield and time profile for a number of concentrations of water-based liquid scintillator, formulated from linear alkylbenzene (LAB) and 2,5-diphenyloxazole (PPO). We find that the scintillation light yield is linear with the concentration of liquid scintillator in water between 1 and 10% w...

This paper presents studies of the performance of water-based liquid scintillator in both 1-kt and 50-kt detectors. Performance is evaluated in comparison to both pure water Cherenkov detectors and a nominal model for pure scintillator detectors. Performance metrics include energy, vertex, and angular resolution, along with a metric for ability to...

A search has been performed for neutrinos from two sources, the $hep$ reaction in the solar $pp$ fusion chain and the $\nu_e$ component of the diffuse supernova neutrino background (DSNB), using the full dataset of the Sudbury Neutrino Observatory. The $hep$ search is performed using both a single-bin counting analysis and a likelihood fit. We find...

This paper presents measurements of the scintillation light yield and time profile of a number of concentrations of water-based liquid scintillator, formulated from linear alkylbenzene (LAB) and 2,5-Diphenyloxazole (PPO). The separation between Cherenkov and scintillation light is quantified using cosmic muons in the CHESS experiment for each formu...

New developments in liquid scintillators, high-efficiency, fast photon detectors, and chromatic photon sorting have opened up the possibility for building a large-scale detector that can discriminate between Cherenkov and scintillation signals. Such a detector could reconstruct particle direction and species using Cherenkov light while also having...

Water-based liquid scintillators (WbLS) present an attractive target medium for large-scale detectors with the ability to enhance the separation of Cherenkov and scintillation signals from a single target. This work characterizes the scintillation properties of WbLS samples based on LAB/PPO liquid scintillator (LS). X-ray luminescence spectra, deca...

Water-based liquid scintillators (WbLS) present an attractive target medium for large-scale detectors with the ability to enhance the separation of Cherenkov and scintillation signals from a single target. This work characterizes the scintillation properties of WbLS samples based on LAB/PPO liquid scintillator (LS). X-ray luminescence spectra, deca...

The SNO+ experiment collected data as a low-threshold water Cherenkov detector from Septem-ber 2017 to July 2019. Measurements of the 2.2-MeV γ produced by neutron capture on hydrogen have been made using an Am-Be calibration source, for which a large fraction of emitted neutrons are produced simultaneously with a 4.4-MeV γ. Analysis of the delayed...

Neutrons produced in nuclear interactions initiated by cosmic-ray muons present an irreducible background to many rare-event searches, even in detectors located deep underground. Models for the production of these neutrons have been tested against previous experimental data, but the extrapolation to deeper sites is not well understood. Here we repo...

New developments in liquid scintillators, high-efficiency, fast photon detectors, and chromatic photon sorting have opened up the possibility for building a large-scale detector that can discriminate between Cherenkov and scintillation signals. Such a detector could exploit these two distinct signals to observe particle direction and species using...

Neutrons produced in nuclear interactions initiated by cosmic-ray muons present an irreducible background to many rare-event searches, even in detectors located deep underground. Models for the production of these neutrons have been tested against previous experimental data, but the extrapolation to deeper sites is not well understood. Here we repo...

Simultaneous measurement of phonon and light signatures is an effective way to reduce the backgrounds and increase the sensitivity of CUPID, a next-generation bolometric neutrinoless double-beta decay ($0\nu\beta\beta$) experiment. Light emission in tellurium dioxide (TeO$_2$) crystals, one of the candidate materials for CUPID, is dominated by fain...

Neutron production in giga electron volt–scale neutrino interactions is a poorly studied process. We have measured the neutron multiplicities in atmospheric neutrino interactions in the Sudbury Neutrino Observatory experiment and compared them to the prediction of a Monte Carlo simulation using genie and a minimally modified version of geant4. We a...

Neutron production in GeV-scale neutrino interactions is a poorly studied process. We have measured the neutron multiplicities in atmospheric neutrino interactions in the Sudbury Neutrino Observatory experiment and compared them to the prediction of a Monte Carlo simulation using GENIE and a minimally modified version of GEANT4. We analyzed 837 day...

The long baseline between Earth and the Sun makes solar neutrinos an excellent test beam for exploring possible neutrino decay. The signature of such decay would be an energy-dependent distortion of the traditional survival probability which can be fit for using well-developed and high-precision analysis methods. Here a model including neutrino dec...

This paper reports results from a search for nucleon decay through invisible modes, where no visible energy is directly deposited during the decay itself, during the initial water phase of SNO+. However, such decays within the oxygen nucleus would produce an excited daughter that would subsequently deexcite, often emitting detectable gamma rays. A...

A measurement of the B8 solar neutrino flux has been made using a 69.2 kt-day dataset acquired with the SNO+ detector during its water commissioning phase. At energies above 6 MeV the dataset is an extremely pure sample of solar neutrino elastic scattering events, owing primarily to the detector’s deep location, allowing an accurate measurement wit...

Experimental tests of Lorentz symmetry in systems of all types are critical for ensuring that the basic assumptions of physics are well founded. Data from all phases of the Sudbury Neutrino Observatory, a kiloton-scale heavy water Cherenkov detector, are analyzed for possible violations of Lorentz symmetry in the neutrino sector. Such violations wo...

The long baseline between the Earth and the Sun makes solar neutrinos an excellent test beam for exploring possible neutrino decay. The signature of such decay would be an energy-dependent distortion of the traditional survival probability which can be fit for using well-developed and high precision analysis methods. Here a model including neutrino...

The long baseline between Earth and the Sun makes solar neutrinos an excellent test beam for exploring possible neutrino decay. The signature of such decay would be an energy-dependent distortion of the traditional survival probability which can be fit for using well-developed and high-precision analysis methods. Here a model including neutrino dec...

Experimental tests of Lorentz symmetry in systems of all types are critical for ensuring that the basic assumptions of physics are well-founded. Data from all phases of the Sudbury Neutrino Observatory, a kiloton-scale heavy water Cherenkov detector, are analyzed for possible violations of Lorentz symmetry in the neutrino sector. Such violations wo...

The ability to separate Cherenkov and scintillation signals in liquid scintillator detectors would enable outstanding background rejection for next-generation neutrino experiments. Reconstruction of directional information, ring imaging, and sub-Cherenkov threshold detection all have the potential to substantially improve particle and event identif...

The CHErenkov / Scintillation Separation experiment (CHESS) has been used to demonstrate the separation of Cherenkov and scintillation light in both linear alkylbenzene (LAB) and LAB with 2g/L of PPO as a fluor (LAB/PPO). This is the first such demonstration for the more challenging LAB/PPO cocktail and improves on previous results for LAB. A time...

The ability to separately identify the Cherenkov and scintillation light components produced in scintillating mediums holds the potential for a major breakthrough in neutrino detection technology, allowing development of a large, low-threshold, directional detector with a broad physics program. The CHESS (CHErenkov / Scintillation Separation) exper...

The T2K off-axis near detector, ND280, is used to make the first differential cross section measurements of muon neutrino charged current single positive pion production on a water target at energies ${\sim}0.8$~GeV. The differential measurements are presented as a function of muon and pion kinematics, in the restricted phase-space defined by $p_{\...

T2K reports its first measurements of the parameters governing the disappearance of ν-μ in an off-axis beam due to flavor change induced by neutrino oscillations. The quasimonochromatic ν-μ beam, produced with a peak energy of 0.6 GeV at J-PARC, is observed at the far detector Super-Kamiokande, 295 km away, where the ν-μ survival probability is exp...

We report the first measurement of the flux-averaged cross section for charged current coherent π^{+} production on carbon for neutrino energies less than 1.5 GeV, and with a restriction on the final state phase space volume in the T2K near detector, ND280. Comparisons are made with predictions from the Rein-Sehgal coherent production model and the...

We report a measurement of the νμ-nucleus inclusive charged-current cross section (=σcc) on iron using data from the INGRID detector exposed to the J-PARC neutrino beam. The detector consists of 14 modules in total, which are spread over a range of off-axis angles from 0° to 1.1°. The variation in the neutrino energy spectrum as a function of the o...

We report a measurement of the νμ-nucleus inclusive charged-current cross section (¼ σcc) on iron using data from the INGRID detector exposed to the J-PARC neutrino beam. The detector consists of 14 modules in total, which are spread over a range of off-axis angles from 0° to 1.1°. The variation in the neutrino energy spectrum as a function of the...

We report the measurement of muon neutrino charged-current interactions on carbon without pions in the final state at the T2K beam energy using 5.734$\times10^{20}$ protons on target. For the first time the measurement is reported as a flux-integrated, double-differential cross-section in muon kinematic variables ($\cos\theta_\mu$, $p_\mu$), withou...

The Tokai to Kamioka (T2K) long-baseline neutrino experiment consists of a muon neutrino beam, produced at the J-PARC accelerator, a near detector complex and a large 295-km-distant far detector. The present work utilizes the T2K event timing measurements at the near and far detectors to study neutrino time of flight as a function of derived neutri...

SNO+ is a large liquid scintillator-based experiment located 2km underground at SNOLAB, Sudbury, Canada. It reuses the Sudbury Neutrino Observatory detector, consisting of a 12m diameter acrylic vessel which will be filled with about 780 tonnes of ultra-pure liquid scintillator. Designed as a multi-purpose neutrino experiment, the primary goal of S...

SNO+ is a large liquid scintillator-based experiment located 2 km underground at SNOLAB, Sudbury, Canada. It reuses the Sudbury Neutrino Observatory detector, consisting of a 12 m diameter acrylic vessel which will be filled with about 780 tonnes of ultra-pure liquid scintillator. Designed as a multipurpose neutrino experiment, the primary goal of...

This paper reports a measurement by the T2K experiment of the νμ charged current quasielastic (CCQE) cross section on a carbon target with the off-axis detector based on the observed distribution of muon momentum (pμ) and angle with respect to the incident neutrino beam (θμ). The flux-integrated CCQE cross section was measured to be ⟨σ⟩=(0.83±0.12)...

T2K reports its first measurements of the parameters governing the disappearance of $\overline{\nu}_\mu$ in an off-axis beam due to flavour change induced by neutrino oscillations. The quasi-monochromatic $\overline{\nu}_\mu$ beam, produced with a peak energy of 0.6 GeV at J-PARC, is observed at the far detector Super-Kamiokande, 295 km away, where...

We report a measurement of the $\nu_{\mu}$-nucleus inclusive charged current cross section (=$\sigma^{cc}$) on iron using data from exposed to the J-PARC neutrino beam. The detector consists of 14 modules in total, which are spread over a range of off-axis angles from 0$^\circ$ to 1.1$^\circ$. The variation in the neutrino energy spectrum as a func...

The first direct observation of the appearance of electron neutrinos in a muon neutrino beam through neutrino oscillation was recently reported by the T2K experiment. The main background in this observation was the presence of the electron neutrino component of the beam, which accounts for 1.2 % of the beam below the 1.2 GeV threshold. This paper p...

We report a measurement of the $\nu_\mu$ charged current quasi-elastic cross-sections on carbon in the T2K on-axis neutrino beam. The measured charged current quasi-elastic cross-sections on carbon at mean neutrino energies of 1.94 GeV and 0.93 GeV are $(11.95\pm 0.19(stat.)_{-1.47}^{+1.82} (syst.))\times 10^{-39}\mathrm{cm}^2/\mathrm{neutron}$ and...

We report on measurements of neutrino oscillation using data from the T2K long-baseline neutrino experiment collected between 2010 and 2013. In an analysis of muon neutrino disappearance alone, we find the following estimates and 68% confidence intervals for the two possible mass hierarchies: Normal Hierarchy: $\sin^2\theta_{23}=0.514^{+0.055}_{-0....

The T2K off-axis near detector ND280 is used to make the first differential cross-section measurements of electron neutrino charged current interactions at energies ∼1 GeV as a function of electron momentum, electron scattering angle, and four-momentum transfer of the interaction. The total flux-averaged νe charged current cross section on carbon i...

As long-baseline neutrino experiments enter the precision era, the difficulties associated with understanding neutrino interaction cross sections on atomic nuclei are expected to limit experimental sensitivities to oscillation parameters. In particular, the ability to relate experimental observables to neutrino energy in previous experiments has re...

The Charged-Current Quasi-Elastic (CCQE) interaction, $\nu_{l} + n \rightarrow l^{-} + p$, is the dominant CC process at $E_\nu \sim 1$ GeV and contributes to the signal in accelerator-based long-baseline neutrino oscillation experiments operating at intermediate neutrino energies. This paper reports a measurement by the T2K experiment of the $\nu_...

The T2K experiment has performed a search for $\nu_e$ disappearance due to sterile neutrinos using $5.9 \times 10^{20}$ protons on target for a baseline of $280 m$ in a neutrino beam peaked at about $500 MeV$. A sample of \nu_e CC interactions in the off-axis near detector has been selected with a purity of 63\% and an efficiency of 26\%. The p-val...

We report the first measurement of the neutrino-oxygen neutral-current quasielastic (NCQE) cross section. It is obtained by observing nuclear deexcitation γ rays which follow neutrino-oxygen interactions at the Super-Kamiokande water Cherenkov detector. We use T2K data corresponding to 3.01×1020 protons on target. By selecting only events during th...

The observation of the recent electron neutrino appearance in a muon neutrino beam and the high-precision measurement of the mixing angle θ13θ13 have led to a re-evaluation of the physics potential of the T2K long-baseline neutrino oscillation experiment. Sensitivities are explored for CP violation in neutrinos, non-maximal sin22θ23sin2⁡2θ23, the o...

The T2K off-axis near detector, ND280, is used to make the first differential cross-section measurements of electron neutrino charged current interactions at energies ~1 GeV as a function of electron momentum, electron scattering angle and four-momentum transfer of the interaction. The total flux-averaged $\nu_e$ charged current cross-section on ca...

We report a measurement of the $\nu_\mu$ inclusive charged current cross sections on iron and hydrocarbon in the T2K on-axis neutrino beam. The measured inclusive charged current cross sections on iron and hydrocarbon averaged over the T2K on-axis flux with a mean neutrino energy of 1.51 GeV are $(1.444\pm0.002(stat.)_{-0.157}^{+0.189}(syst.))\time...

We report the first measurement of the neutrino-oxygen neutral-current quasi-elastic (NCQE) cross section. It is obtained by observing nuclear de-excitation \gamma-rays which follow neutrino-oxygen interactions at the Super-Kamiokande water Cherenkov detector. We use T2K data corresponding to $3.01 \times 10^{20}$ protons on target. By selecting on...

The T2K experiment has reported the first observation of the appearance of electron neutrinos in a muon neutrino beam. The main and irreducible background to the appearance signal comes from the presence in the neutrino beam of a small intrinsic component of electron neutrinos originating from muon and kaon decays. In T2K, this component is expecte...

New data from the T2K neutrino oscillation experiment produce the most precise measurement of the neutrino mixing parameter theta_{23}. Using an off-axis neutrino beam with a peak energy of 0.6 GeV and a data set corresponding to 6.57 x 10^{20} protons on target, T2K has fit the energy-dependent nu_mu oscillation probability to determine oscillatio...

The Tokai to Kamioka (T2K) experiment studies neutrino oscillations using a beam of muon neutrinos produced by an accelerator. The neutrinos travel from J-PARC on the east coast of Japan and are detected 295 kilometers further away in the Super-Kamiokande detector. A complex of near detectors located 280 meters away from the neutrino production tar...

The T2K experiment has observed electron neutrino appearance in a muon neutrino beam produced 295 km from the Super-Kamiokande detector with a peak energy of 0.6 GeV. A total of 28 electron neutrino events were detected with an energy distribution consistent with an appearance signal, corresponding to a significance of 7.3σ when compared to 4.92±0....