Javed Qureshi

• PhD
• Professor (Associate) at Taylor's University

Objective: As Meropenemis a potential drug for drug-delivery systems, a reliable reverse-phase high performance liquid chromatographic (RP-HPLC) method was developed and validated, for the detection of various Meropenem samples. Methods: Chromatographic conditions involved a reverse-phase C-18 column with the mobile phase consisting of 0.03 M di-hy...

Purpose: To develop and determine the in vivo performance of a capsule-based pulsatile drug delivery system containing salbutamol sulphate Methods: A controlled pulsatile release of drug after a programmed 4 h lag period was achieved from cross-linked gelatin capsule shells containing salbutamol pellets, and sealed with a suitable mixture of sodium...

The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective permeability coefficient obtained with that of drug solution and micellar solution. The prepared SMEDDS and micelles formulations were inve...

The objective of this study was to develop and evaluate an oral chronomodulated drug delivery system (CDDS) for the treatment of rheumatoid arthritis with a distinct predetermined lag time of 6 h (+/- 0.25 h). The basic design of the system consisted of an inner core, an intermediate swelling layer and an external acid-resistant enteric layer appli...

A time dependent pulsed release system consisting of an effervescent core surrounded by consecutive layers of swelling and rupturable polymers was prepared and evaluated. The cores containing salbutamol sulphate as bioactive agent were prepared by direct compression method using different ratios of microcrystalline cellulose and effervescent agent...

In the present study a hydrodynamically balanced system of celiprolol hydrochloride was developed as single unit floating capsule. Various grades of low density polymers were used for formulation of this system. They were prepared by physical blending of celiprolol hydrochloride and the polymer in varying ratios. The formulation was optimized on th...

Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile rel...