Jason Hickok

Jason Hickok
Hospital Corporation of America | HCA

Master of Business Administration

About

44
Publications
4,075
Reads
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1,127
Citations
Citations since 2016
15 Research Items
817 Citations
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2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120

Publications

Publications (44)
Article
Full-text available
Background ICU universal decolonization with daily chlorhexidine (CHG) baths plus mupirocin nasal decolonization reduces all-cause bloodstream infections (BSI) and MRSA clinical cultures. We assessed nasal iodophor, an antiseptic less susceptible to resistance, in place of mupirocin. Methods We conducted a cluster randomized non-inferiority trial...
Article
Full-text available
Background Up to 40% of hospitalized patients receive unnecessary or inappropriately broad antibiotics despite a low risk of multidrug-resistant organism (MDRO) infection. Empiric standard spectrum antibiotic use would reduce extended-spectrum (ES) antibiotic exposure and future resistance. We evaluated whether computerized prescriber order entry p...
Article
Full-text available
Background Up to 40% of hospitalized patients receive unnecessary or inappropriately broad antibiotics despite a low risk of multidrug-resistant organism (MDRO) infection. Empiric standard spectrum antibiotic use would reduce extended-spectrum (ES) antibiotic exposure and future resistance. We evaluated whether computerized prescriber order entry p...
Article
Introduction: Transfusion-related acute lung injury (TRALI), an adverse event occurring during or within 6 hours of transfusion, is a leading cause of transfusion-associated fatalities reported to the US Food and Drug Administration. There is limited information on the validity of diagnosis codes for TRALI recorded in inpatient electronic medical...
Article
Background: Suicide is a leading cause of death among children, adolescents, and young adults (AYA), and mental health disorders are a major contributing factor. Yet, suicidal behaviors among children and AYA with mental health concerns remain understudied and age-specific risk factors are poorly understood. We examined the risk factors for suicid...
Article
Full-text available
Background: The Centers for Medicare and Medicaid Services (CMS) use colon surgical site infection (SSI) rates to rank hospitals and apply financial penalties. CMS's risk adjustment model omits potentially impactful variables that might disadvantage hospitals with complex surgical populations. Methods: We analyzed adult patients who underwent co...
Article
Variability in hospital-level sepsis mortality rates may be due to differences in case mix, quality of care, or diagnosis and coding practices. Centers for Disease Control and Prevention's Adult Sepsis Event definition could facilitate objective comparisons of sepsis mortality rates between hospitals but requires rigorous risk-adjustment tools. We...
Article
Background Universal skin and nasal decolonisation reduces multidrug-resistant pathogens and bloodstream infections in intensive care units. The effect of universal decolonisation on pathogens and infections in non-critical-care units is unknown. The aim of the ABATE Infection trial was to evaluate the use of chlorhexidine bathing in non-critical-c...
Article
Full-text available
Background Administrative claims data are commonly used for sepsis surveillance, research, and quality improvement. However, variations in diagnosis, documentation, and coding practices may confound efforts to benchmark hospital sepsis outcomes using claims data. Methods We evaluated the sensitivity of claims data for sepsis and organ dysfunction...
Article
Objectives: Administrative claims data are commonly used for sepsis surveillance, research, and quality improvement. However, variations in diagnosis, documentation, and coding practices for sepsis and organ dysfunction may confound efforts to estimate sepsis rates, compare outcomes, and perform risk adjustment. We evaluated hospital variation in...
Article
In this multicenter retrospective cohort study of over 1 million patients at 150 US hospitals, proton pump inhibitors increased the odds of a patient having hospital-onset Clostridium difficile infection as did third and fourth generation cephalosporins, carbapenems, and piperacillin/tazobactam. These findings support appropriate prescribing of aci...
Article
Full-text available
Background Universal decolonization with daily chlorhexidine (CHG) bathing with and without nasal decolonization has significantly reduced positive MRSA clinical cultures and bloodstream infections in adult ICUs in several clinical trials. We evaluated whether decolonization was similarly effective in a lower risk hospitalized population. Methods...
Article
Whether targeted or universal decolonization strategies for control of methicillin-resistant Staphylococcus aureus (MRSA) select for resistance to decolonizing agents is unresolved. The REDUCE MRSA trial provided an opportunity to investigate this question. REDUCE-MRSA was a 3-arm, cluster-randomized trial of screening and isolation without decolon...
Article
Full-text available
Background: Challenges exist in implementing evidence-based strategies, reaching high compliance, and achieving desired outcomes. The rapid adoption of a publicly available toolkit featuring routine universal decolonization of intensive care unit (ICU) patients may affect catheter-related blood stream infections. Methods: Implementation of unive...
Article
Background: Urinary tract infections (UTIs) are common health-care-associated infections. Bacteriuria commonly precedes UTI and is often treated with antibiotics, particularly in hospital intensive care units (ICUs). In 2013, a cluster-randomised trial (REDUCE MRSA Trial [Randomized Evaluation of Decolonization vs Universal Clearance to Eradicate...
Article
Full-text available
Previous studies suggested that a bundled intervention was associated with lower rates of Staphylococcus aureus surgical site infections (SSIs) among patients having cardiac or orthopedic operations. To evaluate whether the implementation of an evidence-based bundle is associated with a lower risk of S aureus SSIs in patients undergoing cardiac ope...
Conference Paper
Background: We conducted a 3 arm cluster randomized trial of three MRSA prevention strategies in 74 ICUs at 43 hospitals which demonstrated universal decolonization with chlorhexidine and mupirocin in adult ICUs resulted in a 44% reduction in risk of bloodstream infection due to all pathogens.(N Engl J Med 2013; 368:2255-2268) Implementing novel ev...
Conference Paper
Background: Our recent meta-analysis found that a bundled intervention can reduce rates of S. aureus surgical site infections (SSIs) among patients having cardiac operations (CO) or total hip (THA) or knee (TKA) arthroplasties. The bundle has not been studied in a multicenter trial. Method: We performed a multicenter quasi-experimental study of p...
Conference Paper
Background: Bacteriuria commonly precedes UTI, and is often treated with antibiotics, especially in ICU patients. The impact of body surface decolonization on bacteriuria and candiduria is unknown. Methods: Secondary analysis of a 3 arm cluster randomized trial of 43 hospitals (74 adult ICUs). Arms included 1) MRSA screening and isolation, 2) tar...
Conference Paper
Background: The degree to which targeted or universal decolonization strategies for control of MRSA select for resistance to decolonizing agents is unresolved. Methods: MRSA isolates were collected during baseline and intervention periods from 74 ICUs in a 43 hospital, 3-arm, cluster-randomized trial of screening and isolation (arm 1), targeted d...
Article
Full-text available
(PDF) LB-1Treatment with Oral ALS-008176, a Nucleoside Analog, Rapidly Reduces RSV Viral Load and Clinical Disease Severity in a Healthy Volunteer Challenge Study. Treatment with Oral ALS-008176, a Nucleoside Analog, RapidlyReduces RSV Viral Load and Clinical Disease Severity in a HealthyVolunteer Challenge Stud
Article
Full-text available
Background. HIV/hepatitis C virus (HCV) coinfection is associated with reduced bone mineral density (BMD) and increased fracture rates, particularly in women. However, the structural underpinnings for the skeletal fragility in coinfected women have not been characterized. We used peripheral quantitative computed tomography (pQCT) and whole-body dua...
Article
Objective To estimate and compare the impact on healthcare costs of 3 alternative strategies for reducing bloodstream infections in the intensive care unit (ICU): methicillin-resistant Staphylococcus aureus (MRSA) nares screening and isolation, targeted decolonization (ie, screening, isolation, and decolonization of MRSA carriers or infections), an...
Article
Full-text available
Objective To determine rates of blood culture contamination comparing 3 strategies to prevent intensive care unit (ICU) infections: screening and isolation, targeted decolonization, and universal decolonization. Design Pragmatic cluster-randomized trial. Setting Forty-three hospitals with 74 ICUs; 42 of 43 were community hospitals. Patients Pati...
Article
Background: Both targeted decolonization and universal decolonization of patients in intensive care units (ICUs) are candidate strategies to prevent health care-associated infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: We conducted a pragmatic, cluster-randomized trial. Hospitals were random...
Article
Methicillin-resistant Staphylococcus aureus (MRSA) infections pose a significant challenge to U.S. healthcare facilities, but there has been limited study of initiatives to reduce infection and increase patient safety in community hospitals. To address this need, a multifaceted program for MRSA infection prevention was developed for implementation...
Article
Patient safety is positively influenced by widespread seasonal influenza vaccination of healthcare workers, but yearly vaccination rates have been unacceptably low. As a result, mandatory vaccination programs have been widely discussed as a means of increasing vaccination rates. In the HCA Inc. healthcare system, the multifaceted Influenza Patient...
Conference Paper
Background: Many states mandate screening of ICU admissions for carriage of MRSA. However, universal decolonization without screening might be a better strategy to reduce MRSA prevalence and prevent infection due to a broader set of pathogens. Methods: We conducted a 3 arm cluster-randomized trial of MRSA prevention strategies. Study design inclu...
Article
Background: A range of strategies and approaches have been developed for preventing health care-associated infections. Understanding the variation in practices among facilities is necessary to improve compliance with existing programs and aid the implementation of new interventions. Methods: In 2009, HCA Inc administered an electronic survey to...
Article
The need for evidence about the effectiveness of therapeutics and other medical practices has triggered new interest in methods for comparative effectiveness research. Describe an approach to comparative effectiveness research involving cluster randomized trials in networks of hospitals, health plans, or medical practices with centralized administr...
Conference Paper
Full-text available
Background: As part of a comprehensive seasonal influenza prevention strategy, the Hospital Corporation of America (HCA) implemented a program that required employees who could infect or become infected by a patient to receive the seasonal influenza vaccine or wear a surgical mask in patient care areas. HCA is the nation's largest provider of healt...
Conference Paper
Background: In 2007, HCA implemented an enterprise wide MRSA reduction campaign for inpatients in 154 hospitals across 20 states, which included Active Surveillance Cultures (ASC) for MRSA among at-risk populations. At-risk populations included surgical patients undergoing total hip and knee joint replacement, open spine and open heart procedures....

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