Jasmin Ortolan- Master Medical- Pharmaceutical Biotechnology
- PostDoc Position at University of Genoa
Jasmin Ortolan
- Master Medical- Pharmaceutical Biotechnology
- PostDoc Position at University of Genoa
|Neuroscience| Cerebellum| Autism| Multiple Sclerosis|
About
7
Publications
445
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18
Citations
Introduction
Studying synaptic and non-synpatic plasticity in the cerebellum (from the structural and functional point of view) and their impairments in mouse models for autism, and MS.
MAIN METHODS: immunohistochemistry, fluorescent/confocal microscopy and morphometric analysis, WB, mice behavior and RNA scope.
Current institution
Additional affiliations
June 2018 - October 2020
Publications
Publications (7)
The transcription factor NRF2 plays a crucial role in the regulation of antioxidant cell responses to stressors. It controls a plethora of genes with pro-surviving activity, among which heme oxygenase 1 (HO-1) has been recognized to play a potent anti-inflammatory activity through its metabolites carbon monoxide (CO) and bilirubin. Macrophages trig...
The inducible enzyme heme oxygenase 1 (HO-1) plays a pivotal role in cell defense against different kind of stressors, from oxidative stress to hypoxia. For this reason, HO-1 overexpression has been correlated to cancer aggressiveness in different tumors, being one of the molecular mechanisms used by tumor cells to become resistant to therapies. In...
Abstract With evidence supporting the prion-like spreading of extracellular tau as a mechanism for the initiation and progression of Alzheimer’s disease (AD), immunotherapy has emerged as a potential disease-modifying strategy to target tau. Many studies have proven effective to clear pathological tau species in animal models of AD, and several cli...
