Jari Peräkylä

Jari Peräkylä
Tampere University | UTA · Medical School

MSc

About

30
Publications
6,463
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456
Citations

Publications

Publications (30)
Article
Full-text available
OBJECTIVES Aortic valve replacement (AVR) surgery is associated with potential risk to cerebral injury. On the other hand, improved cardiovascular functioning after the surgery may have positive impact on brain health. The aim of this preliminary study was to investigate the impact of AVR surgery on cognition, specifically on higher cognitive contr...
Article
Full-text available
The mediodorsal nucleus of the thalamus (MD) with its extensive connections to the lateral pFC has been implicated in human working memory and executive functions. However, this understanding is based solely on indirect evidence from human lesion and imaging studies and animal studies. Direct, causal evidence from humans is missing. To obtain direc...
Article
Full-text available
Vagus nerve stimulation (VNS) is used for treating refractory epilepsy and major depression. While the impact of this treatment on seizures has been established, its impact on human cognition remains equivocal. The goal of this study is to elucidate the immediate effects of vagus nerve stimulation on attention, cognition, and emotional reactivity i...
Article
Full-text available
Patients with lesion to the orbitofrontal cortex (OFC) experience challenges in emotional control and emotion-guided behaviors. The OFC is known to participate in executive functions and attentional control of emotion and our previous research suggests OFC lesion alters the balance between voluntary and involuntary attention and cognitive control w...
Article
Full-text available
Patients treated with deep brain stimulation (DBS) provide an opportunity to study affective processes in humans with "lesion on demand" at key nodes in the limbic circuitries, such as at the anterior thalamic nuclei (ANT). ANT has been suggested to play a role in emotional control with its connection to the orbitofrontal cortex and the anterior ci...
Article
Full-text available
Introduction As burnout has become a global pandemic, there is a call for improved understanding and detection of alterations in brain functions related to it. We have previously reported challenges in executive functions (EFs) in daily life, especially in metacognition, in subjects with occupational burnout, along with alterations in cardiac physi...
Article
Full-text available
Burnout is becoming a global pandemic jeopardizing brain health, with a huge impact on quality of life, available workforce, and the economy. Knowledge of the impact of burnout on cognition, physiology, and physical activity (PA) in daily life allows for an improved understanding of the health consequences and everyday ramifications of burnout. Twe...
Article
Full-text available
Background: Alterations in executive functions, emotion regulation, and their interaction are common concomitants of depression. Executive dysfunction frequently lingers after treatment, has adverse effects on daily life, and predisposes to recurrence of depression. Yet, sensitive measures of executive function for reliable assessment of cognitive...
Article
Full-text available
Objective findings of brain injury or dysfunction are typically lacking in mild traumatic brain injury (MTBI) despite prolonged post-concussion symptoms in some patients. Thus, there is a need for objective biomarkers of MTBI that reflect altered brain physiology underlying subjective symptoms. We have previously reported increased attention to thr...
Article
Full-text available
Executive functions (EF) rely on intact fronto-subcortical networks. An insult, disorder or treatment compromising brain health may impair the functioning of these widespread networks and consequently disrupt EF. Changes in brain health due to treatment or disorder can be assessed by repeating an EF test at different time points, but practice effec...
Article
Full-text available
Neuromodulation techniques targeting limbic circuits can be used to treat refractory psychiatric or neurological disorders. However, objective measure for the impact of neuromodulation on affective brain circuits is lacking. Deep brain stimulation at a key node of the limbic circuit, the anterior thalamic nuclei (ANT-DBS), is used to treat refracto...
Poster
Vagus nerve stimulation is used for treating refractory epilepsy and major depression. This method has been shown to have a positive outcome in treatment on seizures in epilepsy, but its impact on human cognition remains unclear. The goal of this study was to study the immediate effects of vagus nerve stimulation on attention, cognition and emotion...
Article
Full-text available
Injury to the orbitofrontal cortex (OFC) is a frequent consequence of head injury and may lead to dysfunctional regulation of emotional and social behavior. Dysfunctional emotional behavior may partly be related to the role of the OFC in emotion-attention interaction, as previously reported. In order to better understand its role in emotion-attenti...
Article
Full-text available
Transcranial extraocular light affects the brains of birds and modulates their seasonal changes in physiology and behavior. However, whether the human brain is sensitive to extraocular light is unknown. To test whether extraocular light has any effect on human brain functioning, we measured brain electrophysiology of 18 young healthy subjects using...
Data
List of p values for the analysis of ERP time windows. (DOCX)
Data
Logistic regression analysis of error types did not reveal significant predictors. (DOCX)
Data
Analysis of Event-related potential data. (DOCX)
Data
Analysis of reaction times. (DOCX)
Article
Full-text available
Mild traumatic brain injury (MTBI) may be associated with compromised executive functioning and altered emotional reactivity. Despite frequent affective and cognitive symptoms in MTBI, objective evidence for brain dysfunction is often lacking. Previously we have reported compromised performance in symptomatic MTBI patients in an Executive-Reaction...
Poster
Full-text available
ANT-DBS affect human emotional processing and cognitive functions
Article
We studied cortical reactivity to auditory, visual, and somatosensory stimuli during moderate and deep levels of isoflurane anesthesia at which the electroencephalogram (EEG) showed burst suppression patterns, defined as alternating high amplitude bursts and periods of suppressed background activity. Fifteen patients scheduled for gynecologic surge...
Article
Full-text available
We studied EEG reactivity to visual stimuli during deep isoflurane (1.5–2.05 vol% end-tidal concentration) anaesthesia. Twelve patients were anaesthetized with isoflurane until burst suppression occurred in the EEG. Red LED goggles were used to give visual stimulation of 60 flashes, 4-ms duration each, at a frequency of 20 Hz. The stimuli, 3-s trai...

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