Jano van Hemert

Jano van Hemert
Amazon · Customer Engagement

MSc, PhD, FRSE

About

191
Publications
29,481
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
3,347
Citations
Citations since 2017
40 Research Items
1711 Citations
20172018201920202021202220230100200300
20172018201920202021202220230100200300
20172018201920202021202220230100200300
20172018201920202021202220230100200300
Introduction
I am an Applied Science Manager at the Amazon Development Centre Scotland. I am a Fellow of the Royal Society of Edinburgh and an Honorary Fellow of the University of Edinburgh. My ambition lies in leading teams in research and development to deliver innovative products into the market. I am also a researcher in the field of computer science with much emphasis on working in an interdisciplinary context.
Additional affiliations
September 2020 - present
Optos (a Nikon company)
Position
  • Managing Director
Description
  • I direct a team of research staff members and co­-supervised PhD students. I align the strategic direction of research and align with product and clinical departments. My team uses data science to transform imaging data into clinical information. We develop novel imaging modalities. We collaborate with clinicians to validate the efficacy and value of prototypes.
April 2016 - September 2020
Optos (a Nikon Company)
Position
  • Research Director
Description
  • I direct a group of researchers to develop, and asses in the clinic and on the bench, novel technology in eye healthcare. I direct the company’s academic relationships with the aim to commercialise research from universities globally.
October 2010 - March 2016
Optos
Position
  • Senior Research Manager, Imaging
Description
  • I lead a group of researchers and engineers to develop novel technology for retinal imaging in eye healthcare. I manage the company’s academic relationships and corresponding budgets with the aim to commercialise research from universities globally.
Education
November 1998 - November 2002
Leiden University
Field of study
  • Mathematics and Physical Sciences; specialisation in Computer Science
September 1993 - September 1998
Leiden University
Field of study
  • Computer Science

Publications

Publications (191)
Conference Paper
Full-text available
Workflow technologies are emerging as the dominant ap- proach to coordinate groups of distributed services. However with a space filled with competing specifications, standards and frameworks from mul- tiple domains, choosing the right tool for the job is not always a straight- forward task. Researchers are often unaware of the range of technology...
Article
Full-text available
In conclusion, in this small series we confirmed that a stereographic projection algorithm using axial length information can produce accurate measurements relative to an intraocular ground-truth standard. This information should be valuable when designing and conducting clinical trials research that require quantitative analysis of fundus images.
Article
Purpose: To assess whether the presence of peripheral nonperfusion on ultrawide field (UWF) fluorescein angiography (FA) is associated with diabetic retinopathy (DR) severity and the presence of predominantly peripheral lesions (PPLs). Design: Single-site, cross-sectional, retrospective study. Participants: Sixty-eight eyes of 37 diabetic subj...
Article
Purpose: To establish the extent of the peripheral retinal vasculature in normal eyes using ultra-widefield (UWF) fluorescein angiography. Design: Prospective, observational study. Participants: Fifty-nine eyes of 31 normal subjects, stratified by age, with no evidence of ocular disease in either eye by history and ophthalmoscopic examination....
Article
Full-text available
Our purpose was to investigate changes to the retina in multiple sclerosis (MS) using established and novel modes of retinal image acquisition and analysis. 72 participants with MS and 80 healthy volunteers underwent retinal scanning with optical coherence tomography (OCT) and ultra-widefield (UWF) scanning laser ophthalmoscopy (SLO), over a two-ye...
Article
Full-text available
Diabetic retinopathy (DR) is characterized by microvascular changes including ischemia. Degradation and metabolic changes of various retinal cells occur during ischemia. Ischemic region containing more cells will lead to greater metabolic impairment. We analyzed the non-perfusion region (NPR) by integrating histologic mapping with ultra-widefield f...
Article
Full-text available
Purpose This study aims to evaluate choroidal vascular alterations in patients with central serous chorioretinopathy (CSC) using ultra-widefield (UWF) indocyanine green angiography (ICGA). Methods This was a retrospective case–control study conducted at a single tertiary eye center. In total, 36 eyes in patients with either unilateral (24 patients...
Article
Purpose: To compute retinal vascular bed area (RVBA) in mm2 on distortion corrected ultra-wide field (UWF) fluorescein angiography (FA) images in eyes with retinal vein occlusion (RVO). Methods: Prospective, observational study. The peripheral distortion of baseline UWF FA (Optos 200Tx) images of 30 patients with RVO from the WAVE study (NCT0171...
Conference Paper
Purpose : Diabetic eyes with predominantly peripheral lesions (PPL) have been suggested to be at higher risk for progression to proliferative diabetic retinopathy (PDR). Retinal nonperfusion is known to increase with increasing severity of diabetic retinopathy. We sought to evaluate the relationship between macula vessel density metrics on optical...
Preprint
Full-text available
Diabetic retinopathy (DR) is characterized by microvascular changes including ischemia. Degradation and metabolic changes of various retinal cells occur during ischemia. Ischemic region containing more cells will lead to greater metabolic impairment. We analyzed the non-perfusion region (NPR) by integrating histologic mapping with ultra-widefield f...
Article
Purpose: To determine the relationship between baseline retinal non-perfusion area (NPA) and retinal vascular bed area (RVBA) on ultra-wide field fluorescein angiography (UWF FA) and long-term response to intravitreal ranibizumab therapy in diabetic macular oedema (DMO). Methods: A post-hoc, 2-year observational case series. Baseline UWF FA imag...
Article
Full-text available
Purpose: To quantify changes of the retinal vascular bed area (RVBA) in mm2 on stereographically projected ultra-wide field (UWF) fluorescein angiography (FA) images by in eyes with proliferative diabetic retinopathy (PDR) following anti-vascular endothelial growth factor (VEGF) injection. Methods: Prospective, observational study. The early-pha...
Article
Full-text available
Aims To quantify retinal vascular bed area (RVBA) in square millimetres on stereographically projected ultra-wide field (UWF) fluorescein angiography (FA) in eyes with diabetic retinopathy (DR). Methods A prospective, observational study. Baseline Optos 200Tx UWF FA images of 80 eyes with DR from the DAVE ( NCT01552408 ) and RECOVERY ( NCT02863354...
Article
Full-text available
Background Ultra-widefiled (UWF) retinal images include significant distortion when they are projected onto a two-dimensional surface for viewing. Therefore, many clinical studies that require quantitative analysis of fundus images have used stereographic projection algorithm, three-dimensional fundus image was mapped to a two-dimensional stereogra...
Article
Full-text available
We aimed to investigate the relationship between non-perfusion on ultra-widefield angiography (UWF FA) and aqueous cytokine levels and central macular thickness (CMT) in eyes with branch retinal vein occlusion (BRVO). Thirty-five eyes with treatment-naïve BRVO were included. Non-perfusion area (NPA) for partial and complete ischemia was manually se...
Article
Purpose To investigate the correlation between macular microvascular alterations on optical coherence tomography angiography (OCTA) and retinal ischemia on ultra-widefield fluorescein angiography (UWF FA) in eyes with branch retinal vein occlusion (BRVO). Design Cross-sectional study Methods This prospective study was performed from September 201...
Article
Full-text available
Polypoidal choroidal vasculopathy (PCV) is a common choroidal vascular disease particularly in Asians. However, the underlying pathogenesis of PCV is still yet to be fully elucidated, and the correlation between choroidal vasculature and treatment response of PCV are poorly understood. Accordingly, we sought to find clues to understand the pathogen...
Preprint
Full-text available
Background: Ultra-widefiled (UWF) retinal images include significant distortion when they are projected onto a two-dimensional surface for viewing. Therefore, many clinical studies that require quantitative analysis of fundus images have used stereographic projection algorithm, three-dimensional fundus image was mapped to a two-dimensional stereogr...
Article
Purpose: To evaluate the association of retinal nonperfusion and diabetic retinopathy (DR) severity with location of vascular caliber measurement using ultrawide field (UWF) imaging. Design: Retrospective image review SUBJECTS: Adult subjects with diabetes mellitus. Methods: All images from subjects with same day UWF fluorescein angiography (F...
Article
Aim To analyse the peripheral extent of choroidal circulation using ultra-widefield (UWF) indocyanine green angiography (ICGA) in healthy eyes. Methods UWF ICGA images of 55 eyes of 36 healthy subjects were captured using the Optos California (Optos, Dunfermline, United Kingdom) in this prospective observational study. Images were analysed to loca...
Preprint
Full-text available
We propose a convolutional neural network for localising the centres of the optic disc (OD) and fovea in ultra-wide field of view scanning laser ophthalmoscope (UWFoV-SLO) images of the retina. Images captured in both reflectance and autofluorescence (AF) modes, and central pole and eyesteered gazes, were used. The method achieved an OD localisatio...
Article
Full-text available
Purpose To analyze the distribution of diabetic retinopathy (DR) lesions in an Indian population using ultra-wide field (UWF) fundus imaging. Methods Seven hundred fifteen subjects (1406 eyes) with diabetic retinopathy in India were enrolled in this multicenter, prospective, observational study using UWF pseudocolor imaging with Optos Daytona Plus...
Chapter
We propose a convolutional neural network for localising the centres of the optic disc (OD) and fovea in ultra-wide field of view scanning laser ophthalmoscope (UWFoV-SLO) images of the retina. Images captured in both reflectance and autofluorescence (AF) modes, and central pole and eyesteered gazes, were used. The method achieved an OD localisatio...
Article
Full-text available
Objective Changes to the retinal vasculature are known to be associated with hypertension independently of traditional risk factors. We investigated whether measurements of retinal vascular calibre from ultra-widefield fundus imaging were associated with hypertensive status. Methods We retrospectively collected and semiautomatically measured ultra...
Article
Full-text available
Purpose: To study the number and distribution of vortex ampullae in healthy eyes using ultra-wide field (UWF) indocyanine green angiography (ICGA). Design: Prospective, observational study. Participants: Thirty-six eyes of 36 healthy participants with no evidence of ocular or systemic disease. Methods: The UWF ICGA images (central and periph...
Article
Purpose: To correlate fractal dimension (FD) of the retinal vasculature with the extent of retinal nonperfusion area in diabetic retinopathy (DR) on ultrawide-field fluorescein angiography (FA). Design: Cross-sectional study. Methods: Baseline Optos 200Tx ultrawide-field FA images of 80 eyes with DR from the DAVE (NCT01552408) and RECOVERY (NC...
Article
Purpose: To quantify retinal nonperfusion area and retinal vascular bed area (RVBA) in mm on ultra-widefield fluorescein angiography in eyes with diabetic macular edema (DME) and explore their relationship with the severity of DME. Methods: Prospective, observational case series. Baseline ultra-widefield fluorescein angiography images of 40 eyes...
Article
Purpose: To explore the distribution of nonperfusion area (NPA) on ultrawide-field fluorescein angiography (UWF FA) in proliferative diabetic retinopathy (PDR) and its relationship with the presence of neovascularization of the optic disc (NVD) and distribution of neovascularization elsewhere (NVE). Design: Prospective, observational case series...
Article
Purpose: To classify retinal nonperfusion regions (NPRs) in patients with diabetic macular edema (DME) and assess the relationship with severity of DME. Design: Prospective, observational case series. Methods: Forty eyes of 29 patients with treatment-naïve center-involved macular edema secondary to diabetes mellitus were included (The DAVE stu...
Article
Background: To evaluate changes in image sharpness across ultrawide field (UWF) images and the effect of phase-plate adjustment on image contrast and extent of visible retinal area (VRA). Methods: This was a single site evaluation of 200° UWF images acquired with phase-plate adjustment (California, Optos, plc) and without (200TX, Optos, plc). Im...
Article
Fundus images from the left eyes of 440 subjects aged 50-59 years enrolled in the Northern Ireland Cohort of Longitudinal Ageing were analyzed. Subjects were categorized as normotensive or hypertensive, according to thresholds on systolic/diastolic blood pressure measurement (140/90 mm Hg) averaged over two sitting measurements in a clinical settin...
Article
Full-text available
Purpose: The purpose of this study was to compare the use of central and montaged ultra-wide-field fluorescein angiography (UWFFA) images for calculating the area of nonperfusion (NP) and ischemic index (ISI) in patients with retinal vein occlusion (RVO) and macular edema (ME) and to correlate these measurements with best-corrected visual acuity (...
Article
Aim To evaluate changes in the ischaemic index (ISI) after targeted retinal photocoagulation (TRP) and to investigate the correlation between these changes and macular oedema (ME). Method Twenty-four eyes of 24 patients with retinal vein occlusion (RVO) with recurrent ME were included. Ultra-widefield fluorescein angiography (UWFFA; Optos 200Tx) w...
Article
Full-text available
Importance Predominantly peripheral disease in eyes with nonproliferative diabetic retinopathy (DR) is suggested as a potential strong risk factor for progression to proliferative disease. However, the reliability and optimal method for the assessment of lesion distribution are still uncertain. Objective To compare agreement between subjective ass...
Article
Purpose: To characterize and quantify the total retinal vascular bed area (RVBA) and vascular density (VD) in normal eyes using stereographically-corrected ultra-wide (UWF) fluorescein angiography (FA). Design: Cross-sectional study Methods: Fifty-nine eyes of 31 normal subjects with no evidence of ocular disease underwent FA using the Optos 200Tx....
Article
Full-text available
This paper proposes a novel Adaptive Region-based Edge Smoothing Model (ARESM) for automatic boundary detection of optic disc and cup to aid automatic glaucoma diagnosis. The novelty of our approach consists of two aspects: 1) automatic detection of initial optimum object boundary based on a Region Classification Model (RCM) in a pixel-level multid...
Article
Full-text available
We demonstrate a multimode detection system in a scanning laser ophthalmoscope (SLO) that enables simultaneous operation in confocal, indirect, and direct modes to permit an agile trade between image contrast and optical sensitivity across the retinal field of view to optimize the overall imaging performance, enabling increased contrast in very wid...
Article
The classification of blood vessels into arterioles and venules is a fundamental step in the automatic investigation of retinal biomarkers for systemic diseases. In this paper we present a novel technique for vessel classification on ultra-wide-fieldof- view images of the retinal fundus acquired with a scanning laser ophthalmoscope. To our best kno...
Article
Purpose To evaluate vortex vein engorgement and choroidal vascular hyperpermeability in patients with central serous chorioretinopathy (CSC) using ultra‐widefield indocyanine green angiography (UWF ICGA). Methods Twenty two patients with unilateral (19 patients) or bilateral (3 patients) CSC were consecutively included and imaged by UWF autofluore...
Article
Purpose To explore the distribution of nonperfusion area (NPA) in eyes with diabetic macular edema (DME) and its relationship with the severity of DME. Design Prospective, observational case series. Methods Forty eyes of 29 patients with treatment-naïve DME who participated in the DAVE study (NCT01552408) were included. Ultra-wide field fluoresce...
Article
Objective: To evaluate detection of hemorrhage and/or microaneurysm (H/Ma) using ultrawide field (UWF) retinal imaging as compared with standard Early Treatment Diabetic Retinopathy Study (ETDRS) 7-field photographs (ETDRS photos). Design: Single-site comparative study of UWF images and ETDRS photos. Participants: One hundred twenty-six eyes o...
Article
Modern scientific collaborations have opened up the opportunity to solve complex problems that require both multidisciplinary expertise and large-scale computational experiments. These experiments typically consist of a sequence of processing steps that need to be executed on selected computing platforms. Execution poses a challenge, however, due t...
Article
Full-text available
Glaucoma is one of the leading causes of blindness worldwide. There is no cure for glaucoma but detection at its earliest stage and subsequent treatment can aid patients to prevent blindness. Currently, optic disc and retinal imaging facilitates glaucoma detection but this method requires manual post-imaging modifications that are time-consuming an...
Conference Paper
Full-text available
Glaucoma is one of the leading cause of blindness but the detection at its earliest stage and subsequent treatment can aid patients to preserve blindness. The existing work has been focusing on global features such as texture, grayscale and wavelet energy of the Optic Nerve Head (ONH) and its surrounding to differentiate between normal and glaucoma...
Article
To determine the calculated, anatomically correct, area of retinal non-perfusion and total area of visible retina on ultra-widefield fluorescein angiography (UWF FA) in retinal vein occlusion (RVO) and to compare the corrected measures of non-perfusion with the ischaemic index. Uncorrected UWF FA images from 32 patients with RVO were graded manuall...
Article
Full-text available
Optical coherence tomography (OCT) and reflectance imaging are used in clinical practice to measure the thickness and transverse dimensions of retinal features. The recent trend towards increasing the field of view (FOV) of these devices has led to an increasing significance of the optical aberrations of both the human eye and the device. We report...
Chapter
In this chapter we will focus on the combination of evolutionary computation (EC ) techniques and constraint satisfaction problems (CSP s). Constraint programming (CP ) is another approach to deal with constraint satisfaction problems. In fact, it is an important prelude to the work covered here as it advocates itself as an alternative approach to...
Article
Full-text available
Features of the retinal vasculature, such as vessel widths, are considered biomarkers for systemic disease. The aim of this work is to present a supervised approach to vessel segmentation in ultra-wide field of view scanning laser ophthalmoscope (UWFoV SLO) images and to evaluate its performance in terms of segmentation and vessel width estimation...
Technical Report
Full-text available
Multiple Sequence Alignment (MSA) constitutes an extremely power-ful tool for important biological applications such as phylogenetic anal-ysis, identification of conserved motifs and domains and structure pre-diction. In spite of the improvement in speed and accuracy introduced by MSA programs, the computational requirements for large-scale align-m...
Technical Report
Full-text available
An 'Intellectual Ramp' enables researchers to move incrementally from their current practice into the adoption of new methods. An investigation of Ramps is an important step towards "crossing the chasm" so that researchers can benefit from new tools, technologies and approaches. This paper will define and explain the concept of Ramps, discuss requi...
Conference Paper
Distinguishing true retinal area from artefacts in SLO images is a challenging task, which is the first important step towards computer-aided disease diagnosis. In this paper, we have developed a new method based on superpixel feature analysis and classification approaches for determination of retinal area scanned by Scanning Laser Ophthalmoscope(S...
Article
Full-text available
Scanning Laser Ophthalmoscopes (SLOs) can be used for early detection of retinal diseases. With the advent of latest screening technology, the advantage of using SLO is its wide Field of View (FOV), which can image a large part of the retina for better diagnosis of the retinal diseases. On the other hand, during the imaging process, artefacts such...
Article
Full-text available
Background and objective: Accurate quantification of retinal surface area from ultra-widefield (UWF) images is challenging due to warping produced when the retina is projected onto a two-dimensional plane for analysis. By accounting for this, the authors sought to precisely montage and accurately quantify retinal surface area in square millimeters...
Conference Paper
Full-text available
We report the design, manufacture and assessment of a phantom eye that can be used to measure the performance and accuracy of ophthalmic-OCT devices. We base our design on a wide-field schematic eye, R. Navarro, J. Opt. Soc. Am. A 2 (1985), to allow the assessment of device performance relative to +/- 70° external field of view. We have fabricated...
Conference Paper
Retinal capillary abnormalities include small, leaky, severely tortuous blood vessels that are associated with a variety of retinal pathologies. We present a prototype image-processing system for detecting abnormal retinal capillary regions in ultra-widefield-of-view (UWFOV) fluorescein angiography exams of the human retina. The algorithm takes as...
Book
This book presents the most up–to–date opportunities and challenges emerging in knowledge discovery, helping readers develop the technical skills to design and develop data–intensive methods and processes. Offering an introduction to the current R and D efforts worldwide, the book includes examples and case studies with strategies for addressing a...
Chapter
This chapter aims at providing data analysis experts with an overview of the most common strategies in knowledge discovery, highlighting those steps or blocks of steps that are most likely to appear in common problem solving in conventional and data-intensive contexts, as well as giving examples that can be replicated in a range of problems in diff...
Chapter
This chapter describes the application of data-intensive methods to the automatic identification and annotation of gene expression patterns in the mouse embryo. The first section of the chapter introduces ideas behind modern computational and systems biology, how the explosion of data in the postgenomic world has led to new possibilities and even g...
Chapter
This chapter presents a set of scenarios that introduce different types of data analysis problems of increasing complexity, which could be handled by a team of data analysts in a telecommunications company, Telco Inc. It starts with a rather conventional scenario where a customer churn prediction model is built from the company's own data sources....
Conference Paper
Full-text available
In this paper, we propose an algorithm based on active shape model for the extraction of Optic Disc boundary. The determination of Optic Disc boundary is fundamental to the automation of retinal eye disease diagnosis because the Op-tic Disc Center is typically used as a reference point to lo-cate other retinal structures, and any structural change...
Article
Full-text available
Manual annotation of enzymatic functions cannot keep up with automatic genome sequencing. In this work we explore the capacity of InterPro sequence signatures to automatically predict enzymatic function. We present EnzML, a multi-label classification method that can efficiently account also for proteins with multiple enzymatic functions: 50,000 in...