Jannatul Ferdous

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Jannatul verified their affiliation via an institutional email.

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• B.Sc and MS in Biotechnology and Genetic Engineering
• Student at Bangabandhu Sheikh Mujibur Rahman Science and Technology University

A previous report suggests that phytol (PHY) may exert its antidepressant effects in mice, possibly through GABAA receptor interaction pathways. We aimed to check its antidepressant effect with possible molecular mechanisms through behavioral and in silico studies. For this, adult mice were randomly divided into different groups (n = 6), namely con...

Linalool (LIN) has some important neuropharmacological activities, including anxiolytic and sedative effects. It is also clear that it protects experimental animals from convulsions and Alzheimer's disease. On the other hand, caffeine (CAF) and sclareol (SCL) have neurostimulatory potential. This study evaluates the sedative effect and possible mol...

Background This study emphasizes evaluating the antiemetic efficacy of the natural food component caffeic acid (CAF) using a copper sulfate pentahydrate (CuSO4.5H2O)‐induced emetic model on chicks, and an in silico approach was also adopted to estimate the possible underlying mechanisms. Methods Two doses (25 and 50 mg/kg b.w.) of CAF and several...

Hinokitiol (HK), a monoterpenoid that naturally occurs in plants belonging to the Cupressaceae family, possesses important biological activities, including an anticancer effect. This review summarizes its anticancer potential and draws possible molecular interventions. In addition, it evaluates the biopharmaceutical, toxicological properties, and c...

Introduction Weissella confusa is an opportunistic pathogen commonly found in various food sources. This study aimed to evaluate the probiotic potential of W. confusa. Methods Twenty samples of milk and milk products were collected from different regions of Bangladesh. Isolation was performed using MRS agar, and several in vitro tests were cond...

The citrus peel flavonoid tangeretin (TAN) has diverse biological activities, including antioxidant, anti-inflammatory, anti-tumor, hepatoprotective, and neuroprotective effects. This study emphasizes evaluating the anxiolytic effect of TAN on mice. Additionally, we conducted in silico investigations to examine the potential molecular mechanisms be...

Sleep disturbance causes many health problems in humans worldwide. This study evaluated the effects and possible mechanisms of sclareol (SCL) and/or linalool (LIN) through in vivo and in silico studies. For this, young chicks SCL (5, 10, and 20 mg/kg) and/or LIN (50 mg/kg) were orally administered thirty minutes before to the thiopental sodium (TS)...

The current study aims to assess the effects of abrine (ABR) in thiopental sodium (TS)‐induced sleeping mice and to explore the sedative impacts of the compound by using in vivo and in silico investigations. ABR (5 and 10 mg k⁻¹g, i.p.) and diazepam (DZP) (2 mg k⁻¹g, i.p.) were administered to the experimental animals either single or combined. TS...

Nigella sativa (black cumin) is a widely recognized medicinal plant in traditional medicine, and its seeds and seed oil are used in the treatment of various diseases. This plant and its bioactive compounds exhibit numerous biological activities such as anti-diabetic, anticancer, antimicrobial, and anti-inflammatory, among others. N. sativa contains...

The current study aims to assess the effects of abrine (ABR) in thiopental sodium (TS)‐induced sleeping mice and to explore the sedative impacts of the compound by using in vivo and in silico investigations. ABR (5 and 10 mg k⁻¹g, i.p.) and diazepam (DZP) (2 mg k⁻¹g, i.p.) were administered to the experimental animals either single or combined. TS...

The thyme monoterpenoid phenol thymol (THY) possesses diverse biological activities, including anti-convulsant effects. However, the possible action mechanism behind this fact has yet to be discovered. This study aimed to evaluate the anti-convulsant effects of THY with possible molecular insights through in vivo and in silico studies. For this, we...

This study aimed at the evaluation of the sedative effect of phytol (PHY) with possible molecular mechanisms through in vivo and in silico studies. For this, adult male mice were randomly divided into six individual groups, namely control (vehicle), two standards (DZP: diazepam at 2 m/kg, FLU: flumazenil at 0.1 mg/kg), three test groups (PHY at 25,...

Study background Linalool (LIN) has some important neuropharmacological activities, including anxiolytic and sedative effects. It is also clear that it protects experimental animals from convulsions and Alzheimer's disease. On the other hand, caffeine (CAF) and sclareol (SCL) have neurostimulatory potential. Aim To evaluate the sedative effect and...

This study evaluates the pharmacological effects of iridoid glucoside loganic acid, a plant constituent with diverse properties, based on literature, and explores the underlying cellular mechanisms for treating several ailments. Data were collected from reliable electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar, etc...

Phytol (PHY), a chlorophyll side chain diterpenoid possesses many health benefits, including neurological activities. A previous report evaluated its anti-depressive effects in mice without any possible mechanism. Our current study aimed at the evaluation of anti-depressive effect of PHY with possible molecular mechanisms through in vivo and in sil...

Natural products are being developed as possible treatment options due to the rising prevalence of cancer and the harmful side effects of synthetic medications. Arctiin is a naturally occurring lignan found in numerous plants and exhibits different pharmacological activities, along with cancer. To elucidate the anticancer properties and underlying...

This study focuses to investigate the pharmacological activities, botanical sources, and biopharmaceutical profile of the phytochemical fraxin based on different preclinical and non-clinical studies to show the scientific evidence and to evaluate the underlying molecular mechanisms of the therapeutic effects against various ailments. For this, data...

Morroniside (MOR) is an iridoid glycoside and the main active principle of the medicinal plant, Cornus officinalis Sieb. This phytochemical is associated with numerous health benefits due to its antioxidant properties. The primary objective of the present study was to assess the pharmacological effects and underlying mechanisms of MOR, utilizing pu...

ABSTRACT Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with a multitude of pharmacological activities. The primary emphasis of this study is on summarizing the anticancer properties with the underlying mechanisms of RA and its derivatives, as well as the pharmacokinetic features. Data was collected (up to date as of November 10...

Ononin is a naturally occurring isoflavone glycoside generally found in various plants like soybeans, legumes, Chinese licorice, Mongolian milkvetch, kudzu, broccoli, and lupine. The compound has exhibited various therapeutic benefits in different laboratory tests. This study aims to evaluate pharmacological effects and biopharmaceutical features b...

Abstract: Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to treat various diseases and ailments. These food items are prominent sources of phytochemicals that exhibit chemopreventive and therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occurring indole alkaloid found in various...

Fruits and vegetables are used not only for nutritional purposes but also as therapeu-tics to treat various diseases and ailments. These food items are prominent sources of phytochemicals that exhibit chemopreventive and therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occurring indole alkaloid found in various Uncaria s...