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Publications (16)
Objective:
Image Registration of whole slide histology images allows the fusion of fine-grained information - like different immunohistochemical stains - from neighboring tissue slides. Traditionally, pathologists fuse this information by looking subsequently at one slide at a time. If the slides are digitized and accurately aligned at cell-level,...
Introduction:
Over the last decade endovascular stenting of aortic aneurysm (EVAR) has been developed from single centre experiences to a standard procedure. With increasing clinical expertise and medical technology advances treatment of even complex aneurysms are feasible by endovascular methods. One integral part for the success of this minimall...
Cancer cell invasion takes place at the cancer-host interface and is a prerequisite for distant metastasis. The relationships between current biologic and clinical concepts like cell migration modes, tumor budding and epithelial-mesenchymal transition (EMT) remains unclear in several aspects, especially for the "real" situation in human cancer. We...
Much insight into metabolic interactions, tissue growth, and tissue organization can be gained by analyzing differently stained histological serial sections. One opportunity unavailable to classic histology is three-dimensional (3D) examination and computer aided analysis of tissue samples. In this case, registration is needed to reestablish spatia...
Motion, like tumor movement due to respiration, constitutes a major problem in radiotherapy and/or diagnostics.
A common idea to compensate for the motion in 4D imaging, is to invoke a registration strategy, which aligns
the images over time. This approach is especially challenging if real time processing of the data and robustness
with respect to...
Diffusion weighted magnetic resonance imaging is a key investigation technique in modern neuroscience. In clinical settings, diffusion weighted imaging (DWI) and its extension to diffusion tensor imaging (DTI) is usually performed applying the technique of echo-planar imaging (EPI). EPI is the commonly available ultrafast acquisition technique for...
In navigated liver surgery it is an important task to align intra-operative data to pre-operative planning data. This work describes a method to register pre-operative 3D-CT-data to tracked intra-operative 2D US-slices. Instead of reconstructing a 3D-volume out of the two-dimensional US-slice sequence we directly apply the registration scheme to th...
The paper deals with the registration of pre-operative 3DCT- data to tracked intra-operative 2D-US-slices in the context of
liver surgery. To bring such a method to clinical practice, it has to be fast and robust. In order to meet these demanding
criteria, we propose two strategies. Instead of applying a time-consuming compounding process to obtain...
A wide range of medical applications in clinic and research exploit images acquired by fast magnetic resonance imaging (MRI) sequences such as echo-planar imaging (EPI), e. g. functional MRI (fMRI) and diffusion tensor MRI (DT-MRI). Since the underlying assumption of homogeneous static fields fails to hold in practical applications, images acquired...
The registration of medical images containing soft tissue like inner organs, muscles, fat , etc., is challenging due to complex
deformations between different image acquisitions. Despite different approaches to get smooth transformations the number of
feasible transformations is still huge and ambiguous local image contents may lead to unwanted res...
Kurzfassung Die Arbeit beschreibt einen neuen Ansatz zur Registrierung von dreidimensionalen CT-Daten mit im Raum aufgenom-menen zweidimensionalen Ultraschallschichten, deren Lage durch ein Trackingsystem beschrieben wird. Derartige Pro-bleme sind für die navigierte Chirurgie relevant. Eine Schwierigkeit besteht in der nicht vollständigen Abdeckung...
In navigated liver surgery the key challenge is the registration of pre-operative planing and intra-operative navigation data. Due to the patients individual anatomy the planning is based on segmented, pre-operative CT scans whereas ultrasound captures the actual intra-operative situation. In this paper we derive a novel method based on variational...
The incorporation of additional user knowledge into a non- rigid registration process is a promising topic in modern registration schemes. The combination of intensity based registration and some in- teractively chosen landmark pairs is a major approach in this direction. There exist difierent possibilities to incorporate landmark pairs into a vari...
