Jana Bender-Liebenthron

Jana Bender-Liebenthron
Universitätsklinikum Düsseldorf | UKD · Frauenklinik, UniCareD am UniKiD

Dr. rer. nat.

About

53
Publications
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Introduction
Jana Bender-Liebenthron currently works at the University Gynaecological Clinic Düsseldorf as Director of UniCareD, University centralized Cryobank for Reproductive Medicine and Fertility Protection. She is highly specialized in ovarian tissue banking and supports national and international hospitals in the field of female fertility protection.

Publications

Publications (53)
Article
Objective: To investigate the effects of a dynamic fluidic culture system on early in vitro folliculogenesis in standardized ovarian cortex biopsies. Design: Cortical small strips were cultured for 6 days in a conventional static or in a dynamic fluidic culture system. Setting: University-affiliated laboratory with an associated cryobank facil...
Article
In the past several scoring systems were proposed for early human development aiming to assist in the identification of the best embryos. Scoring criteria are usually assessed at static developmental time points by microscopy. For almost every scoring system controversial results on its benefit can be found in the literature. With the introduction...
Article
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Objective: This article reports the first live birth after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency in China. Methods: A patient with myelodysplastic syndrome received ovarian tissue cryopreservation before hematopoietic stem cell transplantation, and six ovarian cortex strips were thawed and transp...
Article
Full-text available
Objective This article reports the first case of pregnancy after frozen–thawed ovarian tissue transplantation to prevent iatrogenic premature ovarian insufficiency in China. Methods Ovarian tissue cryopreservation was performed in a patient with myelodysplastic syndrome (MDS) before multi-agent chemotherapy and hematopoietic stem cell transplantat...
Article
The feasibility of freezing and thawing ovarian tissue is nowadays widely documented. However, ovarian tissue transplantation (OTT) is happening at a much slower pace, and clinical experience is somewhat limited. In this review, five European centers present their collective experience of transplanting ovarian tissue in 285 women. The focus is on s...
Chapter
Cryopreserved ovarian cortex tissue can be used to improve or restore female fertility. It can be used for cancer patients to restore fertility after chemotherapy treatment or for social reasons for women who want to postpone their pregnancy wish. In order to preserve ovarian tissue viability in these cases, the tissue needs to be stored by cryopre...
Article
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PurposeThe main objective of Repro-Can-OPEN Study Part 2 is to learn more about oncofertility practices in optimum resource settings to provide a roadmap to establish oncofertility best practice models.Methods As an extrapolation for oncofertility best practice models in optimum resource settings, we surveyed 25 leading and well-resourced oncoferti...
Article
Full-text available
PurposeFemale fertility preservation prior to gonadotoxic therapies can be achieved by the cryopreservation of ovarian cortical tissue. Immature oocytes may be recovered during the preparation, matured in vitro and lead to live births, thereby providing an additional option for fertility preservation. The purpose of this study was to test the feasi...
Chapter
Half an ovary or a whole ovary can be removed laparoscopically for tissue cryopreservation. As a rule, removal of half an ovary is enough. The removal of a whole ovary is only recommended for children, in case of pelvic radiotherapy or stem cell transplantation. It is advisable to exclude metastases in a small piece of tissue to determine the folli...
Chapter
Cryopreservation of ovarian tissue using the slow freezing method is an established fertility preservation procedure in post-pubertal patients. In comparison to cryopreservation of oocytes, only a few days are required, and therefore gonadotoxic treatment does not necessarily need to be postponed. In diseases with a low risk of ovarian metastasis,...
Chapter
Cryopreservation of oocytes has become one of the most important fertility preservation techniques in females. After ovarian stimulation and follicle aspiration, oocytes are either cryopreserved fertilized or unfertilized. The method of choice, especially in unfertilized oocytes, is vitrification, a technique that allows the solidification of the o...
Article
Objectives To evaluate the prognostic value of anti-Mullerian hormone (AMH) levels in estimating the ovarian density of primordial and primary follicles, which can be assumed to reflect the real ovarian reserve. Study design A total of 537 women, average age 30.4 years (range 8.0–43.7 years), underwent ovarian tissue cryopreservation prior to gona...
Article
Introduction Supporting and counselling couples with fertility issues prior to starting ART is a multidisciplinary diagnostic and therapeutic challenge. The first German-language interdisciplinary S2k guideline on “Diagnosis and Therapy Before Assisted Reproductive Treatments (ART)” was published in February 2019. The guideline was developed in the...
Article
Full-text available
Study question: How do anti-Müllerian hormone (AMH) serum concentrations and follicle densities (FDs) change with age and disease and what are the implications for fertility preservation? Summary answer: AMH concentrations and FD do not correlate in young women, and AMH but not FD is reduced in some diseases, limiting the value of AMH as a predi...
Article
Research question: Is overnight transportation of ovarian tissue before cryopreservation in a centralized cryobank from the FertiPROTEKT network feasible? Design: Data from 1810 women with cryopreserved ovarian tissue after overnight transportation from December 2000 to December 2017 were analysed with a focus on transportation, tissue activity...
Article
Full-text available
Premature gonadal failure is a common problem in patients with systemic lupus erythematosus (SLE) when gonadotoxic therapies are applied. The preservation of gonadal function and fertility is of great importance to many predominantly young SLE patients. Some fertility preservation methods are well established and well known, whereas others are cons...
Article
Objective: Premature ovary insufficiency is frequent after chemotherapy/radiotherapy in cancer patients. Ovarian tissue (OT) cryopreservation and later retransplantation, the routine method in Europe, has recently been implemented at the first center in China. We investigated the protective effect of the antioxidant N-acetyl-l-cysteine (NAC) during...
Article
The cryopreservation of ovarian tissue with subsequent transplantation of the tissue represents an established method of fertility protection for female patients who have to undergo gonadotoxic therapy. The procedure can be performed at any point in the cycle and thus generally does not lead to any delay in oncological therapy. With the aid of this...
Article
Full-text available
Onkologische und nichtonkologische Erkrankungen können die gegenwärtige oder zukünftige Fertilität beeinträchtigen, entweder durch die Krankheit selbst oder durch notwendig chirurgische Eingriffe, hormonelle und/oder gonadotoxische Behandlungen. Sie erfordern damit einen adäquaten fertilitätsprotektiven Ansatz – sprich eine unbedingte Beratung und,...
Article
Der verfrühte Eintritt einer Frau in die Wechseljahre kommt häufig unerwartet und unerwünscht. Üblicherweise ist zu diesem Zeitpunkt der Kinderwunsch noch nicht erfüllt. Hinzu kommen Wechseljahresbeschwerden, die die Patientin körperlich und psychisch belasten. Die Diagnose der prämaturen Ovarialinsuffizienz wird durch die Bestimmung der erhöhten G...
Article
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Study question: Does preimplantation genetic testing for aneuploidy (PGT-A) by comprehensive chromosome screening (CCS) of the first and second polar body to select embryos for transfer increase the likelihood of a live birth within 1 year in advanced maternal age women aged 36-40 years planning an ICSI cycle, compared to ICSI without chromosome a...
Poster
Study question: What is the prognostic value of Anti mullerian hormone (AMH) to estimate the ovarian density of ovarian primordial and primary follicles?
Article
Full-text available
Aim The aim of this official guideline published by the German Society of Gynecology and Obstetrics (DGGG) and coordinated with the German Society of Urology (DGU) and the German Society of Reproductive Medicine (DGRM) is to provide consensus-based recommendations, obtained by evaluating the relevant literature, on counseling and fertility preserva...
Article
Zusammenfassung Hintergrund Fertilitätsprotektive Massnahmen vor gonadotoxischen Therapien spielen aufgrund steigender Überlebensraten bei Krebs- und Autoimmunerkrankungen im reproduktiven Alter eine zunehmende Rolle. Obwohl die Fertilität von Kindern und Jugendlichen durch gonadotoxische Therapien relevant eingeschränkt sein kann, wird die Möglich...
Article
Full-text available
PurposeIn addition to guidelines focusing on scientific evidence, practical recommendations on fertility preservation are also needed. MethodsA selective literature search was performed based on the clinical and scientific experience of the authors. This article (Part II) focuses on fertility preservation techniques. Part I, also published in this...
Article
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Introduction Modern anti-cancer strategies have distinctly increased survival rates; nevertheless, often accompanied by sterility. Currently, the only option for preserving fertility in prepubertal females is to cryopreserve ovarian tissue and re-transplant frozen-thawed tissue to restore fertility after treatment. Our aim was to report the occurre...
Article
Fertility-preserving measures are becoming important for patients receiving oncological treatment. One method involves cryopreservation of ovarian tissue and transplanting it when treatment is completed. We report complications resulting from surgical and fertility medicine, and the results of procedures for the removal and transplantation of ovari...
Chapter
Ovarian tissue cryopreservation is gaining much interest since the publication of the first live birth after retransplantation of frozen-thawed tissue in 2004 (Donnez et al., Lancet 364:1405–1410, 2004). In contrast to cryopreservation of gametes and embryos, ovarian tissue freezing is a complex requiring a proper approach in order to make this a v...
Article
Full-text available
STUDY QUESTION What is the success rate in terms of ovarian activity (menstrual cycles) as well as pregnancy and delivery rates 1 year after orthotopic ovarian transplantations conducted in a three-country network? SUMMARY ANSWER In 49 women with a follow-up >1 year after transplantation, the ovaries were active in 67% of cases and the pregnancy a...
Article
Fragestellung: Die einzige realistische Moglichkeit zum Fertilitatserhalt bei an Krebs erkrankten Madchen vor der Pubertat ist die Kryokonservierung von Ovargewebe. Bis heute ist noch nicht eindeutig bewiesen, dass vor der Pubertat entnommenes Ovargewebe nach einer Transplantation nach Abschluss der onkologischen Therapie Funktionszeichen wie das E...
Article
Fertility-preservation techniques for medical reasons are increasingly offered in national networks. Knowledge of the characteristics of counselled patients and techniques used are essential. The FertiPROTEKT network registry was analysed between 2007 and 2013, and included up to 85 university and non-university centres in Germany, Austria and Swit...
Article
Full-text available
Purpose: To evaluate the effect of cryopreservation and thawing of ovarian tissue from oncological patients opting for fertility preservation on ovarian tissue viability. Methods: In this prospective cohort study, the ovarian tissue viability before and after cryopreservation and thawing was measured for 25 newly diagnosed oncological patients who...
Article
Full-text available
Background Current strategies in cancer treatment have markedly increased the rates of remission and survival for cancer patients, but are often associated with subsequent sterility. While there are various options available to an adult female depending on the patient’s particular situation, the only realistic option for preserving fertility in pre...
Article
Hat die Frau ihren Kinderwunsch zu lange hinausgezögert, kann auch die Reproduktionsmedizin keine Wunder vollbringen. Liegen jedoch andere Einschränkungen der männlichen oder weiblichen Fertilität vor, so verhilft die moderne Reproduktionsmedizin vielen Paaren zu einem Kind.

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