Jan Willem de Gee

Jan Willem de Gee
Baylor College of Medicine | BCM · Department of Neuroscience

PhD

About

18
Publications
3,187
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761
Citations
Additional affiliations
September 2018 - present
Baylor College of Medicine
Position
  • PostDoc Position
July 2014 - September 2019
University Medical Center Hamburg - Eppendorf
Position
  • PhD Student

Publications

Publications (18)
Article
Full-text available
A number of studies have shown that pupil size increases transiently during effortful decisions. These decision-related changes in pupil size are mediated by central neuromodulatory systems, which also influence the internal state of brain regions engaged in decision making. It has been proposed that pupil-linked neuromodulatory systems are activat...
Article
Full-text available
Changes in pupil diameter can reflect high-level cognitive signals that depend on central neuromodulatory mechanisms. However, brain mechanisms that adjust pupil size are also exquisitely sensitive to changes in luminance and other events that would be considered a nuisance in cognitive experiments recording pupil size. We implemented a simple audi...
Preprint
A bstract To meet their survival needs, organisms must continuously select which sensory stimuli to attend to and decide how much attention to pay. Attention’s selective aspect has been a cornerstone of behavioral and physiological study, whereas attentional intensity is poorly understood. Autonomic arousal is thought to strongly influence attentio...
Article
Full-text available
While functional magnetic resonance imaging (fMRI) at ultra‐high field (7 T) promises a general increase in sensitivity compared to lower field strengths, the benefits may be most pronounced for specific applications. The current study aimed to evaluate the relative benefit of 7 over 3 T fMRI for the assessment of responses evoked in different brai...
Article
Full-text available
Central to human and animal cognition is the ability to learn from feedback in order to optimize future rewards. Such a learning signal might be encoded and broadcasted by the brain's arousal systems, including the noradrenergic locus coeruleus. Pupil responses and the positive slow wave component of event-related potentials reflect rapid changes i...
Article
Full-text available
Vagus nerve stimulation (VNS) is thought to affect neural activity by recruiting brain-wide release of neuromodulators. VNS is used in treatment-resistant epilepsy, and is increasingly being explored for other disorders, such as depression, and as a cognitive enhancer. However, the promise of VNS is only partially fulfilled due to a lack of mechani...
Preprint
Full-text available
Central to human and animal cognition is the ability to learn from feedback in order to optimize future rewards. Such a learning signal might be encoded and broadcasted by the brain's arousal systems, including the noradrenergic locus coeruleus. Pupil responses and the P3 component of event-related potentials reflect rapid changes in the arousal le...
Article
Full-text available
Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems are activated during such decisions. In previous work in humans, we found that evoked responses of arousal systems during decisions are reported by rapid dilations of the pupil and track a suppression of biases in the accumulation of decision-relevant...
Preprint
Full-text available
Significant progress has been made in ultra-high field functional magnetic resonance imaging (fMRI) at 7 Tesla (T). While fMRI at 7 T promises a general increase in sensitivity compared to lower field strengths, the benefits may be most pronounced for specific applications. The current study aimed to evaluate the relative benefit of 7 T over 3 T fM...
Preprint
Full-text available
A bstract Vagus nerve stimulation (VNS) is thought to alter the state of the brain by recruiting global neuromodulators. VNS is used in treatment-resistant epilepsy, and is increasingly being explored for other brain disorders, such as depression, and as a cognitive enhancer. However, the promise of VNS is only partially fulfilled due to a lack of...
Article
Full-text available
Perceptual choices depend not only on the current sensory input but also on the behavioral context, such as the history of one’s own choices. Yet, it remains unknown how such history signals shape the dynamics of later decision formation. In models of decision formation, it is commonly assumed that choice history shifts the starting point of accumu...
Preprint
Full-text available
A bstract Perceptual choices depend not only on the current sensory input, but also on the behavioral context. An important contextual factor is the history of one’s own choices. Choice history often strongly biases perceptual decisions, and leaves traces in the activity of brain regions involved in decision processing. Yet, it remains unknown how...
Article
Full-text available
Decision bias is traditionally conceptualized as an internal reference against which sensory evidence is compared. Instead, we show that individuals implement decision bias by shifting the rate of sensory evidence accumulation toward a decision bound. Participants performed a target detection task while we recorded EEG. We experimentally manipulate...
Preprint
Decision bias is traditionally conceptualized as an internal reference against which sensory evidence is compared. Instead, we show that individuals implement decision bias by shifting the rate of sensory evidence accumulation towards a decision bound. Participants performed a target detection task while we recorded EEG. We experimentally manipulat...
Article
Full-text available
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Article
Full-text available
Perceptual decisions about the state of the environment are often made in the face of uncertain evidence. Internal uncertainty signals are considered important regulators of learning and decision-making. A growing body of work has implicated the brain's arousal systems in uncertainty signaling. Here, we found that two specific computational variabl...
Article
Full-text available
Decision-makers often arrive at different choices when faced with repeated presentations of the same evidence. Variability of behavior is commonly attributed to noise in the brain's decision-making machinery. We hypothesized that phasic responses of brainstem arousal systems are a significant source of this variability. We tracked pupil respon...