Jan-Sebastian Grigoleit

Jan-Sebastian Grigoleit
Lundbeck A/S · Lundbeck La Jolla Research Center

Dr. rer. medic. (PhD)

About

38
Publications
3,676
Reads
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970
Citations
Additional affiliations
April 2017 - present
Janssen Pharmaceutical Companies of Johnson & Johnson
Position
  • Fellow
January 2014 - April 2017
Salk Institute for Biological Studies
Position
  • Fellow
December 2012 - December 2013
University of Duisburg-Essen
Position
  • Research Associate
Education
November 2007 - November 2012
University of Duisburg-Essen
Field of study
  • Behavioral Immunobiology
October 2001 - February 2007
Philipps University of Marburg
Field of study
  • Neuroimmunology

Publications

Publications (38)
Article
Human genetic studies have pointed to a prominent role for innate immunity and lipid pathways in immunological and neurodegenerative disorders. Our understanding of the composition and function of immunomodulatory lipid networks in innate immune cells, however, remains incomplete. Here, we show that phospholipase Cγ2 (PLCγ2 or PLCG2)—mutations in w...
Article
Drug-induced colony-stimulating factor 1 receptor (CSF1R) blockage is now a commonly used tool to cause reversible microglia depletion in mice. However, microglial depletion is not complete with a remaining fraction of approximately 5% of the original microglia. In order to characterize this remarkably stable portion of the microglia we used fluore...
Article
Emerging data continues to point towards a relationship between neuroinflammation and neuropsychiatric disorders. ATP-induced activation of P2X7 results in IL-1β release causing neuroinflammation and microglial activation. This study describes the in-vitro and in-vivo neuropharmacology of a novel brain-penetrant P2X7 antagonist, JNJ-55308942, curre...
Article
Activation of the hypothalamo-pituitary-adrenal (HPA) axis by inflammatory stressors (e.g., bacterial lipopolysaccharide) is thought to involve vascular transduction of circulating cytokines, with perivascular macrophages (PVMs) along with endothelia, effecting activation of HPA control circuitry via inducible (cyclooxygenase-2- or COX-2- dependent...
Article
The hypothalamic-pituitary-adrenal (HPA) axis undergoes critical developments during adolescence. Therefore, stressors experienced during this period potentially have long-term effects on adult HPA axis function. We hypothesized that adolescent intermittent ethanol (AIE) exposure would affect adult HPA axis function, resulting in altered responses...
Article
Lipopolysaccharide (LPS) administration is a well-established model to assess afferent immune-to-brain communication and behavioral aspects of inflammation. Nevertheless, only few studies in comparatively small samples have assessed state anxiety as a psychological component of sickness behavior despite possible clinical implications for the pathop...
Conference Paper
Experimental endotoxin administration is a well-established model to analyze the effect of inflammation on the development of mood impairments. However, it remains unknown from previous studies in comparatively small samples whether pre-existing inter-individual differences modulate the behavioral response during endotoxemia. We addressed this ques...
Article
Full-text available
Salivary alpha-amylase activity (sAA) and plasma noradrenaline (NA) concentrations are often considered to be surrogate markers of sympathetic activation in response to stress. However, despite accumulating evidence for a close association between sAA and noradrenaline and other indicators of sympathetic activity, reliability and generality of this...
Chapter
Systemic inflammation is among the most prominent and most frequently observed responses of the immune system. From everyday challenges like mild infections to severe forms such as chronic inflammatory diseases or sepsis, inflammatory states can develop in many ways over the lifespan. Over the past few decades, it has become clear that inflammatory...
Article
Background: Inflammation-induced pain amplification and hypersensitivity play a role in the pathophysiology of numerous clinical conditions. Experimental endotoxemia has recently been implemented as model to analyze immune-mediated processes in human pain. In this study, we aimed to analyze dose- and time-dependent effects of lipopolysaccharide (L...
Article
Systemic inflammation is among the most prominent and most frequently observed responses of the immune system. Over the past decades, it has become clear that inflammatory cytokines not only affect immune and metabolic functions but also cause a wide range of behavioral and mood changes. Based on experimental findings in animals and observations in...
Article
Systemic inflammation is among the most prominent and most frequently observed responses of the immune system. Over the past decades, it has become clear that inflammatory cytokines not only affect immune and metabolic functions but also cause a wide range of behavioral and mood changes. Based on experimental findings in animals and observations in...
Article
Increases in peripheral cytokines during acute inflammation may affect various neuropsychological functions. The aim of this functional magnetic resonance imaging (fMRI) study was to investigate the effects of acute endotoxemia on mood and the neural response to emotionally aversive visual stimuli in healthy human subjects. In a double-blind, rando...
Article
We previously showed that experimentally-induced endotoxemia leads to visceral hyperalgesia in healthy males (Benson et al., Pain 2012;153(4):794–9). However, it remains unclear whether and to what extent these effects are mirrored by altered pain processing within the brain. Hence, we designed a follow-up study to analyze behavioral and neural res...
Article
Background and purpose: Toll like receptor 4 (TLR4) is the major recognition receptor for lipopolysaccharides and plays a major role in the inflammatory response. CD11b is expressed on the surface of many leukocytes including monocytes. The CD11b/CD18 complex is involved in the inflammatory response by mediating migration and adhesion of leukocyte...
Article
Full-text available
Acute peripheral inflammation with corresponding increases in peripheral cytokines affects neuropsychological functions and induces depression-like symptoms. However, possible effects of increased immune responses on social cognition remain unknown. Therefore, this study investigated the effects of experimentally induced acute inflammation on perfo...
Article
Salivary α-amylase (sAA) is a digestive enzyme that plays also an important role in mucosal immunity. Secretion of the sAA is largely under the control of the autonomic nervous system and increases in sAA activity have repeatedly been observed in response to various stressors. The present study aimed at investigating whether and to what extent sAA...
Article
Full-text available
Factors that are associated with pain perception remain incompletely understood, especially in the visceral pain field. Therefore, the current study aimed to investigate possible psychological and biological predictors of visceral pain sensitivity in healthy subjects. In a sample of 59 healthy premenopausal female subjects on hormonal contraceptive...
Article
Clinical and experimental studies demonstrate that inflammation and increased concentrations of pro-inflammatory cytokines are associated with depression-like symptoms and neuropsychological impairments in humans. However, it has not been satisfactorily elucidated to what extent cognitive functions such as memory, attention or social cognition are...
Article
Growing evidence suggests that systemic immune activation plays a role in the pathophysiology of pain in functional bowel disorders. By implementing a randomized crossover study with an injection of endotoxin or saline, we aimed to test the hypothesis that endotoxin-induced systemic inflammation increases visceral pain sensitivity in humans. Eleven...
Data
Stimuli examples for long-term memory task. Emotional stimuli rated with high arousal and low valence score (A) and neutral stimuli rated with low arousal and medium valence score (B). (TIF)
Data
Illustration of the n-back task paradigm. After a training phase a consecutive sequence of 155 letters was presented on a computer screen with a presentation time of 1 second for each letter and a 30 seconds break after every 31 letters. The participants were instructed to press a button whenever the letter currently presented was identical to the...
Article
Full-text available
Clinical and experimental evidence document that inflammation and increased peripheral cytokine levels are associated with depression-like symptoms and neuropsychological disturbances in humans. However, it remains unclear whether and to what extent cognitive functions like memory and attention are affected by and related to the dose of the inflamm...
Article
Immunological responses to bacterial endotoxin can be behaviorally conditioned in rodents. However, it is unclear whether an acute systemic inflammatory response can be behaviorally conditioned in humans. Thus, in a double-blind placebo-controlled study, 20 healthy, male subjects received either a single injection of lipopolysaccharide (LPS) or sal...
Article
Systemic inflammatory processes induced by infectious diseases, sepsis or chronic inflammatory auto-immune diseases can affect mood, neuropsychological functions and behavior. Typically, those behavioral changes include symptoms such as psychomotor slowing, social withdrawal, anhedonia and depressed mood, and are collectively termed “sickness behav...
Article
Systemic immune activation occurring together with release of peripheral cytokines can affect behavior and the functioning of the central nervous system (CNS). However, it remains unknown whether and to what extent cognitive functions like memory and attention are affected during transient immune activation. We employed a human endotoxemia model an...

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