Jan Roediger

Jan Roediger
Charité Universitätsmedizin Berlin | Charité · Neurology, Neurosurgery and Psychiatry

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18
Publications
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252
Citations

Publications

Publications (18)
Article
Full-text available
Background: Deep brain stimulation (DBS) is an established therapy for patients with Parkinson’s disease. In silico computer models for DBS hold the potential to inform a selection of stimulation parameters. In recent years, the focus has shifted towards DBS-induced firing in myelinated axons, deemed particularly relevant for the external modulatio...
Article
Full-text available
Background: Deep Brain Stimulation (DBS) electrode implant trajectories are stereotactically defined using preoperative neuroimaging. To validate the correct trajectory, microelectrode recordings (MER) or local field potential recordings (LFP) can be used to extend neuroanatomical information (defined by magnetic resonance imaging) with neurophysio...
Preprint
Full-text available
Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is highly effective in controlling motor symptoms in patients with Parkinson’s Disease (PD). However, correct selection of stimulation parameters is pivotal to treatment success and currently follows a time-consuming and demanding trial-and-error process. We conducted a double...
Article
Full-text available
Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation with the sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during stimulation and to validate beta-band activity as a biomarker for bradykinesia. Subthal...
Article
Full-text available
Background: Finding the optimal deep brain stimulation (DBS) parameters from a multitude of possible combinations by trial and error is time consuming and requires highly trained medical personnel. Objective: We developed an automated algorithm to identify optimal stimulation settings in Parkinson's disease (PD) patients treated with subthalamic...
Preprint
Full-text available
Deep brain stimulation (DBS) is an established therapy for patients with Parkinson’s disease. In silico computer models for DBS allow to pre-select a set of potentially optimal stimulation parameters. If efficacious, they could further carry insight into the mechanism of action of DBS and foster the development of more efficient stimulation approac...
Preprint
Full-text available
Deep Brain Stimulation (DBS) electrode implant trajectories are stereotactically defined using preoperative neuroimaging. To validate the correct trajectory, microelectrode recordings (MER) can be used to match the neuroanatomy with expected neurophysiological activity patterns, commonly using up to five trajectories in parallel. However, understan...
Article
Background: Recent technological advances in deep brain stimulation (DBS) (e.g., directional leads, multiple independent current sources) lead to increasing DBS-optimization burden. Techniques to streamline and facilitate programming could leverage these innovations. Objective: We evaluated clinical effectiveness of algorithm-guided DBS-programm...
Article
Full-text available
Objective: To investigate whether functional sweetspots of deep brain stimulation (DBS) in the subthalamic nucleus (STN) can predict motor improvement in PD patients. Methods: Stimulation effects of 449 DBS settings in 21 PD patients were clinically and quantitatively assessed through standardized monopolar reviews and mapped into standard space...
Article
Introduction: We sought to assess the effect of subthalamic deep brain stimulation (STN DBS) on Parkinson's disease (PD)-associated postural abnormalities. Methods: A computerized analysis of posture was used to quantify the thoracolumbar, thoracic, and cervical-occipital ventral angles, as well as the thoracolumbar and cervical-occipital latera...
Article
Full-text available
Objective: The objective of this study was to investigate whether directional deep brain stimulation (DBS) of the subthalamic nucleus in Parkinson's disease (PD) offers increased therapeutic windows, side-effect thresholds, and clinical benefit. Methods: In 10 patients, 20 monopolar reviews were conducted in a prospective, randomized, double-bli...
Poster
Full-text available
Abstract: Objective: To find the neuroanatomical origins of Deep Brain Stimulation (DBS) induced effects using probabilistic mapping. Background: While DBS of the subthalamic nucleus (STN) and the ventral intermediate nucleus of the thalamus (VIM) are well-established therapies for Parkinson’s disease (PD), open questions remain regarding the neuro...
Poster
Full-text available
Abstract Objective: To investigate whether directional DBS of the subthalamic nucleus in Parkinson’s disease (PD) offers increased therapeutic windows, side effect thresholds and clinical benefit. Background: Directional leads have been the most recent technological step in the development of new deep brain stimulation (DBS) paradigms. Methods: Twe...

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