Jan Meuldijk

Jan Meuldijk
Eindhoven University of Technology | TUE · Department of Chemical Engineering and Chemistry

About

218
Publications
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Introduction

Publications

Publications (218)
Article
Full-text available
In pursuit of understanding structure–property relationships for the melting point depression of binary eutectic mixtures, the influence of the anion on the solid–liquid (S–L) phase behavior was explored for mixtures of glutaric acid + tetraethylammonium chloride, bromide, and iodide. A detailed experimental evaluation of the S–L phase behavior rev...
Article
Full-text available
Liquid-phase adsorption has hardly been established in micro-flow, although this constitutes an industrially vital method for product separation. A micro-flow UV-photo isomerization process converts cis-cyclooctene partly into trans-cyclooctene, leaving an isomeric mixture. Trans-cyclooctene adsorption and thus separation was achieved in a fixed-be...
Article
Full-text available
The design of molecularly recyclable polymers contributes to a possible solution to the end‐of‐use issue of polymeric materials and gives a closed‐loop approach toward a circular materials economy. The biobased semi‐aromatic polyesters (e.g., poly(phloretic acid), poly(dihydroferulic acid), and poly(dihydro‐sinapinic acid)), described in this paper...
Article
Full-text available
Three different bio-based styrene monomer alternatives, i.e., 4-vinylphenol derivatives, were synthesized starting from lignin building blocks. The synthetic route encompassed a green Knoevenagel condensation followed by two decarboxylation steps and acetylation. High isolated yields for the decarboxylation were obtained in a polar aprotic solvent,...
Article
Full-text available
In the green Knoevenagel reaction of benzaldehyde and malonic acid, the carbon–carbon formation reaction is catalyzed by a double Schiff base formed by benzaldehyde and ammonia. A mechanism for this green Knoevenagel has been proposed. A closed catalytic cycle explains why various ammonium salts, including ammonium bicarbonate, have been correctly...
Article
Organic waste streams can be converted into volatile fatty acids (VFAs) via fermentation. VFAs can be used as intermediates in the synthesis of added-value chemicals. In this work, hydrophobic eutectic mixtures were designed for the liquid-liquid extraction of VFAs from dilute aqueous solutions. The eutectic behaviour was screened for over 100 comb...
Article
Aim and objective: Because of the low abundance of 3,4-unsubstituted coumarins in plants combined with the complex purification process required, synthetic routes towards 3,4-unsubstituted coumarins are especially valuable. In the present work, we explore the possibilities of a solvent-free Green Knoevenagel condensation on various 2-hydroxybenzal...
Article
Full-text available
The centrifuge method is a novel, equilibrium-based, analytical procedure that allows the construction of solid-liquid phase diagrams of binary eutectic mixtures. In this paper, the development, optimization, and successful verification of the centrifuge method are described. Contrary to common dynamic analysis techniques - differential scanning ca...
Article
This paper presents mechanistic considerations on an efficient, green, and solvent-free Knoevenagel procedure for the chemical transformation of furanic aldehydes into their corresponding α,β-unsaturated compounds. In the proposed mechanism furanic aldehydes react with ammonia, released from ammonium salts, to form a catalytically active double Sch...
Article
Full-text available
For gas sweetening, physical solvents (e.g. Selexol, Rectisol and Fluor) are favored over chemical solvents when the partial pressure of CO2 in the flue gas is high. The CO2 rich solvent is usually regenerated by reducing the pressure without adding heat. The current work presents a comparative study of the low-viscous ionic liquid (IL) 1-hexyl-3-m...
Article
Highly filled, high solids content, water-borne polymer–Gibbsite nanocomposites are prepared with Gibbsite contents as high as 35 wt%. The polymer–Gibbsite nanocomposites are synthesised via conventional starved feed emulsion polymerization using negatively charged butyl acrylate-co-acrylic acid oligomers, which functioned as electrosteric stabiliz...
Article
Full-text available
This paper presents a novel, green Knoevenagel procedure for the chemical transformation of benzaldehydes into their corresponding α,β-unsaturated acids. The essential part of this procedure is a solvent-free condensation which uses environmentally benign amines or ammonium salts as catalysts instead of pyridine and piperidine as used in the tradit...
Article
Full-text available
A penetrometer pushes a solid object into a product and measures the resistance against deformation or flow. Many factories of semi-liquid/semi-solid foods or pastes use penetrometry devices for quality control, typically measuring the resistance force at a single penetration velocity. Furthermore, the physical texture characterization obtained by...
Article
Hydrogen is a promising renewable energy source that can be produced from biomass using Aqueous Phase Reforming (APR). Here, using data obtained from AspenPlus and the literature, we evaluated the phase state, temperature-dependent enthalpy, and Gibbs free energy for the APR of small biomass model substrates. Phase equilibrium studies reveal that,...
Article
Full-text available
Using ethylene glycol dimethacrylate (EGDMA) as a cross-linker Gibbsite platelets were succesfully encapsulated fully using an ATRP-mediated emulsion polymerisation technique. Previously we reported, a “muffin-like” morphology which was obtained using the same approach without cross-linker. This morphology was attributed to the mobility of the grow...
Article
Water-borne anisotropic polymer-Gibbsite latex particles were prepared by a conventional and an atom transfer radical polymerisation (ATRP) based starved-feed emulsion polymerisation without any chemical modification of the platelet surface. Anionic co-oligomers, synthesised via ATRP, were used in both approaches. In the conventional-based route ch...
Article
Full-text available
The solubility and diffusivity of CO2 in a series of 1-alkyl-3methylimidazolium tricyanomethanide ionic liquids ([Cnmim][TCM] with n = 2, 4, 6, 7, 8; ILs) was studied using a magnetic suspension balance at temperatures ranging from 298 to 353 K and pressures up to 2 MPa. The effects of temperature, pressure, and alkyl chain length on CO2 solubility...
Article
Gibbsite platelets were successfully encapsulated via starved-feed conventional emulsion polymerisation using anionic co-oligomers without the need for any surface modification of the platelets. Charged co-oligomers, consisting of butyl acrylate and acrylic acid units, were synthesized using atom transfer radical polymerisation (ATRP) and used as s...
Article
Successful miniemulsion polymerizations of very hydrophobic monomers, such as lauryl methacrylate and 4-tert-butyl styrene, initiated by very hydrophobic (i.e., completely water-insoluble) lauroyl peroxide, are reported. Conversion-time histories, as well as final latex properties, for example, the particle size distribution, are different from sim...
Article
Full-text available
In this article, the synthesis of bio-based polyamides for powder coating applications and their evaluation in a solventborne coating system are reported. The Mn values of the resins were between 3000 and 4000 g mol−1 and the resins displayed Tg values from 60 to 80°C. Both amine and carboxylic acid functionalities (total ~0.6 mmol g−1) were introd...
Article
Polymer-Gibbsite composite latex particles were synthesised via an atom transfer radical polymerisation (ATRP) based approach. A random ATRP cooligomer, consisting of acrylic acid and butyl acrylate units, was synthesized using ATRP. This cooligomer was used as a stabiliser for the Gibbsite platelets and served as a macroinitiator for copper-mediat...
Article
The droplet size distribution determines some crucial properties for high internal phase emulsion (HIPE) products such as product structure, mouth feel and color. This research describes the development of a population balance model which aims at the prediction of the droplet size distribution. The objective is to find one set of parameters which i...
Article
Full-text available
Sinapinic acid is a widespread compound in vegetable material and is as such common in the human diet. Recently it has drawn attention because of its biological activities. Sinapinic acid can be synthesized from syringaldehyde via the Knoevenagel-Doebner condensation. However this reaction is limited by the formation of 4-vinylsyringol after a seco...
Article
To optimize the sensory product attributes by changing the processing conditions or product recipe was the main objective of this research. A mathematical framework was built containing process and sensory models. First, a typical mayonnaise production line was modeled. The line consisted of two mixing steps; in mixer 1 the objective was to prepare...
Article
In this work we develop a simulated moving bed reactor model for the parallel isomerization and separation of fructose and glucose. The model consists of component balances and equilibrium relations. The appropriate computation of the cyclic steady state forms the core of the model. The resulting partial differential equation system is discretized...
Article
Full-text available
A novel procedure was developed to determine the direction of silica growth during the formation of a silica shell around aqueous microdroplets in water-in-oil Pickering emulsions. Two fluorescently labeled silica precursors were added consecutively and the resulting microcapsules were visualized via confocal fluorescence microscopy, allowing the c...
Article
In this paper, we present a series of amorphous non-isocyanate poly(hydroxy urethane)s (PHU) synthesized from diglycerol dicarbonate in bulk conditions at mild temperatures, without using a catalyst. Diglycerol dicarbonate has been synthesized from diglycerol and dimethyl carbonate and was subsequently reacted with various diamines to form PHUs. Th...
Article
Tea polyphenols are claimed to have many health benefits. The fact that tea is such a popular drink, together with all the potential health benefits, has led to an increased interest in the recovery and purification of the polyphenols. The most interesting groups of polyphenols present in black tea are the catechins and the theaflavins. To the best...
Article
Polyphenolic compounds present in fresh tea leaves are related to health benefits, and they can be used as food items and vitamin supplements. However, during conventional tea processing that includes cutting, rolling, and drying, the extraction step is missing. Moreover, process conditions are harsh for example, to destroy the remaining enzymes an...
Article
In this paper, the last levels of the product-driven process synthesis methodology are used to formulate a conceptual process design for the production of a purified catechins powder. First a two stage adsorption process for the separation of the catechins was designed. Secondly a spray drying process is modeled to determine the equipment and the o...
Chapter
The present work describes the product driven process synthesis (PDPS) methodology for the conceptual design of extraction of intact oil bodies from soybeans. First, in this approach consumer needs are taken into account and based on these needs application of the final product (oil bodies) is defined to use extracted oil bodies for food industry a...
Article
Catechins are the main polyphenols present in a green tea and have been associated to several health benefits due to the antioxidant, antimutagenic and antiviral properties. They are, therefore, regarded as desired components with several applications in a variety of areas such as foods, cosmetics and pharmaceuticals. In this study a macroporous po...
Article
Decisions in an oil refinery are made at three levels: planning, scheduling and control. Existing facilities have to be operated close to their maximum capacity, while continuously responding to cost fluctuations. In many of the currently reported planning models each decision level has its own model and is used separately. Integration of these mod...
Article
A new scale-up concept for microwave assisted flow processing is presented where modular scale-up is achieved by implementing microwave cavities in series. The scale-up concept is demonstrated for case studies of a packed-bed reactor and a wall-coated tubular reactor. With known kinetics and reaction temperature, a packed-bed reactor gave a convers...
Article
This article describes the results of a modeling study performed to understand the microwave heating process in continuous-flow reactors. It demonstrates the influence of liquid velocity profiles on temperature and microwave energy dissipation in a microwave integrated milli reactor-heat exchanger. Horizontal co-current flow of a strong microwave a...
Article
Full-text available
Lactobacillus plantarum strain 423 was encapsulated in hollow poly(organosiloxane) microcapsules by templating water-in-oil Pickering emulsion droplets via the interfacial reaction of alkylchlorosilanes. The bacteria were suspended in growth medium or buffer to protect the cells against pH changes during the interfacial reactions with alkylchlorosi...
Article
A feasibility study in state‐of‐the‐art multi‐ and monomode microwave cavities was conducted to outline important functionalities necessary in a microwave setup for continuous fine‐chemicals synthesis. For multimode operation, the heating efficiency depends on the position as well as on the volume distribution of the load. For monomode operation, t...
Article
High pressure homogenization is at the heart of many emulsification processes in the food, personal care and pharmaceutical industry. The droplet size distribution is an important property for product quality and is aimed to be controlled in the process. Therefore a population balance model was built in order to predict the droplet size distributio...
Article
Miniemulsions, consisting of submicron droplets of very hydrophobic lauryl methacrylate or 4-tert-butyl styrene, are successfully polymerized using water-soluble sodium persulfate. Monitoring the calorimetric profile as well as the droplet and particle size distribution with conversion manifests a process of monomer redistribution, droplet disappea...
Article
Full-text available
In this contribution we report the synthesis of hybrid poly(styrene-co-maleic anhydride)–SiO2 microcapsules by cross-linking of the stabilizing particles of an inverse Pickering emulsion droplet at the interface. This was achieved by the ring-opening aminolysis reaction of the maleic anhydride residue of poly(St-co-MAh) with amine-functionalized si...
Article
Black tea cream formation is an inhibitor for the polyphenols separation since it decreases the amount of available polyphenols. Four factors that are considered to have an impact in the amount of tea cream and polyphenols availability are studied: temperature, amount of solids, pH and amount of EDTA. By using a design of experiments instead of a o...
Article
The adsorption of sterically stabilized colloids at water-oil (w/o) interfaces is studied experimentally by the formation of Pickering emulsions. Specifically, the effect of the steric stabilizer with respect to the rate of particle adsorption is investigated. Uniform, μm-sized poly(methyl methacrylate) (pMMA) particles, which are sterically stabil...
Article
This article presents results on cost and performance benefit analysis of optimization and intensification activities of a pharmaceutical process. A batch process for the production of a low-volume, high value active pharmaceutical ingredient, developed at Sanofi (France), has been used as a case study. With the scale of 100 kg/y and a product pric...
Article
Electrically conductive composites consisting of carbon nanotubes (CNTs) in a poly(2,6‐dimethyl‐1,4‐phenylene ether)/polystyrene (PPE/PS) blend are prepared by latex technology. The latter consists of 4 steps: preparation of an aqueous dispersion of CNTs, mixing with a polymer latex, solvent removal by freeze–drying and processing. In the first rou...
Article
A novel optimization framework is presented which aims at optmizing the sensory properties of consumer products by changing the product formulation and the processing conditions. A crucial first step is to find a suitable model which allows predictions of the scores on certain sensory product attributes. Extensive panel testing resulted in the sens...
Article
A special type of a high pressure homogenizer valve was studied for the dispersive mixing of oil-in-water emulsions. Various hydrodynamic regimes and flow fields were identified using the commercial computational fluid dynamics (CFD) software ANSYS and, for each regime the stable droplet sizes were estimated. Experimental validation was carried out...
Article
Black tea polyphenols are formed during the fermentation step of green tea leaves. Tea cream is considered an inhibitor for the polyphenols separation since it decreases the amount of polyphenols available in the clear phase. The main objective of this work is to assess which from the four selected factors (temperature, tea percentage of solids, pH...
Article
A parametric study of the factors that influence C–O bond formation reactions has been carried out to elucidate the mechanism by which copper mediates the Ullmann-type nucleophilic aromatic substitution (SNAr) of 4-chloropyridine with potassium phenolate. Process conditions such as temperature, reactant concentrations, catalyst concentration, and a...
Article
Dispersions of micron-sized styrene droplets in water were produced by straight through microchannel arrays. The monomer droplets have been polymerized by suspension polymerization using an initiator system, which was only oil soluble. A significant amount of submicron particles was formed by secondary nucleation. The side reaction was emulsion pol...
Article
The use of very hydrophobic monomers in heterogeneous polymerisations is restricted because of insufficient mass transfer as a result of limited aqueous phase diffusion. Experimental evidence for a mass transfer mechanism in miniemulsion polymerisation that is based on the direct interaction between droplets as well as between droplets and particle...
Article
Full-text available
Threonine aldolase (TA) from Thermotoga maritima was immobilized on an Eupergit support by both a direct and an indirect method. The incubation time for the direct immobilization method was optimized for the highest amount of enzyme on the support. By introducing the immobilized TA in a packed-bed microreactor, a flow synthesis of phenylserine was...
Article
Activator regenerated by electron transfer atom-transfer radical polymerization of butyl acrylate and methyl methacrylate was successfully adapted from a batch process to a continuous stirred tank reactor (CSTR) with 50 ppm copper. A series of batch polymerizations were first performed to identify a solvent mixture to enhance the polymerization rat...
Article
The transesterification of ethyl butyrate with 1-butanol to give butyl butyrate catalyzed by Novozym 435 was performed in a batch slurry reactor and in a packed-bed microreactor. The observed reaction rate is strongly influenced by external and intra-particle transport limitations. However, the packed-bed microreactor allows for higher specific enz...
Article
The methodology of processing biomass for the production of fuels and chemicals has been well established; however, these processes are often not economical due to the high cost of materials and low selectivity. In order to more efficiently use the raw materials, and to decrease processing (and developing) time, it is necessary to consider novel sy...
Chapter
Emulsion copolymerisation allows the production of materials with properties which cannot be obtained by latex products consisting of one monomer, that is, homopolymer latexes, or by blending homopolymers. This chapter focuses on key features to understand the emulsion copolymerisation kinetics and on the influence of the mode of operation on the c...
Article
Full-text available
In this contribution, we present the silica microencapsulation of hydrophilic compounds by templating Pickering emulsion droplets without contamination of the dispersed phase by either the catalyst or the silica precursor. This is accomplished by the use of an amphiphilic catalyst, which situates around the Pickering emulsion droplets and directs t...
Patent
The present invention relates to a (process for preparation of a) carbon nanotubes reinforced polymer, wherein the matrix polymer has both a low molecular weight fraction as well as a high molecular weight fraction, as a result of which the level of conductivity of the resulting composite can be controlled.
Article
A μ(2) -process in the Ullmann-type CO coupling of potassium phenolate and 4-chloropyridine was successfully performed in a combined microwave (MW) and microflow process. Selective MW absorption in a micro-fixed-bed reactor (μ-FBR) by using a supported Cu nanocatalyst resulted in an increased activity compared to an oil-bath heated process. Yields...
Conference Paper
This paper describes a production scheduling model that can be run for an emulsion polymerization (EP) production process. This scheduling model is used to maximize the total profit of the production process by calculating a production plan which optimizes costs and profits. These costs include production, reactor cleaning, component storage and pu...
Article
In the design of emulsion-based products, consumer appreciation is the key aspect. While the most commonly applied product/process design strategies lack the incorporation of consumer desires, this contribution describes a design approach where consumer appreciation is the main objective. The first step of the design is to translate the consumer ne...
Article
Flexibility in manufacturing processes is essential not only to handle a variety of feed stocks or to produce multiple product grades but also to accommodate process or catalyst inventions to improve productivity or quality. While designing in litheness we should ensure the robustness of the process output. In this paper, through a case study of bi...
Conference Paper
Microwave assisted flow processing: coupling of electromagnetic and hydrodynamic phenomena Narendra G. Patil,1 Erik Esveld,2 Faysal Benaskar,1 Evgeny V. Rebrov,3 Lumbertus A. Hulshof,1 Jan Meuldijk,1 Volker Hessel1 and Jaap C. Schouten1 1Laboratory of Chemical Reactor Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindho...
Article
The productivity of microwave-assisted continuous specialty chemical synthesis has been brought to a commercially interesting scale of 1 kg/day. To that end, a counter-current multitubular millireactor/heat exchanger (MTMR) assembly has been developed with the reactant flow through millitubular reactors, while the coolant flows in the shell side. T...
Article
This paper consists of two parts – a detailed experimental investigation on the activity of supported threonine aldolase for use in a microreactor/flow reactor and a generic, explorative outline on potential productivity of enzymatic microreactors; with the need to use data from other enzymes here as well. Threonine aldolase was immobilized on diff...
Article
The combination of milli-scale processing and microwave heating has been investigated for the Cu-catalyzed Ullmann etherification in fine-chemical synthesis, providing improved catalytic activity and selective catalyst heating. Wall-coated and fixed-bed milli-reactors were designed and applied in the Cu-catalyzed Ullmann-type CO coupling of phenol...