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Publications (255)
Background and Objectives: Metabolic syndrome (MS) represents several diseases encompassing a heterogeneous group of biochemical and physiological abnormalities characterized by structural and functional alterations in the myocardium, including the endothelium of the coronary arteries. MS also affects a substantial portion of the global population....
Toxic metal exposure is a pervasive global health concern, with significant implications for human health. Toxic metals such as lead, mercury, arsenic, and cadmium are widely distributed in the environment due to natural processes and human activities. Industrial emissions, mining, smelting, and agricultural practices contribute to environmental co...
Despite increased availability of effective drug therapy for treatment of heart failure (HF), the morbidity and mortality in chronic heart failure (CHF) are unacceptably high. Therefore, there is an urgent need to ascertain new imaging techniques to identify early sub-clinical forms of cardiac dysfunctions, to guide early relevant treatment. It see...
Digital pathology has emerged as a revolutionary field, transforming traditional diagnostic practices by integrating advanced imaging technologies, computational tools, and artificial intelligence (AI). Adopting digital slides over conventional glass slides enables high-resolution imaging, facilitating remote consultations, second opinions, and tel...
Atherosclerotic cardiovascular disease (ASCVD) and consequent acute coronary syndromes (ACS) are substantial contributors to morbidity and mortality across Europe. Fortunately, as much as 2/3 of this diseases burden is modifiable, in particular by lipid-lowering therapy (LLT). Current guidelines are based on the sound premise that with respect to l...
The Global Burden of Diseases study estimates indicate that the prevalence of heart failure (HF) in the United States and Canada is 1.5% to 1.9% of the population and in Europe 1% to 2%. In Asia, the Ram B Singh, Jan Fedacko, Narsingh Verma et al. 128 prevalence of HF may be 0.5% to 1.0%. There is evidence that HF occurs due to the interaction of c...
Introduction
The growing interest in Vitamin D deficiency as a potential contributor to coronary artery disease (CAD) has prompted increased scrutiny. Nevertheless, its status as a confirmed risk factor remains unestablished. This study seeks to explore the connection between serum vitamin D levels and CAD.
Material and methods
Employing a cross-s...
Epidemiology and mortality due to heart failure
Objectives
The present study included 40 participants to investigate the association of circadian locomotor output cycles kaput (CLOCK) rs4580704 polymorphism with myocardial infarction (MI) cases.
Materials and Methods
In this study, we enrolled 20 male and 20 female cases with MI. Genomic DNA extraction was done from lymphocytes using convention...
The sustainable development goals (SDG) of the UNO would be difficult to achieve without prevention of non-communicable diseases (NCDs). Western diet and lifestyle, which are major risk factors of NCDs, are known to cause oxidative stress and decrease in production of molecular hydrogen in the intestines which leads to a decline in endogenous antio...
Diet and lifestyle choices, notably the Western-type diet, are implicated in oxidative stress and inflammation, factors that elevate the risk of cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM). In contrast, the Mediterranean of diet, rich in antioxidants, appears to have protective effects against these risks. This article highli...
Background: The deleterious effects of these heavy metals are contingent on the quantity ingested, the issue of exposure mode, exposure duration, and whether it is acute or chronic. Additionally, heavy metals interfere with numerous cellular functions, encompassing growth, proliferation, differentiation, DNA damage repair, and programmed cell death...
Background:
Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and chronic respiratory failure. This study aims to determine if hydrogen-rich water (HRW) can enhance oxygen saturation among patients with chronic lung diseases.
Methods:
Ten patients...
Objective:
The aim: To study the clinical and the genetic association of 5-HTTVNTR and the 5-HTTLPR polymorphisms in women with FMS.
Patients and methods:
Materials and methods: 105 FMS patients and 105 controls were enrolled in the study. Polymerase chain method was used to analyse the 5-HTTLPR & 5-HTTVNTR gene polymorphism. The psychopathology...
Aim: Evaluation of role of supplementation of omega-3 polyunsaturated fatty acids on endothelial function in patients with metabolic syndrome. Methods: Total of 80 patients with metabolic syndrome were enrolled to two groups. We evaluated endothelial function in subjects before and after three-month treatment with omega-3 polyunsaturated fatty acid...
Bioactive compounds are the food constituents, providing beneficial health effects to functional foods and nutraceuticals. These compounds have antioxidants activity including anti-inflammatory, antifungal, and have additional preventative actions. Since these compounds are important constituents enhancing function of the foods, therefore, these co...
The sustainable development goals(SDG) of the UNO would be difficult to achieve without prevention of metabolic diseases and other non-communicable diseases (NCDs). Western diet and lifestyle, which are major risk factors of NCDs, are known to cause oxidative stress and decrease in production of molecular hydrogen in the intestines which leads to a...
Background: Dementia has become a public health problems due to its association with behavioural risk factors; smoking, alcoholism, sedentary behaviour, western type diet, obesity, diabetes, and hypercholesterolemia. Most of these behavioural risk factors appear to be associated with dementia as well as with risk of cardiovascular diseases (CVDs) a...
There is evidence that behavioral risk factors such as western type diet, and life style can predispose to oxidative stress, deficiency in antioxidant status, hyperglycemia, dyslipidemia and increase in inflammation in tissues of various organs: beta cells of the pancreas, LDL receptors in the hepatocytes, endothelium, neurons, osteocytes and gut....
Background/Aim: Dementia has become a public health problem due to its association with biological risk factors; obesity, diabetes, hypertension and hypercholesterolaemia. Most of these risk factors, appear to be associated with dementia as well as with risk of coronary artery diseases (CADs) and stroke. This study aimed to find out the association...
Citation: Singh, R.B.; Nabavizadeh, F.; Fedacko, J.; Pella, D.; Vanova, N.; Jakabcin, P.; Fatima, G.; Horuichi, R.; Takahashi, T.; Mojto, V.; et al. Dietary Approaches to Stop Hypertension via Indo-Mediterranean Foods, May Be Superior to DASH Diet Intervention. Nutrients 2023, 15, 46. https:// Abstract: Western-type diet with high salt and sugar, s...
Objective:
The aim: To determine the clinical and the genetic association of the COMT rs4680 SNP in women with FMS.
Patients and methods:
Materials and methods: Extracted DNA from peripheral blood samples were utilized as template for the PCR and RFLP analysis.
Results:
Results: A significant difference was found in the distribution of the COM...
There is evidence that behavioral factors, in particular western diet can predispose dementia, whereas mediterranean type of diet is protective. It seems that, early diagnosis of dementia is possible among patients consuming these diets, in particular among elderly population. This study aims to find out the association of dietary patterns in a urb...
The exact pathophysiology of heart failure (HF) is not yet known. Western diet, characterized by highly sweetened foods, as well as being rich in fat, fried foods, red meat and processed meat, eggs, and sweet beverages, may cause inflammation, leading to oxidative dysfunction in the cardiac ultra-structure. Oxidative function of the myocardium and...
Heart failure (HF) has become a public health problem, but exact pathophysiology is still unknown. Western diet characterised with high sugar, high fat, red meat and processed meat, eggs, fried foods and sweetened beverages, may cause oxidative stress and inflammation, leading to oxidative dysfunction and adverse effects on cardiac-ultra-structure....
Background: Since, behavioural factors can also predispose dementia, there is an unmet need to develop methods for its early diagnosis, which appears to be crucial for its prevention. This study aims to find out the prevalence of dementia, emphasizing on early symptoms, to validate a new modified questionnaire. Study Design and Setting. Cross-secti...
Epidemiological studies indicate that skipping breakfast as a universal behavior, may have adverse effects on cardiovascular diseases [CVDs}and metabolic diseases. However, eating breakfast regularly, may increase satiety, thereby reducing overeating later in the day which prevents weight gain. Recent studies indicate that skipping breakfast increa...
Background: Repeated episodes of hypoxia by coronary artery ligation, precondition the myocardium to adapt against ischemic cardiac damage and arrhythmias. This case aims to highlight the role of hypoxia induced adaptation in exercise tolerance. Case and methods: A male physician aged 77 years, presented with COVID-19 on April 17, 2021. Acute phase...
Previous studies suggested that adherence to a healthy dietary pattern could be associated with decreased risk of dementia, whereas eating western diet may be a risk factor of dementia. In a previous study Morris et al reported a type of Mediterranean diet which may be safe and efficacious in the prevention of neurodegenerative disorders, which nee...
Background
Several psychiatric disorders have been found associated with serotonin transporter gene polymorphisms. The purpose of this study was to explore the correlation between serotonin gene polymorphism (5-HTTLPR & 5-HTTVNTR) in North Indian Women with Fibromyalgia Syndrome (FMS).
Results
105 FMS patients and 105 controls were enrolled in the...
The Seven Country study showed that traditional Japanese diet and Mediterranean diets are protective against cardiovascular diseases (CVDs). Japanese diet is considered the healthiest because it provides highest longevity and health to Japanese. DASH diet and Mediterranean style diets are also considered the healthy diets, although, it is possible...
Chronic heart failure (CHF) has different stages and includes pre-HF (PHF), a state of high risk of developing myocardial dysfunction and advanced CHF. Some major behavioral risk factors of PHF might predispose to biological risk factors such as obesity, diabetes mellitus, dyslipidemia, hypertension, myocardial infarction, and cardiomyopathy. These...
Nuts should be an important component of a diet rich in functional foods designed for food security, owing to several nutritional benefits on their contents of omega-3 fatty acids, monounsaturated fatty acids, essential and nonessential amino acids, vitamins, flavonoids, folic acids, and plant sterols. Nuts are often combined with fruits and vegeta...
Malnutrition in all its forms includes undernutrition (wasting, stunting, underweight), inadequate vitamins or minerals, overweight, obesity, and resulting diet-related non-communicable diseases (NCDs). It should be emphasized that 1.9 billion adults are overweight or obese, while 462 million are underweight, indicating a double burden of NCDs. One...
Recent evidence indicates that a Western-style diet is important in the pathogenesis of deaths, owing to non-communicable diseases (NCDs), whereas a Mediterranean-style diet is protective. The key ingredients of Mediterranean-style diets include olive oil, fresh fruits and vegetables, protein-rich legumes, fish, poultry, including eggs, and whole g...
The United Nations Decade of Action on Nutrition initiative for 2016–25 includes prevention of both undernutrition because of micronutrient deficiencies and overweight, or obesity, to reduce the burden of diet-related non-communicable diseases (NCDs) in all age groups. Changes in nutrition due to economic growth and affluence are associated with in...
Free radical stress and deficiency of antioxidants due to environmental factors may be risk factors for non-communicable diseases (NCDs). Further studies indicate that increased consumption of cocoa products (e.g., cocoa, and chocolate) may be associated with a decreased risk of NCDs, including cardiovascular diseases (CVDs), coronary artery diseas...
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Today, there are many parameters used for cardiovascular risk quantification and to identify many of the high-risk subjects; however, many of them do not reflect reality. Modern personalized medicine is the key to fast and effective diagnostics and treatment of cardiovascular diseases. One step towards this goal is a better understanding of connect...
Introduction:In this study we evaluated the connivance of oxidative and antioxidative parameters in the pathogenesis of spinal cord injury (SCI). Although the etiology and pathogenesis of SCI remain to be fully understood, it has been suggested that reactive oxygen species (ROS) and oxidative stress may play a significant role in the pathophysiolog...
Atherosclerotic cardiovascular disease (ASCVD) and consequent acute coronary syndromes (ACS) are substantial contributors to morbidity and mortality across Europe. Much of these diseases burden is modifiable, in particular by lipid-lowering therapy (LLT). Current guidelines are based on the sound premise that with respect to low density lipoprotein...
Background: Corona virus infection has become a public health problem in the 2020. This retrospective pilot study aims to determine the prevalence of risk factors and protective factors among patients with COVID-19. Study Design, case control study in a hospital Subjects and Methods: This study included 147 cases ofCOVID-19, confirmed by rt PCR tes...
Abstract
Objective: This single-arm real-world observation aims to examine the effects of empagliflozin (EMPA) on coronary risk factors among subjects with known diabetes.
Materials and methods: Records of 63 subjects with type 2 diabetes mellitus, receiving EMPA were drawn for this study. Of 63 patients with diabetes, 6 were excluded, and the re...
Chronic heart failure has been divided into 4 stages that range from pre-heart failure (PHF), a state of high risk of developing myocardial dysfunction, to advanced chronic heart failure {CHF). The primary risk factors of PHF are: Western diet, tobacco use, alcoholism, chronic mental disorders that are known to predispose to biological risk factors...
Introduction:
Currently, just a few major parameters are used for cardiovascular (CV) risk quantification to identify many of the high-risk subjects; however, they leave a lot of them with an underestimated level of CV risk which does not reflect the reality.
Material and methods:
The submitted study design of the Kosice Selective Coronarography...
Despite progress in both primary and secondary prevention, cardiovascular diseases (CVD) are still the largest group of ailments contributing to morbidity and mortality worldwide. Atherosclerotic changes, the primary pathological substrate for CVD, are closely related to hypercholesterolemia. Therefore, the treatment of hypercholesterolemia is a ke...
Statins Administration for Primary Prevention of Stroke and Coronary Artery Disease
Somatostatin analogs mantain their major role in the treatment of patients with advanced neuroendocrine tumors (NETs) and have multiple modulatory effects on the immune system. Here, we evaluated the effects of lanreotide treatment on expression of Th1, Th2 cytokine patterns in serum of patients with NETs and in bronchial and pancreatic NET cell li...
Background: Cohort studies indicate that the risk of chronic anxiety, aggression and depression may vary according to social class
Introduction: Diabetes mellitus has become a global public health problem, characterized by increased intake of western style diets and decline in physical activities which are pro-inflammatory. Food diversity, nutrient profile, glycemic index and lower content of salt sugar and Tran’s fat are an important consideration for a healthy anti-inflammat...
The aim of the study was to evaluate the safety and efficacy of a new therapeutic approach to skin defects resulting from split thickness grafting. Within the study, nanofiber-based dressings fabricated using polyvinyl alcohol (PVA) and poly-?-caprolactone (PCL) were used, with different mass density. The study was performed in 1 female minipig. Ni...
Stem cells are undifferentiated elements capable to acquire a specific cellular phenotype under the influence of specific stimuli, thus being involved in tissue integrity and maintenance. In the skin tissue self-renewal and wound healing after injury is a complex process, especially in adulthood, due to the aging process and the continuous exposure...
Our Abstract is already on the ResearchGate.
The underlying mechanism for clinical and biochemical manifestations of chronic heart failure (HF) may be due in part to neurohumoral adaptations, such as activation of the renin-angiotensin-aldosterone and sympathetic nervous systems in the periphery and the brain. Internet search and discussion with colleagues are the methods for this study. Sinc...
