Jan Willem W Coebergh

Erasmus University Rotterdam | EUR · Department of Public Health (MGZ)

Background With epidemiologic analyses of population-based trends in incidence and outcomes, we ascertained progress against non-Hodgkin's lymphoma (NHL) in children and young adolescents in the Netherlands since 1990. Methods Tumour characteristics were extracted from the Netherlands Cancer Registry for patients aged <18 years at diagnosis, betwe...

Background This is the first national study on trends in cancer survival and mortality for children and young adolescents in the Netherlands including unique information on stage at diagnosis. Methods All neoplasms in patients <18 years, diagnosed between 1990 and 2015 (N = 14,060), were derived from the Netherlands Cancer Registry. Cohort and per...

We assessed the epidemiologic progress against childhood and adolescent acute lymphoblastic leukaemia (ALL) in the Netherlands over a 26 year period. ALL patients <18 years were selected from the Netherlands Cancer Registry and the Dutch Childhood Oncology Group. Trend analyses were performed over time and by age group and ALL subtype. Between 1990...

Background This is the first national study on trends in cancer incidence for children and young adolescents in the Netherlands, including stage at diagnosis as a potential marker of early diagnosis and better staging. Methods All neoplasms in patients younger than 18 years, diagnosed between 1990 and 2017 (N = 15,233), were derived from the Nethe...

Population‐based studies that assess long‐term patterns of incidence, major aspects of treatment and survival are virtually lacking for Hodgkin lymphoma (HL) at a younger age. This study assessed the progress made for young patients with HL (<25 years at diagnosis) in the Netherlands during 1990–2015. Patient and tumour characteristics were extract...

Purpose: Long-term trends in neuroblastoma incidence and survival in unscreened populations are unknown. We explored trends in incidence, stage at diagnosis, treatment and survival of neuroblastoma in the Netherlands from 1990 to 2014. Methods: The Netherlands Cancer Registry provided data on all patients aged <18 years diagnosed with a neurobla...

Variation in survival of pediatric acute myeloid leukemia (pAML) over time and between Western European countries exists. The aim of the current study is to assess the progress made for the Dutch pAML population (0–17 years) during 1990–2015, based on trends in incidence, survival and mortality. Data from the population-based Netherlands Cancer Reg...

Breast cancer will increasingly affect the lives of older women, especially in developed countries. In the last three decades, women of all age groups have experienced the benefits of a lowering mortality rate though earlier diagnosis and effective treatment. These benefits have been counteracted by the rising incidence, resulting from higher level...

The availability of population-based cancer registry (CR) data is paramount in the development of modern oncology. Major contributions consisted in accurately measuring cancer burden (incidence, survival and prevalence, beside mortality), identifying and quantifying risk factors (case control and cohort studies that, in the last two decades, includ...

Background: A deceleration in the increase in cancer incidence in children and adolescents has been reported in several national and regional studies in Europe. Based on a large database representing 1·3 billion person-years over the period 1991-2010, we provide a consolidated report on cancer incidence trends at ages 0-19 years. Methods: We inv...

Mortality rates and five-year relative survival for malignant melanoma (MM) of the skin in Croatia are poor compared with most European countries. Epidemiological data recorded at the National Cancer Registry (CNCR) are used for informing various decision-makers and researchers, as well as for comparisons with other countries. We analyzed CNCR data...

Background: Due to the complexity of diagnosis and treatment, care for children and young adolescents with cancer preferably occurs in specialised paediatric oncology centres with potentially better cure rates and minimal late effects. This study assessed where children with cancer in the Netherlands were treated since 2004. Methods: All patient...

Randomised clinical trials (RCTs) are considered the basis of evidence-based medicine. It is recognised more and more that application of RCT results in daily practice of clinical decision-making is limited because the RCT world does not correspond with the clinical real world. Recent strategies aiming at substitution of RCT databases by improved p...

Background Marked variations exist in the incidence and mortality trends of major cancers in South-Eastern European (SEE) countries which have now been detailed by age for breast cancer (BC) to seek clues for improvement. Methods We brought together and analysed data from 14 cancer registries (CRs), situated in SEE countries or directly adjacent....

PurposeCigarette smoking is the leading preventable cause of death and disability from cancer in the U.S. Smoking prevalence varies by racial and ethnic group, and therefore the smoking-related burden of cancer is expected to vary accordingly. Methods We estimated the cigarette smoking-attributable Disability-Adjusted Life Years (DALYs) lost to can...

Purpose: To investigate whether the Geriatric 8 (G8) and the Timed Get Up and Go Test (TGUGT) and clinical and demographic patient characteristics were associated with acute toxicity of radiation therapy and noncompliance in elderly cancer patients being irradiated with curative intent. Methods and materials: Patients were eligible if aged ?65?y...

Background: In the Netherlands, like in many other European countries, pancreatic cancer mortality was found to be systematically higher than the incidence. This suggests that there is an underestimation of the reported incidence of pancreatic cancer. Aim: We aimed to study the incidence of pancreatic cancer in the Rotterdam area and to compare...

Introduction: In the U.S., people of different races/ethnicities have differences in cancer incidence, mortality, survival, stage at diagnosis, and receipt of treatment, resulting in variances in cancer burden. The burden of cancer in 2011 was assessed by race/ethnicity for 24 cancers using disabilityadjusted life years (DALYs). Methods: In 2014–20...

Since it was discovered that UV radiation was the main environmental cause of skin cancer, primary prevention programs have been started. These programs advise to avoid exposure to sunlight. However, the question arises whether sun-shunning behaviour might have an effect on general health. During the last decades new favourable associations between...

During the last decades new, mainly favorable, associations between sunlight and disease have been discovered, initially ascribed to vitamin D. There is, however, accumulating evidence that the formation of nitric oxide, melatonin, serotonin, endorphin, photodegradation of folic acid, immunomodulation, photoadaptation, and the effect of (sun)light...

Proposals to improve implementation, monitoring and evaluation of breast, cervical and colorectal cancer screening programmes have been developed in a European project involving scientists and professionals experienced in cancer registration (EUROCOURSE). They call for a clear and more active role for cancer registries through better interfaces wit...

Introduction: Cancer registration coverage and cancer control programmes in South Eastern (SE) Europe, embracing about six new EU member states, remain thin, despite a relatively high incidence and mortality burden from avoidable cancers, particularly in males. We assembled the most recent cancer registry data to estimate the burden of the 17 most...

Most patients with non-small cell lung cancer (NSCLC) die within the first few years after diagnosis, and significant excess mortality remains beyond 5 years. We investigated death rates and the distribution of causes of death for NSCLC patients by age and stage at diagnosis during long-term follow-up. All 72,021 patients aged 45-89 years diagnosed...

A Dutch research group has calculated how much cancer in the Netherlands can be prevented and how much the incidence of cancer deaths could be diminished by reducing pathogenic factors associated with behaviour. This has been known for a long time, but that does not change the behaviour that is driven by habits, environment and addiction. Health lo...

Only a small number of patients with aggressive B-cell lymphoma participates in clinical trials, particularly elderly patients are underrepresented. Therefore, we studied data of the population-based nationwide Netherlands Cancer Registry to determine trends in incidence, treatment and survival in an unselected patient population. We included all p...

Proposals to improve implementation, monitoring and evaluation of breast, cervical and colorectal cancer screening programmes have been developed in a European project involving scientists and professionals experienced in cancer registration (EUROCOURSE). They call for a clear and more active role for cancer registries through better interfaces wit...

Based on prior studies, we concluded that the female advantage in melanoma survival is caused by biological factors and not by differences in patient behavior. In this study, we investigated whether this biological advantage was caused by more aggressive tumors in males, as measured by mitotic rate (MR). Data for patients with complete information...

Background: Little has been reported on costs of cancer registration, and standard indicators have not yet been identified. This study investigated costs and outcomes of a sample of 18 European registries covering a population of 58.8 million inhabitants. Methods: Through a questionnaire, we asked registries for real cost data including personne...

Background: Most South-Eastern European countries share common political, socio-economic and demographic changes i.e. increased longevity, low but rising age at childbirth, decreased fertility rates, adoption of some ‘western’ life style patterns e.g. increasing alcohol and tobacco use among younger women, and rapid diffusion of mammography in the...

Cancer of the larynx is a frequently occurring head and neck cancer in the Netherlands. The main risk factors are smoking and excessive alcohol consumption. The aim of this study was to evaluate the progress against laryngeal cancer by studying trends in incidence, mortality and survival in the Netherlands. All patients in the Netherlands Cancer Re...

Background Cancer survival is a key measure of the effectiveness of health-care systems. EUROCARE—the largest cooperative study of population-based cancer survival in Europe—has shown persistent differences between countries for cancer survival, although in general, cancer survival is improving. Major changes in cancer diagnosis, treatment, and reh...

Summary Background Survival and cure rates for childhood cancers in Europe have greatly improved over the past 40 years and are mostly good, although not in all European countries. The EUROCARE-5 survival study estimates survival of children diagnosed with cancer between 2000 and 2007, assesses whether survival differences among European countries...

Gynecological malignancies – cancer of the cervix, ovaries, uterus, vagina, vulva, and the fallopian tubes – affect many women each year: one in eight tumors among women is gynecologic. This chapter focuses on the four most common gynecological cancers: uterine, ovary, cervical, and vulvar cancer. To present the epidemiology of these gynecological...

To estimate the population-based conditional 5-year relative survival rates for prostate cancer patients. All 98,672 patients diagnosed in the Netherlands with prostate cancer (clinical T stage 1-4) in 1989-2008 aged 45-89 years were selected from the Netherlands Cancer Registry and followed until 2010. Conditional 5-year relative survival was esti...

Individual country- and cancer site-specific studies suggest that the age-adjusted incidence of many common cancers has increased in European populations over the past two decades. To quantify the extent of these trends and the recent burden of cancer, here we present a comprehensive overview of trends in population-based incidence of the five comm...

Background: Alopecia is a frequently occurring side effect of chemotherapy that often can be prevented by cooling the scalp during the infusion. This study compared effects and costs of scalp cooling with usual general oncological care, i.e. purchasing a wig or head cover. Material and methods: Scalp-cooled patients (n = 160) were compared with...

Background: In the current study, mammography adherence of women who had experienced a false-positive referral is evaluated, with emphasis on the probability of receiving surveillance mammography outside the national screening programme. Methods: We included 424 703 consecutive screens and collected imaging, biopsy and surgery reports of 3463 wome...

Survival rates at diagnosis are often too negative for cancer survivors. Conditional relative survival better reflects actual prognosis during follow-up. All 54,015 patients newly diagnosed in the Netherlands with B-cell non-Hodgkin lymphoma during 1989-2008, aged 15-89 years (Netherlands Cancer Registry) were selected. Five-year conditional relati...

Background: Worldwide marked changes have been observed in the incidence and survival of testicular cancer (TC) during the last decades. We conducted a study on trends in TC incidence, treatment, survival, and mortality in the Netherlands during the period 1970-2009 with specific focus on trends according to age, histology and stage of disease. M...

Melanoma is a significant health problem in Caucasian populations. The most recently available data from cancer registries often have a delay of several months up to a few years and they are generally not easily accessible. To assess recent age- and sex-specific trends in melanoma incidence and make predictions for 2010 and 2015. A retrospective re...

The aim of this study was to assess the difference in explained variance of Health-Related Quality of Life (HRQoL) between comorbidity, sociodemographic characteristics and cancer characteristics. This association was assessed among thyroid cancer, colorectal cancer, and (non-)Hodgkin's lymphoma patients. Data from three large population-based surv...

To compare overall survival between women with unilateral breast cancer (UBC) and contralateral breast cancer (CBC). Women with UBC (N = 182,562; 95 %) and CBC (N = 8,912; 5 %) recorded in the Netherlands Cancer Registry between 1989 and 2008 were included and followed until 2010. We incorporated CBC as a time-dependent covariate to compute the ove...

With the increasing number and diversity of cancer survivors, studies of survivors' physical, emotional, and social health and well being are of growing importance. Population-based cancer registries, which collect data on incident cases, can play an important role in quality-of-life (QoL) studies. In this review, the authors provide an overview of...

Background: Diagnostic surgical breast biopsies have several disadvantages, therefore, they should be used with hesitation. We determined time trends in types of breast biopsies for the workup of abnormalities detected at screening mammography. We also examined diagnostic delays. Methods: In a Dutch breast cancer screening region 6230 women were r...

PURPOSETo study sex differences in survival and progression in patients with stage III or IV metastatic melanoma and to compare our results with published literature. PATIENTS AND METHODS Data were retrieved from three large, randomized, controlled trials of the European Organisation for Research and Treatment of Cancer in patients with stage III a...

There is little information available on the patterns of chemotherapy regimens administered in daily practice to patients with early stage and metastatic or recurrent breast cancer. To determine the trends in type of chemotherapy regimens used in breast cancer patients, newly diagnosed breast cancer patients in the period 2000-2008 who received che...

Comorbidity has large impact on colorectal cancer (CRC) treatment and outcomes and may increase as the population ages. We aimed to evaluate the prevalence and time trends of comorbid diseases in patients with CRC from 1995 to 2010. The Eindhoven Cancer Registry registers comorbidity in all patients with primary CRC in the South of the Netherlands....

Purpose: The aims of the study were to describe the follow-up of colorectal cancer (CRC) patients in southern Netherlands and examine their overall and disease-free survival. Methods: Patients newly diagnosed with CRC in 2003-2005 and 2008 with a survival of at least 1 year after diagnosis and recorded in the retrospective Eindhoven Cancer Regis...

Over the last two decades, the use of High-dose Melphalan and novel agents like thalidomide, lenalidomide and bortezomib has changed the management of patients with multiple myeloma (MM) and extended overall survival. For patients <66 years, efficacy and survival improvement are convincing based on randomized controlled trials in contrast to older...

Background Complete cancer prevalence data in Europe have never been updated after the first estimates provided by the EUROPREVAL project and referred to the year 1993. This paper provides prevalence estimates for 16 major cancers in Europe at the beginning of the year 2003.Patients and methodsWe estimated complete prevalence by the completeness in...

The aim of this study is to assess time trends of the risk of melanoma as a second primary cancer (MSPC) among cancer patients in the Netherlands during 1989-2008. Data from the population-based Netherlands Cancer Registry (NCR) were used for an analysis of time trends in the risk of MSPC in a fixed inception cohorts design (1989-1990, 1996-1997, a...

The incidence of thyroid cancer (TC) is increasing worldwide, partly due to increased detection. We therefore assessed combined trends in incidence, survival and mortality of the various types of TC in The Netherlands between 1989 and 2009. We included all patients ≥ 15 years with TC, diagnosed in the period 1989-2009 and recorded in The Netherland...

Cancer incidence and mortality estimates for 25 cancers are presented for the 40 countries in the four United Nations-defined areas of Europe and for the European Union (EU-27) for 2012. We used statistical models to estimate national incidence and mortality rates in 2012 from recently-published data, predicting incidence and mortality rates for th...

Background. Proportion cured is a potentially more informative cancer outcome measure than five-year survival. We present population-based cured estimates for young patients diagnosed with acute lymphoblastic leukemia in Europe from 1982 to 2002. Design and methods. Thirty-five European cancer registries provided data. Survival was estimated by age...

Background: Compared with the general population, patients with a previous colorectal cancer are at higher risk for a second colorectal cancer, but detailed risk analysis by subsite is scarce. Objective: Our goal was to investigate the risk of a second cancer in relation to subsite as a basis for planning surveillance strategies. Design, settin...

ABSTRACT Population-based series analyzing clinical implications of nodal versus extranodal presentation of marginal zone lymphoma(MZL) are lacking. We studied clinical differences and trends in incidence, therapy and survival of nodal and extranodal MZL, and of MZL at different extranodal sites, in a population-based cohort. All patients with loca...

Objective: To investigate if socioeconomic status (SES) played a role in the selection of prostate cancer treatment and overall survival. Methods: Treatment and survival by SES of all newly diagnosed patients with prostate cancer (1998-2008) from the population-based Eindhoven Cancer Registry (n = 11,086) were studied. Results: Younger patient...

Epidemiological trends for urological malignancies are presented, as reported by population-based cancer registries from Europe and the United States.

Background: In parallel with increasing numbers of cancer patients and improving cancer survival, the occurrence of second primary cancers becomes a relevant issue. The aim of our study was to evaluate risk of prostate cancer as second primary cancer in a population-based setting. Methods: Data from the Netherlands Cancer Registry were used to e...

Cancer registration coverage and cancer control programmes in South Eastern (SE) Europe, embracing about six new EU member states, remain thin, despite a relatively high incidence and mortality burden from avoidable cancers, particularly in males. We assembled the most recent cancer registry data to estimate the burden of the 17 most common cancers...

The number of studies reporting on the association between sunlight exposure, vitamin D and cancer risk is steadily increasing. We reviewed all published case-control and cohort studies concerning colorectal-, prostate-, breast cancer, non-Hodgkin's lymphoma (NHL) and both sunlight and vitamin D to update our previous review and to verify if the ep...

Aim: To describe educational inequalities in cancer survival and to what extent these can be explained by comorbidity and health behaviours (smoking, physical activity and alcohol consumption). Methods: The GLOBE study sent postal questionnaires to individuals in The Netherlands in 1991 resulting in 18 973 respondents (response 70%). Questions w...

Background: Although scrotal cancer is traditionally regarded as an occupational disease, there is increasing evidence that factors which are involved in cutaneous and genital carcinogenesis might play a role in the carcinogenesis of scrotal cancer. Objective: This exploratory study aimed to detect exposures that might have an aetiological relat...

Major surgery for cancer has become safer, including for elderly patients with co-morbidity. The aim of this study was to investigate the association between patient characteristics, resection rates and survival among patients with oesophageal or gastric cancer. The prospective Dutch population-based Eindhoven Cancer Registry for oesophagogastric c...

Basal cell carcinoma (BCC) incidence rates are increasing. From 1973 to 2009, data on all first histologically confirmed BCCs were gained from the Eindhoven Cancer Registry to estimate trends in patient-based BCC incidence rates by sex, age group, and site in the southeast Netherlands. Trends in European age-standardized rates and age- and site-spe...

Background: Migrant populations usually experience a health transition with respect to their cancer risk as a result from environmental changes and acculturation processes. We investigated potentially contrasting experiences with breast and stomach cancer risk and survival in migrants to the Netherlands in a retrospective cohort study. Methods:...

ABSTRACT Population-based studies analyzing clinical implications of nodal versus extranodal(EN) presentation of diffuse large B-cell lymphoma (DLBCL) are scarce. We studied clinical differences and trends in incidence, treatment and survival of nodal and EN DLBCL in a population-based cohort. All patients newly diagnosed with localized (AAS I & II...