Jan Brož

Jan Brož
Charles University in Prague | CUNI · Department of Internal Medicine (2. LF)

Assoc. Prof., Doctor of Medicine

About

146
Publications
9,766
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
728
Citations

Publications

Publications (146)
Article
Background: Influenza infection represents a significant health problem associated with multiple complications including death. Patients with diabetes are more threatened by severe course of influenza in comparison with non-diabetic population. Anti-influenza vaccination is a key preventive measurement. The study compares one-year (2013-2014) preva...
Article
Non-severe hypoglycemia in people with diabetes is usually treated with rapid-acting carbohydrate, of which glucose is the most suitable form. A quantity of 15 g is recommended and repeated after 15 minutes if hypoglycemia persists. This recommendation has not changed for several years despite the introduction of continuous glucose monitoring, more...
Article
Risk of type 2 diabetes mellitus (T2DM) is higher in tobacco smokers compared to non-smokers. The risk declines after smoking cessation. However, ex-smokers are also more prone to the metabolic syndrome. The question thus is, whether ex-smokers could temporarily have a higher risk of T2DM than current smokers. The available studies on this topic ar...
Article
Objective: The aim of the study was to determine the prevalence of arterial hypertension and its awareness rate and control rate among diabetes mellitus (DM) patients in the Czech Republic between 25-64 years of age and to compare the results with those in age-matched non-diabetic patients. Materials and methods: Blood pressure measurement data...
Article
A new parameter of metabolic control derived from the results of continuous blood glucose monitoring is time in range (TIR). According to current recommendations, in pregnant women with diabetes, this glycemic range is defined by values of 3.5 to 7.8 mmol/L, with the aim of keeping glycemia in this range as much time as possible, and at the same ti...
Article
Full-text available
The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male pa...
Article
Choosing wisely in metabolic and endocrine diseases shows the inutility of some, in clinical practice often used, ways of management. In diabetology, the routine recommendation for selfmonitoring of type 2 diabetic patients not treated with insulin represents a contraversial issue. On the contrary, there is a consensus on rational targets of glycem...
Article
Full-text available
Alarms in continuous glucose monitoring systems (CGM) represent a very important feature enabling to patients with diabetes who use these systems to keep their blood glucose level in the target range and to avoid excursion to hypoglycemia or hyperglycemia. The possibility to warn the patient that the target range has been crossed means one of the m...
Article
Introduction Circulating insulin concentrations mediate vascular-inflammatory and prothrombotic factors. However, whether interindividual differences in circulating insulin levels are associated with different inflammatory and prothrombotic profiles in type 1 diabetes (T1D) is unknown. We applied an unsupervised, machine-learning approach to assess...
Article
The ketogenic diet (KD) is an effective treatment for intractable epilepsy in children. Hypoglycemia can be one of its side-effects, which is considered to be present mainly during the introductory phase of KD. Continuous glucose monitoring in a 6-year old non-diabetic child treated with KD for more than 8 months revealed long periods of asymptomat...
Article
Full-text available
In contrast to the decreasing burden related to cardiovascular disease (CVD), the burden related to dysglycemia and adiposity complications is increasing in Czechia, and local drivers must be identified. A comprehensive literature review was performed to evaluate biological, behavioral, and environmental drivers of dysglycemia and abnormal adiposit...
Article
Arterial hypertension is one of the most frequent comorbidities of patients with type 2 diabetes, the rates are approximately three times higher among diabetics than in general population. The presence of both diseases increases the cardiovascular risk of the patients two to three times. Therefore, it is essential to control the blood pressure valu...
Article
Cushing´s syndrome is a rare disease with the population prevalence about 40 patients per 1 million inhabitants, the number among patients with diabetes mellitus (DM) is probably higher. The screening of CS among the DM patients showed the prevalence between 0-2.9% in the groups of outpatients and 2-2.9% among the patients admitted to the hospital...
Article
Full-text available
IntroductionDespite the continuously growing number of therapeutic options for type 2 diabetes mellitus (T2DM) including insulins, a large percentage of patients fail to achieve HbA1c targets. Several real-world studies focused on patients with T2DM receiving insulin treatment in outpatient settings were conducted, but information about real-world...
Article
Latent Autoimmune Diabetes in Adults (LADA) is an autoimmune disease arising at adulthood. LADA is characterized by a less intensive autoimmune process, slower progression and a mild metabolic decompensation at onset compared with young-onset type 1 diabetes mellitus. The onset of LADA is usually in non-obese patients over 30, without prominent fea...
Article
Glucagon is actually used in the treatment of severe hypoglycemia. Due to technological difficulties with stability in solution, glucagon in currently available preparations was contained in a form of powder, which needs to be first dissolved in the water before application. This particular administration of glucagon was associated with a certain d...
Article
Full-text available
Alcohol is an important risk factor for development of numerous chronic diseases and it is a cause of 3 million deaths worldwide every year. The Czech Republic is one of the countries with highest alcohol consumption per capita in the world. AUDIT and CAGE are examples of fast and easy screening tools for early diagnostics of patients at risk that...
Article
Full-text available
Aims/Hypothesis The need for understanding obesity as a chronic disease, its stigmatization, and the lack of actionability related to it demands a new approach. The Adiposity‐Based Chronic Disease (ABCD) model is based on adiposity amount, distribution, and function, with a 3‐stage complication‐centric rather than a body mass index (BMI) centric ap...
Article
Prediabetes is an important topic for the general practitioners due to its increasing prevalence and a new option to bill the code for care for a prediabetic patient. The prevalence of prediabetes in the Czech Republic based on HbA1c measurement was 26.6% in men and 25,3% in women in a population aged 25–64. We present a review that focuses on pred...
Article
Full-text available
Aims The Dysglycemia-Based Chronic Disease (DBCD) model includes 4 distinct stages and prompts early prevention to avert diabetes and cardiometabolic complications. This paper presents the prevalence rate and associated risk factors for each DBCD stage. Methods Subjects between 25 to 64 years old from a random population-based sample were evaluate...
Article
Illicit drug use is quite prevalent in the Czech population with a lifetime prevalence of illicit drug use being 29.7 % in 2018. People who use illicit drugs can use health care services more often and they are thus relevant in early identification of illicit substance use disorders and in providing brief intervention. Primary evaluation of presenc...
Article
Full-text available
Diabetes is an established risk factor of cardiovascular disease including the coronary heart disease (CHD) and elevates the risk of cardiovascular death 2 times. Based on current evidence the risk of acquiring the CHD increases accordingly to the level of fasting blood glucose even in the prediabetic range. In the range of 5.6-6.0mmol/l the risk i...
Article
Aims The aim of this study is to establish the prevalence of diabetes (DM) and prediabetes in the Czech population aged 25–64 years and to evaluate the relationships with various cardiometabolic, sociodemographic, and lifestyle risk factors. Methods This was an epidemiological study with a stratified, crosssectional, random sampling design. Sociod...
Article
Full-text available
PurposeScreening of gestational diabetes/GDM (although different in different countries) represents a standard procedure allowing to identify women with pregnancy-associated diabetes. Some of the women with GDM (up to 5%) may, however, suffer from previously undiagnosed MODY (Maturity-Onset Diabetes of the Young). Currently, no international or loc...
Article
Full-text available
Mobile and wearable technologies offer patients with diabetes mellitus new possibilities for data collection and their more effective analysis. The Diabesdagboga smartphone application and the Diani web portal enable to collect and analyze glycaemia values, carbohydrates intake, insulin doses and the level of physical activity. The data are not onl...
Article
Full-text available
Lifetime prevalence of illicit drug use is high in the Czech Republic (CR) - it reached 31.2 % of the population in the age group 15-64 years in 2017. Diabetes mellitus (DM) applies to 8.8 % of the Czech population. Risks of illicit drug use in diabetic patients are related both to their effect on glucose metabolism and to the lifestyle associated...
Article
Objective: The aim of this article is to present a summary of the actual diagnostic possibilities and differentiation of MODY (Maturity-Onset Diabetes of the Young) from gestational diabetes (GDM) found during routine screening, and specific aspects of care and treatment of MODY during pregnancy and early postpartum period. Design: Rewiev. Sett...
Article
Maturity onset diabetes of the young (MODY) is a heterogeneous group of diseases caused by a single mutation in one of the 14 genes involved in the regulation of glucose homeostasis. GCK, HNF1A, and HNF4A genes are among the most common genes affected. Expression of these genes in the key organs for defense against hypoglycemia and their participat...
Article
Maturity onset diabetes of the young (MODY) represents a diabetes type which has an enormous clinical impact. It significantly alters treatment, refines a patient’s prognosis and enables early detection of diabetes in relatives. Nevertheless, when diabetes is manifested the vast majority of MODY patients are not correctly diagnosed, but mostly fals...
Article
Full-text available
Background: The prevalence of diabetes and the use of electronic health (eHealth) are increasing. People with diabetes need frequent monitoring and follow-up of health parameters, and eHealth services can be highly valuable. However, little is known about the use of eHealth in different socioeconomic groups among people with diabetes. Objective:...
Article
Full-text available
The results of two large multicentric, observational and cross-sectional studies (the DIAINFORM study and BALI study) reflecting routine clinical practice for insulin treatment in type 2 diabetes mellitus in the Czech Republic were published recently. In this commentary, we analyze these results and compare them with the findings of similar studies...
Article
Full-text available
A recent letter, "Hypoglycemia in the elderly: Watch for atypical symptoms" (J Fam Pract. 2019;68:116) provided an incomplete list of the letter's authors. The list should have read: Jan Brož, MD, Jana Urbanová, MD, PhD, Prague, Czech Republic; Brian M. Frier, MD, BSc, Edinburgh, United Kingdom.
Article
Recurrent, unexplained, eventually severe hypoglycemias in patients with type 1 diabetes mellitus (T1DM) may be rarely but yet associated with the onset of adrenal insufficiency (AI), present in approximately 0.5 % of patients with T1DM, appearing usually several years after diabetes diagnosis, usually in middle age and more frequently in women. Sc...
Article
Alcoholic drinks are one of the risk factors for hypoglycemia. Ethanol inhibits gluconeogenesis, decreases a level of growth hormone and impairs hypoglycemia awareness. The risk of hypoglycemia while drinking alcohol can be reduced by parallel ingestion of food (saccharides). Some recommendations also mention the change of insulin doses.
Article
A review of medical fitness to hold a drivers license in diabetes mellitus patients occurs when applying for the license and then at least every three years in non professional drivers and 1 year in professional ones. Severe hypoglycemic events are an important criterion with the view of eligibility loss to drive a vehicle, among the others the vis...
Article
Full-text available
Despite the continuously improving treatment options, many patients with type 1 (T1DM) and type 2 diabetes (T2DM) still do not achieve the recommended treatment goals. The article provides summary and commentary of the results of DIAINFORM study focused on the level of metabolic control in T1DM and T2DM patients treated with insulin in the Czech an...
Article
Hypoglycemia particularly severe one is important side effect of diabetes therapy with impact on patient´s quality of life and mortality. The highest risk of hypoglycemia is connected with insulin therapy followed by derivates of sulfonylurea (SU) and glinides. The risk of hypoglycemia found in observational studies were 2-3 times higher in patient...
Article
Hypoglycemia is a side effect of the therapy primarily with insulin, sulphonylurea derivates and glinides. Its therapy is based on the immediate ingestion of sacharides, preferably glucose. Amount of 15-20 g is recommended as its optimal dose, although several recent studies are suggesting amount related to the patient´s weight. The therapy of seve...
Article
DIABETES MELLITUS PREVALENCE AMONG TRADITIONAL ROMA WOMEN IN SERBIA: RESPONSE TO ČVOROVIČ - Volume 51 Issue 3 - Marisa A. Nunes, Jan Brož
Article
DIABETES PREVALENCE AMONG TRADITIONAL ROMA WOMEN IN SERBIA: A COMMENTARY ON ČVOROVIČ (2018) - Volume 51 Issue 3 - Jan Brož, Marisa A. Nunes
Article
Full-text available
Introduction Despite the continuously growing number of therapeutic options for patients with type 2 diabetes mellitus (T2DM), a large percentage of these individuals fail to achieve their glycated hemoglobin (HbA1c) target. The aim of this study was to determine the change in metabolic control in insulin-naïve T2DM patients inadequately controlled...
Article
Full-text available
Background: The aim of this study was to estimate the prevalence of diabetes mellitus in the Roma population and compare it to the prevalence in the Caucasian population. Methods: Using the words "Roma", "Gypsies", "Romani", and "traveler" in combination with "diabetes, "metabolic syndrome", "cardiovascular disease" and "health status" we search...
Article
Full-text available
Background: The prevalence of diabetes and the use of electronic health (eHealth) are increasing. People with diabetes need frequent monitoring and follow-up of health parameters, and eHealth services can be of great value. However, little is known about the association between the use of eHealth and provider-based health care services among peopl...
Article
Full-text available
Cardiovascular disease is the major cause of death in diabetic patients. Diabetes mellitus patients have a 4-fold-higher risk of having a cardiovascular event than people without diabetes. Cardiac autonomic neuropathy is a frequent and severe complication of diabetes mellitus. Definite cardiac autonomic neuropathy is present in one fifth of diabeti...
Article
Full-text available
The authors acknowledge the observations of the reviewer. The pitfalls and challenges with HBA1c assessment and interpretation in patients with malaria, especially severe malaria, where the red blood corpuscle (RBC) turnover is increased, is the reason why we have not highlighted the use of HbA1c for diagnosis and management of diabetes in malaria....
Article
Full-text available
Introduction: The aim of the study was to determine the level of metabolic control in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) patients in the Czech and Slovak Republics. Methods: A non-interventional prospective (observational) study was conducted from January 2015 until April 2016 in routine clinical practice setting...