Jan Brogger

Jan Brogger
Haukeland University Hospital · Department of Neurology

MD PhD

About

81
Publications
10,686
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2,310
Citations
Introduction
Jan Brogger currently works at the Department of Neurology, Haukeland University Hospital. Jan does research in clinical neurophysiology. Their current project is 'SCORE EEG.'

Publications

Publications (81)
Article
Full-text available
Purpose: A challenge in EEG interpretation is to correctly classify suspicious focal sharp activity as epileptiform or not. A predictive score was developed from morphologic features of the first focal sharp discharge, which can help in this decision. Methods: From a clinical standard EEG database, the authors identified 2,063 patients without a...
Article
Objective This study assessed the association between respiratory symptoms and mortality in four cohorts of the general population in Norway aged 15–75 years and in selected subgroups in the pooled sample. Methods The study comprised 158,702 persons, who were drawn randomly from the Norwegian population register. All subjects received a standardiz...
Article
Full-text available
Objective: To investigate whether the occurrence and morphology of interictal epileptiform discharges (IEDs) in scalp-EEG change by age. Methods: 10,547 patients who had a standard or sleep deprived EEG recording reported using the SCORE standard were included. 875 patients had at least one EEG with focal IEDs. Focal IED morphology was analyzed...
Article
Full-text available
Zusammenfassung Eine 2013 von der „International Federation of Clinical Neurophysiology“ gegründete Taskforce hat eine international konsensfähige EEG-Terminologie entwickelt. Im Folgenden soll das Resultat – die 2. Version des Standardized Computer-based Organized Reporting of EEG (SCORE) - vorgestellt werden. Die Terminologie wurde im Rahmen eine...
Article
Introduction Some epilepsy syndromes are associated with an EEG phenotype, specific epileptiform patterns with respect to morphology, localization, activating factors and ictal patterns. However, there are limited data on how aspects of interictal epileptiform discharges (IEDs) varies by age. No data is availability on how IEDs are described using...
Article
Full-text available
Objective Visual EEG analysis is the gold standard for clinical EEG interpretation and analysis, but there is no published data on how long it takes to review and report an EEG in clinical routine. Estimates of reporting times may inform workforce planning and automation initiatives for EEG. The SCORE standard has recently been adopted to standardi...
Article
Standardized terminology for computer-based assessment and reporting of EEG has been previously developed in Europe. The International Federation of Clinical Neurophysiology established a taskforce in 2013 to develop this further, and to reach international consensus. This work resulted in the second, revised version of SCORE (Standardized Computer...
Research
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In diabetic sensorimotor neuropathy there is substantial evidence of concomitant cutaneous, cardiac and visceral autonomic neuropathies. The neuropathy may reduce quality of life and explain the higher prevalence of gastrointestinal complaint
Article
Readmission after stroke is frequent, but limited data are available in Europe. This study aimed at assessing frequencies, causes, and factors associated with early and late unplanned readmissions within 1 year after discharge from ischemic stroke hospitalization. All surviving ischemic stroke patients admitted to the Department of Neurology, Hauke...
Article
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Aims Gastrointestinal complaints are common in diabetes mellitus. However, its association to peripheral sensorimotor and autonomic neuropathies is not well investigated. The aim was to assess skin, muscle, bone and visceral sensitivity in diabetes patients with sensorimotor neuropathy, and correlate these with gastrointestinal symptoms and degree...
Article
The diagnosis of nonconvulsive status epilepticus (NCSE) relies largely on electroencephalography (EEG) findings. The lack of a unified EEG terminology, and of evidence-based EEG criteria, leads to varying criteria for and ability to diagnose NCSE. We propose a unified terminology and classification system for NCSE, using, as a template, the Standa...
Article
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The electroencephalography (EEG) signal has a high complexity, and the process of extracting clinically relevant features is achieved by visual analysis of the recordings. The interobserver agreement in EEG interpretation is only moderate. This is partly due to the method of reporting the findings in free-text format. The purpose of our endeavor wa...
Article
Background: Many patients with acute ischaemic stroke do not receive intravenous thrombolysis due to contraindications. We aimed to assess safety, short-term clinical development, short-term outcome and mortality in patients treated off-label with tissue plasminogen activator (tPA). Methods: Stroke patients treated with tPA within 4.5 h after sy...
Article
Purpose: Transcranial color-coded sonography (TCCS) and CT-angiography (CTA) are reliable tools for detection of intracranial stenosis. Current ultrasonographic criteria for middle cerebral artery (MCA) stenosis are usually limited to a dichotomized grading (< or ≥ 50 %). As for carotid arteries, continuity equation might provide a more accurate e...
Article
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Many patients with cerebral infarction suffer from symptoms such as pain, fatigue, and depression. The aim of this study was to evaluate these symptoms in relation to health-related quality of life (HRQoL) on long-term follow-up. All surviving stroke patients admitted to the Stroke Unit, Haukeland University Hospital, Norway between February 2006 a...
Article
Many patients with cerebral infarction suffer from symptoms such as pain, fatigue and depression. Most studies focus on single symptoms, but these symptoms often occur together. Whereas symptom clusters have been studied in cancer patients, little is known about different symptom clusters in patients with cerebral infarction. The aim was to evaluat...
Article
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A possible synergic role of serum uric acid (SUA) with thrombolytic therapies is controversial and needs further investigations. We therefore evaluated association of admission SUA with clinical improvement and clinical outcome in patients receiving rt-PA, early admitted patients not receiving rt-PA, and patients admitted after time window for rt-P...
Article
The main objective of this study was to investigate the circadian distribution of subtypes of ischemic stroke. The time of onset of stroke in consecutive stroke patients was registered and categorized into the following time intervals: midnight-6 am, 6 am-noon, noon-6 pm, and 6 pm-midnight. Patients with unknown onset of stroke were categorized as...
Article
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Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer cells with an immature stem-like phenotype are hypothesised to play a role in radioresistance. Since the progenitor marker neuron...
Article
To evaluate characteristics and mortality related to post-stroke fatigue (PSF). All surviving stroke patients admitted to the Stroke Unit, Haukeland University Hospital, between February 2006 and November 2008 were sent a postal questionnaire including the Fatigue Severity Scale (FSS), the hospital anxiety and depression scale (HADSD), and the Bart...
Article
Treatment of acute cerebral infarction has greatly improved over the last 15 years. The purpose of this article is to describe patients with acute cerebral infarction admitted to a stroke unit from a geographically well defined population between 2007 and 2009. All patients were included aged over 15 years with acute cerebral infarction living in a...
Article
Development of stroke units during the last decade has changed management of patients with stroke. The aim of this study is to assess unselected patients admitted to an acute stroke unit with respect to daily functioning (neurological deficits), treatment and 7-day outcome. All patients with suspected neurovascular disease were admitted to the stro...
Data
Full-text available
Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiother-apy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer cells with an immature stem-like phenotype are hypothesised to play a role in radioresistance. Since the progenitor marker neuro...
Article
To assess the influence of depression prior to stroke (PD) on stroke severity on admittance, functional outcome (short- and long-term), mortality, and long-term depression (PSD). Consecutive acute stroke patients were screened for PD. The National Institute of Health Stroke Scale score was obtained on admission. Short-term functional state was regi...
Article
High body temperature may promote clot lysis whereas low body temperature is neuroprotective in patients with cerebral infarction. We hypothesized that high body temperature is associated with favorable outcome in patients treated with tissue plasminogen activator (tPA) and that low body temperature is associated with favorable outcome in patients...
Article
The objective of this study is to evaluate characteristics and mortality related to long-term post-stroke pain (PSP). All surviving stroke patients admitted to the Stroke Unit, Haukeland University Hospital, between February 2006 and July 2009 received a postal questionnaire including the fatigue severity scale (FSS), the hospital anxiety and depre...
Article
Full-text available
No large study has compared the yield of diffusion-weighted imaging (DWI) with clinical examination in order to differentiate lacunar stroke from other stroke subtypes. This differentiation is important for guiding further investigations and treatment. Consecutive patients admitted with cerebral infarction were classified according to the Oxfordshi...
Article
We hypothesized that patients with cerebral infarction on preadmission warfarin have less severe neurological deficits on admittance, less severe neurological deficits 1 week after the onset of cerebral infarction and a larger improvement as to neurological deficits within 1 week of acute cerebral infarction. All patients with cerebral infarction w...
Article
Animal studies show a neuroprotective effect of serum albumin in ischemic stroke. The neuroprotective effect of albumin in ischemic stroke in humans is not well studied. This study was aimed to determine the association of serum albumin with outcome and mortality after ischemic stroke. In a prospective study, we included 444 patients with ischemic...
Article
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There is growing evidence that inflammation plays an important role in atherogenesis. Previous studies show that C-reactive protein (CRP), an inflammatory marker, is associated with stroke outcomes and future vascular events. It is not clear whether this is due a direct dose-response effect or rather an epiphenomenon. We studied the effect of CRP m...
Article
To study the age-related occurrence of specific features of generalised epileptiform activity (GEA), their correlation with EEG background activity (BA), and their internal correlation. 17,723 consecutive routine EEGs from 12,511 patients were annotated and categorised into a database. The first EEG containing GEA from all 325 patients with such ac...
Article
Body temperature, blood glucose, and blood pressure (BP) may interfere with outcome in patients with acute ischemic stroke treated with thrombolysis. We prospectively studied 127 patients who received thrombolysis with tissue plasminogen activator for acute stroke in Bergen, Norway. Body temperature, blood glucose, and BP were measured before throm...
Article
There is substantial interest in use of the Internet for surveys, but there have been few health-oriented, large, randomized trials of general population surveys on the Internet. It is unclear whether providing the option to respond via Internet increases the response rate, and to what degree the results will differ. The aim of the study was to eva...
Article
The literature shows wide variations of recurrence rates (RRs) after abdominal surgery for rectal prolapse. The aim of this meta-analysis was to evaluate the accuracy of published RRs. An electronic search was performed with no restrictions. Inclusion criterion was abdominal surgery in at least 10 adults with follow-up evaluation of any length of t...
Article
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There is evidence of a hereditary component in chronic obstructive pulmonary disease (COPD). A number of genetic association studies have been performed to find susceptibility genes of COPD. The current authors performed a case-control, genetic-association study and a meta-analysis of 16 studies, involving seven polymorphisms in three well-studied...
Article
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In recent years, several new studies have estimated the incidence of adult asthma. These studies vary in design and quality. The current paper summarises the findings of major population studies in the adult incidence of asthma. The pooled estimate of the adult incidence of asthma was 4.6 per 1000 person-years in women and 3.6 per 1000 person-years...
Article
Evidence is accumulating that there has been an increase in the adult population burden of obstructive lung disease. Has this increased the burden of symptoms? It is possible that diagnostic efficiency has improved, so that milder asthma cases are being diagnosed. To investigate changes in symptom burden by asthma diagnosis, age and sex. We perform...
Article
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There is evidence for an increase in adult asthma prevalence. Several retrospective studies have shown an increase in asthma incidence by year of birth, consistent with an increasing trend in asthma incidence. The validity of this retrospective approach is unknown. Retrospective and prospective asthma incidence by year of birth were compared in the...
Article
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The burdens of chronic obstructive airway diseases among the elderly in Europe, and worldwide, are increasing. Although asthma is common in all ages, the main airway disease affecting the elderly is chronic obstructive pulmonary disease (COPD). The aim of this paper is to review the prevalence and incidence of COPD on the basis of population studie...
Article
Full-text available
Achieving a high response rate is often expensive and time consuming. Does an extensive survey effort change prevalence estimates and exposure-disease relations? In 1998-1999, the authors conducted a population-based respiratory health survey in two Norwegian counties (Oslo, n = 20,000; Hordaland, n = 5,000) of a random sample of the adult populati...
Article
Background. There are no previous studies concerning survival after hospitalisation for obstructive lung disease in Norway. Methods. We recorded all patients 15 years and older who were discharged with a diagnosis of obstructive lung disease from hospitals in Bergen hospital district between 1 April and 15 June 1997. 142 patients (62% women) were f...
Article
Achieving a high response rate is often expensive and time consuming. Does an extensive survey effort change prevalence estimates and exposure-disease relations? In 1998–1999, the authors conducted a population-based respiratory health survey in two Norwegian counties (Oslo, n = 20,000; Hordaland, n = 5,000) of a random sample of the adult populati...
Article
Full-text available
There has been an increase in asthma prevalence among children. Little evidence is available regarding long-term changes in asthma prevalence in adults. Two cross-sectional studies were performed among adults aged 15-70 yrs in Oslo, Norway, in 1972 and again in 1998-1999 (n=39,998). A postal self-completed questionnaire was used. Exactly the same q...
Article
Needleholders with in-line handles (ILH) and those with pistol-grip handles (PGH) were compared in terms of operative end-product quality (OEPQ), procedure effectiveness (PE), and surgeon forearm workload (SFWL) during suturing in a laparoscopic simulator. A 90% power crossover design at alpha 0.05 required 46 surgeons. Block randomization generate...
Article
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Little is known about the comparability of postal and telephone survey modes in epidemiology. A cross-sectional, population-based study (n = 25,000) of lung disease was performed in 1998-1999 in two regions of Norway. Initial surveying was done by postal questionnaire. A 1% random sample (n = 171) of previous postal responders were resurveyed by te...
Article
This program will compute the required sample size for a simple crossover trial, that is AB/BA, or two-period two-treatment cross-over. It will estimate the power for a given sample size, too.
Article
gprefscode generates code to set the graphics preferences. It takes the settings already in place for one of the schemes, and outputs Stata code which sets the scheme to those values.
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sskapp computes the sample size for the kappa-statistic measure of interrater agreement. It is a modification of M. E. Reichenheim's sskdlg, published in STB-58 (q.v.)
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genvars generates new variables in a recursive fashion. This is best illustrated by example: .genvars age(0(10)100) generates a new variable age that has observations 0,10,20..100. This is version 1.1 of the software.
Article
svmatf saves a matrix as a dataset. It can be saved as a separate dataset - or it can be added to an existing dataset. This module makes use of Nicholas J. Cox' routine svmat2, which must be downloaded from STB-56.
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lincom2 computes multiple lincom expression, and puts them into a matrix. This matrix can be used with lrplot (q.v.).
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grlogit plots the logit of one variable against categories of another variable. This may be of some use in the beginning of logistic regression modelling. You could use this program to confirm visually that there isn't a non-linear relationship of the logit of the dependent variable to the predictor variable. Thus, you could screen your explanatory...
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lrchg displays the coefficients in two logistic models, and calculates the proportion of change in coefficients between two models. This is useful in logistic regression modelling in epidemiology.
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lrmatx must be run after a logistic regression. It stores the output that you see from a logistic regression as easily accessible matrices. It is intended for use during model building. By making coefficients accessible, you can easily compare changes in coefficients between different models.
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Plots the coefficients from a logistic regression with confidence intervals, on a log scale. Simplest use: do lrplot immediately after a logistic regression.
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spaces parses a string for certain delimiters that are commonly used in Stata output. The string is returned in r(s). The delimiters are replaced by chr(). Default is ";", which is useful when importing into Excel.
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This module contains several utilities for logistic regression which may be loaded as a single package via lrutil.
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title prints some lines with blank lines, stars and then the title text. This is useful in organising logs. The "size" of the title can be specified.
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grfreq plots proportions of one variable by categories of another. For a binary variable, this could be the prevalence of a trait. By default, the proportion of interest is that of the minimal value of the outcome variable. The outcome of interest can be changed.
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readlog reads in a file and processes it using some or all of the specified options. readlog reads in a file line by line. Only certain lines are output. The processing includes starting and stopping at lines containing certain strings, including all lines with certain strings. readlog may also try to process files for reading in a spreadsheet prog...
Article
Limited data is available as to what extent Norwegian hospital doctors ask their patients about their smoking habits, and to what extent doctors offer their patients help in smoking cessation. A random sample of 1,025 hospital doctors was mailed a questionnaire. After 14 days a reminder letter was sent to non-responders; 76% of the doctors responde...
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showgph shows graphs previously saved as .gph files and present in the same directory or folder. Graphs are drawn one at a time in alphanumeric filename order. This is version 1.1.0 of the software.
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forfile executes a command for each file matching a file pattern. If no command is specified, it does -graph using- If no filespec is specified, it uses *.gph
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printgph displays and prints all Stata graphics files specified by a file pattern. If no filespec is specified, it uses *.gph
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Comparisons in performance of questionnaires are of interest in international comparisons of prevalences and risk factors, after translation and development of new questionnaires. Factors such as sex, age, educational level and smoking habits may influence the performance of questionnaires. 1) To discuss questionnaire comparisons in general, using...
Article
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Information on how health professionals perceive tobacco use as well as their attitudes toward tobacco control is scarce. This study assessed the attitudes and perceptions of public health students toward tobacco use and tobacco control, which constitutes a necessary first step in designing effective training strategies. Although the majority of re...

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