James Whiting

James Whiting
University of the West of England, Bristol | UWE Bristol · Department of Computer Science and Creative Technologies

EngD, BSc

About

41
Publications
6,848
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415
Citations
Citations since 2017
11 Research Items
234 Citations
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201720182019202020212022202301020304050

Publications

Publications (41)
Article
Full-text available
Neuromorphic computing devices attempt to emulate features of biological nervous systems through mimicking the properties of synapses, towards implementing the emergent properties of their counterparts, such as learning. Inspired by recent advances in the utilisation of liquid marbles (microlitre quantities of fluid coated in hydrophobic powder) fo...
Preprint
Neuromorphic computing devices attempt to emulate features of biological nervous systems through mimicking the properties of synapses, towards implementing the emergent properties of their counterparts, such as learning. Inspired by recent advances in the utilisation of liquid marbles (microlitre quantities of fluid coated in hydrophobic powder) fo...
Article
Full-text available
As the extent to which aquatic environments are polluted with nano-scale objects is becoming known, we are presented with an urgent need to study their effects on various forms of life and to clear and/or detoxify them. A range of methods exist to these ends, but a lack of inter-study comparability arising from an absence of experimental standardis...
Chapter
Slime mould Physarum polycephalum is a large single cell capable of distributed sensing, concurrent information processing, parallel computation, and decentralised actuation. The ease of culturing and experimenting with Physarum makes this slime mould an ideal substrate for real-world implementations of unconventional sensing and computing devices....
Article
Full-text available
Cilia are finger-like cell-surface organelles that are used by certain varieties of aquatic unicellular organisms for motility, sensing and object manipulation. Initiated by internal generators and external mechanical and chemical stimuli, coordinated undulations of cilia lead to the motion of a fluid surrounding the organism. This motion transport...
Article
Full-text available
The aquatic unicellular organism Paramecium caudatum uses cilia to swim around its environment and to graze on food particles and bacteria. Paramecia use waves of ciliary beating for locomotion, intake of food particles and sensing. There is some evidence that Paramecia pre-sort food particles by discarding larger particles, but intake the particle...
Preprint
We exploit chemo- and galvanotactic behaviour of Paramecium caudatum to design a hybrid device that allows for controlled uptake, transport and deposition of environmental micro- and nanoparticulates in an aqueous medium. Manipulation of these objects is specific, programmable and parallel. We demonstrate how device operation and output interpretat...
Article
Full-text available
The nanotechnology revolution has allowed us to speculate on the possibility of hybridising nanoscale materials with live substrates, yet significant doubt still remains pertaining to the effects of nanomaterials on biological matter. In this investigation, we cultivate the ciliated protistic pond-dwelling microorganism Paramecium caudatum in the p...
Article
Motile cilia are cell-surface organelles whose purposes, in ciliated protists and certain ciliated vertebrate epithelia, include generating fluid flow, sensing and substance uptake. Certain properties of cilia arrays, such as beating synchronisation and manipulation of external proximate particulate matter, are considered emergent, but remain incom...
Preprint
The nanotechnology revolution has allowed us to speculate on the possibilities of hybridising nanoscale materials with live substrates, yet significant doubt still remains pertaining to the effects of nanomaterials on biological matter. In this investigation we cultivate the ciliated protistic pond-dwelling microorganism Paramecium caudatum in the...
Preprint
Motile cilia are cell-surface organelles whose purposes, in ciliated protists and certain ciliated vertebrate epithelia, include generating fluid flow, chemosensation, mechanosensation and substance uptake. Certain properties of cilia arrays, such as beating synchronisation and manipulation of external proximate particulate matter, are considered e...
Article
Full-text available
Networks of protoplasmic tubes of organism Physarum polycehpalum are macro-scale structures which optimally span multiple food sources to avoid repellents yet maximize coverage of attractants. When data are presented by configurations of attractants and behaviour of the slime mould is tuned by a range of repellents, the organism preforms computatio...
Chapter
We report the progress of using the plasmodium of Physarum as a biological electronic component. We provide blue prints of experimental prototypes of Physarum wires and analyse their transfer function, discuss how lifespan of a Physarum can be increased. We overview our experimental laboratory results on using Physarum wires with buffers and evalua...
Chapter
We overview families of Boolean logical gates and circuits implemented in computer models and experimental laboratory prototypes of computing devices made of living slime mould Physarum polycephalum. These include attraction gates, based on chemo-tactic behaviour of slime mould; ballistic gates, employing inertial movement of the slime mould’s acti...
Chapter
We show how the slime mould can be used as a chemical sensor and investigate how the organism combines different sensory information. We have produced a biosensor using protoplasmic tubes of Physarum which is capable of detecting various biologically active chemicals in the local environment; this progress is akin to developing a biological nose us...
Article
Full-text available
Purpose Protoplasmic tubes of Physarum polycephalum, also know as Physarum Wires (PW), have been previously suggested as novel bio-electronic components. Until recently, practical examples of electronic circuits using PWs have been limited. These PWs have been shown to be self repairing, offering significant advantage over traditional electronic co...
Article
Computing devices are composed of spatial arrangements of simple fundamental logic gates. These gates may be combined to form more complex adding circuits and, ultimately, complete computer systems. Implementing classical adding circuits using unconventional, or even living substrates such as slime mould Physarum polycephalum, is made difficult and...
Article
Full-text available
The slime mould Physarum polycephalum is a large single celled myxomycete; its plasmodium consists of tubes which extend to find sources of food. It has been previously shown that the tubes are conductive with a resistance of approximately 3MΩ, and have been used in basic DC circuits. Hybrid slime mould-electronic circuits have been proposed, using...
Article
Full-text available
The Phychip project is a collaborative European research initiative to design and implement computation using the organism Physarum polycephalum; it is funded by the Seventh Framework Programme (FP7) by the European Commission within CORDIS and the FET Proactive scheme. Included in this presentation are details the development of a Physarum based b...
Article
Full-text available
A plurality of whole cell biosensors have been developed using many different cell types. Biosensors incorporate biomolecular components or whole cells to facilitate specific analyte interaction; research documented here presents a novel whole cell biosensor based on the slime mould Physarum polycephalum (PP). The electrical response of PP when exp...
Article
Physarum polycephalum is a large single amoeba cell, which in its plasmodial phase,forages and connects nearby food sources with protoplasmic tubes. The organism forages for food by growing these tubes towards detected food stuffs, this foraging behaviour is governed by simple rules of photoavoidance and chemotaxis. The electrical activity of the t...
Article
Surface electrical potential and observational growth recordings were made of a protoplasmic tube of the slime mould Physarum polycephalum in response to a multitude of stimuli with regards to sensory fusion or multisensory integration. Each stimulus was tested alone and in combination in order to evaluate for the first time the effect that multipl...
Article
Plasmodium of slime mould Physarum polycephalum is a large single celled organism visible unaided by the eye. This slime mould is capable of optimising the shape of its protoplasmic networks in spatial configurations of attractants and repellents. Such adaptive behaviour can interpreted as computation. When exposed to attractants and repellents, Ph...
Article
Plasmodium of slime mould Physarum polycephalum is a large single celled organism visible unaided by the eye. This slime mould is capable of optimising the shape of its protoplasmic networks in spatial configurations of attractants and repellents. Such adaptive behaviour can interpreted as computation. When exposed to attractants and repellents, Ph...
Article
Full-text available
There is a high incidence of inflammation and metaplasia at the gastro-oesophageal junction (GOJ) in asymptomatic volunteers. Additionally, the majority of patients with GOJ adenocarcinomas have no history of reflux symptoms. We report the effects of waist belt and increased waist circumference (WC) on the physiology of the GOJ in asymptomatic volu...
Article
Full-text available
Introduction Epidemiology demonstrates an association between obesity, hiatus hernia and acid reflux but mechanism is unclear. We have examined the structure and function of the gastro-oesophageal (GO) junction in healthy subjects with and without obesity and the effects of elevating intra-abdominal pressure with belt. Methods We recruited 8 subjec...
Article
Full-text available
Abstract Understanding the physiology of gastroesophageal junction (GEJ) is important as failure of its function is associated with reflux disease, hiatus hernia, and cancer. In recent years, there have been impressive developments in high resolution technologies allowing measurement of luminal pressure, pH, and impedance. One obvious deficiency is...
Conference Paper
Full-text available
Transient lower oesophageal sphincter relaxations (TLOSRs) occur frequently and are the main mechanism of acid reflux. The only means of currently detecting TLOSRs is intra-luminal manometry and the probes themselves may stimulate TLOSRs. The squamo-columnar junction moves 4-5 centimeters proximally during TLOSRs and this provides a means of detect...
Article
Full-text available
Transient lower oesophageal sphincter relaxations (TLOSRs) occur frequently and are the main mechanism of acid reflux. The only means of currently detecting TLOSRs is intra-luminal manometry and the probes themselves may stimulate TLOSRs. The squamo-columnar junction moves 4-5 centimeters proximally during TLOSRs and this provides a means of detect...
Article
Background Proximal displacement of the gastro-esophageal junction (GEJ) is present in hiatus hernia but also occurs transiently during transient lower esophageal sphincter relaxations (TLESRs) and swallows. Using a novel magnetic-based technique we have performed detailed examination of the GEJ movement during TLESRs and swallows in healthy subjec...
Article
Introduction In hiatus hernia there is proximal displacement of the gastro-oesophageal junction (GOJ) relative to the crural diaphragm impairing barrier function. Fluoroscopic studies have indicated proximal migration of the GOJ during TLOSRs but detailed study has been limited by radiation exposure. Using a non-radiological technique we have perfo...
Article
The high resolution esophageal manometry system manufactured by Sierra Scientific Instruments is widely used. The technology is liable to 'thermal drift', a change in measured pressure due to change in temperature. This study aims to characterize 'thermal drift' and minimize its impact. Response of the system to immediate temperature change (20 °C...
Article
Most pathology of the upper gastrointestinal tract now occurs close to the gastro-oesophageal squamo-columnar junction (SCJ). Studying the pathophysiology of this region even using high resolution pH, impedance and manometry is unreliable due to constant movement with respiration, swallowing and transient lower oesophageal sphincter relaxations. A...
Article
Full-text available
Introduction The position of the squamo-columnar (SC) junction is constantly changing and this precludes accurate monitoring of acid exposure of the most distal oesophagus. The authors have developed a novel probe to allow continuous monitoring of the SC junction location. The method involves endoscopically clipping a small magnet (2 mm diameter an...
Article
Full-text available
Introduction The gastro-oesophageal junction is very mobile and constantly changing position with breathing, swallowing and transient lower oesophageal sphincter relaxation (TLESR). The only method currently available for studying its location is fluoroscopic screening and this is limited by radiation exposure. We have developed a method allowing c...
Article
Introduction High resolution manometry (HRM) is a sophisticated and widely used technology allowing detailed examination of oesophageal function. A described limitation of the HRM system is its propensity to ‘thermal drift’. Thermal drift is a false change in the measured pressure attributed to the change from ambient to body temperature. In prolon...

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Projects

Projects (2)
Archived project
We aim to investigate the sensorial-actuation capabilities of the cilia possessed by the unicellular protozoan Paramecium caudatum towards uncovering design principles for artificial biomimetic cilia capable of exhibiting similar emergent behaviours.