James Scott

James Scott
Near East University · Department of Business Administration

About

151
Publications
19,148
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3,207
Citations
Citations since 2016
83 Research Items
1826 Citations
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
Introduction
Skills and Expertise

Publications

Publications (151)
Preprint
The evolution of the capacity for language remains a contested and important subject. Newer approaches consider language evolution to be a protracted and mosaic process, with selection operating in different contexts through multiple drivers. This research examines two potential factors in language evolution: cognitive-structuring functions of lang...
Preprint
The evolution of the capacity for language remains a contested and important subject. Newer approaches consider language evolution to be a protracted and mosaic process, with selection operating in different contexts through multiple drivers. This research examines two potential factors in language evolution: cognitive-structuring functions of lang...
Article
In this article we explore what a programme of ‘reglobalization’ could look like for the governance of global trade. Our focus is on the centrepiece of the current commercial order, the World Trade Organization (WTO). Our aim is to illustrate the potential value of a reformulated WTO not just for commercial relations globally but also for other are...
Conference Paper
We present a design of an always-on system connecting long-distance couples at bedtime, a time and space partners normally share together. The system offers a novel, real-time shared inking space for creative interactivity, a slow photo stream to balance privacy and remote presence. It adapts to the local light level in order to stay in the backgro...
Article
Full-text available
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. C...
Article
Integrating point-of-care ultrasound (POCUS) to enhance diagnostic availability in resource-limited regions in Africa has become a main initiative for global health services in recent years. In this article, we present lessons learned from introducing POCUS as part of the Global Health Service Partnership (GHSP), a collaboration started in 2012 bet...
Conference Paper
Full-text available
We describe a concept smartphone Display Cover, a secondary screen designed to improve productivity and convenience. Motivated by user research highlighting some of the limitations of current smartphones, the aim of this concept was to explore a practical solution which allows users to be more productive.
Article
Full-text available
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understand...
Data
Summary of biological description for novel BP loci. Information summary of the nearest genes for blood pressure novel loci. (DOCX)
Data
Study design of SNV x alcohol interactions for BP. Schematic study design of the joint model of SNV main effect and SNV-alcohol consumption interaction; Blood pressure (BP) traits: systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP); Alcohol consumption was defined by two categories: (I) as current drinking...
Data
Description of participating studies. Study descriptions of discovery cohorts (Stage 1) and replication cohorts (Stage 2). (DOCX)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for SBP in current drinkers (A) and in light/heavy drinkers (B) in European ancestry. Novel loci are highlighted in blue. (TIF)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for SBP in current drinkers (A) and in light/heavy drinkers (B) in African ancestry. Novel loci are highlighted in blue. (TIF)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for DBP in current drinkers (A) and in light/heavy drinkers (B) in African ancestry. (TIF)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for SBP (A) and DBP (B) in current drinkers in Asian ancestry. (TIF)
Data
Protein-protein interactions network. In the figure, ellipses in black represent all novel genes; ellipses in red represent novel from EA; squares in blue represent potential novel findings from African ancestry; and triangles in black from correlated-meta. Labeled with A and B free-hand circles are proteins that have two connections, while labeled...
Data
Protein-protein interactions between tankyrase and beta-catenin. Tankyrase (from TNKS gene) and β-catenin (from CTNNB1 gene). (TIF)
Data
Wnt signaling KEGG pathway. TNKS interacts with CTNNB1. (TIF)
Data
Descriptive analyses for discovery data (Stage 1) in current drinkers. Characteristics of blood pressure (BP) in current drinkers (yes or no), within sub-sample of individuals with or without anti-hypertensive (BP Lowering) medications, and in combined samples; SBP, systolic BP; DBP, diastolic BP; MAP, mean arterial pressure; PP, pulse pressure; N,...
Data
Descriptive analyses for blood pressure (BP) stratified by alcohol consumption for discovery data (Stage 1). Characteristics of systolic BP and diastolic BP, after correcting for BP lowering medication and winsorizing observations. (XLSX)
Data
Descriptive analyses for replication data (Stage 2) in current drinkers. Characteristics of blood pressure (BP) within current drinkers (CURD: yes or no), and in alcohol combined samples; SBP, systolic BP; DBP, diastolic BP; MAP, mean arterial pressure; PP, pulse pressure; N, number of individuals; mean, mean levels; SD, standard deviation of mean;...
Data
Demographic statistics for replication data (Stage 2). N, Number of subjects; % Hypertensive, defined whether participants presented: (i) SBP ≥ 140 mm Hg, (ii) DBP ≥ 90 mm Hg, and/or (iii) taking anti-hypertensive medication; Mean, age mean; SD, standard deviation of mean; Min, minimum age; Max, maximum age. (XLSX)
Data
SNVs/genes associated with BP traits in European ancestry. Variants previously reported for blood pressure (BP) in genome-wide association studies. The most significant associated SNVs are shown per gene for each Blood Pressure (BP) trait and alcohol status. Abbreviations: Nb, order number based on genes; SNV, single nucleotide variant; Chr, chromo...
Data
SNVs/genes associated with BP traits in multi-ancestry meta-analysis in combined Stage 1 and Stage 2. Variants previously reported for blood pressure (BP) in genome-wide association studies. The most significant associated SNVs are shown per gene for each Blood Pressure (BP) trait and alcohol status. Abbreviations: Nb, order number based on genes;...
Data
Novel SNVs/genes associated with BP traits for eSNV/eQTL using GTEx. Target genes (Tissues and P-Values). Association findings from European Ancestry (novel) and correlated meta-analysis (novel variants). The annotation of variants was sourced from NCBI dbSNP build 138 (hg19) during the analyses and updated to dbSNP build 150 (hg38) for reporting r...
Data
Data analysis tools and databases. (DOCX)
Data
QQ plots for BP traits for light/heavy drinkers. Meta-analysis distributions of–log10 P-values of observed versus–log10 P-values expected (QQ plots) for light/heavy drinkers (1–7 drinks/week or ≥8 drinks/week) in European ancestry (A) and in African ancestry (B). (TIF)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for DBP in current drinkers (A) and in light/heavy drinkers (B) in European ancestry. Novel loci are highlighted in blue. (TIF)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for PP in current drinkers (A) and in light/heavy drinkers (B) in European ancestry. Novel loci are highlighted in blue. (TIF)
Data
Descriptive analyses for replication data (Stage 2) in light/heavy drinkers. Characteristics of blood pressure (BP) within light/heavy drinkers (LHD: 1–7 drinks/week or ≥8 drinks/week), and in alcohol combined samples; SBP, systolic BP; DBP, diastolic BP; MAP, mean arterial pressure; PP, pulse pressure; N, number of individuals; mean, mean levels;...
Data
Characteristics of each study and their genotype data for replication data (Stage 2). Study design, population-based or cohort-unrelated; Principal components used; Other covariates entered in the model; Genotyping platforms; Genotyping calling algorithm; Imputation reference panel; NCBI dbSNP build; Analysis software; Robust or model-based statist...
Data
Novel SNVs/ genes associated with BP traits in multi-ancestry and specific-ancestry meta-combined results. Top significant associated SNVs are shown per gene for each trait and alcohol exposure. (XLSX)
Data
SNVs/genes associated with BP traits in African ancestry. Variants previously reported for blood pressure (BP) in genome-wide association studies. The most significant associated SNVs are shown per gene for each Blood Pressure (BP) trait and alcohol status. Abbreviations: Nb, order number based on genes; SNV, single nucleotide variant; Chr, chromos...
Data
Regional association plots on 16q12. SNV x current drinker interaction for SBP (A), DBP (B), MAP (C) and PP (D) in European Ancestry. (TIF)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for MAP in current drinkers (A) and in light/heavy drinkers (B) in European ancestry. Novel loci are highlighted in blue. (TIF)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for PP in current drinkers (A) and in light/heavy drinkers (B) in African ancestry. Novel loci are highlighted in blue. (TIF)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for MAP (A) and PP (B) in current drinkers in Asian ancestry. (TIF)
Data
Descriptive analyses for discovery data (Stage 1) in light/heavy drinkers. Characteristics of blood pressure (BP) in light/heavy drinkers (1–7 drinks/week or ≥8 drinks/week), within sub-sample of individuals with or without anti-hypertensive (BP Lowering) medications, and in combined samples; SBP, systolic BP; DBP, diastolic BP; MAP, mean arterial...
Data
SNVs/genes associated with BP traits for regulatory features using HaploReg and RegulomeDB. Association findings from European Ancestry (novel), African Ancestry (potential) and correlated meta-analysis (novel variants). The annotation of variants was sourced from NCBI dbSNP build 138 (hg19) during the analyses and updated to dbSNP build 150 (hg38)...
Data
QQ plots for BP traits for current drinkers. Meta-analysis distributions of–log10 P-values of observed versus–log10 P-values expected (QQ plots) for current drinkers (yes/no) European ancestry (A) and in African ancestry (B). (TIF)
Data
Regional association plots on 8p23. SNV x current drinker interaction for SBP (A), DBP (B), MAP (C) and PP (D) in European Ancestry; four linkage disequilibrium (LD) blocks (see also Fig 1). (TIF)
Data
Manhattan plots of combined Stage 1 and Stage 2 meta-analysis for MAP in current drinkers (A) and in light/heavy drinkers (B) in African ancestry. (TIF)
Data
Characteristics of each study and their genotype data for discovery data (Stage 1). Study design, population-based or cohort-unrelated; Principal components used; Other covariates entered in the model; Genotyping platforms; Genotyping calling algorithm; Quality Control Filters; Imputation reference panel; Number of SNVs (single nucleotide variants)...
Article
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and dias...
Article
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and dias...
Article
Full-text available
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-freque...
Conference Paper
In this paper, we challenge the current approach to calm technology as described by Weiser and its goals, highlighting individual user different expectations, suggesting that user needs to be in the center of defining what does calm mean for them. We discuss how applications could support the notion of calmness, and describe a prototype "calm displ...
Article
Full-text available
Summarises the geographical contributions made to understanding democracy, representation and the role of the political party Focuses attention on the internal spatial dynamics of the political party. Explores the British Labour Party’s experiment with community organising techniques between 2010 and 2015. Evaluates the work of Movement for Change,...
Article
We present a system for making emissive computer displays (LCDs) look like they are reflective, i.e. not emitting light but instead reflecting ambient light, an effect that we call a “calm display”. We achieve this effect by using a light sensor and a one-time calibration process to drive an algorithm which controls the display's backlight intensit...
Article
Full-text available
Background: Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk....
Article
Space-heating accounts for more than 40% of residential energy consumption in some countries (e.g. the UK and the US) and thus is a key area to address for energy efficiency improvement. To do so, intelligent domestic heating systems (IDHS) equipped with sensors and technologies that minimize user-input, have been proposed for optimal heating contr...
Article
Full-text available
To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We ide...
Article
Full-text available
L-arginine is the essential precursor of nitric oxide, and is involved in multiple key physiological processes, including vascular and immune function. The genetic regulation of blood L-arginine levels is largely unknown. We performed a genome-wide association study (GWAS) to identify genetic factors determining serum L-arginine levels, amongst 901...
Conference Paper
Full-text available
BACKGROUND Multiple studies have shown that extent of surgical resection (EoR) is an independent prognostic factor for patients with newly-diagnosed glioblastoma. Previous work has proposed the inclusion of EoR in a risk stratification algorithm but does not incorporate recent advances in the molecular characterization of tumors. OBJECTIVE To deve...
Conference Paper
Full-text available
We explore the design space of energy-neutral situated displays , which give physical presence to digital information. We investigate three central dimensions: energy sources, display technologies, and wireless communications. Based on the power implications from our analysis, we present a thin, wireless, photovoltaic-powered display that is quick...
Conference Paper
Full-text available
Platypus is the first system to localize and identify people by remotely and passively sensing changes in their body electric potential which occur naturally during walking. While it uses three or more electric potential sensors with a maximum range of 2 m, as a tag-free system it does not require the user to carry any special hardware. We describe...
Data
South Asian replication cohort description. (DOCX)
Data
South Asian GWAS–Association of SNPs with WHR by chromosome position. (A) Additive inheritance model. (B) Dominant inheritance model. (C) Recessive inheritance model. (TIF)
Data
South Asian GWAS–Relationship of observed association statistics with those expected under the null distribution. (A) Additive inheritance model (Lambda = 1.025). (B) Dominant inheritance model (Lambda = 1.015). (C) Recessive inheritance model (Lambda = 1.015). (TIF)
Data
South Asian exome-array analysis–Association of SNPs with WHR by chromosome position. (TIF)
Data
Characteristics of participants in the genotyping cohorts. (DOCX)
Data
South-Asian GWAS targeted analysis of population-specific SNPs. Relationship of observed association statistics with those expected under the null distribution (MAF>2%, Lambda = 1.022). (TIF)
Data
Genotyping cohort platforms and quality metrics. (DOCX)
Data
Comparison of 48 known WHR SNPs in South Asians (N = 12,240; extended analysis) and Europeans. (DOCX)
Data
South Asian exome-array analysis–Relationship of observed association statistics with those expected under the null distribution (Lambda = 0.996). (TIF)
Data
Known WHR SNPs. (A) Comparison of risk allele frequencies in South Asians, extended analysis (N = 12,240) and Europeans (reported). (B) Comparison of effect sizes (β WHR) in South Asians and Europeans, extended analysis. Green–men and women combined (37 SNPs in South Asians (N = 12,240) and Europeans (reported)); orange–women alone (11 SNPs in Sout...
Data
Study power to identify single variants associated with variation in WHR amongst South Asians, and replicate known WHR SNPs amongst South Asians. (DOCX)
Data
South Asian GWAS–Top ranking single markers at P<1x10-5 under an additive, dominant and recessive inheritance models inheritance model. (DOCX)
Data
South Asian exome-array analysis–Top ranking single markers at P<1x10-3, with replication among South Asians (GWAS) and Europeans (GIANT consortium meta-analysis [20]). (DOCX)
Data
South Asian exome-array analysis–Top ranking gene-based association results at P<1x10-3. (DOCX)
Data
South Asian GWAS targeted analysis–Top ranking population-specific markers under an additive inheritance model. (DOCX)
Article
Researchers have studied pervasive computing in many domains, but few are as complex as the home. Decades of early-adopter use of smart home technologies have blazed the path and highlighted numerous research challenges. Today, the long-standing vision of pervasive computing, commonly referred to as the Internet of Things, is finally starting to co...
Article
Full-text available
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new a...
Article
Full-text available
This paper explores the contribution that pragmatist philosophy can make to the way that we do research and teaching in human geography. It provides a historical overview of the key ideas in the tradition, their influence on the Chicago School of Sociology and community organizing, and the implications of this work for epistemological practice. The...
Chapter
In-home deployments can be used to study current behavior patterns or to evaluate prototype systems. Compared to other options such as lab studies, interviews, or surveys, in-home deployments offer unparalleled realism due to the in-situ nature of the deployment as part of the participants' normal lives. However, in-home deployments require careful...
Conference Paper
Full-text available
BACKGROUND: There is no standard treatment for patients with recurrent malignant gliomas (MGs) and after antiangiogenic therapy, 15% recur in a distant location suggesting the development of VEGF independent invasive mechanisms. We hypothesized that p75NTR expression could be associated to the pattern of recurrence/progression in patients with MGs...
Patent
Full-text available
Power transfer between devices such as laptop computers, mobile phones, personal digital assistants, media players and other devices is described. In an embodiment power transfer is achieved either from a power source at a device or to a power source at that device using a bidirectional power transfer connector. In some embodiments a power manageme...
Conference Paper
A key challenge for intelligent domestic heating systems is to obtain sufficient knowledge of the thermal dynamics of the home to build an adaptive thermal model. We present a study where stochastic grey-box modelling is used to develop thermal models and an extended Kalman filter is used for parameter estimation for a room in a family home.
Article
People respond emotionally to other people, animals, or even objects like furniture. While current furniture is static in appearance, embedded electronics can enable furniture to change its appearance. A couch could show excitement during a party or anger when a pet scratches it. But would emotional furniture delight or annoy people? To explore the...
Article
Furniture is the building block of the spaces we inhabit. Its design and its functions shape how we use spaces, as individuals and as groups. While being an integral part of our lives, furniture is unaware of what happens around it. But what if furniture could change its appearance? What situations should it respond to? How might it communicate its...
Conference Paper
We present Picco, a tiny situated display for drawings and simple animations, which are created on a dedicated tablet app. Picco was designed to support playful messaging in the workplace through a glanceable desktop device that would place minimal demands on users. Two studies of the device at work demonstrated how crafting was an expression of in...