James Randall

• Limestone College

Background: In this study, we evaluated the potential of DNA polymerase epsilon (POLE) and DNA polymerase delta 1 (POLD1) as prognostic biomarkers for immune checkpoint inhibitor (ICI) treatment in patients with advanced stage non-small cell lung cancer (NSCLC). Methods: Disease stage, PD-L1 positivity, histological subtypes, POLE/POLD1 mutation...

PURPOSE We developed a deep neural network that queries the lung computed tomography–derived feature space to identify radiation sensitivity parameters that can predict treatment failures and hence guide the individualization of radiotherapy dose. In this article, we examine the transportability of this model across health systems. METHODS This mu...

Purpose/Objective(s) In order for deep learning (DL) models to successfully predict local recurrence of lung tumors from image-based features, uncertainties of the model must be quantified. One potential source of uncertainty for the DL model is lung tumor motion. We aimed to evaluate the association of motion magnitude with the prediction accuracy...

Purpose/Objective(s) The current standard of thoracic stereotactic body radiotherapy (SBRT) relies on varied dose prescriptions and is not currently guided by individual tumor features. A deep neural network (DNN) was previously developed that queries thoracic computer tomography (CT)-derived feature space and identifies radiation sensitivity param...

Background Image guided radiotherapy (IGRT) has made multiple advances that allow for more precise delivery of dose. Incorporation of magnetic resonance imaging (MRI) into workflows has provided the next incremental step. MRI capable linear accelerators (MR-Linac) provides the ability for treatment adaptation and replanning, which requires signific...

Image-guided radiotherapy (IGRT) enables optimal tumor targeting and sparing of organs-at-risk, which ultimately results in improved outcomes for patients. Magnetic resonance imaging (MRI) revolutionized diagnostic imaging with its superior soft tissue contrast, high spatiotemporal resolution, and freedom from ionizing radiation exposure. Over the...

Introduction Deep learning (DL) models that use medical images to predict clinical outcomes are poised for clinical translation. For tumors that reside in organs that move, however, the impact of motion (i.e., degenerated object appearance or blur) on DL model accuracy remains unclear. We examine the impact of tumor motion on an image‐based DL fram...

Advances in image-guided radiotherapy have brought about improved oncologic outcomes and reduced toxicity. The next generation of image guidance in the form of magnetic resonance imaging (MRI) will improve visualization of tumors and make radiation treatment adaptation possible. In this review, we discuss the role that MRI plays in radiotherapy, wi...

Introduction Deep learning (DL) models that use medical images to predict clinical outcomes are poised for clinical translation. For tumors that reside in organs that move, however, the impact of motion ( i.e . degenerated object appearance or blur) on DL model accuracy remains unclear. We examine the impact of tumor motion on an image-based DL fra...

This work firstly addresses the microwave-assisted, catalytic, hydrothermal liquefaction (MAC-HTL) of a mixture of pine and spruce biomass, examining the effects of the temperature (150-250 ºC), pressure (50-120 bar), time (0-2 h) and catalyst amount (Ni-Co/Al-Mg; 0-0.25 g catalyst/g biomass). This hydrothermal process turned out to be a very promi...

This first issue of Ploughshares 40th anniversary volume year features selections of poetry and prose made by award-winning writer Colm Tibn, including new work from poets such as Eavan Boland, Nick Laird, Paul Muldoon, CK Williams, and Bruce Bond, and prose writers Tessa Hadley, Thomas Mallon, Rabih Alameddine, Ewa Hryniewicz-Yarbrough, and Hester...

Technical specifications are essential for procuring first quality equipment. Newly revised standards from the American Petroleum Institute are in the final stages of preparation for a critical group of equipment for the chemical process industries: positive displacement (PD) pumps. The currently established standards in this application are formal...

Typescript. Thesis (Ph. D.)--University of Illinois at Urbana-Champaign, 1990. Vita. Includes bibliographical references (leaves 84-88). Available on microfilm from University Microfilms.

Thesis (Ph.D.)--Cornell University, Aug., 2004. Includes bibliographical references.

Vita. Thesis (Ph. D.)--Pennsylvania State University.

Thesis (M.S.)--Pennsylvania State University.

Thesis (M.M. Ed.)--Lamar University. Includes bibliographical references (leaves 86-91). Vita. Microfilm. s

To the Editor:— Your special report on Henry Fuseli's painting, "The Nightmare," written by Jerome M. Schneck, MD, recalled to mind some remarks by Dr. Kurt R. Eisseler. As a discussant by invitation at a scientific session of the Psychoanalytic Association of New York, Dr. Eisseler observed that the only way the unconscious being can say "no" or...