James Potchen

• MD
• Chair at Michigan State University

Power! Where will it come from, how safe will it be? The concern of the ecologists and the finite limit of natural resources have forced our power-hungry society to thoughtfully consider answers to these questions. This book is the outgrowth of a local meeting to appraise the Minnesota state law which requires more stringent controls for nuclear po...

In this interview, a representative of academe (E. James Potchen) and one from industry (Bill Clarke) discuss the ways in which their interests intersect for the good of U.S. patients. The focus here is on imaging, which shows great promise in transforming medical treatment from invasive practices involving hospital stays to imaging procedures that...

All decisions made under conditions of uncertainty have error rates. All meaningful decisions are made under conditions of uncertainty. Can this uncertainty be measured? Can variations in how different observers deal with this uncertainty be ascertained? The ability to measure observer performance in diagnostic imaging was one of the issues that in...

Massachusetts Institute of Technology, Alfred P. Sloan School of Management. Thesis. 1973. M.S. MICROFICHE COPY ALSO AVAILABLE IN DEWEY LIBRARY. Unnumbered leaf inserted after leaf 52. Includes bibliographical references. by Edgar H. Twine [and] E.J. Potchen. M.S.

Disease is the product of how the genes of individuals relate to the environment. The answer to why some people will contract a disease upon exposure (e.g., tuberculosis) and others will not is found in the makeup of the genome of each individual. The human genome is the blueprint of life; it provides the recipe for the anatomy, susceptibility, and...

Information is the key to practicing modern medicine. A radiologist provides information to patients, to the team that works with the radiologist, and to other healthcare providers. Information is defined as diminished randomness. Radiologists add value by decreasing randomness or diminishing uncertainty. They are in the business of uncertainty red...

This paper reports an application of magnetic resonance imaging (MRI) to the study of penetration by waterborne wood preservatives into wood. Samples of three wood species, red maple (Acer rubrum L.), ponderosa pine (Pinus ponderosa Dougl. ex Laws.), and aspen (Populus tremuloides), containing different anatomical features such as sapwood, heartwoo...

The value of diagnostic radiology rests in its ability to provide information. Information is defined as a reduction in randomness. Quality improvement in any system requires diminution in the variation in its performance. The major variation in performance of the system of diagnostic radiology occurs in observer performance and in the communicatio...

The hypothesis that increased muscle T2 after exercise is caused by increased extracellular fluid volume was tested by comparing the effects of exercise versus external leg negative pressure on muscle T2 relaxation in normal human subjects. T2 in lower leg muscles was measured by echo-planar imaging at 63 echo times from 24 to 272 ms, and the relax...

Concerns about legal implications affect many decisions of the average radiologist, and physicians do not always appreciate the validity of these concerns. However, such concerns often influence radiologists' decisions more than is warranted. An improved understanding of the law and its ramifications may serve to prevent adverse legal effects found...

This paper describes the history of mammography quality assurance legislation in Michigan, the first of its kind in the nation. It discusses the collaboration of multiple organizations in the legislative process as well as in the implementation of it. It describes the effect of the legislation on the quality of mammography throughout the state and...

Magnetic resonance images of plant tissues typically are manifestations of water protons in tissues. Within oilseeds, however, lipids contain a major portion of the mobile protons, which should enable specific imaging of lipids. In this study, experiments were done to demonstrate spin-echo imaging (SEI) and chemical-shift imaging (CSI) of lipid wit...

THE AMERICAN Medical Association (AMA) has participated in the accreditation of educational programs since the first publication of an "ideal standard" for undergraduate medical education in 1905. This report is to inform the House of Delegates of the current status of accreditation activities in undergraduate, graduate, and continuing medical educ...

Data obtained on 426 consecutive patients referred to a breast center by 122 physicians, including family practitioners, general surgeons, and other specialists, showed that the obstetricians-gynecologists referred the greatest average number of patients per physician, with more than 50% of these referrals for screening mammography. Internists refe...

Magnetic resonance imaging using a 1.5 tesla magnet and a spin echo technique has revealed a remarkably intense signal from abnormal tissue in the human paranasal sinuses. Inflammatory disease in the maxillary, sphenoid, ethmoid, and frontal sinuses has been detected and demonstrated with greater clarity than any other available technique. The path...

An information-theoretic pattern recognition method was used to construct descriptive models of data related to 1,674 radioisotope lung scan referrals for the purpose of assessing lung scan influence on diagnosis and management of pulmonary embolism. It was observed that, relative to other clinical information available prior to the scan, the lung...

An algorithm was devised for the evaluation of patients with acute head trauma. The effectiveness of this strategy was tested with a retrospective chart review of 608 patients seen in a community hospital emergency room. The results of the algorithmic approach were compared to the original management of the patients. A financial savings of 65% was...

A significant proportion of diagnostic medical procedures are used in response to public or private policy rather than in response to an individual patient-physician interaction. We have studied the system whereby such policies are developed and implemented in the case of employment-related chest and lumbar spine roentgenograms, which were found to...

A case is described in which renal arteriography and Gelfoam embolization were used to diagnose and treat an arterio-caliceal fistula of traumatic origin.

We assume that clinical judgment is a complex, multi-dimensional process. We will attempt to examine the process in terms of one dimension of the patient-physician interaction, i.e., that dimension which relates to the generation and use of clinical data. We propose that although the flow of data between the clinician and his patient is meaningful,...

We have discussed alternative diagnostic strategies in patients with potential or established cerebral metastases prior to the initiation of steroid and radiotherapy. This approach is based upon the potential information content that can be attained from alternative diagnostic techniques in the face of a spectrum of clinical symptoms. There is obvi...

This article has no abstract; the first 100 words appear below. Approximately 14 years ago the Committee on Radiology of the National Research Council embarked on a program to publish a series of tumor atlases similar in concept to the eminently successful Atlas of Tumor Pathology published by the Armed Forces Institute of Pathology. The project wa...

The blood clearance of canine fibrinogen labeled with radioactive iodine by the chloramine-T method has been examined in dogs, and the distribution of *I studied with a gamma scintillation camera. The labeled fibrinogen prepared by this method is more than 85 per cent clottable, but less than 20 per cent of the label remains attached to the fibrino...

In his New Horizons for Radiologists Lecture, the author points to a synergy between radiology and physiology. He first emphasizes radiology's role in applying photons to develop our knowledge of cardiovascular pathophysiology, particularly the cardiac ejection fraction and myocardial dyssynergy. He then turns to the microvascular system. Subtopics...

What is nuclear medicine? This book characterizes the dilemma in defining a discipline. Although well written, the work is a poorly balanced compilation of "wet-tests" and other peripherally related topics. Specific areas are excellent. Dr. Raeside is to be complimented for his section on classical physics, which is an excellent overview of a very...

The effects of dexamethasone were investigated in experimental brain edema induced by triethyl tin intoxication and cerebral microembolism. Large doses of steroid (1.25 mg/kg/day) significandy reduced brain water and sodium in triethyl tin poisoned rats. However, in experimental microembolism, steroids had no effect on mortality, severity of edema,...

Nuclear medicine laboratories are currently evaluating regional physiology by the use of lung perfusion and ventilation scans. The standard lung perfusion scan has an important and accepted position in the clinical detection of pulmonary emboli. Ventilation quantitation by several techniques are under investigation in many laboratories. We have sur...

The medical elite, defined as the leaders of medical thought, obtain their position largely through the addition of research and teaching responsibilities to patient care. Professor Miller, a sociologist, spent 18 months with the interns at Boston City Hospital to "clarify the processes by which new members of the medical profession are recruited f...

Using a dual isotope technique we have identified regional characteristics of microvascular permeability to macromolecules in the rat. Much of the difference between organs is consistent with the electron microscopic observations of different capillary endothelia. Although cardiac and skeletal muscle have similar endothelial anatomy we discerned a...

Mechanisms for localization of radionuclides in soft tissue tumors are discussed in relationship to a sequential observation of the label from the time it enters the intravascular space until the time it can be identified in a tumor in greater concentration than in surrounding normal structures. In the case of soft tissue lymphoma identification wi...

What is basic science? How does it relate to modern medicine? More important, how can priorities in scientific endeavor affect the future of man? In an effort to answer these questions, the National Academy of Science, through its Committee on Science and Public Policy, undertook a massive statement-ofthe-arts survey which is condensed in this book...

This is an outstanding book! The Rockefeller Foundation study group chose Dr. Bryant to present their material on health care in developing countries. The title is somewhat forbidding and may limit reader appeal; however, the book contains the most moving series of case histories I have ever read. Dr. Bryant successfully presents in a highly readab...

Of 50 patients with brain abscess 16 underwent brain scanning with 203Hg chlormerodrin, 197Hg chlormerodrin, and 99mTc pertechnetate; scans were positive in all cases. In addition, 2 patients with surgically proved Herpes simplex encephalitis showed positive scans. Autopsy in 1 revealed numerous smaller abscesses scattered throughout the brain in a...

"The effort to understand the only being who has made an effort to understand will keep man occupied, one suspects, for a long time to come." Considerations of our very existence are amply put forth by the contributors to this discussion resulting from the Nobel conference at Gustavus Adolphus College in 1968. This book presents a series of papers...

A model is proposed whereby serum albumin synthesis is expressed in terms of production of inorganic sulfate in the liver or in the entire organism, following the administration of 35S-l-cystine. The feasibility of the proposed method was tested by comparing the synthesis rate of rat serum albumin with the catabolic rate of the radioiodinated prot...

Morbidity and possible mortality associated with contrast angiography lead to its cautious use. A noninvasive method for screening and further delineating known abnor- malities would be welcomed. This article reviews the initial results and application of MR imaging to vascular imaging in the head and neck. By using the three-dimensional phase-sens...

Traducción de: Principles of diagnostit radiology Incluye bibliografía e índice

The rapid growth of nuclear medicine is largely due to our ability to map out the anatomic deposition of radionuclides. These scintiscanning techniques are uniquely useful in assessing some alterations in regional physiology. Although many recent books contain similar material, Clinical Scintillation Scanning is the most comprehensive text devoted...

This authoritative monograph represents the definitive treatise on a narrow subject, one which will interest physicians dealing with spinal cord disease. The authors have developed clinical techniques to identify the spinal cord vessels. The book emphasizes myelography and selective angiography, while at the same time recognizing the limitations of...

THE COMPLEXITY of data retrieval and burdensome calculations have limited the wide-spread application of the multiprobe inert gas method to the clinical assessment of regional cerebral blood flow (rCBF). Lassen1 has attempted to overcome this obstacle by observing the analogue readout of the early curve slope as an index of rCBF. Their approach is...

THE CLINICAL determination of the regional cerebral blood flow (rCBF), based upon the inert gas washout technique of Kety and Schmidt1 and developed by Lassen, Ingvar, Hø-Rasmussen et al2-5 has become an established procedure in many laboratories. This technique is currently advocated as the most physiologic means to measure regional blood flow and...

The clinical application of radionuclides to medical care has burgeoned in the past decade. Some 15 years ago, the first edition of Quimby, Fidelberg, and Silver entitled Radioactive Isotopes in Medicine was widely received as an authoritative book and was a forerunner of modern texts in nuclear medicine. As with the second edition, Dr. Silver now...

The radiologic assessment of renal blood flow leaves much to be desired. The orthoiodohippurate renogram measures an integration of many variables including blood flow, tubular enzymatic function, tubular transport, and renal pelvic storage. The mercury renogram is even more complex. These technics are therefore useful only as an index of total ren...

Indium In 113m, a generator-produced radionuclide, has been useful as a protein-bound metal and a colloidal aggregate to scan the cardiac blood pool, placenta, liver, spleen, bone marrow, lung, and brain. The wide applicability and ease of preparation in addition to the physical characteristics of this radiopharmaceutical suggest that it may well b...