About
9
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Introduction
Postdoctoral Research Fellow at the Tasmanian Centre for Mental Health Service Innovation
Current institution
Additional affiliations
August 2015 - August 2018
January 2014 - July 2014
Publications
Publications (9)
Psychostimulants, such as amphetamine, are widely used to treat attentional deficits. In humans, response to dopaminergic medications is complex with improvement often dependent on baseline performance. Our goal was to determine if attention in rats could be improved by low dose amphetamine in a baseline-dependent manner by examining the relationsh...
Considerable evidence suggests that the learning and performance of instrumental actions depends on activity in basal ganglia circuitry; however, these two functions have generally been considered independently. Whereas research investigating the associative mechanisms underlying instrumental conditioning has identified critical cortical and limbic...
The posterior dorsomedial striatum (pDMS) is necessary for goal-directed action;
however, the role of the direct (dSPN) and indirect (iSPN) spiny projection neurons in the pDMS in such actions remains unclear. In this series of experiments, we examined the role of pDMS SPNs in goal-directed action in rats and found that whereas dSPNs were critical...
Studies in rodents have described a prefrontostriatal network that functions as a learning and memory system to encode and retrieve goal-directed actions. Prelimbic cortex (PL) plays a key role in the encoding process as a form of short-term working memory for specific action-outcome associations that are then encoded in the posterior dorsomedial s...
The posterior dorsomedial striatum (pDMS) is necessary for goal-directed action, however the role of the direct (dSPN) and indirect (iSPN) spiny projection neurons in the pDMS in such action remains unclear. In this series of experiments, we examined the role of pDMS SPNs in goal-directed action and found that, whereas dSPNs were critical for goal-...
Neuropsychiatric research has utilised cognitive testing in rodents to improve our understanding of cognitive deficits and for preclinical drug development. However, more sophisticated cognitive tasks have not been as widely exploited due to low throughput and the extensive training time required. We developed a modified signal detection task (SDT)...
