James G Ndukui

The Catholic University of Eastern Africa · Nursing

Background The emergence and spread of Extended-spectrum β-lactamases (ESBLs) in Enterobacteriaceae through the plasmid-mediated exchange have become a major threat to public health by complicating the treatment of severe infections in both animals and humans. Therefore, the current study focused on evaluating the manifestation of ESBLs production...

Background: Antibiotic resistance is putting the commercial poultry production systems across the globe at risk of losses due to the failure of treatments for animals and human health which has been associated with overuse and misuse of antibiotics in poultry farming. One possible approach to the resistance problem is ensuring adequate knowledge, a...

Abstract Introduction: In the last two decades, the treatment of enteric infections has been complicated by the emergence of antimicrobial resistant strains. Occurrence of multidrug resistant Extended Spectrum Beta Lactamase (ESBL) producing Enterobactaeraceae poses the greatest risk to public health by raising morbidity and mortality by six folds...

Cite this article: Kateregga JN, Atuheire C, Nalunga J, James N. Effect of antiretroviral drugs on the renal function of HIV seropositive patients attending ISS clinic of Mulago Hospital, Uganda. Ann Biotechnol. 2018; 4: 1016. Abstract Background: Highly Active Antiretroviral Therapy (HAART) consisting of at least three active drugs against HIV inf...

Background: Multidrug resistant tuberculosis is the TB bacilli revealing resistance to at least isoniazid and/or rifampicin drugs. Tuberculosis is one of the world's leading causes of adult morbidity and mortality with an estimated 8.8 million incident cases and 1.4 million deaths in 2010 mainly in Sub-Saharan Africa. The etiologic agents are Mycob...

Background: Consumption of bottled water is increasing rapidly in developing countries as it is generally perceived to be pure, clean and of good quality. This has led to the sale of different brands of bottled water in several markets including Kitale town. Aim of the Study: This study was conducted to assess the bacteriological quality of bottled...

This study was conducted in three districts (Moroto, Nakapiripirit and Napak) of Karamoja Region, Uganda, to identify and document indigenous knowledge of the pastoralists regarding the control of helminthosis and ticks. Participatory methods in form of focus group discussions (30) with livestock keepers (9-12 per group) in 30 settlement areas (man...

Resistance to extended-spectrum cephalosporins among Enterobacteriaceae has been reported yet they serve as the last line treatment for severe infections in Uganda and other countries. This resistance often leads to nosocomial infection outbreaks and therapeutic failures from multidrug resistant bacteria. The main objective of this study was to det...

This was an experimental study carried out to evaluate the hematological and histopathological effects of cyanobacteria (blue-green algae) collected from Lake Victoria shores in Swiss mice. A crude aqueous cyanobacterial extract was prepared by oven drying the cyanobacteria previously preserved in 4% formalin at 45oC. First, the acute toxicity of t...

Ethnopharmacological relevance: Plectranthus amboinicus is used in traditional medicine to treat several diseases and ailments including opportunistic infections associated with HIV/AIDS. However, there is little insight as to the possible toxic effects of this herbal formulation on major organ systems of the body. This study was designed to ass...

The study evaluated effect of aqueous leaf extracts of C. articulata and M. aethiopicum on serum levels of testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin in male albino rats as well as on organ weights and histological structure of the testis. The phytochemical composition of the extracts was also qualitati...

The study was conducted to validate the anti diarrheal activity of ethanolic fresh root bark extract of Mondia whitei using white albino rats. We also determined the acute toxicity and phytochemical composition of the extract. The study was carried out in May, 2013. The ethanolic extract of root bark of Mondia whitei was evaluated for castor oil in...

Ginger (Zingiber officinale) has for long been used as an anti-sore throat remedy in African societies. This study evaluated the in-vitro activity of ethanol and hexane rhizome extracts of ginger against Streptococcus pyogenes, the most common bacterial cause of the condition and determined the levels of selected phytochemicals in the extracts. Gin...

Aim: This study was designed to evaluate the antidiarrheal activity of ethanolic leaf extract of Leonotis nepetifolia in wistar albino rats. Methods: This study was done in February 2013. The ethanolic leaf extract of L. nepetifolia was evaluated for its antidiarrheal activity. A total of sixty rats were used in the study. At first, thirty rats in...

Aim: Many serious adverse effects of new xenobiotics are detected thorough toxicological studies. In this present study, the safety profile of C.articulata L. (Rutaceae) and M.aethiopicum (Celastraceae) leaf aqueous extracts was evaluated by acute and sub-chronic toxicity tests in male wistar rats. Methods: Acute oral toxicity was investigated in 8...