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Publications (59)
Purpose: To evaluate the safety and efficacy of primary photodynamic therapy (PDT) for posterior choroidal amelanotic melanomas.
Methods: Patients with posterior choroidal amelanotic melanomas up to 6 mm in height were treated with PDT using verteporfin as the photosensitizing agent. Treatment was repeated every 3 months until the tumor was flat u...
Purpose:
Aniridia is a congenital disorder caused by variants in thePAX6gene. In this study, we assessed the involvement ofPAX6in patients with aniridia from Australasia and Southeast Asia.
Methods:
Twenty-nine individuals with aniridia from 18 families originating from Australia, New Caledonia, Cambodia, Sri Lanka, and Bhutan were included. The...
Purpose:
To determine the incidence of endophthalmitis in a large clinical series using aqueous chlorhexidine for antisepsis before intravitreal injection and to review the ophthalmic literature regarding chlorhexidine efficacy and safety.
Design:
Multicenter retrospective case series.
Participants:
All patients receiving intravitreal injectio...
Purpose:
To determine and compare the major causes of childhood blindness and severe visual impairment in Bhutan and Laos.
Design:
Independent cross-sectional surveys.
Methods:
This survey consists of 2 cross-sectional observational studies. The Bhutanese component was undertaken at the National Institute for Vision Impairment, the only dedica...
Background:
To investigate visual and anatomical outcomes in eyes with exudative age-related macular degeneration treated with intravitreal aflibercept following prior treatment with intravitreal ranibizumab.
Materials and methods:
Retrospective, single-center study of 192 eyes treated with 0.5 mg intravitreal ranibizumab every 4 weeks for three...
Limited data are available about cataract surgery outcomes from developing regions in South-East Asia, but are necessary to monitor the impact of ongoing program delivery as outlined in the World Health Organization Vision 2020 directives.
We conducted a retrospective cohort study of 488 eyes of 449 patients who had undergone cataract surgery in 20...
Background
Ocular surface squamous neoplasia (OSSN) characterized by diffuse conjunctival or corneal spread is much less common than localized conjunctival disease. However, it is an important subcategory of the disease because of the difficulty it poses to treatment. It is rarely amenable to simple excision, and a purely surgical approach usually...
To report rates of recurrence and complications of localised ocular surface squamous neoplasia treated with 5-fluorouracil or mitomycin C as adjunctive treatment to surgical excision.
Long-term follow-up of two prospective, non-comparative interventional case series.
153 eyes with histologically confirmed localised, non-invasive ocular surface squa...
There are over 300 million people living in the world today who are visually impaired and a further 45 million who are blind. The large majority (90%) of these people live in developing countries and up to 75% of the blindness are avoidable. With cataracts being the major cause of blindness and visual impairment, many ophthalmic aid programmes are...
Vientiane Province is an urbanizing region in Southeast Asia. We aimed to determine the prevalence of refractive error and visual impairment in primary school-aged children in this region.
Prospective, cross-sectional survey.
A total of 2899 schoolchildren from Vientiane Province, Lao People's Democratic Republic (Lao PDR).
Ten districts from Vient...
To assess the prevalence of refractive error in schoolchildren aged 12-14 years in urban and rural settings in Cambodia's Phnom Penh and Kandal provinces.
Ten schools from Phnom Penh Province and 26 schools from Kandal Province were randomly selected and surveyed in October 2010. Children were examined by teams of Australian and Cambodian optometri...
Anterior segment dysgenesis describes a group of heterogeneous developmental disorders that affect the anterior chamber of the eye and are associated with an increased risk of glaucoma. Here, we report homozygous mutations in peroxidasin (PXDN) in two consanguineous Pakistani families with congenital cataract-microcornea with mild to moderate corne...
To report the outcome of treatment of localised non-invasive ocular surface squamous neoplasia (OSSN) where topical 5-fluorouracil (5-FU 1%) is used as an adjuvant to surgical excision.
The study was a prospective non-comparative interventional case series. 55 cases of primary localised OSSN and 10 cases of recurrent localised OSSN were treated wit...
To estimate the proportion of cataract surgery performed at various visual acuity and lens opacity thresholds that would coincidentally treat early angle-closure disease, and to estimate the effect of this surgery on the incidence of primary angle-closure glaucoma.
Cross-sectional, population-based survey in Meiktila, Myanmar.
Total of 2076 inhabit...
To report the distribution of histopathological diagnoses in patients who underwent excision of localised limbal lesions that were clinically suspected to be squamous neoplasia (intra-epithelial neoplasia or squamous cell carcinoma).
162 consecutive patients of a single ocular oncologist underwent an excisional biopsy between 1998 and 2009 for susp...
To identify the causes of blindness and severe visual impairment (BL/SVI) in children attending schools for the blind in Sri Lanka, and to provide optical devices and ophthalmic treatment where indicated.
Two hundred and six children under 16 years from 13 schools for the blind in Sri Lanka were examined by a team of ophthalmologists and optometris...
To identify the causes of blindness and severe visual impairment (BL/SVI) in children attending four schools for the blind in Cambodia and to provide spectacles, low vision aids, orientation and mobility training and ophthalmic treatment.
Children < 16 years of age were recruited from all 4 schools for the blind in Cambodia. Causes of visual impair...
AIM To report the outcome of treatment of non-invasive ocular surface squamous neoplasia (or conjunctival-corneal intra-epithelial neoplasia (CCIN)) where topical mitomycin C (MMC) has been used in the treatment regimen. DESIGN Prospective, non-comparative interventional case series. PARTICIPANTS 91 primary or recurrent CCIN lesions from 90 patient...
To investigate the efficacy of intravitreal bevacizumab for the treatment of neovascular age-related macular degeneration (AMD) using an as required dosing regimen.
A retrospective study of 210 patients (231 eyes) with choroidal neovascularization resulting from neovasacular AMD. Patients were treated with 1.25 mg intravitreal bevacizumab at a vitr...
To determine the causes of visual impairment and blindness amongst children in schools for the blind in Myanmar; to identify the avoidable causes of visual impairment and blindness; and to provide spectacles, low vision aids, orientation and mobility training and ophthalmic treatment where indicated.
Two hundred and eight children under 16 years of...
To report on the use of Mitomycin-C as adjuvant therapy to excision and cryotherapy in patients with sebaceous gland carcinoma (SGC) in high-risk locations.
Retrospective, consecutive, case series.
Three patients with SGC of the upper palpebral conjunctiva or caruncle, but without clinical pagetoid spread.
Following excision and double freeze-thaw...
Purpose:
The aim of this study is to determine the cataract surgical coverage and investigate the barriers to cataract surgery as reported by those with cataract-induced visual impairment in rural Myanmar.
Methods:
A cross-sectional, population-based survey of inhabitants 40 years of age and over from villages in the Meiktila District (central M...
To describe the ocular biometry and determinants of refractive error in an adult population in Myanmar.
A cross-sectional, population-based survey of the inhabitants 40 years of age and over from villages in the Meiktila District was performed; 2481 eligible participants were identified, and 2076 participated in the study. Biometric components incl...
To determine the prevalence of and risk factors for cataracts in a rural region of central Myanmar.
A cross-sectional, population-based survey of inhabitants >or=40 years of age from villages of central Myanmar; 2076 participated, and 2044 (82.3%) had an examinable lens in at least one eye. Data recording included smoking history, occupation, educa...
The aim of this study was to report on the prevalence and correlates of pseudoexfoliation syndrome (PXF) in a rural Burmese population.
The study was a cross-sectional, population-based survey of the inhabitants > or =40 years in the Meiktila District. Ophthalmic examination included Snellen visual acuity, slit lamp examination, tonometry, goniosco...
To evaluate the safety and efficacy of intravitreal injection of bevacizumab as a treatment option for radiation maculopathy secondary to plaque radiotherapy.
Interventional case series of five patients who developed radiation maculopathy complicating plaque radiotherapy with ruthenium 106 for choroidal melanoma. One to two intravitreal injections...
To report a group of children with neurofibromatosis type 1 and orbital plexiform neurofibroma who developed axial myopia in the associated eye.
The clinical records and imaging of 3 patients with neurofibromatosis type 1 and orbital plexiform neurofibromas were reviewed.
Three patients were identified who were diagnosed with orbital plexiform neur...
To determine correlates of central corneal thickness (CCT) and its relationship to intraocular pressure (IOP) in a Burmese population.
We performed a population-based survey of inhabitants 40 years or older in Myanmar; of 2076 participants, data from 1909 nonglaucomatous subjects who underwent ultrasound pachymetry and Goldmann applanation tonometr...
To determine the prevalence and risk factors for anisometropia in a rural adult population in central Myanmar.
A population-based ophthalmic survey was conducted in rural villages in central Myanmar. Ansiometropia was assessed in subjects with phakic eyes. The severity of anisometropia was defined as the absolute difference of the spherical equival...
Background:
Diabetes is an increasing problem in Myanmar with more than three million people affected. There are no data on awareness of diabetic retinopathy among the general practitioners (GPs) or diabetic population of Myanmar. This study aims to evaluate the awareness of diabetes-related eye disease among GPs and diabetic patients in Yangon, M...
To determine risk factors for early angle-closure disease (AD) in a Burmese population.
A cross-sectional, population-based survey of the inhabitants, 40 years of age and over, from villages in the Meiktila District was performed; 2481 eligible participants were identified, 2076 participated in the study, and 2050 could be categorized as having ear...
Ethmoidal pneumocele is a rare condition with little known about its etiology. We report a 5-year-old boy who had recurrent right orbital cellulitis, non-axial proptosis, and inferolateral globe displacement. Initial radiological investigations demonstrated an ethmoidal mucocele. There was complete resolution of inflammatory signs with endoscopic d...
To determine the prevalence of refractive error and associated risk factors in the Meiktila District of central rural Myanmar.
Population-based cross-sectional study.
Randomized stratified cluster sampling of the inhabitants 40 years or older from villages in Meiktila was performed; 2481 eligible participants were identified, 2076 participated in t...
To determine the prevalence and causes of visual impairment in the Meiktila district of central, rural Myanmar.
Population-based cross-sectional study.
Random, stratified, cluster sampling of the inhabitants 40 years of age and older from villages in the Meiktila district was performed; 2481 eligible participants were identified and 2076 participat...
To report the risk factors associated with primary open-angle glaucoma (POAG) in the Burmese population.
The Meiktila Eye study, a population-based cross-sectional study, included inhabitants 40 years of age and over from villages in the Meiktila District. Of 2481 eligible participants identified, 2076 participated in the study and sufficient exami...
Eyelid colobomas are congenital defects caused by failure of fusion of the mesodermal lid folds.1,2 The timing and approach to surgical repair depend on the severity of the defect and exposure keratopathy.1-7 Tarsomarginal grafts have been well described in eyelid reconstructions following tumor excision.8,9 Descriptions of lid coloboma repair usin...
We report the case of a systemically well 4-year-old Aboriginal boy who developed a choroidal abscess after being poked in the left eye with a blunt object.
This boy presented with redness and reduced vision in the left eye after a blunt object was poked into his eye by his sibling. He was noted to have a choroidal mass which finally manifested as...
To determine the prevalence of preglaucomatous angle-closure disease in central Myanmar.
A population-based survey of inhabitants >or=40 years in the Meiktila District was carried out; 2481 subjects were identified, 2076 participated and 2060 underwent gonioscopy of at least one eye. Eyes with angles traditionally described as "occludable" were rec...
To determine the prevalence of glaucoma in the Meiktila district of central, rural Myanmar.
A cross-sectional, population-based survey of inhabitants > or =40 years of age from villages in Meiktila district, Myanmar, was performed; 2481 eligible participants were identified and 2076 participated in the study. The ophthalmic examination included Sne...
To describe the prevalence of trachomatous trichiasis and corneal opacity (CO) within central Myanmar.
Population-based cross-sectional ophthalmic survey.
Random, stratified, cluster sampling of the inhabitants > or =40 years of age from villages in the Meiktila District was performed; 2481 eligible participants were identified and 2076 participate...
To determine the complications associated with mitomycin C (MMC) in the treatment of ocular surface neoplasia.
A retrospective and consecutive study of 100 eyes in 91 patients with ocular surface neoplasia treated with MMC in a single centre between November 1998 and January 2005. Outcome measures included complications of MMC and the treatment req...
Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is a pigmented fundus lesion associated with familial adenomatous polyposis (FAP). CHRPE prevalence has been reported to be increased in subjects with familial or sporadic non-polyposis colorectal cancer (CRC), suggesting that some individuals with non-polyposis CRC have an attenuated...
An unusual presentation of sebaceous carcinoma of the eyelid is described in a 96-year-old man who presented with a large papillomatous palpebral conjunctival lesion in the left upper eyelid. The patient underwent a shave excision of the lesion, followed by a full thickness excision with paraffin section margin control. Histopathology revealed a se...
Aberrant facial nerve regeneration (AFR) following facial nerve palsy may give rise to ptosis because of increased orbicularis tone. We describe a series of patients presenting with ptosis where the underlying aetiology of AFR was often not recognized by the referring clinicians.
Retrospective case review.
A total of 15 cases with ptosis, secondary...
To report the outcome of topical mitomycin C (MMC) used as adjunctive treatment following primary excision of ocular surface squamous neoplasia (OSSN).
Prospective, non-comparative interventional case series of 27 primary OSSN lesions from 26 patients treated in a single ocular oncology centre over a 4 year period.
27 cases of OSSN received a treat...
Retinoblastoma is the most common malignant ocular tumour of childhood. It results from mutations in the retinoblastoma gene, RB1, which may be sporadic or heritable. Only 10-25% of patients have a family history of retinoblastoma and can be assumed to have a heritable RB1 mutation. A small proportion of the remaining patients may have a heritable...
Steroid-induced ocular hypertension is generally attributed to alterations in the trabecular meshwork, reducing aqueous outflow.
A case with several episodes of steroid-induced ocular hypertension is presented. Later, with unremitting intraocular pressures above 50 mmHg, despite maximal hypotensive medication, there is evidence of extensive failure...
