
James Lyons-WeilerIndependent Researcher · Administration
James Lyons-Weiler
Doctor of Philosophy
About
40
Publications
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Introduction
After a hiatus (of writing three books), primary research is coming back into my life. Pediatric dosing of aluminum, traumatic brain injury, mechanisms of action of hyperbaric oxygen therapies, biomarkers to avoid adverse events from vaccines (vaccine risk screening). Reviews forthcoming on microglial activations and pathophysiologies of autism. Past collaborators please feel free to share your new research with me, I read thousands of studies per year.
Publications
Publications (40)
Controversy over a reported increase in office visits specifically scheduled for illnesses and conditions in children has stalled progress in understanding adverse outcomes associated with an increasingly crowded schedule of pediatric vaccines. Studies finding associations between vaccines and adverse conditions have been targeted for retraction. H...
We report flaws and inconsistencies in a critically important study of autism risk following maternal Tdap vaccination. The authors of the 2018 study, Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder (BC18), concluded that Tdap gestational vaccination is not associated with increased autism risk and claimed...
Human evolution sits at several important thresholds. In organic evolution, interplay between exogenous environmental and genetic factors rendered new phenotypes at rates limited by genetic variation. The interplay took place on adaptive fitness landscapes determined by correspondence of genetic and environmental relationships. Human evolution invo...
No published assessment of revenue variation associated with variance in pediatric vaccine uptake exists. Using data from patients in a pediatric practice that provides full-service with informed consent, we provide a detailed analysis of the financial realities of respecting informed consent and allowing parents to exercise their legal right to re...
Response to anonymous critic who contacted the journal and requested that our study be retracted because people might stop using the MMR vaccine if they learn about the toxicity of aluminum in pediatric vaccines (even though the MMR does not contain any aluminum).
COVID-19 public health responses, including lockdowns and diagnostic testing strategies, have had consequences. Economic costs (see the CHD paper in this issue) could reach $16 trillion dollars, 90% of the US annual GDP. While harm to small businesses, unemployment, worsening poverty, death from cancer, increased suicides, social isolation, and res...
It’s not the public that needs more monitoring and oversight: it is the US regulatory agency of public health network and the pharmaceutical companies that run them. In this paper, I provide a blueprint for a bona fide public health infrastructure based on independence of freedom from corporatism.
We performed a retrospective analysis spanning ten years of pediatric practice focused on patients with variable vaccination born into a practice, presenting a unique opportunity to study the effects of variable vaccination on outcomes. The average total incidence of billed office visits per outcome related to the outcomes were compared across grou...
Fibrosis is a chronic disease with heterogeneous clinical presentation, rate of progression, and occurrence of comorbidities. Systemic sclerosis (scleroderma, SSc) is a rare rheumatic autoimmune disease that encompasses several aspects of fibrosis, including highly variable fibrotic manifestation and rate of progression. The development of effectiv...
Background:
The COVID-19 pandemic has placed significant stressors on the medical community and on the general public. Part of this includes patients skipping well-child visits to reduce risk of exposure to SARS-CoV-2 virus. Published estimates of the duration of whole-body aluminum (Al) toxicity from vaccines in infants from birth to six months i...
Homology between human and viral proteins is an established factor in viral- or vaccine-induced autoimmunity. Failure of SARS and MERS vaccines in animal trials involved pathogenesis consistent with an immunological priming that could involve autoimmunity in lung tissues due to previous exposure to the SARS and MERS spike protein. Exposure pathogen...
Like the mechanisms of action as adjuvants, the pharmacodynamics of injected forms of aluminum commonly used in vaccines are not well-characterized, particularly with respect to how differences in schedules impact accumulation and how factors such as genetics and environmental influences on detoxification influence clearance. Previous modeling effo...
FDA regulations require safety testing of constituent ingredients in drugs (21 CFR 610.15). With the exception of extraneous proteins, no component safety testing is required for vaccines or vaccine schedules. The dosing of aluminum in vaccines is based on the production of antibody titers, not safety science. Here we estimate a Pediatric Dose Limi...
Neurodevelopmental disorders, including Autism Spectrum Disorders, have a complex biological and medical basis involving diverse genetic risk and myriad environmental exposures. Teasing apart the role of specific stressors is made challenging due to the large number of apparently contributing associations, gene X environment interactions and phenom...
Mycobacterium tuberculosis (Mtb) is a global health threat, compounded by the emergence of drug-resistant strains. A hallmark of pulmonary tuberculosis (TB) is the formation of hypoxic necrotic granulomas, which upon disintegration, release infectious Mtb. Furthermore, hypoxic necrotic granulomas are associated with increased disease severity and p...
Personalized medicine has failed to prove sufficiently disruptive to existing medico-pharma paradigms to yield its true translational potential. The result has been market capture via. addiction of health providers to mandated health insurance. Forthcoming regulatory controls limiting innovation have stymied the full translation of 30 years of rese...
Preface by Richard Frye, MD, PhD
Autism Spectrum Disorder (ASD) has grown tremendously in prevalence over the last several decades. While 30 years ago this disorder was considered rare, it now has become very common, affecting about 2% of children. This is more than many childhood diseases which have launched campaigns to eradicate and find cures...
ABSTRACT
Pathologies associated with Zika virus infection include partial progressive paralysis (Guillan Barre Syndrome) and microcephaly in Brazil and Panama. We identified an 85 nucleotide stem loop structure in the 3' end of Zika virus sfRNA (position (343-428) with the canonical structural and sequence characteristics of a miRNA. In comparison,...
Phenylalanine hydroxylase deficient phenylketonuria (PKU) is the paradigm for a treatable inborn error of metabolism where maintaining plasma phenylalanine (Phe) in the therapeutic range relates to improved clinical outcomes. While Phe is the presumed intoxicating analyte causal in neurologic damage, the mechanism(s) of Phe toxicity has remained el...
While phenylalanine (PHE) is the toxic insult in phenylketonuria (PKU), mechanisms underlying PHE toxicity remain ill-defined. Altered DNA methylation in response to toxic exposures is well-recognized. DNA methylation patterns were assessed in blood and brain from PKU patients to determine if PHE toxicity impacts methylation. Methylome assessment,...
Misfolded membrane proteins are retained in the endoplasmic reticulum (ER) and subject to ER associated degradation, which clears the secretory pathway of toxic species. While the transcriptional response to environmental stressors has been extensively studied, limited data exist describing the response to misfolded membrane proteins. We hypothesiz...
The book is a narrative of the unfolding of the Ebola virus disease outbreak from a scientific view point. The author provides an analysis of the scientific basis of public health policies that have influenced the public′s, and the medical community′s, abilities to understand the virus and the disease. This is done in the context of providing insig...
We have recently reported the creation and initial characterization of an etiology-based recombinant mouse model of a severe and inherited form of Major Depressive Disorder (MDD). This was achieved by replacing the corresponding mouse DNA sequence with a 6-base DNA sequence from the human CREB1 promoter that is associated with MDD in individuals fr...
Background
Circadian gene disruptions are associated with the development of psychiatric disorders, including addiction. However, the mechanisms by which circadian genes regulate drug reward remain poorly understood.
Methods
We used mice with a mutation in Npas2, and AAV-shRNA mediated knock-down of Npas2 and Clock in the nucleus accumbens (NAc)....
Maternal PKU Syndrome (MPKU) is an embryopathy resulting from in utero phenylalanine (PHE) toxicity secondary to maternal phenylalanine hydroxylase deficient phenylketonuria (PKU). Clinical phenotypes in MPKU include mental retardation, microcephaly, in utero growth restriction, and congenital heart defects. Numerous in utero toxic exposures alter...
Breast cancer still imposes significant healthcare burden on women worldwide. Mammography is currently the benchmark for screening, but mammography may not; a) detect all early stage breast cancers especially in young women with dense breast, b) unequivocally distinguish between benign disease and cancer and c) be beneficial to people in remote and...
A test that can detect the influence of differential lineage sorting on phylogenetic signal in integrated studies with two
or more loci is presented. Hitherto unexplored consequences of relationships among gene trees and species trees are made explicit,
revealing potential influences of differential lineage sorting on phylogenetic signal. These inf...
Questions
Question (1)
Esp considering your 2004 study "Frequent Simian Foamy Virus Infection in Persons Occupationally Exposed to Nonhuman Primates", it would seem rational to follow-up on cancer rates, etc given the multinucleation especially. -JLW