James M Hyman

James M Hyman
University of Nevada, Las Vegas | UNLV · Department of Psychology

Ph.D.

About

34
Publications
8,274
Reads
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1,933
Citations
Introduction
Projects include examining the interactions between the anterior cingulate cortex and hippocampus during goal-directed behavior, neural prediction error at a single cell and LFP level in the ACC, and how chronic neuroimflammation affects ACC and HC spatial working memory.
Additional affiliations
July 2007 - July 2014
University of British Columbia - Vancouver
Position
  • University of British Columbia
September 2000 - May 2007
Boston University
Position
  • PhD Student
August 1997 - August 1998
Virginia Commonwealth University
Position
  • Research Assistant

Publications

Publications (34)
Article
The function of the anterior cingulate cortex (ACC) remains controversial, yet many theories suggest a role in behavioral adaptation, partly because a robust event-related potential, the feedback-related negativity (FN), is evoked over the ACC whenever expectations are violated. We recorded from the ACC as rats performed a task identical to one tha...
Article
Full-text available
Consolidation studies show that, over time, memory recall becomes independent of the medial temporal lobes. Multiple lines of research show that the medial frontal cortex, including the anterior cingulate cortex (ACC), is involved with contextual information processing and remote recall. We hypothesize that interactions between the ACC and hippocam...
Article
We navigate through space using the coordinated activity of spatially sensitive cells in the hippocampus. A new study shows that moderate prenatal alcohol exposure alters multiple features of hippocampal spatial responses, leading to inflexible and less precise representations of our surroundings.
Article
Violent behavior is the product of a diverse network of neural structures. A new study shows that the anterior cingulate cortex is important for helping to restrain overly aggressive acts, even within a fight, to ensure animals match their behavioral intensity with the challenge posed by their opponents.
Article
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Diabetes mellitus is a metabolic disease associated with dysregulated glucose and insulin levels and an increased risk of developing Alzheimer’s disease (AD) later in life. It is thought that chronic hyperglycemia leads to neuroinflammation and tau hyperphosphorylation in the hippocampus leading to cognitive decline, but effects on hippocampal netw...
Article
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In recent years, two separate research streams have focused on information sharing between the medial prefrontal cortex (mPFC) and hippocampus (HC). Research into spatial working memory has shown that successful execution of many types of behaviors requires synchronous activity in the theta range between the mPFC and HC, whereas studies of memory c...
Article
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Unlabelled: The frontal cortex has been implicated in a number of cognitive and motivational processes, but understanding how individual neurons contribute to these processes is particularly challenging as they respond to a broad array of events (multiplexing) in a manner that can be dynamically modulated by the task context, i.e., adaptive coding...
Article
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The feedback-related negativity (FRN) refers to a difference in the human event-related potential (ERP) elicited by feedback indicating success versus failure: the difference appears negative when subtracting the success ERP from the failure ERP (Miltner, Braun, and Coles, 1997). Although source localization techniques (e.g., BESA) suggest that the...
Article
Full-text available
The function of a given brain region is often defined by the coding properties of its individual neurons, yet how this information is combined at the ensemble level is an equally important consideration. We recorded multiple neurons from the anterior cingulate cortex (ACC) and the dorsal striatum (DS) simultaneously as rats performed different sequ...
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When performing sequences of actions, we constantly keep track of our current position in the sequence relative to the overall goal. The present study searched for neural representations of sequence progression in corticostriatal circuits. Neurons within the anterior cingulate cortex (ACC) and its target region in the dorsal striatum (DS) were reco...
Article
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Apart from being associated with working memory, neurons in the rodent medial prefrontal cortex (mPFC) are known to be involved in encoding of spatial and temporal contexts [1], the deduction of rules [2], and decision making [3]. The context-dependent organization of neural assemblies encoding for different task events, stimuli or decisions [3,4],...
Article
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Foraging typically involves two distinct phases, an exploration phase where an organism explores its local environment in search of needed resources and an exploitation phase where a discovered resource is consumed. The behavior and cognitive requirements of exploration and exploitation are quite different and yet organisms can quickly and efficien...
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Full-text available
Although there are numerous theories regarding anterior cingulate cortex (ACC) function, most suggest that it is involved in some form of action or outcome processing. The present study characterized the dominant patterns of ACC activity on a task in which actions and outcomes could vary independently. Patterns of activity were detected using a mod...
Article
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Contextual representations serve to guide many aspects of behavior and influence the way stimuli or actions are encoded and interpreted. The medial prefrontal cortex (mPFC), including the anterior cingulate subregion, has been implicated in contextual encoding, yet the nature of contextual representations formed by the mPFC is unclear. Using multip...
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There has been considerable interest in the importance of oscillations in the brain and in how these oscillations relate to the firing of single neurons. Recently a number of studies have shown that the spiking of individual neurons in the medial prefrontal cortex (mPFC) become entrained to the hippocampal (HPC) theta rhythm. We recently showed tha...
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Brain stimulation and imaging studies in humans have highlighted a key role for the prefrontal cortex in clinical depression; however, it remains unknown whether excitation or inhibition of prefrontal cortical neuronal activity is associated with antidepressant responses. Here, we examined cellular indicators of functional activity, including the i...
Article
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Performance of memory tasks is impaired by lesions to either the medial prefrontal cortex (mPFC) or the hippocampus (HPC); although how these two areas contribute to successful performance is not well understood. mPFC unit activity is temporally affected by hippocampal-theta oscillations, with almost half the mPFC population entrained to theta in b...
Conference Paper
A multitude of theories have attempted to describe the complex and elusive function of the prefrontal cortex (PFC). Most accounts have been based on the behaviorally specific deficits that lesions cause. However imaging and recording studies have revealed similar activity during PFC-dependent and PFC-independent tasks (see Hyman et al. abstract). W...
Conference Paper
The traditional localization viewpoint in neuroscience is based on the assumption that damage or activation of a specific region provides information about the normal function of the region. Damage to the primate and rodent prefrontal cortex (PFC) affects only a small number of complex tasks (e.g. working memory, set shifting, conflict and response...
Article
Introduction The local field potential from the hippocampus of an awake, stationary animal is filled with seemingly random low-amplitude high-frequency activity and arrhythmic high-amplitude low-frequency activity. To the untrained eye it is nearly impossible to discern any clear patterns or relationships of the signal to behavior, as the local fie...
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Both the hippocampus and the medial prefrontal cortex are essential for successful performance in learning- and memory-related tasks. Within the hippocampus the theta rhythm plays an integral role in the timing of action potentials of hippocampal neurons responding to elements of any given task. Medial prefrontal cortex (mPFC) neurons display firin...
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Experimental evidence suggests that the hippocampal theta rhythm plays a critical role in learning. Previous studies have shown long-term potentiation (LTP) to be preferentially induced with stimulation on the peak of local theta rhythm in region CA1 in anesthetized rats and with stimulation of the perforant path at the peak of theta in both anesth...
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These experiments examine changes in theta power as measured by wavelet analysis in five rats performing a conditional visual discrimination task and a simple running task. In the conditional task, rats were trained to press one lever to initiate a trial and then to press one of two choice levers, each corresponding to one of two cue lights. Analys...
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Phencyclidine (PCP) produces psychotomimetic effects in humans that resemble schizophrenia symptoms. In an effort to screen compounds for antipsychotic activity, preclinical researchers have investigated whether these compounds block PCP-induced behaviors in animals. In the present study, the atypical antipsychotic clozapine was tested in combinati...
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Full-text available
Patients with schizophrenia exhibit a number of behavioral and physiological abnormalities which are reflected in their EEG activity. In rats, repeated exposure to the psychostimulant D-amphetamine models many of the behavioral and anatomical pathologies observed in schizophrenic patients, such as disruptions of prepulse- and latent- inhibition and...

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