James Folsom

James Folsom
Lonza Specialty Ingredients · R&T

Ph. D.

About

13
Publications
3,668
Reads
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561
Citations
Additional affiliations
October 2016 - present
Lonza Bioscience
Position
  • Sr. Research Microbiologist
May 2015 - August 2016
Lonza Bioscience
Position
  • Sr. Research Microbiologist
July 2009 - February 2014
Montana State University
Position
  • PostDoc Position
Education
August 1999 - May 2006
University of Georgia
Field of study
  • Food Science & Technology
August 1996 - May 1999
University of Georgia
Field of study
  • Food Science & Technology
August 1993 - June 1996
University of Georgia
Field of study
  • Food Science & Technology

Publications

Publications (13)
Article
Full-text available
Escherichia coli physiological, biomass elemental composition, and proteome acclimations to ammonium-limited chemostat growth were measured at four levels of nutrient scarcity controlled via chemostat dilution rate. These data were compared to published iron- and glucose-limited growth data collected from the same strain and at the same dilution ra...
Article
Enhanced tolerance of biofilm-associated bacteria to antibiotic treatments is likely due to a combination of factors that include changes in cell physiology as the bacteria adapt to biofilm growth and inherent physiological heterogeneity of biofilm bacteria. A transcriptomics approach was used to identify genes differentially regulated during biofi...
Article
Full-text available
Elementary flux mode analysis (EFMA) decomposes complex metabolic network models into tractable biochemical pathways, which have been used for rational design and analysis of metabolic and regulatory networks. However, application of EFMA has often been limited to targeted or simplified metabolic network representations due to computational demands...
Article
Full-text available
Iron bioavailability is a major limiter of bacteria growth in mammalian host tissue and thus represents an important area of study. Escherichia coli K-12 metabolism was studied at four levels of iron limitation in chemostats using physiological and proteomic analyses. The data documented an E. coli acclimation gradient where progressively more seve...
Article
The purpose of this study was to evaluate the antimicrobial efficacy of thirteen bismuth thiol preparations for bactericidal activity against established biofilms formed by two bacteria isolated from human chronic wounds. Single species biofilms of a Pseudomonas aeruginosa or a methicillin-resistant Staphylococcus aureus were grown in either colony...
Data
Full-text available
P. aeruginosa transcriptional profiling data sets used for comparison with colored symbol key.
Conference Paper
Evolutionary selection has produced fit microbes capable of adapting their metabolic functioning to cope with competitive environments while utilizing limited resource pools. Physiological and proteomic characteristics of Escherichia coli cultures grown in either nitrogen- or iron-limited chemostat conditions were predicted and interpreted using an...
Article
Full-text available
Transcriptome analysis was applied to characterize the physiological activities of Pseudomonas aeruginosa grown for three days in drip-flow biofilm reactors. Conventional applications of transcriptional profiling often compare two paired data sets that differ in a single experimentally controlled variable. In contrast this study obtained the transc...
Article
Full-text available
Following exposure of Listeria monocytogenes Scott A (SA) to hypochlorous acid, rough colony variants were identified that were tolerant of hypochlorous acid and produced increased amounts of biofilm. A derivative of one of these variants was smooth, produced even more biofilm, and exhibited greater biofilm chlorine resistance. The objective of thi...
Article
Full-text available
Strains of Listeria monocytogenes vary in their ability to produce biofilms. This research determined if cell density, planktonic chlorine resistance, or subtype are associated with the resistance of L. monocytogenes biofilms to chlorine. Thirteen strains of L. monocytogenes were selected for this research based on biofilm accumulation on stainless...
Article
Full-text available
Strains of Listeria monocytogenes differ in their ability to form biofilms. The objectives of this study were to determine whether genetically related strains have similar biofilm-forming capacities and what effect nutrient concentration has on the ability of different strains to produce biofilms. Biofilms of 30 strains of L. monocytogenes, obtaine...
Article
Full-text available
Exposure of Escherichia coli O157:H7 to chlorine before heat treatment results in increased production of heat shock proteins. Current heating regimens for pasteurizing apple cider do not account for chlorine exposure in the wash water. This research determined the effect of sublethal chlorine treatment on thermal inactivation of E. coli O157:H7. D...

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