James Patrick Farmer

James Patrick Farmer
Queen's University | QueensU · Department of Ophthalmology

About

39
Publications
2,295
Reads
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293
Citations
Citations since 2017
14 Research Items
179 Citations
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2017201820192020202120222023010203040
2017201820192020202120222023010203040

Publications

Publications (39)
Article
Purpose: We describe a case vision-threatening sclerouveitis as a probable adverse drug reaction to ibrutinib. Methods: Case report. Results: Ibrutinib is an inhibitor of Bruton's kinase which has shown success in the treatment of hematological malignancies such as chronic lymphocytic leukemia. Despite being generally well tolerated, recent studi...
Article
Vitamin D has emerged as a potentially important molecule in ophthalmology. To date, all ophthalmic data pertaining to vitamin D has been restricted primarily to tear and serum analysis in human patients. Considering the isolated nature of the eye, we sought to determine the presence of intraocular vitamin D in ocular disease. Methods: 25-hydroxy...
Article
Objective: To implement a double-staining technique to identify the most sensitive and specific combinations of melanoma antigen recognized by T cells (Melan-A), microphthalmia-associated transcription factor (MITF), human melanoma black 45 (HMB45), and Ki67 aiming to assist in the diagnosis of atypical melanocytic conjunctival lesions that are mo...
Article
Objective: Giant cell arteritis (GCA) is a systemic vasculitis, affecting medium- and large-sized vessels. Temporal artery biopsies (TABs) are currently the benchmark for diagnosing suspected cases of GCA. Often, the temporal artery is "skeletonized," and surrounding soft tissue is discarded at the time of biopsy. The purpose of this study was to...
Article
Purpose: Intratarsal keratinous cysts (IKCs) are a recently described entity that is frequently misdiagnosed clinically as chalazia and mislabeled in the literature as "intratarsal epidermal inclusion cysts" or "epidermoid cysts." It is important to accurately diagnose IKCs and distinguish them from chalazia because IKCs require a complete surgica...
Article
We report the case of an 11-year-old girl with a rare finding of silicone oil migration into the periorbital space surrounding an extraocular muscle, discovered during strabismus surgery for a sensory exotropia that had developed after retinal detachment repair by pars plana vitrectomy with intraocular silicone oil. © 2018 American Association for...
Article
Full-text available
Purpose: To determine the positive yield (utility rate) of temporal artery biopsy (TAB) in patients with suspected giant cell arteritis (GCA). Study Design: Systematic review (CRD42017078508) and meta-regression. Materials and Methods: All articles concerning TAB for suspected GCA with English language abstracts from 1998 to 2017 were retrieved. Ar...
Article
Full-text available
Purpose A patient’s presentation and clinical diagnosis can at times be clouded by their past medical history. Clinicians’ anchoring bias towards initial information, such as a history of cancer, may lead them astray when creating a differential diagnosis for a patient who presents with new signs and symptoms of a mass lesion, assuming metastatic d...
Article
Objective Temporal artery biopsy (TAB) is the gold standard for confirming the diagnosis of giant cell arteritis (GCA) when positive. However, the clinical significance of healed/healing (HH) arterial injury on TAB is not well understood. The purpose of this study was to evaluate the clinical significance of this finding on TAB by determining its a...
Article
Periorbital infections after strabismus surgery are rare. We describe the first reported case of necrotizing group A streptococcal infection of the conjunctiva and Tenon's capsule complicating uneventful strabismus surgery in a 23-month-old boy, successfully managed with conservative intraoperative debridement and with targeted local and systemic a...
Article
We report a case of a 44-year-old man who presented with a left medial canthal mass and epiphora. Imaging was suggestive of a mass continuous with the nasolacrimal sac. Subsequent surgical exploration revealed a mass adherent to bone with invasion of the lacrimal system. Histological examination revealed a squamous/transitional cell papilloma overl...
Article
Purpose: To investigate the effect of anti-inflammatory therapy on selective laser trabeculoplasty (SLT) outcomes. Design: Randomized, double-masked, placebo-controlled trial. Participants: Patients with primary open-angle or pseudo-exfoliation glaucoma. Methods: Patients undergoing SLT were randomized to receive placebo (artificial tears),...
Article
Importance Immunohistochemical analyses may assist in the diagnosis of precancerous and cancerous conjunctival lesions.Objective To use Vector Red (VR) to identify an immunologic marker that is sensitive for all melanocytes and another that is sensitive and specific for activated and/or atypical conjunctival melanocytic lesions (MLs).Design, Sett...
Article
Salivary gland lymphoproliferative disorders (SGLD) are very rare tumors and clinicopathological data is sparse. In a Canadian series of 30 cases, extracted from the surgical pathology files of The Ottawa Hospital between 1990 and 2010, a clinical, histopathological, and immunophenotypic analysis was conducted. Tumors were staged using the Ann Arbo...
Article
Full-text available
Malignant melanoma of the conjunctiva is a relatively infrequent neoplasm that can be associated with significant morbidity and cause diagnostic difficulty to both the ophthalmologist and pathologist. We herein describe the first reported case in North American and European databases of a rare variant-signet ring cell melanoma - arising in the back...
Article
Full-text available
We present a case of an unusual retinal infiltrate requiring retinal biopsy for definitive diagnosis. A 62-year-old man with treated lymphoma presented with decreased vision in the right eye associated with a white retinal lesion, which extended inferonasally from an edematous disc. Intraocular lymphoma was considered as a diagnosis; thus, the pati...
Article
Objective: To report three cases of malignant melanoma of the uvea that were diagnosed by aspiration biopsy of the intraocular tumors, using three different aspiration techniques. Methods: In Case 1, fine-needle aspiration biopsy was used. In Case 2, tumor excision was performed by internal resection and aspiration. In Case 3, bilateral vitreous he...
Article
Full-text available
Background: Conjunctival lymphoproliferative lesions have not been selected for independent analysis with newer immunohistochemical and molecular genetic techniques to highlight their unique profile. Methods: Retrospective case series examined biopsies from 16 consecutive patients with conjunctival lymphoproliferative lesions. The histopathologi...
Article
Full-text available
Case report: A 57-year-old woman presented with a 16-month history of a slowly growing mass in the medial aspect of her right lower eyelid. On radiologic examination, the mass was seen to extend into the anterior orbit. Initial attempt at excision was complicated by problems with hemostasis and only a portion was removed. Histopathologic examinati...
Article
To report a patient with conjunctival T-cell lymphoma, an extremely rare entity. Single case report. Based on clinical examination, an excisional biopsy and immunostaining were performed on the conjunctival lesion. For management, we excised and performed triple freeze-thaw cryotherapy to the involved area, and we consulted the oncology service. T-...
Article
Objective: To report 3 cases of malignant melanoma of the uvea that were diagnosed by aspiration biopsy of the intraocular tumors, using 3 different aspiration techniques. Methods: In Case 1, fine-needle aspiration biopsy was used. In Case 2, tumor excision was performed by internal resection and aspiration. In Case 3, bilateral vitreous hemorrhage...
Article
Lacrimal gland lymphoproliferative disorders are usually classified as orbital adnexal tumours. Because the lacrimal gland is the only orbital structure with native lymphocytes, we examined cases with primary involvement of the gland. The 14 cases were selected from a review of all cases in the surgical pathology files of the Ottawa Hospital betwee...
Article
Objective: To report 3 cases of malignant melanoma of the uvea that were diagnosed by aspiration biopsy of the intraocular tumors, using 3 different aspiration techniques. Methods: In Case 1, fine-needle aspiration biopsy was used. In Case 2, tumor excision was performed by internal resection and aspiration. In Case 3, bilateral vitreous hemorrhage...
Article
Maintenance of a normal to low intraocular pressure during ocular surgery is of critical importance. The prime considerations for anaesthetic management include adequate depth of anaesthesia, normal carbon dioxide and arterial oxygen tensions, stable cardiovascular status and avoidance of stimuli likely to raise central venous pressure. Non-depolar...

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