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Publications (248)
The increase of brain dimensions and complexity has characterized the evolution of the genus Homo. According to the available fossil and genetic evidence, a crucial stage came before the divergence of Neanderthals, Denisovans and Homo sapiens , during the Middle Pleistocene. We consider a specimen of about 400 ka, whose phenotype is at the roots of...
One of the features that distinguishes modern humans from our extinct relatives and ancestors is the globular shape of the braincase. As the endocranium closely mirrors the outer shape of the brain, these differences might reflect altered neural architecture. However, in the absence of fossil brain tissue the underlying neuroanatomical changes as w...
During collation of the Supplemental Information for this article, a formatting error occurred that affected the small values that were in scientific notation in the original text file. All data values reported in the paper and shown in the figures are correct, and this error in formatting the Supplemental Information for publication did not have a...
One of the features that distinguishes modern humans from our extinct relatives and ancestors is a globular shape of the braincase [1–4]. As the endocranium closely mirrors the outer shape of the brain, these differences might reflect altered neural architecture [4, 5]. However, in the absence of fossil brain tissue, the underlying neuroanatomical...
Background
This is one of the first studies to examine the structural brain anatomy and connectivity associated with an ADHD diagnosis and child as well as adult ADHD symptoms in young adults. It was hypothesized that an adult ADHD diagnosis and in particular childhood symptoms, are associated with widespread changes in the brain macro- and microst...
JAC Map-Diagnosis.
(GZ)
Axial Diffusivity Map-Adult Symptoms.
(GZ)
White Matter-Diagnosis.
(GZ)
Fractional Anisotropy Map-Diagnosis.
(GZ)
Mean Diffusivity Map-Diagnosis.
(GZ)
Mean Diffusivity Map-Childhood Symptoms.
(GZ)
Radial Diffusivity Map-Childhood Symptoms.
(GZ)
Axial Diffusivity Map-Childhood Symptoms.
(GZ)
Fractional Anisotropy Map-Adult Symptoms.
(GZ)
Radial Diffusivity Map-Adult Symptoms.
(GZ)
Study Specific Anatomical Template.
(GZ)
Grey Matter Map-Diagnosis.
(GZ)
Radial Diffusivity Map-Diagnosis.
(GZ)
Axial Diffusivity Map-Diagnosis.
(GZ)
Fractional Anisotropy Map-Childhood Symptoms.
(GZ)
Mean Diffusivity Map-Adult Symptoms.
(GZ)
The cover image, by Fabio Macciardi et al., is based on the Research Article LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family, DOI: 10.1002/ajmg.b.32437.
Epigenetic programming and reprogramming are at the heart of cellular differentiation and represent developmental and evolutionary mechanisms both in germ-line and somatic cell lines. Only about 2% of our genome is composed of protein-coding genes, while the remaining 98%, once considered "junk" DNA, codes for regulatory/epigenetic) elements that c...
Recent studies show that human-specific LINE1s (L1HS) play a key role in the development of the central nervous system (CNS) and its disorders, and that their transpositions within the human genome are more common than previously thought. Many polymorphic L1HS, that is, present or absent across individuals, are not annotated in the current release...
Transposable Elements (TEs) or transposons are low-complexity elements (e.g., LINEs, SINEs, SVAs, and HERVs) that make up to two-thirds of the human genome. There is mounting evidence that TEs play an essential role in genomic architecture and regulation related to both normal function and disease states. Recently, the identification of active TEs...
Functional brain imaging is a common tool in monitoring the progression of neurodegenerative and neurological disorders. Identifying functional brain imaging derived features that can accurately detect neurological disease is of primary importance to the medical community. Research in computer vision techniques to identify objects in photographs ha...
A neural probe device includes a housing configured to receive a nerve fiber of a subject and an anchor disposed within the housing and configured to fix the nerve fiber relative to the housing. The device further includes a plurality of actuatable, moveable electrodes disposed in the housing along a length of the nerve fiber, each moveable electro...
We investigated the genome-wide distribution of CNVs in the Alzheimer's Disease (AD) Neuroimaging Initiative (ADNI) sample (146 with AD, 313 with Mild Cognitive Impairment (MCI), and 181 controls). Comparison of single CNVs between cases (MCI and AD) and controls show overrepresentation of large heterozygous deletions in cases (p-value<0.0001). The...
Careful selection of the reference region for non-quantitative positron emission tomography (PET) analyses is critically important for Region of Interest (ROI) data analyses. We introduce an empirical method of deriving the most suitable reference region for computing neurodegeneration sensitive (18)fluorodeoxyglucose (FDG) PET ratios based on the...
The imaging genetics approach to studying the genetic basis of disease leverages the individual strengths of both neuroimaging and genetic studies by visualizing and quantifying the brain activation patterns in the context of genetic background. Brain imaging as an intermediate phenotype can help clarify the functional link among genes, the molecul...
The dorsolateral prefrontal cortex (DLPFC) is a brain region that has figured prominently in studies of schizophrenia and working memory, yet the exact neuroanatomical localization of this brain region remains to be defined. DLPFC primarily involves the superior frontal gyrus and middle frontal gyrus (MFG). The latter, however is not a single neuro...
Working memory studies in schizophrenia (SZ), using functional magnetic resonance imaging (fMRI) and univariate analyses, have led to observations of hypo- or hyperactivation of discrete cortical regions and subsequent interpretations (e.g. neural inefficiencies). We employed a data-driven, multivariate analysis to identify the patterns of brain-be...
We previously demonstrated that infusion of transforming growth factor (TGF)-alpha after chronic middle cerebral artery occlusion (MCAO) stimulates stem and progenitor cell proliferation, migration, and neuronal differentiation associated with the amelioration of neurologic impairment. But the use of TGF-alpha in humans is impeded by impracticality...
The authors compared regional cerebral blood flow in the brains of 12 psychiatric patients who completed the act of suicide with groups of healthy and nonsuicidal depressed subjects using statistical parametric mapping. Results were consistent with prior imaging studies on depression and were indicative of impaired impulse control and limbic dysreg...
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
QT analysis of SNPs associated with genes or chromosomal regions as reported in Table 3 of the manuscript. Physical map of the SNPs associated with genes or chromosomal regions in the ADNI sample produced by WGAViewer. The top of the figure is the ideogram of the chromosome; the vertical red line depicts the relative location of locus of interest....
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
Quantitative trait analysis for the interaction between left and right hippocampi for the SNPs and related genes or chromosomal regions listed in Table 3 of the manuscript. The SNP chromosome, gene, base-pair position, rs number, consequence type and SNP alleles are presented. The p-values for the left and right hippocampi indicate the interaction...
We studied the neural correlates of rapid eye movement during sleep (REM) by timing REMs from video recording and using rapid event-related functional MRI. Consistent with the hypothesis that REMs share the brain systems and mechanisms with waking eye movements and are visually-targeted saccades, we found REM-locked activation in the primary visual...
Cortico-limbic brain activity associated with anger may be susceptible to nicotine and, thus, may contribute to smoking initiation and nicotine addiction. The purpose of the study was to identify the brain regions that are most reactive to nicotine and show the greatest association with anger task performance. Twenty adult nonsmokers (9 women, 11 m...
Metabolic averages in response to nicotine versus placebo associated with anger provocation. The data provide means and standard deviations for each region of interest in response to nicotine and placebo.
We have discovered two genes, RSRC1 and ARHGAP18, associated with schizophrenia and in an independent study provided additional support for this association. We have both discovered and verified the association of two genes, RSRC1 and ARHGAP18, with schizophrenia. We combined a genome-wide screening strategy with neuroimaging measures as the quanti...
Transforming growth factor-alpha (TGFalpha) is a powerful endogenous mitogen and neurotrophic factor, which has previously been shown to induce a massive proliferative response in the brains of Parkinson's disease model rats injured by an acute neurotoxic lesion. We now show that TGFalpha can also produce a massive proliferative response in rat bra...
With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown.
We completed a genome-wide association study on 381 participants in the ADNI (Alzheimer's Disease Neuroimaging Initiative) study. Samples were genotyped using the Illumina Human610-Quad BeadChip. 516,645 unique Single Nucle...
Genome-wide association studies (GWASs) are increasingly used to identify risk genes for complex illnesses including schizophrenia. These studies may require thousands of subjects to obtain sufficient power. We present an alternative strategy with increased statistical power over a case-control study that uses brain imaging as a quantitative trait...
Evidence is presented to show that cells of the ependymal layer surrounding the ventricles of the mammalian (rat) forebrain act as neural stem cells (NSCs), and that these cells can be activated to divide by a combination of injury and growth factor stimulation. Several markers of asymmetric cell division (ACD), a characteristic of true stem cells,...
