James Clinton Dooley

James Clinton Dooley
Purdue University | Purdue · Department of Biological Sciences

Doctor of Philosophy
I study how self-generated movements—including twitches produced during sleep—promote age-appropriate development.

About

32
Publications
9,387
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480
Citations
Introduction
Infants continually explore and interact with the world around them, and these experiences are critical for normal sensorimotor development. Although it’s generally assumed that the important movements occur while we’re awake, my lab’s research calls this assumption into question. Specifically, I’ve found that myoclonic twitches (brief movements produced during REM sleep) drive neural activity throughout the brain that, in turn, promotes sensorimotor integration and development.
Additional affiliations
January 2016 - September 2022
University of Iowa
Position
  • PostDoc Position
September 2009 - December 2015
University of California, Davis
Position
  • PhD Canidate
January 2008 - June 2009
University of Chicago
Position
  • Undergraduate Volunteer

Publications

Publications (32)
Article
Full-text available
In developing rats, behavioral state exerts a profound modulatory influence on neural activity throughout the sensorimotor system, including primary motor cortex (M1). We hypothesized that similar state-dependent modulation occurs in prefrontal cortical areas with which M1 forms functional connections. Here, using 8- and 12-day-old rats cycling fre...
Article
A defining feature of early infancy is the immense neural plasticity that enables animals to develop a brain that is functionally integrated with a growing body. Early infancy is also defined as a period dominated by sleep. Here, we describe three conceptual frameworks that vary in terms of whether and how they incorporate sleep as a factor in the...
Preprint
Full-text available
In developing rats, behavioral state exerts a profound modulatory influence on neural activity throughout the sensorimotor system, including primary motor cortex (M1). We hypothesized that similar state-dependent modulation occurs in higher-order cortical areas with which M1 forms functional connections. Here, using 8- and 12-day-old rats cycling f...
Article
Introduction Myoclonic twitches are abundantly produced during REM sleep in skeletal muscles across the body. In infant rats, movements are produced by the red nucleus (RN), with the RN both sending motor commands and receiving sensory feedback from twitches. The RN’s role in producing twitches contrasts with that of primary motor cortex (M1), whic...
Article
Full-text available
With our eyes closed, we can track a limb’s moment-to-moment location in space. If this capacity relied solely on sensory feedback from the limb, we would always be a step behind because sensory feedback takes time: for the execution of rapid and precise movements, such lags are not tolerable. Nervous systems solve this problem by computing represe...
Article
Full-text available
Primary motor cortex (M1) undergoes protracted development in mammals, functioning initially as a sensory structure. Throughout the first postnatal week in rats, M1 is strongly activated by self-generated forelimb movements-especially by the twitches that occur during active sleep. Here, we quantify the kinematic features of forelimb movements to r...
Preprint
Full-text available
To execute complex behavior with temporal precision, adult animals use internal models to predict the sensory consequences of self-generated movement. Here, taking advantage of the unique kinematic features of twitches-the brief, discrete movements of active sleep-we captured the developmental onset of a cerebellar-dependent internal model. Using r...
Article
Full-text available
In humans and other mammals, the stillness of sleep is punctuated by bursts of rapid eye movements (REMs) and myoclonic twitches of the limbs.¹ Like the spontaneous activity that arises from the sensory periphery in other modalities (e.g., retinal waves),² sensory feedback arising from twitches is well suited to drive activity-dependent development...
Conference Paper
Full-text available
Introduction In neonatal rats, movements of the whiskers and limbs occur profusely during sleep, follow a stereotyped phenotype (e.g. rapid displacement of the whisker followed by a slower return to a new baseline position) (Dooley et al. 2020, Nasretdinov et al. 2020)), and may be required for typical sensorimotor development. Here we examined whe...
Article
Full-text available
It is generally supposed that primary motor cortex (M1) receives somatosensory input predominantly via primary somatosensory cortex (S1). However, a growing body of evidence indicates that M1 also receives direct sensory input from the thalamus, independent of S1; such direct input is particularly evident at early ages before M1 contributes to moto...
Preprint
Full-text available
Sleep, the predominant state of early infancy, is divided into two sub-states: active sleep (AS; or REM sleep) and quiet sleep (QS; or non-REM sleep). Behaviorally, AS is distinguished from QS by the presence of rapid eye movements (REMs) and abundant twitches across the body. Here, in the early postnatal period in human infants, we report the unex...
Preprint
Full-text available
A bstract Primary motor cortex (M1) undergoes protracted development in rodents, functioning initially as a sensory structure. As we reported previously in neonatal rats (Dooley and Blumberg, 2018), self-generated forelimb movements—especially the twitch movements that occur during active sleep—trigger sensory feedback (reafference) that strongly a...
Article
Cortical development is an activity-dependent process [1, 2, 3]. Regarding the role of activity in the developing somatosensory cortex, one persistent debate concerns the importance of sensory feedback from self-generated movements. Specifically, recent studies claim that cortical activity is generated intrinsically, independent of movement [3, 4]....
Preprint
Full-text available
S ummary Cortical development is an activity-dependent process [1–3]. Regarding the role of activity in developing somatosensory cortex, one persistent debate concerns the importance of sensory feedback from self-generated movements. Specifically, recent studies claim that cortical activity is generated intrinsically, independent of movement [3, 4]...
Article
Full-text available
Given the prevalence of sleep in early development, any satisfactory account of infant brain activity must consider what happens during sleep. Only recently, however, has it become possible to record sleep-related brain activity in newborn rodents. Using such methods in rat pups, it is now clear that sleep, more so than wake, provides a crucial con...
Article
Full-text available
Purpose of Review Sleep-wake states modulate cortical activity in adults. In infants, however, such modulation is less clear; indeed, early cortical activity comprises bursts of neural activity driven predominantly by peripheral sensory input. Consequently, in many studies of sensory development in rodents, sensory processing has been carefully inv...
Article
Full-text available
Before primary motor cortex (M1) develops its motor functions, it functions like a somatosensory area. Here, by recording from neurons in the forelimb representation of M1 in postnatal day (P) 8-12 rats, we demonstrate a rapid shift in its sensory responses. At P8-10, M1 neurons respond overwhelmingly to feedback from sleep-related twitches of the...
Article
Full-text available
Early loss of vision produces dramatic changes in the functional organization and connectivity of the neocortex in cortical areas that normally process visual inputs, such as the primary and second visual area. This loss also results in alterations in the size, functional organization and neural response properties of the primary somatosensory area...
Preprint
Full-text available
Before primary motor cortex (M1) develops its motor functions, it behaves like a somatosensory area. Here, by recording from neurons in the forelimb representation of M1 in postnatal day (P) 8-12 rats, we demonstrate a rapid change in the types of movements that trigger sensory responses. At P8-10, M1 neurons respond overwhelmingly to sleep-related...
Article
Amputees who wish to rid themselves of a phantom limb must weaken the neural representation of the absent limb. Conversely, amputees who wish to replace a lost limb must assimilate a neuroprosthetic with the existing neural representation. Whether we wish to remove a phantom limb or assimilate a synthetic one, we will benefit from knowing more abou...
Article
Full-text available
In the current investigation we examined the number and proportion of neuronal and non-neuronal cells in the primary sensory areas of the neocortex of a South American marsupial, the short-tailed opossum (Monodelphis domestica). The primary somatosensory (S1), auditory (A1) and visual (V1) areas were dissected from the cortical sheet and compared w...
Article
Full-text available
The gray short-tailed opossum (Monodelphis domestica) is a nocturnal South American marsupial that has been gaining popularity as a laboratory animal. However, compared to traditional laboratory animals like rats, very little is known about its behavior, either in the wild or in a laboratory setting. Here we investigated the photic preference of th...
Article
Full-text available
The current experiments build upon previous studies designed to reveal the network of parietal cortical areas present in the common mammalian ancestor. Understanding this ancestral network is essential for highlighting the basic somatosensory circuitry present in all mammals, and how this basic plan was modified to generate species specific behavio...
Article
Full-text available
The neocortex is the part of the mammalian brain that is involved in perception, cognition, and volitional motor control. It is a highly dynamic structure that is dramatically altered within the lifetime of an animal and in different lineages throughout the course of evolution. These alterations account for the remarkable variations in behavior tha...
Article
Full-text available
Throughout development both the body and the brain change at remarkable rates. Specifically, the number of cells in the brain undergoes dramatic non-linear changes; first exponentially increasing in cell number and then decreasing in cell number. Importantly, different cell types, such as neurons and glia, undergo these changes at different stages...
Article
Full-text available
In several vertebrate species, the effects of estrogens on male aggressive behavior can be modulated by environmental cues. In song sparrows and rodents, estrogens modulate aggression in the nonbreeding season or winter-like short days, respectively. The behavioral effects of estrogens are rapid, which generally is considered indicative of nongenom...
Article
Full-text available
The current experiment is one of a series of comparative studies in our laboratory designed to determine the network of somatosensory areas that was present in the neocortex of the mammalian common ancestor. Such knowledge is critical for appreciating the basic functional circuitry that all mammals possess and how this circuitry was modified to gen...
Article
Full-text available
In seasonally breeding mammals, vernal reproductive development is not directly triggered by increases in day length, rather, an endogenous program of photorefractoriness to short winter days initiates spontaneous development in advance of spring. The transition to the reproductive phenotype is energetically demanding. How food availability in late...
Article
Full-text available
Monodelphis domestica (short-tailed opossum) is an emerging animal model for studies of neural development due to the extremely immature state of the nervous system at birth and its subsequent rapid growth to adulthood. Yet little is known about its normal sensory discrimination abilities. In the present investigation, visual acuity was determined...
Article
Full-text available
Most of what we know about cortical map development and plasticity comes from studies in mice and rats, and for the somatosensory cortex, almost exclusively from the whisker-dominated posteromedial barrel fields. Whiskers are the main effector organs of mice and rats, and their representation in cortex and subcortical pathways is a highly derived f...

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