Jamal M Arif

Jamal M Arif
Shaqra University · College of Medicine

PhD

About

123
Publications
30,432
Reads
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1,614
Citations
Citations since 2017
26 Research Items
586 Citations
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Additional affiliations
January 2020 - present
Shaqra University
Position
  • Professor
Description
  • I am working as Professor of Biochemistry and Coordinator for the Quality and Accreditation with full responsibility of national and international accreditation of the College of Medicine at Shaqra and Dawademi.
February 2017 - January 2018
Integral University
Position
  • Pro Vice Chancellor and Vice Chancellor (Acting)
July 2016 - April 2018
Integral University
Position
  • Head of Faculty

Publications

Publications (123)
Book
Full-text available
Cancer is a leading cause of death worldwide. A systematic and complicated mechanism is involved in the transformation of a normal cell into cancerous form. In human body, most cell functions are controlled by genes through cell growth, signal transduction, protein transcription, cell cycle, apoptosis and DNA repair. Proto-oncogenes are essential f...
Article
Full-text available
The research aims to identify the inhibitory potential of natural dietary phytochemicals against non-insulinotropic target protein alpha-glucosidase and its possible implications to diabetes mellitus type 2.A data set of sixteen plant-derived dietary molecules viz., 4,5-dimethyl-3-hydroxy-2(5H)-furanone, apigenin, bromelain, caffeic acid, cholecalc...
Article
Background: As per the International Diabetes Federation statistics 2019, about 463 million people aged between 20-79 years have diabetes, in which mortality of 1.6 million individuals have been recorded each year, especially in developing and economically impoverished countries. Despite the people’s equal access to basic facilities of appropriate...
Article
Full-text available
Dibenzo[a,l]pyrene (DBP), an environmental pollutant, undergoes a series of enzymatic reactions yielding electrophilic diastereomeric diol-epoxides (DEs) that subsequently bind to DNA covalently and hampers the healing mechanism of cascaded biological pathways resulting in onset of different diseases. In the proposed work, we meticulously investiga...
Article
Full-text available
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a ruthless killer of the human population and highly transmissible, has become a big threat to public health by spreading one of the most infectious coronavirus diseases (COVID-19). Vaccine production is of paramount importance at present, albeit it is a gradual and time taking process....
Article
Full-text available
Breast cancer has become the most commonly diagnosed cancer among Indian women. An increase in breast cancer incidence is being reported from various regions of the country, necessitating the identification of the risk factors associated with the disease. Various demographic and clinical parameters are believed to modulate the risk of cancer occurr...
Article
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It is an ongoing task to keep exploring and applying the best available technology to alleviate the pain and sufferings of the cancer patients. Since the discovery of robotic surgery, da Vinci surgical systems have played a special and significant role in cancer surgeries worldwide, however, surgeons are still skeptical with the clinical and oncolo...
Article
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The present study was accomplished to examine and compare the effect of specific antioxidant-rich oils on hyperglycemia, dyslipidemia, renal function markers and oxidative renal damage in diabetic rats for four weeks. Papaya (P), olive (O), fenugreek (Fe), bitter gourd (B) and fish (Fi) oils were used for this purpose. Streptozotocin (STZ) was inje...
Article
Full-text available
Breast cancer is the leading cause of death among women worldwide. It is a multi-factorial disease caused by genetic and environmental factors. Vitamin D has been hypothesized to lower the risk of breast cancer via the nuclear vitamin D receptor (VDR). Genetic variants of these vitamin D metabolizing genes may alter the bioavailability of vitamin D...
Article
Background- The increasing rate of cancer in younger generation is an issue of concern in 21st century. It is highly concerned to know that the available methods of cancer therapy like, radiotherapy and chemotherapy have several side effects causing infertility and neuronal diseases. Radiotherapy is one of the main modalities for the treatment of c...
Chapter
Increasing rate of cancer incidence has put a global demand of high and advanced level of diagnosis methods. Although surgery (surgical treatment), radiotherapy, and chemotherapy are well-known traditional methods for cancer treatment, the use of novel, advanced, and reliable drug delivery methods (nanodrugs, DNA origami, nanoparticles, and exosome...
Article
Background: Designing a novel antagonist against VEGFR-2 is being applied currently to inhibit cancer growth and metastasis. Because of the unexpected side effects incurred by the contemporary anticancer medications, the focus has been laid towards identifying natural compounds that might carry the potential to inhibit tumor progression. VEGR-2 re...
Article
Full-text available
To study the biochemical adaptive responses of the blue green algae Nostoc muscorum to the salinity- induced stress they were exposed to various concentrations (5, 10, 15, 20 or 200 mM) of sodium chloride (NaCl). A dose-dependent inhibition of total protein content showed an adverse effect of NaCl on the growth of N. muscorum. Four-day treatment of...
Article
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Zika virus (ZIKV) is a mosquito-borne flavivirus distributed all over Africa, South America and Asia. The infection with the virus may cause acute febrile sickness that clinically resembles dengue fever, yet there is no vaccine, no satisfactory treatment, and no means of evaluating the risk of the disease or prognosis in the infected people. In the...
Article
Full-text available
IntroductionPeriodontitis is a chronic, non-reversible inflammatory disease of the oral cavity leading to destruction of periodontal tissues. Thus, the estimation of bacterial metabolite, tissue damage and secretory metabolites of the triggered inflammatory cells likely to yield results. It may be of value for understanding the pathophysiology of t...
Article
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Survivin (IAP proteins) remains an important target for anticancer drug development as it is reported to be over-expressed in tumor cells to enhance resistance to apoptotic stimuli. The study focuses on virtual screening of marine compounds inhibiting survivin, a multifunctional protein, using a computational approach. Structures of compounds were...
Article
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To establish in silico model to predict the structural insight into the metabolic bioactivation pathway of xenobiotics, we considered two specific and one non-specific mammary procarcinogen [e.g., dibenzo[a,l]pyrene (DBP), 7,12-dimethylbenz[a]anthracene (DMBA), and benzo[a]pyrene (BP)]. The CYP1A1, 1B1, 2C9, 1A2 and 2B6 reported in wet-lab studies...
Article
Background: The present study clarifies the molecular interactions of human BACE1 with novel natural ligands and also with the well-known ligand 2, 2, 4-trihydroxychalcone and Galangin for comparison. Objective: The study of enzyme- ligands interaction is interest, description of ligands binding to the active site of target molecule could be ben...
Article
Full-text available
In the proposed work, we have explicated the mechanism of dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) modulated cell proliferation by assessing the plausible binding with CASPASES, BAX, Bcl-2, MDM2, p53, p21, p16, CylinD1-CDK4 complex, CylinE1-CDK2 complex, H-Ras, K-Ras, BRCA1, and BRCA2 through exploiting the inherent potential of AutoDock To...
Article
Full-text available
Background: Malignant tumors are the leading cause of death in humans. Due to the tedious efforts and investigations made in the field of marine drug discovery, there is now a scientific bridge between marine and pharmaceutical sciences. However, currently only few marine drugs have been lined towards anticancer direction yet many more to are be e...
Article
Human T-cell leukemia virus type 1 (HTLV-1) is a single-stranded diploid RNA genome (9,030-9,040 nucleotides long) belonging to the deltaretrovirus family that causes adult T- cell leukemia (ATL) and HTLV-1-associated myelopathy and tropical spastic paraparesis (HAM/TSP). As there is neither a satisfactory treatment nor a vaccine against this chron...
Article
Breast cancer is a leading cause of death among women, around the world. It is a multifactorial disease involving genetic and environmental factors. Vitamin D is known to modulate biological processes like immune response, bone metabolism, cell growth regulation. The protective actions of vitamin D in cancer development are only sparsely understood...
Article
Full-text available
4-hydroxy-tetrahydrodipicolinate synthase (DHDPS) is an important enzyme needed for the biosynthesis of lysine and many more key metabolites in Mycobacterium tuberculosis (Mtb). Inhibition of DHDPS is supposed to a promising therapeutic target due to its specific role in sporulation, cross-linking of the peptidiglycan polymers and biosynthesis of a...
Article
Exposure to exogenous and endogenous chemicals and subsequent cellular and molecular changes has been linked to enhanced cell proliferation and restricted apoptosis phenomenon. Though in the past decades numerous anticancer drugs inducing programmed cell death in cancer cells by targeting specific apoptotic markers have reached the market, they hav...
Article
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Several studies suggested that Berenil, an anti-trypanosomal drug, acting as minor groove binders intercalates with DNA subsequently providing thermal stabilization to the drug-DNA complex. In the present study, we theoretically analyzed Berenil binding with calf thymus DNA using experimental models of De-Abreu et al (2008) to explain the melting b...
Article
Full-text available
Brugia and Wuchereria are the mosquito born nematodes and causes major tropical disease lymphatic filariasis. More than 100 million people are infected and at risk of acute lymphangitis and elephantiasis. Vaccine against filariasis may be developed by targeting stage specific proteins like 2nd stage larval(L2) protein transglutaminase and 3rd stage...
Article
Full-text available
Carica papaya Linn is commonly known as papaya in English and Papita in Hindi. Papaya is well known for its nutritional and medicinal values throughout the world. The properties of different parts of papaya plant are also well known in traditional system of medicine. Since past few decades medicinal applications of papaya are well considered by res...
Article
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Indoor air may contain pathogenic and non-pathogenic live or dead bacteria, fungi, viruses, allergens, endotoxins, pollen, plant fibres, etc. Microorganisms (bacteria and fungi) are considered significant part of the indoor air as causal agents of respiratory disorder and lung dysfunction in occupational (indoor) and non-occupational environment (D...
Article
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Diabetes mellitus (DM) is a complex, progressive disease, which is accompanied by multiple complications. One of the major complication confronted by patients with diabetes is an increased risk of developing diabetic nephropathy (DN) that often progresses to end-stage renal disease.Pathogenesis of DN is multifactorial. The role of hyperglycemia in...
Article
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Metal ions are required for many critical functions in living systems. Scarcity of some metal ions can lead to disease. A characteristic of metals is that they easily lose electrons from the familiar elemental or metallic state to form positively charged ions which tend to be soluble in biological fluids. Role of zinc, calcium and copper ions in th...
Article
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This study describes in silico validation of the wet lab data from aeroplysinin-1, curcumin and halofuginone using Autodock Tools 4.0. The inhibition patterns of the vascular endothelial cell differentiation and capillary tube formation mediated by anti-angiogenic growth factors from these test compounds were found quite comparable with the in sili...
Article
Full-text available
Targeted therapy has been gaining momentum to be a promising strategy for drug development research. Natural compounds and their synthetic analogues have provided several promising anticancer drugs. Erysolin present in the Eruca sativa better known as rocket plant has been scarcely studied. In the present study, we assessed the anticancer potential...
Article
The 2,4,5-triaryl imidazole derivatives (API) were designed, screened and characterized kinetically & thermodynamically against Pepsin and their activity was also tested on the in silico platform. The docking studies of API with Pepsin show that these are novel and unique inhibitors of Aspartic protease. Drug like properties of these compounds were...
Article
Full-text available
Amylases have most widely been reported to occur in microorganisms, although they are also found in plants and animals. Microbial cold-active α-amylases confer high activities at low temperature that favours production of comparatively insubstantial compounds. Cold-active α-amylases have an advantage under extreme low temperature conditions due to...
Chapter
Full-text available
Nature has equipped living organisms with a wide array of bioactive compounds for their nutritional, functional, defensive, and biochemical needs. The beneficial applications of natural bioactive compounds from marine organisms and plants are not unknown in pharmaceutical, diagnostic, chemical, and agro-food industries. In the recent past, another...
Article
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In this investigation, we report respiratory toxicity in bone-based industrial workers in India. Industrial workers significantly showed higher prevalence of respiratory symptoms as compared with reference group (47.4% vs. 9.9%). The primary respiratory impairment was found to be bronchial obstruction (18.64%) in the exposed workers in comparison t...
Article
Study presents, the kinetic models explaining, product formation (actinomycin-D), substrate utilization (carbon and nitrogen source) and biomass generation (Streptomyces sindenensis mutant M-46) for batch fermentation. Actinomycin D production appears to be inhibited by high substrate (carbon source) concentration in the initial phase. However a hi...
Article
Currently used hypolipidemic drugs, Fluvastatin and Atorvastatin, act via inhibiting the rate-limiting enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase of the mevalonate pathway. The associated severe side-effects of these statins led us to explore the therapeutic potentials of naturally occurring Tocomin (mixture of dietary α-, β-...
Article
Full-text available
Tocotrienol (Tocomin) are naturally occurring analogues of vitamin E family and has been reported to possess a potent free radical scavenging activity. In the present study we have initially investigated protective role of tocotrienol against infection and inflammation induced alterations in tissues antioxidant defense system, as well as speculated...
Article
In the present study preliminary phytochemical analysis of methanol extract of leaf and flower indicated the presence of alkaloids, phenols, tannin, saponins and flavonoids. The antibacterial activity of different extracts (hexane, petroleum ether, chloroform and methanol) of leaf and flower of Vernonia cinerea were tested separately against both g...
Article
Full-text available
A large variety of ornamental and decorative items are manufactured from bone waste by various unorganized sectors in India. An initial survey indicated that workers were exposed at various phases of final product. The subjects (12 industrial units) were tested for total suspended particulate matter (TSPM), particulate matter <10 microm (PM(10)), a...
Article
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CYP1A1 and CYP1B1 are the inducible forms of cytochrome P450 expressed in extrahepatic tissues, which are responsible for the biotransformation of numerous exogenous compounds including carcinogens, xenobiotics and drugs. To test the interaction of exogenous compounds and CYP1A1 and CYP1B1, the unavailability of 3-D structures prompted us to constr...
Article
In this in vitro study we investigated the toxic responses in hepatocytes treated with occupational dust to which workers are exposed in bone-based industrial units. The present study investigated the toxicity mechanism of bone-based occupational dust, from a particular industrial unit, on isolated rat hepatocytes. The hepatocytes were isolated by...
Article
Full-text available
Multidrug resistance (MDR) in microorganisms is a cause of major concern for clinicians and pharmaceutical industries. Continuous development of new antimicrobial drugs with multiple targets and potentials is expected to efficiently combat MDR in these microorganisms. In a continued exploration of new antimicrobial drug leads, 11 marine natural pro...
Article
Full-text available
Copper at all the concentrations (2, 4, 8 and 16 μM) inhibited the survival, growth and photosynthetic pigment content in Nostoc muscorum. The effect of copper on phycocyanin was more pronounced which was followed by chlorophyll a and carotenoids. The accelerated lipid peroxidation, and rise in the level of peroxide and superoxide was recorded in c...
Article
Full-text available
Receptor tyrosine kinases (RTKs) are crucial targets in the pathway of angiogenesis and the currently used antiangiogenic drugs have limited efficiency with associated toxicity. In our continuous search for new and potent multitarget anti-angiogenic lead compounds, we have conducted in-silico interaction and inhibition studies of the selected aglyc...
Article
Full-text available
Absolutely the largest proportion of the Earth's biosphere is comprised of organisms that thrive in cold environments are known as psychrophiles and psychrotrophs. Their ability to proliferate in the cold is predicated on a capacity to synthesize cold-adapted enzymes like amylases, proteases, lipases, pectinases, cellulases, etc. that could be used...
Article
Full-text available
The routine testing of any carcinogen are generally performed in the cell free, cell culture and animal models, however, due to involvement of specific isozymes of metabolic activation and detoxification enzymes, these tests become extremely time consuming and expensive in testing metabolic activity of any carcinogens or drugs. The emergence of the...
Article
Full-text available
The present study deals with the growth characteristics of several cyanobacterial strains (Anabaena variabilis, Oscillatoria sp., Chroococcus sp. Nostoc sp., Plectonema boryanum and Scytonema sp.), evaluation of their antibacterial activity and free radical scavenging ability. The maximum specific growth rate was noticed in Nostoc sp. and Scytonema...
Article
The routine testing of any carcinogen are generally performed in the cell free, cell culture and animal models, however, due to involvement of specific isozymes of metabolic activation and detoxification enzymes, these tests become extremely time consuming and expensive in testing metabolic activity of any carcinogens or drugs. The emergence of the...
Article
Antibacterial activity of hexane, petroleum ether, chloroform and methanol extracts obtained from the aerial parts (leaf, flower and stem) of Tridax procumbens was tested against both gram positive (Staphylococcus aureus and Bacillus subtilis) and gram negative (Enterobacter aerogenes) bacteria using the agar well diffusion method. The susceptibili...
Article
Many potent compounds rich in therapeutic potential have been isolated from marine sponges but they have failed to make it to the clinical trials or rather failed in the clinical trials because of the extreme cytotoxicity they possess. In the present study we have evaluated the biological potential of synthetic analogues of dibromotyrosine where we...
Article
Full-text available
The unwarranted connection between diabetes mellitus and breast cancer has gained new ground in recent years. Breast cancer in Saudi females accounts for approximately 21% of all cancers and the prevalence of diabetes mellitus (DM) in Saudi females is also 21.5%. DM is diagnosed in the age group of 30+ years with possible exposure to predisposing f...
Article
Full-text available
ABSTRACT – The present study deals with the growth characteristics, biomass production, phycochemical screening, antibacterial activity and free radical scavenging ability of cyanobacteria (Tolypothrix sp., Cylindrospermum sp., Nostoc muscorum and Phormidium sp.). The maximum specific growth rate with high biomass production was noticed in Tolypoth...
Article
Full-text available
Nigella sativa has been used traditionally as spice, carminative, condiment, aromatic, stimulant, diuretic, stomachic, liver tonic and digestive. The rate at which the bacterial strains are becoming resistant to the available antibiotics has necessitated the demands for a renewed effort to investigate for new antimicrobial agents. Nigella sativa se...
Article
Despite several marine anticancer compounds to be DNA-interactive, causing from reductive DNA cleavage to DNA adduct formation, not much attention has been given to the DNA adduct as early biomarker in the screening and development of marine anticancer drugs. Most of these compounds have been tested in vitro by high-throughput cost-effective screen...
Article
Full-text available
Dimethyl 4,4' -(O-phenylene)bis(3-thioallophanate), commonly known as methyl thiophanate (MT), is a systemic fungicide and suspected carcinogen to humans. In this study, the oxidative potential of this category-III acute toxicant has been ascertained based on its capacity of inducing reactive oxygen species (ROS) and promutagenic 8-oxo-7,8-dihydro-...
Article
This study is designed to investigate the impact of DNA damage on pregnancy and fertilization rate outcome in a sub-sample of women undergoing IVF treatment. Blood and follicular fluid samples (n = 60) were analyzed for DNA adducts. While no BPDE-DNA adducts were detected, other unknown lipophilic adducts were seen in blood and follicular fluid. Wo...
Article
Full-text available
Preventing or curing an immune-mediated disease requires functional immune cells, in particular T cells, including helper (CD4+; Th) and cytotoxic (CD8+; Tc) T cells. Based on the type of the antigen presenting cells, the nature of antigens, and the cytokine milieu, CD4+ T cells exhibit high plasticity to differentiate into different subsets with s...