Jakub Javurek

• Ph.D.
• Product Marketing Manager at TESCAN

Some freshwater phytoplankton species have been suggested to produce estrogenic compounds in concentrations which could cause adverse effects to aquatic biota, while other studies showed no estrogenic effects after exposure to phytoplankton extracts or pointed out possible sources of the overestimation of the estrogenic activity. This study aimed t...

Volume electron microscopy (volume EM) brings invaluable information about the three dimensional organisation of tissues and other biological materials, but traditional 2D imaging of samples remains an important function of any scanning electron microscope (SEM). Previously, volume EM techniques required dedicated SEM systems with limited usage for...

Stagnant freshwaters can be affected by anthropogenic pollution and eutrophication that leads to massive growth of cyanobacteria and microalgae forming complex water blooms. These can produce various types of bioactive compounds, some of which may cause embryotoxicity, teratogenicity, endocrine disruption and impair animal or human health. This stu...

Securing new sources of renewable energy and achieving national self-sufficiency in natural gas have become increasingly important in recent times. The study described in this paper focuses on three geologically diverse underground gas reservoirs (UGS) that are the natural habitat of methane-producing archaea, as well as other microorganisms with w...

The egg plays a pivotal role in the reproduction of our species. Nevertheless, its fundamental biology remains elusive. Transmission electron microscopy is traditionally used to inspect the ultrastructure of female gametes. However, two-dimensional micrographs contain only fragmentary information about the spatial organization of the complex oocyte...

Study question Is volume electron microscopy suitable for high-resolution oocyte imaging in three dimensions (3D)? Summary answer Focused Ion Bean Scanning Electron Microscopy (FIB-SEM) allows 3D visualization and quantitative analysis of ultrastructural features in the large human oocyte volume. What is known already Transmission electron micros...

Study question Is volume electron microscopy suitable for high-resolution oocyte imaging in three dimensions (3D)? Summary answer Focused Ion Bean Scanning Electron Microscopy (FIB-SEM) allows 3D visualization and quantitative analysis of ultrastructural features in the large human oocyte volume. What is known already Transmission electron micros...

The oocyte plays a pivotal role in the reproduction of our species. Nevertheless, its biology remains poorly understood. Electron microscopy is traditionally used to inspect the ultrastructure of female gametes. However, two-dimensional micrographs contain only fragmentary information about the spatial organization of the complex oocyte cytoplasm....

TESCAN Cryo FIB-SEM as a Flexible Tool for Advanced Sample Analysis - Volume 25 Supplement - Rostislav Váňa, Kristýna Rosíková, Jakub Javůrek, Tomáš Nováček, Jana Havránková, Samuel Záchej

Despite the advances in the treatment of rheumatoid arthritis (RA) achieved in the last few years, several patients are diagnosed late, do not respond to or have to stop therapy because of inefficacy and/or toxicity, leaving still a huge unmet need. Tissue-specific strategies have the potential to address some of these issues. The aim of the study...

Freshwater ecosystems are commonly affected by multiple stressors including compounds of both anthropogenic and natural origin. Harmful water blooms are causing a number of problems such as decreased oxygen content, shading of green algae and changes in water chemistry. Cyanobacteria are also a source of toxic metabolites that can be released into...

Organisms in the environment are exposed to complex mixtures of both natural and anthropogenic compounds. Specific types of these mixtures might be associated with occurrence of cyanobacterial water blooms in freshwater environment. The compounds associated namely with water blooms of greater densities can include known cyanotoxins, but also other...