Jakob Agergaard

Jakob Agergaard
Institute of Sports Medicine Copenhagen | ISMC

PhD, Postdoctoral researcher

About

34
Publications
4,495
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601
Citations

Publications

Publications (34)
Article
Objective Cartilage collagen has very limited repair potential, though some turnover and incorporation has not been fully excluded. We aim to determine the regional turnover of human osteoarthritis cartilage. Design Patients scheduled for knee joint replacement surgery due to osteoarthritis were recruited in this prospective study of four weeks du...
Article
Full-text available
PurposeDuring the last decade more researchers have argued in favor of an increased protein intake for older adults. However, there is a lack of knowledge on the long-term effects of conforming to such a high protein intake with regards to the basal and postprandial muscle protein turnover. The purpose of this study was to compare the postprandial...
Article
Full-text available
Purpose Age-related decrease in muscle mass is, among several other factors, caused by suboptimal dietary protein intake. The protein intake of the general population has a skewed distribution towards the evening meal. However, it is hypothesised that an intake of protein with an even meal distribution leads to a more frequently maximised protein s...
Article
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This study explores if unhealthy lipoprotein distribution (LPD) impairs the anabolic and amino acid sensing responses to whey-protein feeding. Thus, if impairment of such anabolic response to protein consumption is seen by the LPD this may negatively affect the skeletal muscle mass. Muscle protein synthesis (MPS) was measured by puromycin labeling...
Article
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The absorption of dietary proteins affects the anabolic response, among others protein synthesis. For elderly, optimal amino acid absorption is warranted to preserve the amino acid pool of the body, especially skeletal muscle proteins. Therefore, the aim of this study was to characterize if hydrolyzing meat protein (HMP) would improve the amino aci...
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Background: Efficacy of protein absorption and subsequent amino acid utilization may be reduced in the elderly. Higher protein intakes have been suggested to counteract this. Objectives: We aimed to elucidate how habituated amounts of protein intake affect the fasted state of, and the stimulatory effect of a protein-rich meal on, protein absorpt...
Article
Background & aims Availability of dietary protein-derived amino acids (AA) is an important determinant for their utilization in metabolism and for protein synthesis. Intrinsic labeling of protein is the only method to directly trace availability and utilization. The purpose of the present study was to produce labeled milk and meat proteins and inve...
Article
Full-text available
Muscle inactivity reduces muscle protein synthesis (MPS), whereas a subsequent period of rehabilitation resistance training (retraining) increases MPS. However, less is known regarding muscle protein breakdown (MPB) during such conditions. Furthermore, nonsteroidal anti-inflammatory drugs (NSAIDs) may have a dampening effect on MPB during periods o...
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Purpose: The responsiveness of older individuals' skeletal muscle to anabolic strategies may be impaired. However, direct comparisons within the same experimental setting are sparse. The aim of this study was to assess the resting and post-resistance exercise muscle protein synthesis rates in response to two types of milk protein and carbohydrate...
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Full-text available
An impaired amino acid sensing is associated with age-related loss of skeletal muscle mass. We tested whether light-load resistance exercise (LL-RE) affects postprandial amino acid transporter (AAT) expression in aging skeletal muscle. Untrained, healthy men (age: +65 years) were subjected to 13 h of supine rest. After 2 1/2 h of rest, unilateral L...
Article
Introduction: Patients with Ehlers Danlos Syndrome are known to have genetically impaired connective tissue and skeletal muscle symptoms in form of pain, fatigue and cramps, however earlier studies have not been able to link these symptoms to morphological muscle changes. Methods: We obtained skeletal muscle biopsies in patients with classic EDS...
Article
Muscle mass in humans is inversely associated with circulating levels of inflammatory cytokines, but the interaction between ageing and training on muscle composition and the intra-muscular signalling behind inflammation and contractile protein synthesis and degradation is unknown. We studied 15 healthy life-long endurance runners, 12 age-matched u...
Article
Introduction: The present study investigated whether well-tolerated light-load resistance exercise (LL-RE) affects skeletal muscle fractional synthetic rate (FSR) and anabolic intracellular signaling as a way to counteract age-related loss of muscle mass. Methods: Untrained healthy men (age: +65 yrs) were subjected to 13 hours supine rest. After...
Article
Purpose: The elderly lose skeletal muscle mass with age, which may be detrimental for function and quality of life. Both inactivity and heavy resistance exercise are known to have marked but opposite effects upon muscle mass. However, the potential effects of daily physical activity upon muscle protein synthesis (MPS) are less investigated. The ai...
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Full-text available
Recent studies have shown that vitamin-D intake can improve skeletal muscle function and strength in frail vitamin-D insufficient individuals. We investigated whether vitamin-D intake can improve the muscular response to resistance training in healthy young and elderly individuals, respectively. Healthy untrained young (n = 20, age 20–30) and elder...
Article
Bed rest-induced muscle loss and impaired muscle recovery may contribute to age-related sarcopenia. It is unknown if there are age-related differences in muscle mass and muscle anabolic and catabolic responses to bed rest. A secondary objective was to determine if rehabilitation could reverse bed rest responses. Nine older and fourteen young adults...
Article
Essential amino acids (EAAs) are a potent stimulator of mechanistic target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis. However, regulators upstream of mTORC1 that are responsive to EAA availability are not well described, especially in human skeletal muscle. The purpose of this study was to determine changes in leucyl-tR...
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Full-text available
Purpose Resistance exercise and amino acid availability are positive regulators of muscle protein net balance (NB). However, anabolic responses to resistance exercise and protein supplementation deserve further elucidation. The purpose was to compare intakes of whey, caseinate (both: 0.30 g/kg lean body mass), or a non-caloric control after heavy...
Article
Introduction: We examined short-term (3-hour) and long-term (12-week) training effects after heavy load [HL; 70% 1RM] and light load (LL; 16% 1RM) exercise. Methods: mRNA expression of genes involved in skeletal muscle remodeling were analyzed and muscle activity (EMG measurements) was measured. Results: Relative muscle activity differed betwe...
Data
Lower IL-1β mRNA expression in muscle of critically ill patients. Interleukin-1β (IL-1β) (left) and monocyte chemoattractant protein-1 (MCP-1) (right) mRNA expression in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with controls (CON). Data are fold change in individual values relative to control mean. Each ci...
Data
Antibodies used for Western blot. Antibodies were diluted in 10% Odyssey blocking buffer (Li-Cor Biosciences) in distilled water with 0.1% v/v Tween 20. All total and phosphorylated protein pairs, except for mTOR, were detected simultaneously on the same membrane. NA: Not applicable. (DOC)
Data
Primers used for RT-qPCR. Abbreviations: RPLP0: acidic ribosomal protein P0, FoxO: Forkhead box O, MuRF1: muscle ring finger 1, IGF-1: insulin-like growth factor, GDF-11: growth differentiation factor 11, TGF-1β: transforming growth factor 1 beta, TNF-α: tumor necrosis factor alpha, IL: interleukin, IL-6R: IL-6 receptor, MCP-1: monocyte chemoattrac...
Data
Lower tenascin-C mRNA expression in muscle of critically ill patients. Tenascin-C mRNA expression in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with controls (CON). Data are fold change in individual values relative to control mean. Each circle represents one subject (black: controls, white: ICU patients) an...
Data
Lower actinin3 mRNA expression in muscle of critically ill patients. IL-6 receptor (IL-6R) (left) and actinin3 (right) mRNA expression in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with controls (CON). Data are fold change in individual values relative to control mean. Each circle represents one subject (bla...
Article
Full-text available
Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3β (GSK3β) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved in muscle mass regulation, we investigated the ph...
Article
Full-text available
Muscle protein turnover following resistance exercise and amino acid availability are relatively well described. By contrast, the beneficial effects of different sources of intact proteins in relation to exercise need further investigation. Our objective was to compare muscle anabolic responses to a single bolus intake of whey or casein after perfo...

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