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Citations since 2017
Publications
Publications (34)
Objective
To assess spatial aggregates of amyotrophic lateral sclerosis (ALS) incident cases, using a solid geo-epidemiological statistical method, in France.
Methods
This population-based study (2003–2011) investigated 47.1 million person-years of follow-up (PYFU). Case ascertainment of incident ALS cases was based on multiple sources (ALS referr...
Introduction
Population-based registers are key to understanding disease patterns. Taking advantage of the long-standing operation of the French register of amyotrophic lateral sclerosis (ALS) in Limousin (FRALim register), we sought to determine the time trends in incidence, clinical features and survival of ALS patients from 2000 to 2020.
Method...
Background: Recent studies have described a low occurrence of Amyotrophic Lateral Sclerosis (ALS) in Latin America. Significant differences in ALS risk have been reported among ethnic populations in the region. We conducted a meta-analysis using population-based data to describe ALS mortality rates in Latin America. We explored sources of heterogen...
Introduction et but de l’étude
Dans la SLA, le statut nutritionnel est associé à l’évolution de la maladie. Il est recommandé une prise en charge nutritionnelle précoce au cours de cette pathologie rapidement létale. L’objectif était d’évaluer l’impact d’une prise précoce de CNO sur l’évolution fonctionnelle, nutritionnelle et respiratoire à 6 mois...
Objective: To assess the availability of health workers and medications for clinical management of amyotrophic lateral sclerosis (ALS) in African hospital centers. Availability and affordability analyses of disease-modifying treatments were performed. Methods: A multicenter observational study involving African hospitals was conducted. A standard q...
BackgroundA noticeable change of the male-to-female sex ratio (SR) has been observed in Amyotrophic Lateral Sclerosis (ALS) leading to an apparent regression of SR with time (SR close to 1:1).
Objective
To provide a global SR estimate and investigate its relation with respect to population age.MethodsA systematic review and meta-analysis was conduc...
Background
according to the hygiene hypothesis, infections by agents such as parasites have a protective role on the risk of developing Multiple Sclerosis (MS). Among parasites, Toxoplasma gondii, an intracellular parasite, showed evidence of a protective effect.
Objective
to summarize the available evidence on the association between Toxoplasma g...
Introduction:
Epilepsy affects >50 million people worldwide, with 80% of them living in low- and middle-income countries (LMICs). Studies with a standardized methodology are required to obtain comparable data on epilepsy and implement health policies in order to reduce the treatment gap and improve the diagnosis and management of epilepsy. In 2000...
Clinically, ALS phenotypes depend on the areas of the body that are affected, the different degrees of involvement of upper and lower motor neurons, the degrees of involvement of other systems, particularly cognition and behavior, and rates of progression. Phenotypic variability of ALS is characteristic and can be declined on the distribution of mo...
Introduction: Heterogeneity of amyotrophic lateral sclerosis (ALS) has been suggested in terms of epidemiology, phenotypes and genetics between geographic areas and populations. However, there is limited information in Latin America. We conducted a systematic review that aimed to describe the epidemiology, frequency of genetic mutations, clinical c...
Background: Assessing clinical progression in amyotrophic lateral sclerosis (ALS) remains a challenge. We evaluated the validity and predictive capabilities of the King’s and Milano-Torino Staging (MiToS) systems in a cohort of patients with ALS to demonstrate their benefit in clinical practice.
Methodology: A cohort study was performed by includin...
La sclérose latérale amyotrophique (SLA) est une maladie neurodégénérative fatale. Les travaux scientifiques suggèrent que l’ethnicité et l’origine ancestrale influencent le risque de développer la maladie. L’ethnicité peut prendre en compte les caractéristiques sociales, culturelles ainsi que les générations antérieures. L’origine ancestrale se ré...
Background
Onchocerciasis is a serious problem in tropical areas. The role of the parasite as a factor associated with neurological diseases needs to be addressed because it might involve a reduction of the risk via elimination strategies. We performed a systematic scoping review to identify available studies on this association and put into perspe...
Study Objectives
To provide an overall estimate of the prevalence of idiopathic REM Sleep Behavior Disorder (iRBD).
Methods
Two investigators have independently searched the PubMed and Scopus databases for population-based studies assessing the prevalence of iRBD. Data about type of diagnosis (polysomnographic diagnosis, defined iRBD [dRBD]; clini...
Although psychiatric and neurological disorders are among the first contributors to the global burden of disease, they remain among the most neglected topics of Global Health. There is a real need to raise their profile, to improve advocacy so that the impact of these diseases is better understood, and greater political efforts are made to improve...
This chapter is dedicated to the epidemiology of common non-bacterial central nervous system infections: parasitic, fungal, and viral infections. Non-bacterial central nervous system infections are public health challenges in developing and developed countries. Clinical manifestations and severity depend on pathogenic characteristics of the agents...
Methodologies of population-based studies on neurological diseases in low- and middle-income countries (LMICs) have not been standardized. The objective of this paper is to provide an overview of the numerous challenges occurring in this context and propose a standard framework for population-based studies in LMICs. We relied on our expertise on fe...
Introduction:
Neurological disorders are an important cause of disability and death worldwide. The distribution of these disorders differs significantly in developing countries. Screening questionnaires have been used as an important tool to detect neurological illnesses. This systematic literature review aimed to report the validity of screening...
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder with an invariable fatal outcome. Current evidence supports ALS variability in terms of incidence, mortality and clinical features between geographic areas and populations. This dissertation offers an updated review of ALS heterogeneity along with two original epidemiological...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown etiology. Mobile communication antennas have increased over the last few decades. Consequently, there has been a steady increase in environmental exposure to ultra high frequency electromagnetic fields (UHF-EMFs) emitted by Global System for Mobile (GSM) communicati...
Relevance: More than 70 million people suffer epilepsy worldwide. Low availability of anti-epileptic drugs, side-effects and drug-resistant epilepsy affect the quality of life of persons with epilepsy in countries with a poorly developed health system. Herbal medicine is frequently used for this neurological condition. Objectives: The main objectiv...
Current evidence suggests heterogeneity of amyotrophic lateral sclerosis (ALS) among geographic areas and populations. Lower mortality rates have been reported in admixed populations compared to European origin populations. We aimed to describe and compare ALS mortality rates among ethnic groups using a population-based approach in a multiethnic co...
Purpose
To describe sociocultural representations of epilepsy in a sub-Saharan Africa rural community using a population-based approach.
Method
A cross-sectional door-to-door survey was underway on a rural community of the Central African Republic in 2015. A two-stage stratified sampling was performed. Trained care personnel performed individual f...
Objective
We describe and compare the sociodemographic and clinical features, treatments, and prognoses and survival times of patients with amyotrophic lateral sclerosis (ALS) in Africa.
Methodology
We conducted a multicentre, hospital-based cohort study in Africa. Patients with ALS diagnosed in the neurology departments of participating hospitals...
Objective
To gain further insight on the association between human toxocariasis and epilepsy in light of the new evidence in the last years.
Methods
A systematic review was conducted without date and language restriction in the following electronic databases: MEDLINE (PubMed), Ingenta Connect, Science Direct (Elsevier), RefDoc, Scopus, HighWire, S...
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with a fatal outcome. This review aims to report key epidemiological features of ALS in relation to the hypothesis of variation between populations, to summarize environmental hypothesis and to highlight current issues that deserve much considerations. Epidemiological ALS studi...
Background:
Epilepsy is felt to be a stigmatizing condition. Stigma has been considered one of the major factors contributing to the burden of epilepsy and to the treatment gap. Stigma has a negative effect on the management of people with epilepsy (PWE). Furthermore, lack of information and inappropriate beliefs are still the factors that most co...
Introduction
L’épilepsie est l’un des troubles neurologiques les plus fréquents avec une estimation globale de 70 millions de cas. Près de 80 % des patients vivent dans les pays en développement dont le problème majeur est le manque d’accès à un traitement approprié. L’objectif de cette étude était de développer un outil permettant d’identifier les...
Introduction
L’épilepsie est l’un des troubles neurologiques le plus fréquent avec une estimation globale de 70 millions de cas dont près de 80 % vivent dans les pays en développement. L’un des problèmes majeurs dans ces pays est le manque d’accès à un traitement approprié.
Objectifs
L’objectif de cette étude est de développer un outil permettant...
