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Jaganmohan Reddy Jangamreddy

Jaganmohan Reddy Jangamreddy
UR Advanced Therapeutics Pvt Ltd

Doctor of Philosophy

About

44
Publications
8,931
Reads
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1,403
Citations
Citations since 2016
16 Research Items
1122 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Additional affiliations
August 2015 - June 2016
Tissue Engineering and Regenerative Medicine International Society European Chapter 2016
Position
  • Program Organisation Committee Chair & Scientific Advisory Committee
November 2013 - November 2013
Linköping University
Position
  • Research Assistant
Description
  • Lecture on laser scanning Cytometry, practical training on the instrument
February 2011 - March 2017
Linköping University
Position
  • Research Associate

Publications

Publications (44)
Preprint
Full-text available
Purpose: Radiotherapy (RT) is a standard adjuvant therapy in progressive rectal cancer patients, but many patients are resistant to RT, leading to poor prognosis. Our study identified microRNA-652 (miR-652) value on RT response and outcome in rectal cancer patients. Methods: miR-652 expression was determined by RT-PCR in primary rectal cancer from...
Chapter
Stem cells of the eye are very important in regeneration of wounded or diseased areas in different parts of the eye. The process of aging and senescence brings about a change in the regenerative capacity of the stem cells involving various signaling pathways. This chapter gives an overview of the various ocular stem cells and their regenerative cap...
Chapter
Correction to Chapter 7: Ocular Cancer Stem Cells: Advances in Therapeutic Interventions in the book titled Cancer Stem Cells: New Horizons in Cancer Therapieshttps://doi.org/10.1007/978-981-15-5120-8_7
Article
Full-text available
Mechanisms of recurrence in oligodendrogliomas are poorly understood. Recurrence might be driven by telomere dysfunction-mediated genomic instability. In a pilot study, we investigated ten patients with oligodendrogliomas at the time of diagnosis (first surgery) and after recurrence (second surgery) using three-dimensional nuclear telomere analysis...
Chapter
Cancers affecting the eye are rare and can be either initiated in the eye, primary intraocular cancers, or invaded into the eye as a malignant tumor started elsewhere, secondary intraocular cancers. Melanoma and non-Hodgkin lymphoma in adults and retinoblastoma and medulloepithelioma in children are the most common intraocular cancers. Similar to o...
Data
Extracellular vesicles (gold colour) in CLP-PEG implanted cornea.
Article
Full-text available
Statement of significance: Although biomaterials comprising full-length recombinant human collagen and extracted animal collagen have been evaluated and used clinically, these macromolecules provide only a limited number of functional groups amenable to chemical modification or crosslinking and are demanding to process. Synthetic, customizable ana...
Article
We have previously shown in animal models and in early clinical studies that collagen-based biomaterials promoted functional regeneration of corneal epithelium, stroma and nerves. Recently, we showed that these fabricated implants were made of collagen fibrils that were fine and aligned, like those in human corneas. There were noticeable difference...
Article
Full-text available
Throughout the world, there are increasing demands for alternate approaches to advanced cancer therapeutics. Numerous potentially chemotherapeutic compounds are developed every year for clinical trial and some of them are considered as potential drug candidates. Nanotechnology-based approaches have accelerated the discovery process, but the key cha...
Article
Full-text available
Unlabelled: Cancer stem-like cells (CSCs) are a rare subpopulation of cancer cells capable of propagating the disease and causing cancer recurrence. In this study, we found that the cellular localization of PKB/Akt kinase affects the maintenance of CSCs. When Akt tagged with nuclear localization signal (Akt-NLS) was overexpressed in SKBR3 and MDA-...
Article
Full-text available
Salinomycin has been used as treatment for malignant tumors in a small number of humans, causing far less side effects than standard chemotherapy. Several studies show that Salinomycin targets cancer-initiating cells (cancer stem cells, or CSC) resistant to conventional therapies. Numerous studies show that Salinomycin not only reduces tumor volume...
Article
Full-text available
Salinomycin has been used as treatment for malignant tumors in a small number of humans, causing far less side effects than standard chemotherapy. Several studies show that Salinomycin targets cancer-initiating cells (cancer stem cells, or CSC) resistant to conventional therapies. Numerous studies show that Salinomycin not only reduces tumor volume...
Article
Full-text available
Monitoring of autophagy is challenging because of its multiple steps and lack of single befitting technique for a complete mechanistic understanding makes the task complicated. Here we evaluate the functionality of autophagy triggered by salinomycin (anti-cancer-stem cell agent) using flow cytometry and advanced microscopy. We show that salinomycin...
Article
Full-text available
Majority of Chronic myeloid leukemia patients experience an adequate therapeutic effect from imatinib however, 26–37% of patients discontinue imatinib therapy due to a suboptimal response or intolerance. Here we investigated derivatives of apoptin, a chicken anemia viral protein with selective toxicity towards cancer cells, which can be directed to...
Article
Full-text available
Despite decades of search for anticancer drugs targeting solid tumours, this group of diseases remains largely incurable, especially if in advanced, metastatic stage. In this review, we draw comparison between reprogramming and carcinogenesis, as well as between stem cells and cancer stem cells, focusing on changing garniture of adhesion molecules....
Article
Full-text available
Autophagy and apoptosis are basic physiologic processes contributing to the maintenance of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic proteins and damaged organelles. It involves a sequential set of events including double membrane formation, elongation, vesicle maturation and finally delivery of the targe...
Article
Full-text available
Autophagy and apoptosis are basic physiologic processes contributing to the maintenance of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic proteins and damaged organelles. It involves a sequential set of events including double membrane formation, elongation, vesicle maturation and finally delivery of the targe...
Article
Full-text available
PALB2/FANCN is a BRCA1- and BRCA2-interacting Fanconi Anemia (FA) protein crucial for key BRCA2 genome caretaker functions. Heterozygous germline mutations in PALB2 predispose to breast cancer and biallelic mutations cause FA. FA proteins play a critical role in the telomere maintenance pathway, with telomeric shortening observed in FA cells. Less...
Article
Full-text available
The molecular mechanism of Salinomycin's toxicity is not fully understood. Various studies reported that Ca(2+), cytochorme c, and caspase activation play a role in Salinomycin-induced cytotoxicity. Furthermore, Salinomycin may target Wnt/β-catenin signaling pathway to promote differentiation and thus elimination of cancer stem cells. In this study...
Conference Paper
Salinomycin, an efficient drug identified for targeting cancer stem like cells compared to the current available chemo-therapeutic drugs, is shown to promote differentiation of cancer stem like cells and thus making a way for normal cell death. To date various studies also report the Ca2+, cytochorme c and caspase activation leading to salinomycin...
Article
Full-text available
The manuscript provides insight into the recently-discovered new form of cell death that may co-exist with autophagy, apop-tosis or necorosis. The described below cellular extrusion of damaged mitochondria, may contribute to ethiology of some autoimmune diseases, as well as to the development of novel antiviral drugs that employ autophagy in their...
Article
Full-text available
In this study we have calculated a 3D structure of apoptin and through modeling and docking approaches, we show its interaction with Bcr-Abl oncoprotein and its downstream signaling components, following which we confirm some of the newly-found interactions by biochemical methods. Bcr-Abl oncoprotein is aberrantly expressed in chronic myelogenous l...
Data
Coordinates of Apoptin docking to BcrAbl. (TXT)
Data
Coordinates of Apoptin docking to BcrAbl. (TXT)
Data
Coordinates of Apoptin docking to BcrAbl. (TXT)
Article
The homeobox transcription factor PROX1 is essential for the development and maintenance of lymphatic vasculature. How PROX1 regulates lymphatic endothelial cell fate remains undefined. PROX1 has been shown to upregulate the expression of Cyclin E, which mediates the G(1) to S transition of the cell cycle. Here we demonstrate that PROX1 activates t...
Article
Full-text available
The transcription factor ZAC1 is expressed in a variety of tissues including the developing heart, but its physiological role is unclear. We examined the role of ZAC1 in regulating expression of the insulin-responsive glucose transporter GLUT4 and whether ZAC1 expression is altered in cardiomyocyte hypertrophy. We demonstrated expression of Zac1 mR...
Thesis
Full-text available
Mutations in the VEGFR-3 gene have been reported in the congenital lymphedema Milroy's disease. Also, there are many studies showing the correlation between the expression of VEGFR-3 and the degree of lymph node metastasis. Adenoviral mediated expression of Prox1 induces VEGFR-3 expression in blood endothelial cells. In this study, we determined th...

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Projects (2)