Jafar Aslani

Jafar Aslani
Baqiyatallah University of Medical Sciences | BMSU · Department of Medicine

About

71
Publications
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Introduction

Publications

Publications (71)
Article
Introduction: Mustard gas (MG) is a chemical warfare agent widely used in the Iran-Iraq War. Its catastrophic effects on the lungs, eyes, and skin have been well studied. However, it also affects the cardiovascular system. We aimed to evaluate the long-term effect of MG on right ventricular (RV) function. Methods: All patients presenting to the...
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Background: Gastro-esophageal reflux disease (GERD) is a common complaint of sulphur mustard (SM)-exposed subjects. Routine treatments such as proton-pump inhibitors (PPIs), H2-blockers and anti-Acids cannot control GERD symptoms completely. Aloe vera is a medicinal plant that has been shown to reduce gastric acid secretion. The efficacy of pantopr...
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Background: Chronic obstructive pulmonary disease (COPD) is usually considered one of the leading causes of death worldwide, so finding proper therapeutic strategies for this disease is of high importance. In this meta-analysis, we reviewed the existing literature on the efficacy and safety of conventional long acting beta agonists (LABAs) in COPD...
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Context: The main objectives of triage are securing patient safety during the process of emergency diagnosis and treatment, and reduction of waiting time for medical services and transport. To date, there is no triage system for nerve agent victims. Evidence acquisition: This systematic review proposes a new triage system for patients exposed to...
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As a developing country, Iran has not had a substantial share in global science production activities; however, this country has recently been the forth country in the world regarding research output publications, and biomedical research has played a crucial role in achieving this honorable position. In this paper, we aimed to introduce the strateg...
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Cough is a common symptom of upper respiratory tract infection. One of the causes of chronic cough is persistent post-infectious cough (PPC). PPC is a cough that persists longer than three weeks after a "common cold". PPC has poor response to routine treatments. The aim of this study was to evaluate and compare the therapeutic effects of prednisolo...
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Background: Sirolimus is immunosuppressive drug used to prevent rejection in kidney transplantation. Pulmonary problems are one of the serious complications which may be seen after administration of this drug and it is believed that it could be life threatening. Case Presentation: Here in this paper we presented a 49-years-old man with bronchiolit...
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Background: Chronic obstructive pulmonary disease (COPD) is a major health dilemma and cause of morbidity and mortality in either industrialized or developing countries and inhaled corticosteroids are widely used worldwide in these patients. In this systematic review, we aimed to analyze the effectiveness of these gents compared to placebo. Methods...
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Persistent post-infectious cough (PPC) is a cough that remains after a common cold or an upper respiratory tract infection for more than three weeks or perhaps for many months. Two of the suggested treatments for PPC are systemic steroid and honey plus coffee. The aim of this study was to evaluate and compare scientifically the therapeutic effects...
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Background and the purpose of the study Existing evidence confirms that no pharmacologic agent ameliorates the decline in the lung function or changes the prognosis of chronic obstructive pulmonary disease (COPD). We tried a critical combination therapy for management of COPD. Current or past smoker (passive or active) COPD patients with moderate t...
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Bronchiolitis obliterans (BO) is the main pulmonary involvement resulting from sulfur mustard (SM) gas exposure that was used against Iranian civilians and military forces during the Iran-Iraq war. The present study aimed to investigate the prevalence of gastro-esophageal reflux (GER) and gastric micro-aspiration in SM gas injured patients with chr...
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Iraq used chemical weapons against thousands of Iranian militaries and civilians. This study aimed to compare the chronic cutaneous side effects of exposure to sulfur mustard (SM) with nerve agents (NA). The study enrolled 154 SM exposed cases and 175 (NA) exposed cases. Presence of any late cutaneous manifestations was evaluated by a dermatologist...
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Invasive mucormycosis is a very rare infection after kidney transplantation. Here, we report 25 renal transplant recipients with mucormycosis; to our knowledge, this is the largest reported population of mucormycosis in these patients. In a retrospective study, we collected all kidney transplants with mucormycosis from 9 Transplant Centers of Iran...
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Exposure to sulfur mustard (SM) causes a variety of respiratory symptoms, such as chronic bronchitis and constrictive bronchiolitis. This study assessed the effectiveness of noninvasive positive-pressure ventilation, adjunct with 79:21 helium:oxygen instead of 79:21 air:oxygen, in 24 patients with a previous exposure to SM presenting with acute res...
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Introduction: Persistent postinfectious cough (PPC) is a cough that persists longer than 3 weeks or perhaps for many months after a common cold or an upper respiratory tract infection (URTI). PPC has poor response to routine treatment modalities, so it can be a vexing problem for the patient and the physician alike. Our hypothesis was that honey an...
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The purpose of this study was to examine whether the degree of air trapping in high resolution computed tomography (HRCT) of patients with histories of sulfur mustard gas exposure during suspended full expiration correlated with various parameters of the cardiopulmonary exercise test as the gold standard for assessment of pulmonary function. In thi...
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Sulfur mustard "bis (2-chlroethyl) sulphide" (SM) is a chemical warfare agent that remains a threat to human health. The aim of this study was to identify protein expression signature or biomarkers that reflect chronic lung damages induced by SM exposure. Prior to analysis, plasma was fractionated using ethanol precipitation. Using two dimensional...
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Occupational exposure to carbon, silica, and quartz particles are predisposing factors for bronchial anthracosis. In some cases anthracosis may be associated with mycobacterium tuberculosis. This study aims to investigate the clinical, radiographic, and bacteriologic findings in bronchial anthracosis patients and its association with tuberculosis....
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Previous pathological investigations have reported bronchiolitis obliterans (BO) as the major long-term sequela of exposure to sulfur mustard. In this study, we investigated whether high-resolution computed tomography (HRCT) could be used as a noninvasive imaging modality to differentiate between mustard lung (as a subtype of BO) and other respirat...
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Sulfur mustard is an alkylating agent that reacts with ocular, respiratory, cutaneous, and bone marrow tissues. Main late respiratory complications are chronic obstructive pulmonary disease, bronchiectasis, asthma, and bronchiolitis obliterans. The aim of the present study was to identify differentially expressed proteins in bronchoalveolar lavage...
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The reduced alpha1-antitrypsin (AAT) activities of some phenotypes have been suggested as contributing to the development of respiratory diseases. One hundred patients with respiratory disease following exposure to sulfur mustard were divided into two groups of 50 based on their respiratory symptoms and compared with a healthy control group. AAT ph...
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The aim of this study was to evaluate the effect of Bacille Calmette Guérin vaccination after long time on tuberculin skin test in adults, because the long-term effect of BCG vaccination is not known in Iran. We carried out a cross-sectional study on 464 on-duty soldiers in a systematic random selection in 2008. Purified protein derivative was inje...
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Administration of N-acetylcysteine may be effective in diseases caused by oxidative-antioxidative imbalance. We aimed to determine the effect administration for 4 months of N-acetylcysteine (1200 mg daily) on sulfur mustard-induced bronchiolitis obliterans in patients with normal pulmonary function test. In a double-blind clinical trial, 144 patien...
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The purpose of our study was to evaluate the late ocular, pulmonary, and cutaneous complications of mustards, 19 years after exposure in 600 patients of the city of Sardasht, Iran. In this case study, we evaluated 600 warfare patients aged 19 to 80 years whose mustard gas injury dated back to 19 years before evaluation in Sardasht. Our results show...
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Dyspnea is the hallmark symptom of some respiratory diseases such as chronic obstructive pulmonary disease and bronchiolitis and is a major reason for which these patients seek medical attention. We performed a randomized triple-blind controlled crossover clinical trial in which we compared the efficacy of inhaled furosemide (4 ml equal to 40 mg in...
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Recent studies have shown strong evidence that bronchiolitis obliterans is the major long-term sequelae of exposure to sulfur mustard (SM). This study is the first to examine the histopathologic spectrum of changes in a large number of surgical lung biopsies from patients exposed to SM. Fifteen patients with chronic respiratory disease from mustard...
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Introduction: Because of exposing to mustard gas a lot of chemical victims suffer from chronic lung disease (such as chronic bronchitis, bronchiolitis and bronchectasia) and hypersensivity of airways that there are different treatments for controlling symptoms. The aim of this survey is comparing the rate of clinical recovery and lungs function fin...
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Long-term prescription of N-acetyl cysteine (NAC) may be effective in diseases caused by active radicals of oxygen species. The aim of this study was to determine the effect of 2- and 4-month administration of NAC (1800 mg daily) on mustard induced bronchiolitis obliterans. In a double blind clinical trial, 144 patients with bronchiolitis obliteran...
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The aim of this study was to determine the occurrence of emphysema and accuracy of Pulmonary Function Test (PFT), comparing with chest High Resolution Computed Tomography (HRCT), in smokers with history of exposure to toxic fumes (Sulfur Mustard; SM). This was a cross sectional study (2003-2004) on 20 symptomatic smokers with mild SM exposure (Grou...
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Organ transplant recipients, on long-term graft preserving immunosuppressive therapy, are at increased risk for life threatening opportunistic fungal infections. In order to evaluate the incidence of invasive fungal infections (IFIs) and to identify the most common fungal pathogens, we conducted a retrospective study on 2410 ESRD cases undergone li...
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The association between severity of exposure to sulfur mustard (SM) and late respiratory complications is not clear. The aim of this study was to determine the presence of late pulmonary complications in patients with mild, moderate, and severe initial symptoms of sulfur mustard exposure. This was a retrospective cohort study on patients with mild,...
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Background: Tuberculosis is a major public health hazard. The tuberculin skin test is one of the diagnostic tools in this regard. Since BCG vaccination is performed during infancy in Iran, a positive tuberculin skin test (PPD) may confuse the physician. For this reason we performed this study on adults. Materials and Methods: A descriptive study wa...
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Introduction: Acute exacerbations of disease symptoms in patients with chronic obstructive pulmonary disease (COPD) often lead to hospitalization and impose a great financial burden on the health care system. Nonetheless, there is a paucity of data regarding the predictors of disease exacerbation in these patients. This study aimed to determine fac...
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Background: The purpose of this study was to calculate and compare the specificity and sensitivity of impulse oscillometry (IOS) as a new technique in the detection of airways dysfunction by means of a simple pulmonary function test in chemical warfare injured cases suffering from respiratory diseases. Methods: The study was performed prospectively...
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Intractable asthma is a challenging clinical problem. This study was conducted to determine whether a subset of patients with Intractable asthma may be misdiagnosed and have a form of bronchiolitis instead and also to determine the effectiveness of macrolide therapy in these patients. Seventy six patients with Intractable asthma were re-treated wit...
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Background: Generic and disease-specific health-related quality of life (HRQoL) questionnaires are commonly used in subjects with chronic obstructive pulmonary disease (COPD). However, it is not clear whether generic and disease-specific measures should be used in parallel, as they focus on different aspects of life. This study aimed to investigate...
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Introduction. The prevalence of active asthma in Iran is between 2.8%-3.8%. A lot of treatments exist for acute and chronic asthma. The goal of chronic asthma treatment is achieve to a condition without any symptoms with a good function of lung by using the lowest dose of drugs. The aim of this survey is comparing the rate of clinical recovery and...
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We examined the role of two regimens of combination inhaler therapy on amount of reversibility of chronic lung complications in mustard gas exposed patients. In a phase III, prospective, randomized clinical trial, 105 participants received either combination form of fluticasone propionate and salmetrol, 500/100 microg daily (group 1; n = 52) or bec...
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Tracheobronchomegaly (TBM) (Mounier-Kuhn syndrome) is dilatation of the trachea and major bronchi because of atrophy or absence of elastic fibers and smooth muscle cells. We present a case of TBM with normal pulmonary function test (PFT). The patient was a 37-year-old man with increasing productive cough and without fever, wheezes, chest pain, weig...
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Scientific articles are indicators of research interest and efforts in every country. The aim of the current study is to describe the characteristics of the transplantation-related research efforts with respect to the domestic published works in Iran between 1993 and 2003. In a descriptive design, we searched IranMedex (Iranian database for indexin...
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Although some studies have described rehospitalization after transplantation, few have focused on risk factors and consequences of prolonged hospital stay. Our goal was to determine the causes, risk factors, and outcomes of prolonged rehospitalizations after renal transplantation. In this retrospective study, 574 randomly selected rehospitalization...
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This is a report of 7 cases of mucormycosis infections in patients who had undergone transplantation and been admitted in the kidney transplant centre of Baqiyatallah Hospital in Tehran, Iran, from 2002 to 2005. We retrospectively reviewed the hospital records for demographic data, symptoms, diagnostic techniques and outcomes. Five patients were ma...
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A unique chronic obstructive pulmonary disease (COPD), provisionally called "mustard lung", which occurs as a late complication of sulfur mustard (SM) exposure among SM-exposed Iranians, is presently poorly characterized. This investigation evaluates p53 immunoreactivity in bronchial epithelium of individuals with histories of tobacco use and/or SM...
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Background: There are several reports on the association between body mass index (BMI) and depression in the general population and in patients with some chronic diseases. However, despite the established effects of weight changes and depression on the outcomes of patients suffering from respiratory disorders, little data exists on the topic in rel...
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Background: The quality of life in patients with chronic obstructive pulmonary disease (COPD) is associated with poor pulmonary function, respiratory symptoms, incapacity to perform daily activities, as well as mental and cognitive disorders. Although there exists some evidence regarding the effect of socioeconomic status on the quality of life in...
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Hemoptysis is one of the mustard exposed patients' symptoms. Data from one study on survivors of Sulfur Mustard attacks during World War I had revealed an increased rate of lung cancer among them. Aim of this study was to determine lung HRCT and fluorescence bronchoscopy findings in mustard exposed patients with hemoptysis. In this cross-sectional...
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Mustard gas primarily affects the eyes, skin, and particularly the respiratory tract. Tracheobronchomalacia (TBM) and air trapping are often observed in high-resolution computerized tomography (HRCT) scans of the chest of mustard gas-exposed patients. To examine the frequency and severity of TBM in a group of Iranian wartime mustard gas-exposed vic...
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Considering the undefinite nature of lung pathology in patients exposed to sulfur mustard (SM) many years after exposure, we conducted this study to document and quantify lung disease in this setting. In a cross sectional study, we selected 23 patients exposed to SM gas approximately 14 years ago during the Iran-Iraq war (1980-1988). We studied the...
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Bronchiolitis has been known to be among the main the pathological features of lung lesions in Mustard Gas (MG) exposed patients. The purpose of this research was to evaluate the efficacy of interferon gamma-1b on the lung function in MG exposed patients with bronchiolitis. Thirty-six bronchiolitis patients, whose lung lesion had been diagnosed thr...
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Chronic parotiditis is a rare disease of the parotid glands. Both infectious (e.g. tuberculosis) and non-infectious causes (e.g. sarcoidosis, autoimmune diseases, malignancy and duct stones) have been enumerated for this condition. Primary tuberculous parotiditis is a rare disease. It was diagnosed in a 20-year-old soldier after obtaining a biopsy...
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Chronic bronchitis is the most frequent late respiratory disease among Iranians exposed to mustard gas during the Iraq-Iran war. The aim of this study was to investigate efficacy of oral and intravenous corticosteroid therapy in improving lung function in mustard gas induced chronic bronchitis patients. 65 mustard gas-exposed chronic bronchitis pat...
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Bronchiolitis has been known as one of the pathological features of lung injuries in mustard gas exposed patients The purpose of this research was to evaluate the efficacy of interferon gamma-1b on the lung function in mustard gas exposed patients with bronchiolitis. In multicenter research interferon gamma-1b was effective in pulmonary fibrosis w...
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Over 100,000 Iranian war veterans suffer from chronic effects of mustard gas exposure. Sulfur mustard was used by Iraq during the Iraqi-imposed war on Iran (between 1980 and 1988). The major complaints of these patients are mild interstitial fibrosis and bronchiolitis. We aimed to determine the state of fibrosis progression and assessed transformin...
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Sulfur mustard inhalation leads to different respiratory complications. In this article, we describe late stenotic effects of mustard gas inhalation on major airways. About 15 yr after exposure, suspect cases suffering from severe respiratory disorders underwent complete workup for central airway stenosis. Patients were evaluated with bronchoscopy...
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Pulmonary complications are known to occur in over half of the patients exposed to sulfur mustard (SM). Chemical weapons of mass destruction (WMD) including SM were used by Iraq during Iran-Iraq war between 1983 and 1989. We undertook this study to evaluate the chest high resolution computerized tomography (HRCT) as a diagnostic tool in patients wi...
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Victims of sulfur mustard (SM) gas exposure experience different types of chronic pulmonary disease, manifested as cough, sputum production, and dyspnea. Conventional therapies (eg, immunosuppressive drugs, corticosteroids) have not been effective in these patients. This study was carried out to determine the efficacy of concomitant administration...
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It is well documented that inhalation of sulfur mustard causes injury of the respiratory system. While all of the reports and surveys thoroughly document long-term pulmonary effects after significant exposure to mustard, there is no direct evidence that addresses the issue of long-term respiratory effects in individuals who were exposed to very low...
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Among the extrapulmonary presentations of tuberculosis, pleural tuberculosis is the second most frequent. Failure to diagnose and treat pleural tuberculosis can result in progressive disease with involvement of other organs in as many as 65% of patients. Conventional methods such as direct examination of pleural fluid, pleural fluid culture and ple...